HRP20230424T1 - Postupci i pripravci za prirodnoubilačke stanice - Google Patents
Postupci i pripravci za prirodnoubilačke stanice Download PDFInfo
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- HRP20230424T1 HRP20230424T1 HRP20230424TT HRP20230424T HRP20230424T1 HR P20230424 T1 HRP20230424 T1 HR P20230424T1 HR P20230424T T HRP20230424T T HR P20230424TT HR P20230424 T HRP20230424 T HR P20230424T HR P20230424 T1 HRP20230424 T1 HR P20230424T1
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- Prior art keywords
- cells
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- plasma
- effector agent
- membrane vesicle
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- 210000000822 natural killer cell Anatomy 0.000 title claims 18
- 239000000203 mixture Substances 0.000 title claims 4
- 238000000034 method Methods 0.000 title claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 10
- 239000012636 effector Substances 0.000 claims 9
- 210000000170 cell membrane Anatomy 0.000 claims 7
- 102100030704 Interleukin-21 Human genes 0.000 claims 4
- 108010074108 interleukin-21 Proteins 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 102100036008 CD48 antigen Human genes 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 2
- -1 41BBL Proteins 0.000 claims 1
- 108010038940 CD48 Antigen Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 101000716130 Homo sapiens CD48 antigen Proteins 0.000 claims 1
- 102100022339 Integrin alpha-L Human genes 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 108020003285 Isocitrate lyase Proteins 0.000 claims 1
- 108010064548 Lymphocyte Function-Associated Antigen-1 Proteins 0.000 claims 1
- 102100030301 MHC class I polypeptide-related sequence A Human genes 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive effect Effects 0.000 claims 1
- 230000000735 allogeneic effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000010445 mica Substances 0.000 claims 1
- 229910052618 mica group Inorganic materials 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K39/4613—
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- A61K39/464499—
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
- C12N2500/80—Undefined extracts from animals
- C12N2500/84—Undefined extracts from animals from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2321—Interleukin-21 (IL-21)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Claims (12)
1. Pripravak koji sadrži plazma-membransku vezikulu pročišćenu iz stanica hraniteljica NK stanica, naznačen time, što su stanice hraniteljice NK stanica ozračene autologne ili alogene mononuklearne stanice periferne krvi (PBMC), RPMI8866, HFWT, K562, ili EBV-LCL, pri čemu plazma-membranska vezikula sadrži najmanje jedno efektorsko sredstvo za NK stanice, i pri čemu je najmanje jedno efektorsko sredstvo za NK stanice IL-21 ili IL-15.
2. Pripravak prema patentnom zahtjevu 1, naznačen time, što plazma-membranska vezikula sadrži još i najmanje jedno dodatno efektorsko sredstvo za NK stanice, pri čemu se najmanje jedno dodatno efektorsko sredstvo za NK stanice bira između citokina, adhezivnog molekula, i sredstva koje aktivira NK stanice.
3. Pripravak prema patentnom zahtjevu 2, naznačen time, što se najmanje jedno dodatno efektorsko sredstvo za NK stanice bira između IL-2, 41BBL, IL-12, IL-18, MICA, 2B4, LFA-1 i BCM1/SLAMF2.
4. Pripravak prema bilo kojem od patentnih zahtjeva 1-3, naznačen time, što je najmanje jedno efektorsko sredstvo za NK stanice IL21 i plazma-membranska vezikula sadrži još i najmanje jedno ili dva dodatna efektorska sredstva za NK stanice koja se biraju između IL-15 i 41BBL.
5. Pripravak prema bilo kojem od patentnih zahtjeva 1 do 3, naznačen time, što je najmanje jedno efektorsko sredstvo za NK stanice IL-15 i plazma-membranska vezikula sadrži još i 41BBL kao najmanje jedno dodatno efektorsko sredstvo za NK stanice.
6. Pripravak prema patentnom zahtjevu 4, naznačen time, što plazma-membranska vezikula sadrži za membranu vezani IL-21 i 41BBL.
7. Pripravak prema patentnom zahtjevu 6, naznačen time, što su stanice hraniteljice stanice K562 transfektirane za membranu vezanim IL-21 i 41BBL.
8. Uporaba pripravka prema bilo kojem od patentnih zahtjeva 1-7 za stimulaciju ili ekspanziju NK stanica u populaciji NK stanica in vitro, primjenom pripravka na populaciji NK stanica in vitro.
9. Postupak za proizvodnju populacije ekspandiranih NK stanica, naznačen time, što uključuje dovođenje u kontakt prve populacije NK stanica in vitro s pripravkom prema bilo kojem od patentnih zahtjeva 1-7.
