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HRP20181608T1 - Korištenje inhibitora pde7 u liječenju bolesti kretanja - Google Patents

Korištenje inhibitora pde7 u liječenju bolesti kretanja

Info

Publication number
HRP20181608T1
HRP20181608T1 HRP20181608TT HRP20181608T HRP20181608T1 HR P20181608 T1 HRP20181608 T1 HR P20181608T1 HR P20181608T T HRP20181608T T HR P20181608TT HR P20181608 T HRP20181608 T HR P20181608T HR P20181608 T1 HRP20181608 T1 HR P20181608T1
Authority
HR
Croatia
Prior art keywords
treatment
movement disorders
pde7 inhibitors
pde7
inhibitors
Prior art date
Application number
HRP20181608TT
Other languages
English (en)
Inventor
John E. Bergmann
Neil S. Cutshall
Gregory A. Demopulos
Vincent A. Florio
George Gaitanaris
Patrick Gray
John Hohmann
Rene Onrust
Hongkui Zeng
Original Assignee
Omeros Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omeros Corporation filed Critical Omeros Corporation
Publication of HRP20181608T1 publication Critical patent/HRP20181608T1/hr

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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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HRP20181608TT 2009-05-04 2018-10-05 Korištenje inhibitora pde7 u liječenju bolesti kretanja HRP20181608T1 (hr)

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US12/435,347 US8637528B2 (en) 2007-03-27 2009-05-04 Use of PDE7 inhibitors for the treatment of movement disorders
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PCT/US2010/001305 WO2010129036A1 (en) 2009-05-04 2010-05-03 Use of pde7 inhibitors for the treatment of movement disorders

