HUE063984T2 - Hidroklorid só forma az EZH2 gátlásához - Google Patents
Hidroklorid só forma az EZH2 gátlásáhozInfo
- Publication number
- HUE063984T2 HUE063984T2 HUE14854272A HUE14854272A HUE063984T2 HU E063984 T2 HUE063984 T2 HU E063984T2 HU E14854272 A HUE14854272 A HU E14854272A HU E14854272 A HUE14854272 A HU E14854272A HU E063984 T2 HUE063984 T2 HU E063984T2
- Authority
- HU
- Hungary
- Prior art keywords
- salt form
- hydrochloride salt
- ezh2 inhibition
- ezh2
- inhibition
- Prior art date
Links
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical group N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 title 1
- 101150090105 Ezh2 gene Proteins 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361891786P | 2013-10-16 | 2013-10-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE063984T2 true HUE063984T2 (hu) | 2024-02-28 |
Family
ID=52828660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE14854272A HUE063984T2 (hu) | 2013-10-16 | 2014-10-15 | Hidroklorid só forma az EZH2 gátlásához |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US10040782B2 (hu) |
| EP (2) | EP3057962B1 (hu) |
| JP (2) | JP6608812B2 (hu) |
| KR (1) | KR102142177B1 (hu) |
| CN (1) | CN105829302B (hu) |
| AU (2) | AU2014337300B2 (hu) |
| CA (1) | CA2925889C (hu) |
| CL (1) | CL2016000866A1 (hu) |
| DK (1) | DK3057962T3 (hu) |
| EA (1) | EA038869B1 (hu) |
| ES (1) | ES2960953T3 (hu) |
| FI (1) | FI3057962T3 (hu) |
| HU (1) | HUE063984T2 (hu) |
| IL (1) | IL244787B (hu) |
| LT (1) | LT3057962T (hu) |
| MA (1) | MA38949A1 (hu) |
| MX (1) | MX2016004703A (hu) |
| MY (1) | MY179802A (hu) |
| PE (1) | PE20161273A1 (hu) |
| PL (1) | PL3057962T3 (hu) |
| PT (1) | PT3057962T (hu) |
| SG (2) | SG10201901977XA (hu) |
| SI (1) | SI3057962T1 (hu) |
| WO (1) | WO2015057859A1 (hu) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3184523T1 (sl) | 2012-04-13 | 2020-04-30 | Epizyme Inc | N-((4,6 dimetil-2-okso-L,2-dihidropiridin-3-IL)metil)-5-(etil (tetrahidro-2H-piran-4-IL)amino)-4-metil-4'-(morfolinometil)-(L, 1'- bifen IL)-3-karboksamid hidrobromid za uporabo pri zdravljenju celične proliferativne motnje hematološkega sistema |
| HUE063984T2 (hu) | 2013-10-16 | 2024-02-28 | Epizyme Inc | Hidroklorid só forma az EZH2 gátlásához |
| US20160303135A1 (en) | 2013-12-06 | 2016-10-20 | Epizyme, Inc. | Combination therapy for treating cancer |
| SG10201811128RA (en) | 2014-06-17 | 2019-01-30 | Epizyme Inc | Ezh2 inhibitors for treating lymphoma |
| WO2016061507A1 (en) | 2014-10-16 | 2016-04-21 | Epizyme, Inc. | Method for treating cancer |
| CN107249591B (zh) * | 2014-11-17 | 2024-01-30 | Epizyme股份有限公司 | 固体药物配制品及其制备方法 |
| SG10201902664RA (en) | 2015-04-20 | 2019-04-29 | Epizyme Inc | Combination therapy for treating cancer |
| AU2016275051A1 (en) | 2015-06-10 | 2017-12-07 | Epizyme, Inc. | EZH2 inhibitors for treating lymphoma |
| JP2018525414A (ja) | 2015-08-24 | 2018-09-06 | エピザイム，インコーポレイティド | 癌を処置するための方法 |
| WO2017132518A1 (en) | 2016-01-29 | 2017-08-03 | Epizyme, Inc. | Combination therapy for treating cancer |
| EP3464643A4 (en) | 2016-06-01 | 2020-04-01 | Epizyme Inc | USE OF EZH2 INHIBITORS FOR THE TREATMENT OF CANCER |
| US11147819B2 (en) | 2016-06-17 | 2021-10-19 | Epizyme, Inc. | EZH2 inhibitors for treating cancer |
| TW201831181A (zh) | 2017-01-19 | 2018-09-01 | 日商第一三共股份有限公司 | 用以用於治療ｈｔｌｖ－１相關脊髓病之醫藥組成物 |
| US11642346B2 (en) | 2017-03-31 | 2023-05-09 | Epizyme, Inc. | Combination therapy for treating cancer |
