HRP20240815T1 - Anti-c5 antitijela i njihove upotrebe - Google Patents
Anti-c5 antitijela i njihove upotrebe Download PDFInfo
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- HRP20240815T1 HRP20240815T1 HRP20240815TT HRP20240815T HRP20240815T1 HR P20240815 T1 HRP20240815 T1 HR P20240815T1 HR P20240815T T HRP20240815T T HR P20240815TT HR P20240815 T HRP20240815 T HR P20240815T HR P20240815 T1 HRP20240815 T1 HR P20240815T1
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- antibody
- antigen
- binding fragment
- disease
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- 239000000427 antigen Substances 0.000 claims 12
- 102000036639 antigens Human genes 0.000 claims 12
- 108091007433 antigens Proteins 0.000 claims 12
- 239000012634 fragment Substances 0.000 claims 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000035913 Atypical hemolytic uremic syndrome Diseases 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 102000000588 Interleukin-2 Human genes 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 208000005777 Lupus Nephritis Diseases 0.000 claims 2
- 208000000733 Paroxysmal Hemoglobinuria Diseases 0.000 claims 2
- 102100036050 Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Human genes 0.000 claims 2
- 206010063897 Renal ischaemia Diseases 0.000 claims 2
- 206010064930 age-related macular degeneration Diseases 0.000 claims 2
- 239000003146 anticoagulant agent Substances 0.000 claims 2
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- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 201000003045 paroxysmal nocturnal hemoglobinuria Diseases 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
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- 229940124599 anti-inflammatory drug Drugs 0.000 claims 1
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- 239000001961 anticonvulsive agent Substances 0.000 claims 1
- 239000002220 antihypertensive agent Substances 0.000 claims 1
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- 208000027134 non-immunoglobulin-mediated membranoproliferative glomerulonephritis Diseases 0.000 claims 1
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- 230000002265 prevention Effects 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 201000008171 proliferative glomerulonephritis Diseases 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
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Classifications
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- C07—ORGANIC CHEMISTRY
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
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- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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Claims (12)
1. Antitijelo, ili njegov fragment koji vezuje antigen, koje se specifično vezuje za protein faktora komplementa 5 (C5), pri čemu antitijelo ili njegov fragment koji vezuje antigen sadrži varijabilnu regiju teškog lanca (HCVR) koji sadrži aminokiselinsku sekvencu navedenu u SEQ ID NO: 98 i varijabilnu regiju lakog lanca (LCVR) koja sadrži aminokiselinsku sekvencu navedenu u SEQ ID NO: 106.
2. Antitijelo ili njegov fragment koji vezuje antigen prema patentnom zahtjevu 1, koji sadrže teški lanac i laki lanac, pri čemu teški lanac sadrži aminokiselinsku sekvencu navedenu u SEQ ID NO: 353 i/ili laki lanac sadrži set aminokiselinskih sekvenci naveden u SEQ ID NO: 354.
3. Antitijelo ili njegov fragment koji vezuje antigen prema patentnom zahtjevu 1 ili patentnom zahtjevu 2, koji sadrže teški lanac i laki lanac, pri čemu teški lanac sadrži aminokiselinsku sekvencu navedenu u SEQ ID NO: 353 i laki lanac sadrži aminokiselinsku sekvencu navedenu u SEQ ID NO: 354.
4. Antitijelo, ili njegov fragment koji vezuje antigen, prema bilo kojem od patentnih zahtjeva 1-3, koje je potpuna molekula antitijela.
5. Farmaceutski sastav koji sadrži antitijelo ili njegov fragment koji vezuje antigen prema bilo kojem od patentnih zahtjeva 1-4 i farmaceutski prihvatljiv nosač ili razblaživač.