10. Pripravak prema bilo kojem od patentnih zahtjeva 1-7 za upotrebu u liječenju raka, virusnih infekcija, bolesti presatka protiv primatelja, ili multiple skleroze.
11. Pripravak za uporabu prema patentnom zahtjevu 10, pri čemu je uporaba liječenje raka, i pri čemu se pripravak primjenjuje u kombinaciji s najmanje jednim terapijskim sredstvom za rak.
12. Pripravak prema bilo kojem od patentnih zahtjeva 1-7, naznačen time, što plazma-membranska vezikula okružuje mikročesticu.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261665591P | 2012-06-28 | 2012-06-28 | |
| EP19175670.9A EP3578201B1 (en) | 2012-06-28 | 2013-06-28 | Methods and compositions for natural killer cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20230424T1 true HRP20230424T1 (hr) | 2023-07-07 |
Family
ID=49783918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20230424TT HRP20230424T1 (hr) | 2012-06-28 | 2013-06-28 | Postupci i pripravci za prirodnoubilačke stanice |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US9623082B2 (hr) |
| EP (3) | EP3578201B1 (hr) |
| AU (4) | AU2013282353B2 (hr) |
| CA (1) | CA2877968A1 (hr) |
| DK (1) | DK3578201T3 (hr) |
| ES (1) | ES2943932T3 (hr) |
| FI (1) | FI3578201T3 (hr) |
| HR (1) | HRP20230424T1 (hr) |
| HU (1) | HUE061931T2 (hr) |
| LT (1) | LT3578201T (hr) |
| PL (1) | PL3578201T3 (hr) |
| PT (1) | PT3578201T (hr) |
| RS (1) | RS64172B1 (hr) |
| SG (2) | SG10201610915XA (hr) |
| SI (1) | SI3578201T1 (hr) |
| WO (1) | WO2014005072A1 (hr) |
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| EP2824112B1 (en) * | 2013-07-10 | 2016-12-21 | Miltenyi Biotec GmbH | Method for inducing proliferation of Natural Killer cells by mobile nanomatrices |
| EP3143134B1 (en) | 2014-05-15 | 2020-10-28 | National University of Singapore | Modified natural killer cells and uses thereof |
| SG11201703397UA (en) * | 2014-10-27 | 2017-05-30 | Univ Central Florida Res Found | Methods and compositions for natural killer cells |
| EP3138905A1 (en) * | 2015-09-04 | 2017-03-08 | Miltenyi Biotec GmbH | Method for natural killer cell expansion |
| WO2017180587A2 (en) | 2016-04-11 | 2017-10-19 | Obsidian Therapeutics, Inc. | Regulated biocircuit systems |
| CN118453850A (zh) * | 2016-10-05 | 2024-08-09 | 弗罗里达中央大学研究基金会 | 涉及nk细胞和抗pdl1癌症治疗的方法和组合物 |
| US10300089B2 (en) * | 2016-11-08 | 2019-05-28 | University Of Central Florida Research Foundation, Inc. | Methods for high scale therapeutic production of memory NK cells |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| WO2018182511A1 (en) | 2017-03-27 | 2018-10-04 | National University Of Singapore | Stimulatory cell lines for ex vivo expansion and activation of natural killer cells |
| WO2018183385A1 (en) | 2017-03-27 | 2018-10-04 | National University Of Singapore | Truncated nkg2d chimeric receptors and uses thereof in natural killer cell immunotherapy |
| AU2018273963B2 (en) * | 2017-05-25 | 2023-07-20 | University Of Central Florida Research Foundation, Inc. | Novel oncolytic viruses for sensitizing tumor cells to killing by natural killer cells |
| CA3089853A1 (en) | 2018-02-01 | 2019-08-08 | Nkmax Co., Ltd. | Method of producing natural killer cells and composition for treating cancer |
| TW202000214A (zh) * | 2018-02-21 | 2020-01-01 | 美國德克薩斯大學系統評議委員會 | 通用抗原呈現細胞及其用途 |
| US20220403001A1 (en) | 2018-06-12 | 2022-12-22 | Obsidian Therapeutics, Inc. | Pde5 derived regulatory constructs and methods of use in immunotherapy |
| CN109627342B (zh) * | 2018-12-10 | 2022-12-06 | 苏州近岸蛋白质科技股份有限公司 | 应用于nk细胞培养的蛋白质、培养基配方组合及制备方法 |
| EP3894011A1 (en) | 2018-12-11 | 2021-10-20 | Obsidian Therapeutics, Inc. | Membrane bound il12 compositions and methods for tunable regulation |
| MX2021008772A (es) * | 2019-01-24 | 2021-09-21 | Univ Central Florida Res Found Inc | Composiciones y metodos para la estimulacion de celulas natural killer. |
| WO2020160009A1 (en) * | 2019-01-28 | 2020-08-06 | Rhode Island Council On Postsecondary Education | Phlip® targeted delivery of potent cytotoxic compounds |
