HRP20220111T1 - Protutijela protiv pd-1 - Google Patents
Protutijela protiv pd-1 Download PDFInfo
- Publication number
- HRP20220111T1 HRP20220111T1 HRP20220111TT HRP20220111T HRP20220111T1 HR P20220111 T1 HRP20220111 T1 HR P20220111T1 HR P20220111T T HRP20220111T T HR P20220111TT HR P20220111 T HRP20220111 T HR P20220111T HR P20220111 T1 HRP20220111 T1 HR P20220111T1
- Authority
- HR
- Croatia
- Prior art keywords
- seq
- amino acid
- acid sequence
- cancer
- set forth
- Prior art date
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 40
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 201000010536 head and neck cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000012752 auxiliary agent Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 102000048362 human PDCD1 Human genes 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
Claims (12)
1. Protutijelo koje se veže na ljudski PD-1 (SEQ ID NO: 1), koje sadrži laki lanac (LC) i teški lanac (HC), gdje laki lanac sadrži varijabilno područje lakog lanca (LCVR), a teški lanac sadrži varijabilno područje teškog lanca (HCVR), naznačeno time što:
(1) LCVR ima aminokiselinski slijed dan u SEQ ID NO: 15, a HCVR ima aminokiselinski slijed dan u SEQ ID NO: 12; ili
(2) LCVR ima aminokiselinski slijed dan u SEQ ID NO: 15, a HCVR ima aminokiselinski slijed dan u SEQ ID NO: 13; ili
(3) LCVR ima aminokiselinski slijed dan u SEQ ID NO: 15, a HCVR ima aminokiselinski slijed dan u SEQ ID NO: 14.
2. Protutijelo u skladu s patentnim zahtjevom 1, naznačeno time što LC ima aminokiselinski slijed dan u SEQ ID NO: 22, a HC ima aminokiselinski slijed dan u SEQ ID NO: 16, SEQ ID NO: 17, SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO: 20, ili SEQ ID NO: 21.
3. Protutijelo u skladu s patentnim zahtjevom 2, naznačeno time što:
(1) LC ima aminokiselinski slijed dan u SEQ ID NO: 22, a HC ima aminokiselinski slijed dan u SEQ ID NO: 16; ili
(2) LC ima aminokiselinski slijed dan u SEQ ID NO: 22, a HC ima aminokiselinski slijed dan u SEQ ID NO: 17; ili
(3) LC ima aminokiselinski slijed dan u SEQ ID NO: 22, a HC ima aminokiselinski slijed dan u SEQ ID NO: 18; ili
(4) LC ima aminokiselinski slijed dan u SEQ ID NO: 22, a HC ima aminokiselinski slijed dan u SEQ ID NO: 19; ili
(5) LC ima aminokiselinski slijed dan u SEQ ID NO: 22, a HC ima aminokiselinski slijed dan u SEQ ID NO: 20; ili
(6) LC ima aminokiselinski slijed dan u SEQ ID NO: 22, a HC ima aminokiselinski slijed dan u SEQ ID NO: 21.
4. Protutijelo u skladu s patentnim zahtjevom 2, koje sadrži dva laka lanca i dva teška lanca, naznačeno time što svaki laki lanac ima aminokiselinski slijed dan u SEQ ID NO: 22, a svaki teški lanac ima aminokiselinski slijed dan u SEQ ID NO: 16, SEQ ID NO: 17, SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO: 20 ili SEQ ID NO: 21.
5. Protutijelo u skladu s patentnim zahtjevom 4, naznačeno time što:
(1) svaki laki lanac ima aminokiselinski slijed dan u SEQ ID NO: 22, a svaki teški lanac ima aminokiselinski slijed dan u SEQ ID NO: 16; ili
(2) svaki laki lanac ima aminokiselinski slijed dan u SEQ ID NO: 22, a svaki teški lanac ima aminokiselinski slijed dan u SEQ ID NO: 17; ili
(3) svaki laki lanac ima aminokiselinski slijed dan u SEQ ID NO: 22, a svaki teški lanac ima aminokiselinski slijed dan u SEQ ID NO: 18; ili
(4) svaki laki lanac ima aminokiselinski slijed dan u SEQ ID NO: 22, a svaki teški lanac ima aminokiselinski slijed dan u SEQ ID NO: 19; ili
(5) svaki laki lanac ima aminokiselinski slijed dan u SEQ ID NO: 22, a svaki teški lanac ima aminokiselinski slijed dan u SEQ ID NO: 20; ili
(6) svaki laki lanac ima aminokiselinski slijed dan u SEQ ID NO: 22, a svaki teški lanac ima aminokiselinski slijed dan u SEQ ID NO: 21.
