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HRP20151430T1 - Pyridine and pyrazine derivative for the treatment of cf - Google Patents

Pyridine and pyrazine derivative for the treatment of cf Download PDF

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Publication number
HRP20151430T1
HRP20151430T1 HRP20151430TT HRP20151430T HRP20151430T1 HR P20151430 T1 HRP20151430 T1 HR P20151430T1 HR P20151430T T HRP20151430T T HR P20151430TT HR P20151430 T HRP20151430 T HR P20151430T HR P20151430 T1 HRP20151430 T1 HR P20151430T1
Authority
HR
Croatia
Prior art keywords
alkyl
optionally substituted
trifluoromethyl
amino
amide
Prior art date
Application number
HRP20151430TT
Other languages
Croatian (hr)
Inventor
Urs Baettig
Kamlesh Jagdis Bala
Emma Budd
Lee Edwards
Catherine Howsham
Glyn Hughes
Darren Mark Legrand
Katrin Spiegel
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HRP20151430T1 publication Critical patent/HRP20151430T1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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Claims (18)

1. Spoj, naznačen time, da ima formulu I: [image] ili njegove farmaceutski prihvatljive soli, u kojoj: A je N ili CR4a; R1 je H; C1-C8 alkil opcijski supstituiran s jednim ili više atoma halogena; C2-C8 alkenil; C2-C8 alkinil; C3-C10 cikloalkil; C5-C10 cikloalkenil; -C1-C4 alkil-C3-C8 cikloalkil; C1-C8 alkoksi opcijski supstituiran s jednim ili više atoma halogena; halogen; SO2NR8R9; SO2R10; S-C1-C8 alkil opcijski supstituiran s jednim ili više atoma halogena; S-C6-C14 aril; CN; NR11R12; C(O)NR13R14; NR13SO2R15; NR13C(O)R15, CrO2R15, -(C0-C4 alkil)-C6-C14 aril; ili -(C0-C4 alkil)- 3- do 14-člana heterociklička skupina, pri čemu se heterociklička skupina sastoji od najmanje jednog heteroatoma odabranog od N,O i S; gdje je svaka od cikloalkilne, cikloalkenilne, arilne i heterocikličke skupine opcijski supstituirana s jednim ili više Z supstituenata; R2 je C1-C4 haloalkil; svaki od R3 i R4a je neovisno H ili C1-C8 alkil opcijski supstituiran s jednim ili više atoma halogena; R4 je H, ili C1-C8 alkil opcijski supstituiran s jednim ili više halogena; R5 je -(CH2)m-NR17R18, -(CH2)m-OR; C1-C8 alkoksi opcijski supstituiran s jednim ili više atoma halogena; -(C0-C4 alkil)-CO2R15-(C0-C4 alkil)-C6-C14 aril ili -3- do 14-člana heterociklička skupina, dok heterociklička skupina ima najmanje jedan heteroatom odabran od N, O i S; gdje su skupine -(C0-C4 alkil)-C6-C14 aril i -(C0-C4 alkil)-3- do 14-člana heterociklička skupina, svaka opcijski supstituirana s jednim ili više Z supstituenata; R6 je C1-C8 alkil opcijski supstituiran s jednim ili više atoma halogena; C3-C10 cikloalkil; -C1-C4 alkil-C3-C8 cikloalkil; C1-C8 alkoksi opcijski supstituiran s jednim ili više atoma halogena; OH; CN; halogen; -(C0-C4 alkil)-C6-C14 aril; ili -(C0-C4 alkil)-3- do 14-člana heterociklička skupina, pri čemu heterociklička skupina sadrži najmanje jedan heteroatom odabran od N, O i S; gdje su skupine cikloalkilna, cikloalkenilna, -(C0-C4 alkil)-C6-C14 arilna i -(C0-C4 alkil)-3- do 14-člana heterociklička skupina, svaka opcijski supstituirana s jednim ili više Z supstituenata; ili R6 je H, i R5 je -(CH2)m-NR17R18, -(CH2)m-OR, C1-C8 alkoksi opcijski supstituiran s jednim ili više atoma halogena; -(C0-C4 alkil)-C6-C14 aril; -(C0-C4alkil)- 3- do 14-člana heterociklička skupina, dok heterociklička skupina sadrži najmanje jedan heteroatom odabran od N, O i