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HRP20220455T1 - Modificirane aminokiseline koje sadrže azid grupu - Google Patents

Modificirane aminokiseline koje sadrže azid grupu Download PDF

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Publication number
HRP20220455T1
HRP20220455T1 HRP20220455TT HRP20220455T HRP20220455T1 HR P20220455 T1 HRP20220455 T1 HR P20220455T1 HR P20220455T T HRP20220455T T HR P20220455TT HR P20220455 T HRP20220455 T HR P20220455T HR P20220455 T1 HRP20220455 T1 HR P20220455T1
Authority
HR
Croatia
Prior art keywords
formula
polypeptide
conjugate
compound
image
Prior art date
Application number
HRP20220455TT
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English (en)
Inventor
Ryan STAFFORD
Wenjin Yang
Christopher D. Thanos
Original Assignee
Sutro Biopharma, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sutro Biopharma, Inc. filed Critical Sutro Biopharma, Inc.
Publication of HRP20220455T1 publication Critical patent/HRP20220455T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C247/04—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/14—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)

Claims (7)

1. Postupak proizvodnje konjugata, koji obuhvaća stupanje u kontakt dijela od značaja povezanog sa alkinom, koji po izboru sadrži vezujući segment između alkina i dijela od značaja, pri čemu dio od značaja je ugljikohidrat; sa polipeptidom koji sadrži jedan ili više aminokiselinskih ostataka spoja sa formulom II: [image] pri čemu W4 je C1-C10 alkilen.
2. Postupak iz patentnog zahtjeva 1, pri čemu spoj formule II je u skladu sa formulom (30): [image]
3. Postupak iz patentnog zahtjeva 1 ili 2, pri čemu polipeptid je antitijelo.
4. Postupak iz bilo kojeg od patentnih zahtjeva 1-3, pri čemu je konjugat formuliran kao farmaceutska kompozicija koja sadrži farmaceutski prihvatljiv nosač dodatno konjugatu.
5. Farmaceutska kompozicija koja sadrži: konjugat koji sadrži polipeptid koji sadrži jedan ili više aminokiselinskih ostataka spoja sa formulom II: [image] pri čemu W4 je C1-C10 alkilen; pri čemu polipeptid je povezan za dio od značaja preko segmenta koji sadrži 1,2,3-triazolilen, koji je formiran reakcijom dijela od značaja povezanog sa alkinom sa N3 jednog ili više aminokiselinskih ostataka, i pri čemu po izboru sadrži vezujući segment između segmenta koji sadrži 1,2,3-triazolilen polipeptida i dijela od značaja; i pri čemu dio od značaja sadrži ugljikohidrat; i farmaceutski prihvatljiv nosač.
6. Farmaceutska kompozicija iz patentnog zahtjeva 5, pri čemu spoj sa formulom II je u skladu sa formulom (30): [image]
7. Farmaceutska kompozicija u skladu sa patentnim zahtjevom 5 ili 6, pri čemu polipeptid je antitijelo.
HRP20220455TT 2012-08-31 2013-08-30 Modificirane aminokiseline koje sadrže azid grupu HRP20220455T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261696087P 2012-08-31 2012-08-31
EP19168498.4A EP3584255B1 (en) 2012-08-31 2013-08-30 Modified amino acids comprising an azido group

Publications (1)

Publication Number Publication Date
HRP20220455T1 true HRP20220455T1 (hr) 2022-05-27

Family

ID=49170897

Family Applications (2)

Application Number Title Priority Date Filing Date
HRP20220455TT HRP20220455T1 (hr) 2012-08-31 2013-08-30 Modificirane aminokiseline koje sadrže azid grupu
HRP20190878TT HRP20190878T1 (hr) 2012-08-31 2019-05-14 Modificirane aminokiseline koje sadrže azidnu grupu

Family Applications After (1)

Application Number Title Priority Date Filing Date
HRP20190878TT HRP20190878T1 (hr) 2012-08-31 2019-05-14 Modificirane aminokiseline koje sadrže azidnu grupu

Country Status (18)

Country Link
US (6) US9682934B2 (hr)
EP (3) EP4074728A1 (hr)
JP (2) JP6826367B2 (hr)
KR (1) KR102182800B1 (hr)
CN (1) CN104981254B (hr)
AU (2) AU2013308494B2 (hr)
BR (1) BR112015004022B1 (hr)
CA (1) CA2881978C (hr)
DK (2) DK2890402T3 (hr)
ES (2) ES2907763T3 (hr)
HK (1) HK1210034A1 (hr)
HR (2) HRP20220455T1 (hr)
HU (1) HUE045227T2 (hr)
IL (1) IL237401B (hr)
PL (2) PL3584255T3 (hr)
SG (1) SG11201501464TA (hr)
SI (2) SI2890402T1 (hr)
WO (1) WO2014036492A1 (hr)

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