6. Protutijelo u skladu s patentnim zahtjevom 4 ili 5, naznačeno time što jedan od teških lanaca tvori disulfidnu vezu između lanaca s jednim od lakih lanaca, a drugi teški lanac tvori disulfidnu vezu između lanaca s drugim lakim lancem, dok jedan od teških lanaca tvori dvije disulfidne veze između lanaca s drugim teškim lancem.
7. Protutijelo u skladu s bilo kojim od patentnih zahtjeva 1-6, naznačeno time što je protutijelo glikozilirano.
8. Stanica sisavca koja sadrži molekulu DNA koja sadrži polinukleotidni slijed koji kodira polipeptid koji ima aminokiselinski slijed SEQ ID NO: 22 i polinukleotidni slijed koji kodira polipeptid koji ima aminokiselinski slijed SEQ ID NO: 17 ili SEQ ID NO: 20, naznačeno time što stanica može eksprimirati protutijelo koje sadrži laki lanac koji ima aminokiselinski slijed SEQ ID NO: 22 i teški lanac koji ima aminokiselinski slijed SEQ ID NO: 17 ili SEQ ID NO: 20.
9. Postupak proizvodnje protutijela koje sadrži laki lanac koji ima aminokiselinski slijed SEQ ID NO: 22 i teški lanac koji ima aminokiselinski slijed SEQ ID NO: 17 ili SEQ ID NO: 20, naznačen time što se sastoji u uzgoju stanice sisavca u skladu s patentnim zahtjevom 8 u takvim uvjetima da se eksprimira protutijelo, te u prikupljanju eksprimiranog protutijela.
10. Farmaceutski pripravak, naznačen time što sadrži protutijelo u skladu s bilo kojim od patentnih zahtjeva 1-7, kao i prihvatljivi nosač, razrjeđivač ili pomoćno sredstvo.
11. Protutijelo u skladu s bilo kojim od patentnih zahtjeva 1-7, naznačeno time što je namijenjeno upotrebi u terapiji, po mogućnosti, namijenjeno upotrebi u liječenju raka, poželjnije, gdje je rak melanom, rak pluća, rak glave i vrata, kolorektalni rak, rak gušterače, rak želuca, rak bubrega, rak mokraćnog mjehura, rak prostate, rak dojke, rak jajnika ili hepatocelularni karcinom.
12. Protutijelo u skladu s bilo kojim od patentnih zahtjeva 1-7, naznačeno time što je namijenjeno upotrebi u istodobnoj, odvojenoj ili uzastopnoj kombinaciji s jednim ili više antitumorskih sredstava, u liječenju raka, po mogućnosti, gdje je rak melanom, rak pluća, rak glave i vrata, kolorektalni rak, rak gušterače, rak želuca, rak bubrega, rak mokraćnog mjehura, rak prostate, rak dojke, rak jajnika ili hepatocelularni karcinom.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2015/086494 WO2017024465A1 (en) | 2015-08-10 | 2015-08-10 | Pd-1 antibodies |
| EP16834640.1A EP3334824B1 (en) | 2015-08-10 | 2016-08-09 | Pd-1 antibodies |
| PCT/CN2016/094122 WO2017025016A1 (en) | 2015-08-10 | 2016-08-09 | Pd-1 antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20220111T1 true HRP20220111T1 (hr) | 2022-04-15 |
Family
ID=57982889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20220111TT HRP20220111T1 (hr) | 2015-08-10 | 2016-08-09 | Protutijela protiv pd-1 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US10316089B2 (hr) |
| EP (1) | EP3334824B1 (hr) |