S; ili -(C0-C4 alkil)-CO2R15, gdje su -(C0-C4 alkil)-C6-C14 aril i -(C0-C4 alkil)-3- do 14-člana heterociklička skupina,skupine koje su opcijski supstituirane s jednim ili više Z supstituenata; ili R4 i R6 zajedno s atomima ugljika za koje su vezani, tvore 3- do 8-člani karbociklički sustav prstena; ili R4 i R5 zajedno tvore okso skupinu (C=O) i R6 je C1-C4 alkil opcijski supstituiran s jednim ili više atoma halogena; C1-C4 alkoksi opcijski supstituiran s jednim ili više atoma halogena; -(C0-C4 alkil)-C6-C14 aril; ili -(C0-C4 alkil)-3- do 14-člana heterociklička skupina, dok heterociklička skupina sadrži najmanje jedan heteroatom odabran od N, O i S, pri čemu su svaka od arilne i heterocikličke skupine opcijski supstituirane s jednim ili više Z supstituenata; ili R5 i R6 zajedno s atomima ugljika na koje su vezani, tvore 5- do 8-člani heterociklički sustav prstena koji sadrži jedan ili više heteroatoma odabranih od N, O i S, dok je sustav prstena opcijski supstituiran s jednim ili više Z supstituenata; ili R4 i R5 i R6 zajedno s atomima ugljika na koje su vezani, tvore 5- do 8-člani heterociklički sustav prstena, koji sadrži jedan ili više heteroatoma odabranih od N, O i S, pri čemu je sustav prstena opcijski supstituiran s jednim ili više Z supstituenata; R je H, ili C1-C8 alkil opcijski supstituiran s jednim ili više halogena; m je 0, 1, 2 ili 3; R8, R11, R13 i R17 su svaki neovisno H, C1-C8 alkil opcijski supstituiran s jednim ili više atoma halogena, C3-C10 cikloalkil ili -(C1-C4 alkil)-C3-C8 cikloalkil; R9, R10, R12, R14, R15 i R18 su svaki neovisno H; C1-C8 alkil opcijski supstituiran s jednim ili više atoma halogena; C2-C8 alkenil; C2-C8 alkinil; C3-C10 cikloalkil; C5-C10 cikloalkenil; -C1-C4 alkil-C3-C8 cikloalkil; -(C0-C4 alkil)-C6-C14 aril; ili -(C0-C4 alkil)- 3- do 14-člana heterociklička skupina, pri čemu heterociklička skupina sadrži najmanje jedan heteroatom odabran od N, O i S, dok je svaka od cikloalkilne, cikloalkenilne, arilne i heterocikličke skupine opcijski supstituirana s jednim ili više Z supstituenata; ili R8 i R9, R11 i R12, R13 i R14, te R17 i R18 zajedno s atomom dušika na kojega su priključeni, mogu tvoriti 4- do 14-članu heterocikličku skupinu opcijski supstituiranu s jednim ili više Z supstituenata; Z je neovisno OH, aril, O-aril, benzil, O-benzil, C1-C6 alkil opcijski supstituiran s jednom ili više OH-skupina ili NH2-skupina, C1-C6 alkil opcijski supstituiran s jednim ili više atoma halogena, C1-C6 alkoksi opcijski supstituiran s jednom ili više OH-skupina ili C1-C4 alkoksi, NR18(SO2)R21, (SO2)NR19R21, (SO2)R21NR18C(O)R21, C(O)NR19R21, NR18C(O)NR19R21, NR18C(O)OR19, NR19R21, C(O)OR19, C(O)R19, SR19, OR19, okso, CN, NO2, halogen ili 3- do 14-člana heterociklička skupina, dok heterociklička skupina sadrži jedan ili više heteroatoma odabranih od N, O i S; R19 i R21 su svaki neovisno H; C1-C8 alkil; C3-C8 cikloalkil; C1-C4 alkoksi-C1-C4 alkil; (C0-C4 alkil)-aril opcijski supstituiran s jednom ili više skupina odabranih od sljedećih: C1-C6 alkil, C1-C6 alkoksi i halogen; (C0-C4 alkil)-3- do 14-člana heterociklička skupina, heterociklička skupina uključujući jedan ili više heteroatoma odabranih od N, O i S, opcijski supstituiran s jednom ili više skupina odabranih od sljedećih: halogen, okso, C1-C6 alkil i C(O)C1-C6 alkil; (C0-C4 alkil)-O-aril opcijski supstituiran s jednom ili više skupina odabranih od sljedećih: C1-C6 alkil, C1-C6 alkoksi