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Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8333008B1 (en) 2005-07-29 2012-12-18 Western Digital (Fremont), Llc Method for manufacturing a perpendicular magnetic recording transducer
US8141235B1 (en) 2006-06-09 2012-03-27 Western Digital (Fremont), Llc Method for manufacturing a perpendicular magnetic recording transducers
US7622593B2 (en) 2006-06-27 2009-11-24 The Procter & Gamble Company Human protein tyrosine phosphatase inhibitors and methods of use
US8637528B2 (en) 2007-03-27 2014-01-28 Omeros Corporation Use of PDE7 inhibitors for the treatment of movement disorders
MX2009010450A (es) * 2007-03-27 2009-11-23 Omeros Corp El uso de inhibidores de la fosfodiesterasa 7 para el tratamiento transtornos del movimiento.
CN103547267A (zh) 2010-11-08 2014-01-29 奥默罗斯公司 使用pde7抑制剂治疗成瘾和冲动控制障碍
US9220715B2 (en) 2010-11-08 2015-12-29 Omeros Corporation Treatment of addiction and impulse-control disorders using PDE7 inhibitors
EP2846805B1 (en) * 2012-05-07 2018-11-21 Omeros Corporation Treatment of addiction and impulse-control disorders using pde7 inhibitors
NZ628130A (en) * 2012-05-07 2017-02-24 Omeros Corp Treatment of addiction and impulse-control disorders using pde7 inhibitors
FR3000404B1 (fr) * 2012-12-28 2015-02-06 Galderma Res & Dev Composition dermatologique comprenant un inhibiteur de pde7 sous forme dispersee, son procede de preparation et son utilisation
ES2544519B1 (es) 2015-05-22 2016-03-04 Consejo Superior De Investigaciones Científicas (Csic) Quinazolinas S-sustituidas y sus aplicaciones terapéuticas para el tratamiento de enfermedades mediadas por PDE7
KR102013257B1 (ko) 2018-07-24 2019-10-21 정민산전(주) 분전반용 콘센트
EP3846788A1 (en) * 2018-09-05 2021-07-14 Universiteit van Amsterdam Use of a pde11 or pde2 inhibitor for the treatment of parkinson's disease
CN112574202B (zh) * 2020-12-11 2021-11-09 台州学院 一种螺喹唑啉-2-酮类衍生物及其制备方法和应用
WO2024038089A1 (en) 2022-08-18 2024-02-22 Mitodicure Gmbh Use of a therapeutic agent with phosphodiesterase-7 inhibitory activity for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE469228T1 (de) 1991-04-19 2010-06-15 Univ Washington Dns, die für phosphodiesterasen von säugetieren kodiert
DE69932153T2 (de) 1998-02-23 2007-05-31 Icos Corp., Bothell Phosphodiesterase 10
EP1146888A2 (en) 1998-10-15 2001-10-24 BioImage A/S Specific therapeutic interventions obtained by interference with redistribution and/or targetting
PT1018559E (pt) 1998-12-23 2007-11-07 Pfizer Enzimas fosfodiesterases
AU4589800A (en) 1999-05-05 2000-11-21 Darwin Discovery Limited 9-(1,2,3,4-tetrahydronaphthalen-1-yl)-1,9-dihydropurin-6-one derivatives as pde7inhibitors
US6627651B1 (en) 1999-05-07 2003-09-30 Takeda Chemical Industries, Ltd. Cyclic compounds and uses thereof
US6146876A (en) 1999-06-11 2000-11-14 Millennium Pharmaceuticals, Inc. 22025, a novel human cyclic nucleotide phosphodiesterase
US7491742B2 (en) 1999-10-21 2009-02-17 Merck Patent Gmbh Imidazole derivatives as phosphodiesterase VII inhibitors
DE19950647A1 (de) 1999-10-21 2001-04-26 Merck Patent Gmbh Imidazolderivate als Phosphodiesterase VII-Hemmer
DE19953025A1 (de) 1999-11-04 2001-05-10 Merck Patent Gmbh Pyrrolderivate als Phosphodiesterase VII-Hemmer
DE19953024A1 (de) 1999-11-04 2001-05-10 Merck Patent Gmbh Isoxazolderivate als Phosphodiesterase VII-Hemmer
DE19953414A1 (de) 1999-11-06 2001-05-10 Merck Patent Gmbh Imidazopyridinderivate als Phospodiesterase VII-Hemmer
DE19954707A1 (de) 1999-11-13 2001-05-17 Merck Patent Gmbh Imidazolverbindungen als Phosphodiesterase VII-Hemmer
CA2400708A1 (en) 2000-02-22 2001-08-30 Cellegy Canada Inc. Methods and compositions for improving sleep
WO2001062904A1 (en) 2000-02-24 2001-08-30 Bayer Aktiengesellschaft Regulation of human gelatinase b-like enzyme 1
GB0007934D0 (en) 2000-03-31 2000-05-17 Darwin Discovery Ltd Chemical compounds
US7345031B2 (en) 2000-04-12 2008-03-18 International Medical Innovations, Inc. Pharmaceutical dopamine glycoconjugate compositions and methods of their preparation and use
GB0015095D0 (en) 2000-06-20 2000-08-09 Celltech Chiroscience Ltd Chemical compounds
EP1195435A1 (en) 2000-09-28 2002-04-10 Warner-Lambert Company Truncated phosphodiesterase-7 polypeptides
EP1193261A1 (en) 2000-10-02 2002-04-03 Warner-Lambert Company New thiadiazoles and their use as phosphodiesterase-7 inhibitors
KR20030045184A (ko) 2000-11-14 2003-06-09 알타나 파마 아게 포스포디에스테라제 억제제로서 (디히드로)이소퀴놀린유도체
WO2002040449A1 (en) 2000-11-14 2002-05-23 Altana Pharma Ag Dihydroisoquinolines as novel phosphodiesterase inhibitors
HUP0600103A2 (en) 2001-03-02 2006-06-28 Bristol Myers Squibb Co Co-administration of melanocortin receptor agonist and phosphodiesterase inhibitor for treatment of cyclic-amp associated disorders
US6617357B2 (en) 2001-03-06 2003-09-09 Smithkline Beecham Corporation Compounds and their use as PDE inhibitors
AP1699A (en) 2001-03-21 2006-12-26 Warner Lambert Co New spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors
US6958328B2 (en) 2001-04-18 2005-10-25 Ortho-Mcneil Pharmaceutical, Inc Arylindenopyridines and related therapeutic and prophylactic methods
US6903109B2 (en) 2001-04-18 2005-06-07 Ortho-Muniel Pharmaceutical, Inc. Arylindenopyridines and related therapeutic and prophylactic methods