| JP (1) | JP6513296B2 (hr) |
| KR (1) | KR102132100B1 (hr) |
| CN (2) | CN110003339B (hr) |
| AR (1) | AR105489A1 (hr) |
| AU (1) | AU2016307002B2 (hr) |
| BR (1) | BR112018002274B1 (hr) |
| CA (1) | CA2990492C (hr) |
| CY (1) | CY1124955T1 (hr) |
| DK (1) | DK3334824T3 (hr) |
| ES (1) | ES2904586T3 (hr) |
| HK (1) | HK1255195B (hr) |
| HR (1) | HRP20220111T1 (hr) |
| HU (1) | HUE058273T2 (hr) |
| IL (1) | IL256844B (hr) |
| LT (1) | LT3334824T (hr) |
| MX (1) | MX365390B (hr) |
| MY (1) | MY199019A (hr) |
| NZ (1) | NZ738979A (hr) |
| PL (1) | PL3334824T3 (hr) |
| PT (1) | PT3334824T (hr) |
| RS (1) | RS62897B1 (hr) |
| RU (1) | RU2686612C1 (hr) |
| SI (1) | SI3334824T1 (hr) |
| TW (1) | TWI674275B (hr) |
| WO (2) | WO2017024465A1 (hr) |
Families Citing this family (188)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL296026B2 (en) | 2013-09-13 | 2024-10-01 | Beigene Switzerland Gmbh | Anti-PD1 antibodies and their uses as drugs and for diagnosis |
| US10544225B2 (en) | 2014-07-03 | 2020-01-28 | Beigene, Ltd. | Anti-PD-L1 antibodies and their use as therapeutics and diagnostics |
| NZ728688A (en) | 2014-07-22 | 2023-06-30 | Cb Therapeutics Inc | Anti-pd-1 antibodies |
| SG11201700687TA (en) | 2014-08-05 | 2017-02-27 | Cb Therapeutics Inc | Anti-pd-l1 antibodies |
| MX2018000621A (es) | 2015-07-13 | 2018-05-11 | Cytomx Therapeutics Inc | Anticuerpos anti-pd-1, anticuerpos anti-pd-1 activables, y metodos de uso de los mismos. |
| CA2993432A1 (en) | 2015-09-01 | 2017-03-09 | Agenus Inc. | Anti-pd-1 antibodies and methods of use thereof |
| EP3355920A4 (en) | 2015-09-29 | 2019-05-15 | Celgene Corporation | PD-1 BINDING PROTEINS AND METHOD OF USE THEREOF |
| CR20180234A (es) | 2015-11-03 | 2018-09-11 | Janssen Biotech Inc | Anticuerpos que se unen especificamente a pd-1 y sus usos |
| CA3026474A1 (en) | 2016-06-20 | 2017-12-28 | Kymab Limited | Anti-pd-l1 and il-2 cytokines |
| WO2018007885A1 (en) | 2016-07-05 | 2018-01-11 | Beigene, Ltd. | COMBINATION OF A PD-l ANTAGONIST AND A RAF INHIBITOR FOR TREATING CANCER |
| WO2018027524A1 (en) * | 2016-08-09 | 2018-02-15 | Innovent Biologics (Suzhou) Co., Ltd. | Pd-1 antibody formulation |
| CA3034326A1 (en) | 2016-08-19 | 2018-02-22 | Beigene, Ltd. | Use of a combination comprising a btk inhibitor for treating cancers |
| US10766958B2 (en) | 2016-09-19 | 2020-09-08 | Celgene Corporation | Methods of treating vitiligo using PD-1 binding antibodies |
| AU2017329024A1 (en) | 2016-09-19 | 2019-03-21 | Celgene Corporation | Methods of treating immune disorders using pd-1 binding proteins |
| US10597454B2 (en) * | 2016-10-15 | 2020-03-24 | Innovent Biologics (Suzhou) Co., Ltd | PD-1 antibodies |
| US20190315865A1 (en) | 2016-10-28 | 2019-10-17 | Bristol-Myers Squibb Company | Methods of treating urothelial carcinoma using an anti-pd-1 antibody |