i halogen; i (C0-C4 alkil)-O- 3- do 14-člana heterociklička skupina, dok heterociklička skupina uključuje jedan ili više heteroatoma odabranih od N, O i S, opcijski supstituirana s jednom ili više skupina odabranih od sljedećih: halogen, C1-C6 alkil ili C(O)C1-C6 alkil; gdje su alkil-skupine opcijski supstituirane s jednim ili više atoma halogena, C1-C4 alkoksi, C(O)NH2, C(O)NHC1-C6 alkil ili C(O)N(C1-C6 alkil)2; ili R19 i R21 zajedno s atomom dušika na kojega su priključeni, tvore 5- do 10-članu heterocikličku skupinu, dok heterociklička skupina uključuje jedan ili više dodatnih heteroatoma odabranih od N, O i S, gdje je heterociklička skupina opcijski supstituirana s jednim ili više supstituenata odabranih od sljedećih: OH; halogen; aril; 5- do 10-člana heterociklička skupina uključuje jedan ili više heteroatoma odabranih od N, O i S; S(O)2-aril; S(O)2-C1-C6 alkil; C1-C6 alkil opcijski supstituiran s jednim ili više atoma halogena; C1-C6 alkoksi opcijski supstituiran s jednom ili više OH-skupina ili C1-C4 alkoksi; i C(O)OC1-C6 alkil, dok su arilna i heterociklička skupina, supstituentske skupine koje su i same opcijski supstituirane sa sljedećima: C1-C6 alkil, C1-C6 haloalkil ili C1-C6 alkoksi.1. A compound characterized by formula I: [image] or its pharmaceutically acceptable salts, in which: A is N or CR4a; R 1 is H; C1-C8 alkyl optionally substituted with one or more halogen atoms; C2-C8 alkenyl; C2-C8 alkynyl; C3-C10 cycloalkyl; C5-C10 cycloalkenyl; -C1-C4 alkyl-C3-C8 cycloalkyl; C1-C8 alkoxy optionally substituted with one or more halogen atoms; halogen; SO2NR8R9; SO2R10; S-C1-C8 alkyl optionally substituted with one or more halogen atoms; S-C6-C14 aryl; CN; NR11R12; C(O)NR13R14; NR13SO2R15; NR13C(O)R15, CrO2R15, -(C0-C4 alkyl)-C6-C14 aryl; or -(C0-C4 alkyl)- 3- to 14-membered heterocyclic group, wherein the heterocyclic group consists of at least one heteroatom selected from N, O and S; wherein each of the cycloalkyl, cycloalkenyl, aryl and heterocyclic groups is optionally substituted with one or more Z substituents; R 2 is C 1 -C 4 haloalkyl; each of R3 and R4a is independently H or C1-C8 alkyl optionally substituted with one or more halogen atoms; R 4 is H, or C 1 -C 8 alkyl optionally substituted with one or more halogens; R 5 is -(CH 2 ) m -NR 17 R 18 , -(CH 2 ) m -OR; C1-C8 alkoxy optionally substituted with one or more halogen atoms; -(C0-C4 alkyl)-CO2R15-(C0-C4 alkyl)-C6-C14 aryl or -3- to 14-membered heterocyclic group, while the heterocyclic group has at least one heteroatom selected from N, O and S; wherein -(C0-C4 alkyl)-C6-C14 aryl and -(C0-C4 alkyl)-3- to 14-membered heterocyclic groups are each optionally substituted with one or more Z substituents; R 6 is C 1 -C 8 alkyl optionally substituted with one or more halogen atoms; C3-C10 cycloalkyl; -C1-C4 alkyl-C3-C8 cycloalkyl; C1-C8 alkoxy optionally substituted with one or more halogen atoms; OH; CN; halogen; -(C0-C4 alkyl)-C6-C14 aryl; or -(C0-C4 alkyl)-3- to 14-membered heterocyclic group, wherein the heterocyclic group contains at least one heteroatom selected from N, O and S; wherein the groups are cycloalkyl, cycloalkenyl, -(C0-C4 alkyl)-C6-C14 aryl and -(C0-C4 alkyl)-3- to 14-membered heterocyclic groups, each optionally substituted with one or more Z substituents; or R 6 is H, and R 5 is -(CH 2 ) m -NR 17 R 18 , -(CH 2 ) m -OR, C 1 -C 8 alkoxy optionally substituted with one or more