| CN110944628A (zh) | 2017-06-02 | 2020-03-31 | Epizyme股份有限公司 | 使用ezh2抑制剂治疗癌症 |
| JP7399079B2 (ja) | 2017-09-05 | 2023-12-15 | エピザイム，インコーポレイティド | 癌を処置するための併用療法 |
| WO2020011607A1 (en) | 2018-07-09 | 2020-01-16 | Fondation Asile Des Aveugles | Inhibition of prc2 subunits to treat eye disorders |
| CN114555112A (zh) | 2019-08-22 | 2022-05-27 | 朱诺治疗学股份有限公司 | T细胞疗法和zeste增强子同源物2(ezh2)抑制剂的组合疗法及相关方法 |
| AU2023262308A1 (en) | 2022-04-27 | 2024-10-03 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate with ezh1 and/or ezh2 inhibitor |
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| CA2155662A1 (en) | 1993-12-27 | 1995-07-06 | Fumihiro Ozaki | Anthranilic acid derivative |
| DE19516776A1 (de) | 1995-05-10 | 1996-11-14 | Boehringer Ingelheim Int | Chromatin-Regulatorgene |
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| SI3184523T1 (sl) | 2012-04-13 | 2020-04-30 | Epizyme Inc | N-((4,6 dimetil-2-okso-L,2-dihidropiridin-3-IL)metil)-5-(etil (tetrahidro-2H-piran-4-IL)amino)-4-metil-4'-(morfolinometil)-(L, 1'- bifen IL)-3-karboksamid hidrobromid za uporabo pri zdravljenju celične proliferativne motnje hematološkega sistema |
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| US10150764B2 (en) | 2013-07-19 | 2018-12-11 | Epizyme, Inc. | Substituted benzene compounds |
| HUE063984T2 (hu) | 2013-10-16 | 2024-02-28 | Epizyme Inc | Hidroklorid só forma az EZH2 gátlásához |
-
2014
- 2014-10-15 HU HUE14854272A patent/HUE063984T2/hu unknown
- 2014-10-15 WO PCT/US2014/060724 patent/WO2015057859A1/en active Application Filing
- 2014-10-15 AU AU2014337300A patent/AU2014337300B2/en active Active
- 2014-10-15 PL PL14854272.3T patent/PL3057962T3/pl unknown
- 2014-10-15 MX MX2016004703A patent/MX2016004703A/es active IP Right Grant
- 2014-10-15 PT PT148542723T patent/PT3057962T/pt unknown
- 2014-10-15 MY MYPI2016000542A patent/MY179802A/en unknown
- 2014-10-15 KR KR1020167011534A patent/KR102142177B1/ko active IP Right Grant
- 2014-10-15 EA EA201690650A patent/EA038869B1/ru unknown
- 2014-10-15 EP EP14854272.3A patent/EP3057962B1/en active Active
- 2014-10-15 CN CN201480056428.6A patent/CN105829302B/zh active Active
- 2014-10-15 SG SG10201901977XA patent/SG10201901977XA/en unknown
- 2014-10-15 PE PE2016000506A patent/PE20161273A1/es unknown
- 2014-10-15 SG SG11201602269QA patent/SG11201602269QA/en unknown
- 2014-10-15 JP JP2016519378A patent/JP6608812B2/ja active Active
- 2014-10-15 CA CA2925889A patent/CA2925889C/en active Active
- 2014-10-15 EP EP23203529.5A patent/EP4324525A3/en active Pending
- 2014-10-15 DK DK14854272.3T patent/DK3057962T3/da active
- 2014-10-15 MA MA38949A patent/MA38949A1/fr unknown
- 2014-10-15 SI SI201432051T patent/SI3057962T1/sl unknown
- 2014-10-15 LT LTEPPCT/US2014/060724T patent/LT3057962T/lt unknown
- 2014-10-15 FI FIEP14854272.3T patent/FI3057962T3/fi active
- 2014-10-15 ES ES14854272T patent/ES2960953T3/es active Active
- 2014-10-15 US US15/029,848 patent/US10040782B2/en active Active
-
2016
- 2016-03-28 IL IL244787A patent/IL244787B/en unknown
- 2016-04-13 CL CL2016000866A patent/CL2016000866A1/es unknown
-
2018
- 2018-06-05 US US16/000,539 patent/US10710987B2/en active Active
- 2018-12-11 JP JP2018231817A patent/JP2019052181A/ja active Pending
-
2019
- 2019-04-02 AU AU2019202246A patent/AU2019202246A1/en not_active Abandoned
-
2020
- 2020-06-03 US US16/891,427 patent/US20210017163A1/en active Pending
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