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| MX2021015097A (es) | 2019-06-12 | 2022-04-01 | Obsidian Therapeutics Inc | Composiciones de ca2 y metodos para regulación ajustable. |
| US20220267398A1 (en) | 2019-06-12 | 2022-08-25 | Obsidian Therapeutics, Inc. | Ca2 compositions and methods for tunable regulation |
| WO2020264043A1 (en) * | 2019-06-25 | 2020-12-30 | City Of Hope | Pdl1 positive nk cell cancer treatment |
| CN112391349B (zh) * | 2019-08-19 | 2023-05-23 | 刘韬 | 滋养层细胞株及其制备方法和体外诱导扩增nk细胞的方法 |
| WO2021040736A1 (en) | 2019-08-30 | 2021-03-04 | Obsidian Therapeutics, Inc. | Tandem cd19 car-based compositions and methods for immunotherapy |
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| WO2021188974A1 (en) * | 2020-03-20 | 2021-09-23 | Orgenesis Inc. | Ribonucleases for treating viral infections |
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| BRPI0821658B8 (pt) * | 2007-12-14 | 2021-05-25 | Novo Nordisk As | anticorpo monoclonal humano ou um fragmento de ligação ao antígeno do mesmo que se liga a hnkg2d e seus usos |
| WO2010071836A1 (en) * | 2008-12-19 | 2010-06-24 | Inserm | Il-15 mediated nk and t cell maturation |
| AR083044A1 (es) * | 2010-09-27 | 2013-01-30 | Regeneron Pharma | Anticuerpos anti-cd48 y usos de los mismos |
| US20140234320A1 (en) * | 2011-06-20 | 2014-08-21 | La Jolla Institute For Allergy And Immunology | Modulators of 4-1bb and immune responses |
| US9844582B2 (en) * | 2012-05-22 | 2017-12-19 | Massachusetts Institute Of Technology | Synergistic tumor treatment with extended-PK IL-2 and therapeutic agents |
| WO2013175237A1 (en) | 2012-05-24 | 2013-11-28 | Ucl Business Plc | Composition comprising a cd2 ligation agent and a nkg2d ligation agent |
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2013
- 2013-06-28 PL PL19175670.9T patent/PL3578201T3/pl unknown
- 2013-06-28 HU HUE19175670A patent/HUE061931T2/hu unknown
- 2013-06-28 SI SI201332041T patent/SI3578201T1/sl unknown
- 2013-06-28 CA CA2877968A patent/CA2877968A1/en active Pending
- 2013-06-28 FI FIEP19175670.9T patent/FI3578201T3/fi active
- 2013-06-28 PT PT191756709T patent/PT3578201T/pt unknown
- 2013-06-28 HR HRP20230424TT patent/HRP20230424T1/hr unknown
- 2013-06-28 EP EP19175670.9A patent/EP3578201B1/en active Active
- 2013-06-28 RS RS20230329A patent/RS64172B1/sr unknown
- 2013-06-28 EP EP23168385.5A patent/EP4279579A3/en active Pending
- 2013-06-28 LT LTEP19175670.9T patent/LT3578201T/lt unknown
- 2013-06-28 ES ES19175670T patent/ES2943932T3/es active Active
- 2013-06-28 SG SG10201610915XA patent/SG10201610915XA/en unknown
- 2013-06-28 US US14/410,787 patent/US9623082B2/en active Active
- 2013-06-28 AU AU2013282353A patent/AU2013282353B2/en active Active
- 2013-06-28 WO PCT/US2013/048678 patent/WO2014005072A1/en active Application Filing
- 2013-06-28 SG SG11201408697QA patent/SG11201408697QA/en unknown
- 2013-06-28 EP EP13809630.0A patent/EP2866834B1/en active Active
- 2013-06-28 DK DK19175670.9T patent/DK3578201T3/da active
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2017
- 2017-04-17 US US15/489,460 patent/US10463715B2/en active Active
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2018
- 2018-09-21 US US16/138,095 patent/US10874715B2/en active Active
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2019
- 2019-01-25 AU AU2019200525A patent/AU2019200525B2/en active Active
- 2019-11-04 US US16/672,949 patent/US11617781B2/en active Active
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2021
- 2021-04-21 AU AU2021202439A patent/AU2021202439B2/en active Active
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2023
- 2023-03-08 US US18/118,941 patent/US20230321191A1/en active Pending
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2024
- 2024-12-02 AU AU2024267081A patent/AU2024267081A1/en active Pending
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