halogen atoms; -(C0-C4 alkyl)-C6-C14 aryl; -(C0-C4alkyl)- 3- to 14-membered heterocyclic group, while the heterocyclic group contains at least one heteroatom selected from N, O and S; or -(C0-C4 alkyl)-CO2R15, where -(C0-C4 alkyl)-C6-C14 aryl and -(C0-C4 alkyl)-3- to 14-membered heterocyclic groups are optionally substituted with one or more Z substituents; or R4 and R6, together with the carbon atoms to which they are attached, form a 3- to 8-membered carbocyclic ring system; or R4 and R5 together form an oxo group (C=O) and R6 is C1-C4 alkyl optionally substituted with one or more halogen atoms; C1-C4 alkoxy optionally substituted with one or more halogen atoms; -(C0-C4 alkyl)-C6-C14 aryl; or -(C0-C4 alkyl)-3- to 14-membered heterocyclic group, wherein the heterocyclic group contains at least one heteroatom selected from N, O, and S, each of the aryl and heterocyclic groups being optionally substituted with one or more Z substituents ; or R5 and R6 together with the carbon atoms to which they are attached form a 5- to 8-membered heterocyclic ring system containing one or more heteroatoms selected from N, O and S, while the ring system is optionally substituted with one or more Z substituents; or R4 and R5 and R6 together with the carbon atoms to which they are attached form a 5- to 8-membered heterocyclic ring system, containing one or more heteroatoms selected from N, O and S, wherein the ring system is optionally substituted with one or more Z substituents; R is H, or C1-C8 alkyl optionally substituted with one or more halogens; m is 0, 1, 2 or 3; R 8 , R 11 , R 13 and R 17 are each independently H, C 1 -C 8 alkyl optionally substituted with one or more halogen atoms, C 3 -C 10 cycloalkyl or -(C 1 -C 4 alkyl)-C 3 -C 8 cycloalkyl; R 9 , R 10 , R 12 , R 14 , R 15 and R 18 are each independently H; C1-C8 alkyl optionally substituted with one or more halogen atoms; C2-C8 alkenyl; C2-C8 alkynyl; C3-C10 cycloalkyl; C5-C10 cycloalkenyl; -C1-C4 alkyl-C3-C8 cycloalkyl; -(C0-C4 alkyl)-C6-C14 aryl; or -(C0-C4 alkyl)- a 3- to 14-membered heterocyclic group, wherein the heterocyclic group contains at least one heteroatom selected from N, O, and S, while each of the cycloalkyl, cycloalkenyl, aryl, and heterocyclic groups is optionally substituted with one or more Z substituents; or R8 and R9, R11 and R12, R13 and R14, and R17 and R18, together with the nitrogen atom to which they are attached, can form a 4- to 14-membered heterocyclic group optionally substituted with one or more Z substituents; Z is independently OH, aryl, O-aryl, benzyl, O-benzyl, C1-C6 alkyl optionally substituted with one or more OH-groups or NH2-groups, C1-C6 alkyl optionally substituted with one or more halogen atoms, C1- C6 Alkoxy optionally substituted with one or more OH-groups or C1-C4 Alkoxy, NR18(SO2)R21, (SO2)NR19R21, (SO2)R21NR18C(O)R21, C(O)NR19R21, NR18C(O)NR19R21, NR18C (O)OR19, NR19R21, C(O)OR19, C(O)R19, SR19, OR19, oxo, CN, NO2, halogen, or a 3- to 14-membered heterocyclic group, while the heterocyclic group contains one or more heteroatoms selected from N, O and S; R 19 and R 21 are each independently H; C1-C8 alkyl; C3-C8 cycloalkyl; C1-C4 alkoxy-C1-C4 alkyl; (C0-C4 alkyl)-aryl optionally substituted with one or more groups selected from the following: C1-C6 alkyl, C1-C6 alkoxy and halogen; (C0-C4 alkyl)-3- to 14-membered heterocyclic group, a heterocyclic group including one or more