US20030032579A1 (en) 2001-04-20 2003-02-13 Pfizer Inc. Therapeutic use of selective PDE10 inhibitors
JP2004526789A (ja) 2001-04-25 2004-09-02 アルタナ　ファルマ　アクチエンゲゼルシャフト 新規フタラジノン
US6849638B2 (en) 2001-04-30 2005-02-01 Bayer Pharmaceuticals Corporation 4-amino-5,6-substituted thiopheno [2,3-d] pyrimidines, pharmaceutical compositions containing the same, and their use in the treatment or prevention of pde7b-mediated diseases and conditions
US20030053980A1 (en) 2001-04-30 2003-03-20 The Gillette Company Shaving compositions containing highly lubricious water soluble polymers
WO2002088079A2 (en) 2001-05-01 2002-11-07 Bristol-Myers Squibb Company Dual inhibitors of pde 7 and pde 4
PE20030008A1 (es) 2001-06-19 2003-01-22 Bristol Myers Squibb Co Inhibidores duales de pde 7 y pde 4
EP1397142A4 (en) 2001-06-19 2004-11-03 Bristol Myers Squibb Co PYRIMIDINE PHOSPHODIESTERASE (PDE) INHIBITORS 7
DE10130167A1 (de) 2001-06-22 2003-01-02 Bayer Ag Imidazotriazine
US20030211040A1 (en) 2001-08-31 2003-11-13 Paul Greengard Phosphodiesterase activity and regulation of phosphodiesterase 1B-mediated signaling in brain
US20060286622A1 (en) 2001-09-28 2006-12-21 Patricia Soulard Polypeptides exhibiting PDE7 activity and their use for selecting compounds which inhibit PDE 7 enzyme activity
CA2439784C (en) 2001-12-13 2010-11-02 Daiichi Suntory Pharma Co., Ltd. Pyrazolopyrimidinone derivatives having pde7 inhibiting action
DE10163991A1 (de) 2001-12-24 2003-07-03 Merck Patent Gmbh Pyrrolo-pyrimidine
WO2003057149A2 (en) 2001-12-28 2003-07-17 Bayer Corporation 4-substituted fused heteropyrimidines and fused hetero-4-pyrimidones
US7378428B2 (en) 2002-01-31 2008-05-27 Ono Pharmaceutical Co., Ltd. Nitrogen-containing bicyclic compounds and drugs containing the same as the active ingredient
US20040082061A1 (en) 2002-02-14 2004-04-29 Anna Astromoff Drug metabolizing enzymes
EP2367224B1 (en) 2002-03-25 2013-01-09 Sumitomo Chemical Company, Limited Method for preparing positive electrode active material for non-aqueous secondary battery
EP1348433A1 (en) 2002-03-28 2003-10-01 Warner-Lambert Company LLC Thiazol-2-yl-imine compounds as PDE-7 inhibitors
EP1348701A1 (en) 2002-03-28 2003-10-01 Warner-Lambert Company LLC (2,4-disubstituted-thiazol-5-yl) amine compounds as PDE7 inhibitors
EP1400244A1 (en) 2002-09-17 2004-03-24 Warner-Lambert Company LLC New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors
EP1597385A1 (en) 2002-11-13 2005-11-23 Bayer HealthCare AG DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH HUMAN PHOSPHODIESTERASE 7A1 (PDE7a1)
ES2217956B1 (es) 2003-01-23 2006-04-01 Almirall Prodesfarma, S.A. Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo.
FR2851856B1 (fr) 2003-02-27 2006-03-03 Peugeot Citroen Automobiles Sa Commande d'une machine electrique d'un vehicule hybride serie
US7217527B2 (en) 2003-04-15 2007-05-15 Vanderbilt University Assay for phosphodiesterase function
JP2006219373A (ja) 2003-06-13 2006-08-24 Daiichi Asubio Pharma Co Ltd Ｐｄｅ７阻害作用を有するピリジニルピラゾロピリミジノン誘導体
JP2006219374A (ja) 2003-06-13 2006-08-24 Daiichi Asubio Pharma Co Ltd Ｐｄｅ７阻害作用を有するイミダゾトリアジノン誘導体
US20050130971A1 (en) 2003-08-22 2005-06-16 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and phosphodiesterase inhibitor for the treatment of ischemic mediated central nervous system disorders or injury
PL2433943T3 (pl) * 2004-07-01 2014-04-30 Daiichi Sankyo Co Ltd Intermediaty dla pochodnych tienopirazolowych wykazujące efekt hamowania PDE 7
BRPI0607402A2 (pt) 2005-03-01 2009-09-01 Pfizer Ltd uso de inibidores de pde7 para o tratamento de dor neuropática
WO2006092692A1 (en) 2005-03-01 2006-09-08 Pfizer Limited Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain
ES2412858T3 (es) 2005-09-26 2013-07-12 Avigen, Inc. Procedimiento para tratar adicciones a drogas y conductuales
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
JP2009517453A (ja) 2005-12-02 2009-04-30 ファイザー・リミテッド Ｐｄｅ７阻害剤としてのスピロ環式キナゾリン誘導体
NL2000323C2 (nl) 2005-12-20 2007-11-20 Pfizer Ltd Pyrimidine-derivaten.
JP5143841B2 (ja) 2006-10-10 2013-02-13 ロス アラモス ナショナル セキュリティー，エルエルシー 高度な薬物開発及び製造
ES2308916B1 (es) 2007-03-22 2009-10-29 Consejo Superior De Investigaciones Cientificas Compuesto inhibidor dual de las enzimas pde7 y/o pde4, composiciones farmaceuticas y sus aplicaciones.
US8637528B2 (en) 2007-03-27 2014-01-28 Omeros Corporation Use of PDE7 inhibitors for the treatment of movement disorders
MX2009010450A (es) * 2007-03-27 2009-11-23 Omeros Corp El uso de inhibidores de la fosfodiesterasa 7 para el tratamiento transtornos del movimiento.
US20100179158A1 (en) 2007-04-20 2010-07-15 Hoffman Charles S Inhibitors of cyclic amp phosphodiesterases
WO2008142550A2 (en) 2007-05-24 2008-11-27 Pfizer Limited Spirocyclic derivatives
WO2009017625A1 (en) 2007-07-27 2009-02-05 Avigen, Inc. Treatment of depression, phychosis, and anxiety

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JP2012526111A (ja) 2012-10-25
ES2689971T3 (es) 2018-11-16
RU2600869C2 (ru) 2016-10-27
JP2015172075A (ja) 2015-10-01
CA2760786A1 (en) 2010-11-11
NZ621806A (en) 2015-10-30
SI2427193T1 (sl) 2018-11-30
AU2010245250A1 (en) 2011-12-22
TR201814245T4 (en) 2018-11-21
KR101741853B1 (ko) 2017-05-30
US9119822B2 (en) 2015-09-01
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US20160015715A1 (en) 2016-01-21
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