| CA3042679A1 (en) | 2016-11-03 | 2018-05-11 | Bristol-Myers Squibb Company | Activatable anti-ctla-4 antibodies and uses thereof |
| KR102603681B1 (ko) | 2016-12-07 | 2023-11-17 | 아게누스 인코포레이티드 | 항체 및 이의 사용방법 |
| JOP20190133A1 (ar) | 2016-12-08 | 2019-06-02 | Innovent Biologics Suzhou Co Ltd | أجسام مضادة لـ Tim-3 لمزجها بأجسام مضادة لـ PD-1 |
| US11512134B2 (en) | 2017-08-01 | 2022-11-29 | Eli Lilly And Company | Anti-CD137 antibodies |
| KR102536145B1 (ko) | 2017-01-20 | 2023-05-30 | 타유 후아시아 바이오테크 메디컬 그룹 컴퍼니 리미티드 | 항-pd-1 항체 및 이의 용도 |
| TWI774726B (zh) | 2017-01-25 | 2022-08-21 | 英屬開曼群島商百濟神州有限公司 | (S)-7-(1-(丁-2-炔醯基)哌啶-4-基)-2-(4-苯氧基苯基)-4,5,6,7-四氫吡唑并[1,5-a]嘧啶-3-甲醯胺的晶型、及其製備和用途 |
| TWI674261B (zh) | 2017-02-17 | 2019-10-11 | 美商英能腫瘤免疫股份有限公司 | Nlrp3 調節劑 |
| KR20240144261A (ko) | 2017-02-28 | 2024-10-02 | 사노피 | 치료적 rna |
| JP7458188B2 (ja) | 2017-03-31 | 2024-03-29 | ブリストル－マイヤーズ スクイブ カンパニー | 腫瘍を処置する方法 |
| TWI788340B (zh) | 2017-04-07 | 2023-01-01 | 美商必治妥美雅史谷比公司 | 抗icos促效劑抗體及其用途 |
| SI3631454T1 (sl) | 2017-05-30 | 2023-12-29 | Bristol-Myers Squibb Company | Zdravljenje lag-3 pozitivnih tumorjev |
| US11723975B2 (en) | 2017-05-30 | 2023-08-15 | Bristol-Myers Squibb Company | Compositions comprising an anti-LAG-3 antibody or an anti-LAG-3 antibody and an anti-PD-1 or anti-PD-L1 antibody |
| AU2018277559A1 (en) | 2017-05-30 | 2019-10-17 | Bristol-Myers Squibb Company | Compositions comprising a combination of an anti-LAG-3 antibody, a PD-1 pathway inhibitor, and an immunotherapeutic agent |
| CN117462668A (zh) | 2017-06-01 | 2024-01-30 | 百时美施贵宝公司 | 用抗pd-1抗体治疗肿瘤的方法 |
| CA3066518A1 (en) | 2017-06-26 | 2019-01-03 | Beigene, Ltd. | Immunotherapy for hepatocellular carcinoma |
| AR112603A1 (es) | 2017-07-10 | 2019-11-20 | Lilly Co Eli | Anticuerpos biespecíficos inhibidores de punto de control |
| US11344543B2 (en) | 2017-07-14 | 2022-05-31 | Innate Tumor Immunity, Inc. | NLRP3 modulators |
| EP3694884A1 (en) | 2017-10-15 | 2020-08-19 | Bristol-Myers Squibb Company | Methods of treating tumor |
| JP2021502344A (ja) | 2017-11-06 | 2021-01-28 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 腫瘍を処置する方法 |
| US11786529B2 (en) | 2017-11-29 | 2023-10-17 | Beigene Switzerland Gmbh | Treatment of indolent or aggressive B-cell lymphomas using a combination comprising BTK inhibitors |
| WO2019129137A1 (zh) | 2017-12-27 | 2019-07-04 | 信达生物制药(苏州)有限公司 | 抗lag-3抗体及其用途 |
| CN109970856B (zh) | 2017-12-27 | 2022-08-23 | 信达生物制药(苏州)有限公司 | 抗lag-3抗体及其用途 |
| US20210363242A1 (en) | 2018-01-16 | 2021-11-25 | Bristol-Myers Squibb Company | Methods of treating cancer with antibodies against tim3 |
| AU2019210332A1 (en) | 2018-01-22 | 2020-09-10 | Pascal Biosciences Inc. | Cannabinoids and derivatives for promoting immunogenicity of tumor and infected cells |
| BR112020014574A2 (pt) | 2018-01-22 | 2020-12-08 | Bristol-Myers Squibb Company | Composições e métodos para o tratamento do câncer |
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