heteroatoms selected from N, O and S, optionally substituted with one or more groups selected from the following: halogen, oxo, C1-C6 alkyl and C(O)C1-C6 alkyl; (C0-C4 alkyl)-O-aryl optionally substituted with one or more groups selected from the following: C1-C6 alkyl, C1-C6 alkoxy and halogen; and (C0-C4 alkyl)-O- a 3- to 14-membered heterocyclic group, wherein the heterocyclic group includes one or more heteroatoms selected from N, O, and S, optionally substituted with one or more groups selected from the following: halogen, C1- C6 alkyl or C(O)C1-C6 alkyl; where the alkyl groups are optionally substituted with one or more halogen atoms, C1-C4 alkoxy, C(O)NH2, C(O)NHC1-C6 alkyl or C(O)N(C1-C6 alkyl)2; or R19 and R21, together with the nitrogen atom to which they are attached, form a 5- to 10-membered heterocyclic group, while the heterocyclic group includes one or more additional heteroatoms selected from N, O, and S, where the heterocyclic group is optionally substituted with one or more substituents selected from the following: OH; halogen; aryl; A 5- to 10-membered heterocyclic group includes one or more heteroatoms selected from N, O, and S; S(O) 2 -aryl; S(O) 2 -C 1 -C 6 alkyl; C1-C6 alkyl optionally substituted with one or more halogen atoms; C1-C6 Alkoxy optionally substituted with one or more OH-groups or C1-C4 Alkoxy; and C(O)OC1-C6 alkyl, while aryl and heterocyclic groups are substituent groups that are themselves optionally substituted with the following: C1-C6 alkyl, C1-C6 haloalkyl or C1-C6 alkoxy. 2. Spoj prema zahtjevu 1, naznačen time, da A je CR4a.2. A compound according to claim 1, characterized in that A is CR4a. 3. Spoj prema zahtjevu 1 ili zahtjevu 2, naznačen time, da R1 je C1-C8 alkil opcijski supstituiran s jednim ili više atoma halogena; C1-C8 alkoksi opcijski supstituiran s jednim ili više atoma halogena; halogen; NR11R12, C6-C14 aril; ili -(C0-C4 alkil)-5- do 6-člana heterociklička skupina, gdje heterociklička skupina sadrži najmanje jedan heteroatom odabran od N, O i S, pri čemu je svaka od arilne i heterocikličke skupine opcijski supstituirana s jednim ili više Z supstituenata.3. A compound according to claim 1 or claim 2, characterized in that R 1 is C 1 -C 8 alkyl optionally substituted with one or more halogen atoms; C1-C8 alkoxy optionally substituted with one or more halogen atoms; halogen; NR11R12, C6-C14 aryl; or -(C0-C4 alkyl)-5- to 6-membered heterocyclic group, wherein the heterocyclic group contains at least one heteroatom selected from N, O, and S, wherein each of the aryl and heterocyclic groups is optionally substituted with one or more Z substituents . 4. Spoj prema bilo kojem od prethodnih zahtjeva, naznačen time, da R4 je H ili C1-C4 alkil opcijski supstituiran s jednim ili više atoma halogena; R5 jeC1-C4 alkoksi opcijski supstituiran s jednim ili više atoma halogena; -(CH2)m-NR17R18, -(CH2)m-OR; ili -(C0-C4 alkil)-3- do 14-člana heterociklička skupina, dok heterociklička skupina sadrži najmanje jedan heteroatom odabran od N, O i S, pri čemu su heterocikličke skupine opcijski supstituirane s jednim ili više Z supstituenata; R6 je C1-C4 alkil opcijski supstituiran s jednim ili više atoma halogena; C1-C4 alkoksi opcijski supstituiran s jednim ili više atoma halogena; ili -(C0-C4 alkil)-C6-C14 aril, dok je aril opcijski supstituiran s jednim ili više Z supstituenata; ili R4 i R6 zajedno s atomima ugljika na koje su