6. Uređaj za isporuku tipa olovke za višekratnu upotrebu koji sadrži farmaceutski sastav prema patentnom zahtjevu 5.
7. Uređaj za isporuku tipa autoinjektora koji sadrži farmaceutski sastav prema patentnom zahtjevu 5.
8. Izolirana polinukleotidna molekula koja sadrži nukleotidnu sekvencu koja kodira HCVR antitijela ili njen fragment koji vezuje antigen, koji su kao što je navedeno u bilo kojem od patentnih zahtjeva 1-4, i nukleotidnu sekvencu koja kodira LCVR antitijela ili njen fragment koji vezuje antigen, koji su kao što je navedeno u bilo kojem od patentnih zahtjeva 1-4.
9. Rekombinirajući ekspresivni vektor koji sadrži polinukleotidnu molekulu prema patentnom zahtjevu 8.
10. Stanica koja sadrži rekombinirajući ekspresivni vektor prema patentnom zahtjevu 9.
11. Antitijelo ili njegov fragment koji vezuje antigen prema bilo kojem od patentnih zahtjeva 1-4, za upotrebu u postupku prevencije, liječenja ili ublažavanja najmanje jednog simptoma ili indikacije bolesti ili poremećaja izabranih iz grupe koju čine atipičan hemolitično-uremični sindrom (aHUS), paroksizmalna noćna hemoglobinurija (PNH), starosna makularna degeneracija, geografska atrofija, uveitis, optički neuromijelitis, multipla skleroza, moždani udar, Guillain-Barreov sindrom, traumatska povreda mozga, Parkinsonova bolest, poremećaj neodgovarajuće ili nepoželјne aktivacije sistema komplementa, komplikacija hemodijalize, hiperakutno odbacivanje alotransplantata, odbacivanje ksenotransplantata, toksičnost inducirana interleukinom-2 tijekom terapije sa IL-2, inflamatorni poremećaj, inflamacija u autoimunoj bolesti, Kronova bolest, sindrom respiratornog distresa kod odraslih, termička povreda, opekotina, promrzlina, reperfuzjsko stanje nakon ishemije, infarkt miokarda, sindrom kapilarnog curenja, pretilost, dijabetes, Alzheimerova bolest, shizofrenija, epilepsija, ateroskleroza, vaskulitis, bulozni pemfigoid, C3 glomerulopatija, membranski proliferativni glomerulonefritis, dijabetična nefropatija, Alportov sindrom, progresivna bubrežna insuficijencija, proteinurijska bolest bubrega, renalna ishemijsko-reperfuzijska povreda, lupusni nefritis, balonska angioplastika, sindrom indukovan ugradnjom pumpe kod kardiopulmonarnog bypassa ili renalnog bypassa, renalna ishemija, reperfuzija mezenterične arterije nakon rekonstrukcije aorte, infektivna bolest, sepsa, poremećaj imunskog kompleksa, autoimuna bolest, renalni poremećaj, reumatoidni artritis, sistemski eritematozni lupus (SLE), SLE nefritis, proliferativni nefritis, hemolitička anemija, astma, kronična opstruktivna bolest pluća (HOPB), emfizem, plućna embolija, infarkt pluća, upala pluća i mijastenija gravis.
12. Antitijelo ili njegov fragment koji vezuje antigen za upotrebu prema patentnom zahtjevu 11, pri čemu:
(a) postupak liječenja je profilaktički;
(b) postupak obuhvaća davanje antitijela ili njegovog fragmenta koji vezuje antigen u kombinaciji s drugim terapijskim agensom; opcionalno, pri čemu je drugi terapijski agens izabran iz grupe koju čine antikoagulans, anti-inflamatorni lijek, antihipertenziv, imunosupresivni agens, agens za snižavanje lipida, anti-CD20 agens kao što je rituksimab, anti-TNF agens kao što je infliksimab, antiepileptik, inhibitor C3, drugo anti-C5 antitijelo i antitrombotički agens; ili
(c) postupak obuhvaća davanje antitijela ili njegovog fragmenta koji vezuje antigen subkutano, intravenski, intradermalno, intraperitonealno, oralno, intramuskularno ili intrakranijalno.
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| EP17731785.6A EP3468990B1 (en) | 2016-06-14 | 2017-06-13 | Anti-c5 antibodies and uses thereof |
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