vezani, tvore 3- do 6-člani karbociklički sustav prstena; ili R5 i R6 zajedno s atomima ugljika na koje su vezani, tvore 5- do 8-člani heterociklički sustav prstena koji sadrži jedan ili više heteroatoma odabranih od N, O i S, gdje je sustav prstena opcijski supstituiran s jednim ili više Z supstituenata; m je 0 ili 1; R17 i R18 su svaki neovisno H; C1-C8 alkil opcijski supstituiran s jednim ili više atoma halogena.4. A compound according to any of the preceding claims, characterized in that R4 is H or C1-C4 alkyl optionally substituted with one or more halogen atoms; R 5 is C 1 -C 4 alkoxy optionally substituted with one or more halogen atoms; -(CH2)m-NR17R18, -(CH2)m-OR; or -(C0-C4 alkyl)-3- to 14-membered heterocyclic group, while the heterocyclic group contains at least one heteroatom selected from N, O and S, wherein the heterocyclic groups are optionally substituted with one or more Z substituents; R 6 is C 1 -C 4 alkyl optionally substituted with one or more halogen atoms; C1-C4 alkoxy optionally substituted with one or more halogen atoms; or -(C0-C4 alkyl)-C6-C14 aryl, while the aryl is optionally substituted with one or more Z substituents; or R4 and R6, together with the carbon atoms to which they are attached, form a 3- to 6-membered carbocyclic ring system; or R5 and R6 together with the carbon atoms to which they are attached form a 5- to 8-membered heterocyclic ring system containing one or more heteroatoms selected from N, O and S, where the ring system is optionally substituted with one or more Z substituents; m is 0 or 1; R 17 and R 18 are each independently H; C1-C8 alkyl optionally substituted with one or more halogen atoms. 5. Spoj prema bilo kojem od prethodnih zahtjeva, naznačen time, da A je CR4a; R1 je C1-C4 alkil opcijski supstituiran s jednim ili više atoma halogena; ili C1-C4 alkoksi opcijski supstituiran s jednim ili više atoma halogena; R2 je CF3; R3 je H, CH3 ili CF3; R4 je H ili Me; R4a je H; R5 je -NR17R18 ili OH, i R6 je C1-C4 alkil opcijski supstituiran s jednim ili više atoma halogena.5. A compound according to any of the preceding claims, characterized in that A is CR4a; R 1 is C 1 -C 4 alkyl optionally substituted with one or more halogen atoms; or C1-C4 alkoxy optionally substituted with one or more halogen atoms; R 2 is CF 3 ; R 3 is H, CH 3 or CF 3 ; R 4 is H or Me; R4a is H; R 5 is -NR 17 R 18 or OH, and R 6 is C 1 -C 4 alkyl optionally substituted with one or more halogen atoms. 6. Spoj, naznačen time, da je predstavljen formulom II, [image] ili njegova farmaceutski prihvatljiva sol, u kojoj A je N ili CR4a; R4a je H ili C1-C4 alkil; R1 je C1-C8 alkil opcijski supstituiran s jednim ili više atoma halogena; C1-C8 alkoksi opcijski supstituiran s jednim ili više atoma halogena; halogen; NR11R12, C6-C14 aril; ili -(C0-C4 alkil)- 5- do 6-člana heterociklička skupina, pri čemu heterociklička skupina sadrži najmanje jedan heteroatom odabran od N, O i S, dok je arilna i heterociklička skupina svaka opcijski supstituirana s jednim ili više Z supstituenata; R3 je H ili CH3; R101 je: [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] R11 je H, C1-C8 alkil opcijski supstituiran s jednim ili više atoma halogena, C3-C10 cikloalkil ili -(C1-C4 alkil)-C3-C8 cikloalkil; R12 i R18 su svaki neovisno H; C1-C8 alkil opcijski supstituiran s jednim ili više atoma halogena; C2-C8 alkenil; C2-C8 alkinil; C3-C10 cikloalkil; C5-C10 cikloalkenil; -C1-C4 alkil-C3-C8 cikloalkil; -(C0-C4 alkil)-C6-C14 aril; ili -(C0-C4 alkil)- 3- do 14-člana heterociklička skupina, dok heterociklička skupina sadrži najmanje jedan heteroatom odabran od N, O i S, gdje je svaka od cikloalkilne, cikloalkenilne, arilne i heterocikličke skupine opcijski supstituirana s jednim ili više Z supstituenata; ili R11 i R12 zajedno s atomom dušika na kojega su priključeni, mogu tvoriti 4- do 14-članu heterocikličku skupinu opcijski supstituiranu s jednim ili više Z supstituenata; Z je neovisno OH, aril, O-aril, benzil, O-benzil, C1-C6 alkil opcijski supstituiran s jednom ili više OH-skupina ili NH2-skupina, C1-C6 alkil opcijski supstituiran s jednim ili više atoma halogena, C1-C6 alkoksi opcijski supstituiran s jednom ili više OH-skupina ili C1-C4 alkoksi, NR18(SO2)R21, (SO2)NR19R21, (SO2)R21NR18C(O)R21, C(O)NR19R21, NR18C(O)NR19R21, NR18C(O)OR19, NR19R21, C(O)OR19, C(O)R19, SR19, OR19, okso, CN, NO2, halogen ili 3- do 14-člana heterociklička skupina, gdje heterociklička skupina sadrži najmanje jedan heteroatom odabran od N, O i S; R19 i R21 su svaki neovisno H; C1-C8 alkil; C3-C8 cikloalkil; C1-C4 alkoksi-C1-C4 alkil; (C0-C4 alkil)-aril opcijski supstituiran s jednom ili više skupina odabranih od sljedećih: C1-C6 alkil, alkoksi i halogen; (C0-C4 alkil)-3- do 14-člana heterociklička skupina, gdje heterociklička skupina uključuje jedan ili više heteroatoma odabranih od N, O i S, opcijski supstituirana s jednom ili više skupina odabranih od sljedećih: halogen, okso, C1-C6 alkil i C(O)C1-C6 alkil; (C0-C4 alkil)-O-aril opcijski supstituiran s jednom ili više skupina odabranih od sljedećih: C1-C6 alkil, C1-C6 alkoksi i halogen; i (C0-C4 alkil)-O-3- do 14-člana heterociklička skupina, dok heterociklička skupina uključuje jedan ili više heteroatoma odabranih od N, O i S, opcijski supstituirana s jednom ili više skupina odabranih od sljedećih: halogen, C1-C6 alkil ili C(O)C1-C6 alkil; pri čemu su alkilne skupine opcijski supstituirane s jednim ili više atoma halogena, C1-C4 alkoksi, C(O)NH2, C(O)NHC1-C6 alkil ili C(O)N(C1-C6 alkil)2; ili R19 i R21 zajedno s atomom dušika na kojega su priključeni, tvore 5- do 10-članu heterocikličku skupinu, gdje heterociklička skupina uključuje jedan ili više dodatnih heteroatoma odabranih od N, O i S, dok je heterociklička skupina opcijski supstituirana s jednim ili više supstituenata odabranih od OH; halogen; aril; 5- do 10-člana heterociklička skupina koja uključuje jedan ili više heteroatoma odabranih od N, O i S; S(O)2-aril; S(O)2-C1-C6 alkil; C1-C6 alkil opcijski supstituiran s jednim ili više atoma halogena; C1-C6 alkoksi opcijski supstituiran s jednom ili više OH-skupina ili s C1-C4 alkoksi; i C(O)OC1-C6 alkil, gdje su arilna i heterociklička supstituenska skupina i same opcijski supstituirane sa sljedećima: C1-C6 alkil, C1-C6 haloalkil ili C1-C6 alkoksi.6. A compound, indicated by the fact that it is represented by formula II, [image] or a pharmaceutically acceptable salt thereof, wherein A is N or CR4a; R4a is H or C1-C4 alkyl; R 1 is C 1 -C 8 alkyl optionally substituted with one or more halogen atoms; C1-C8 alkoxy optionally substituted with one or more halogen atoms; halogen; NR11R12, C6-C14 aryl; or -(C0-C4 alkyl)- 5- to 6-membered heterocyclic group, wherein the heterocyclic group contains at least one heteroatom selected from N, O and S, while the aryl and heterocyclic group are each optionally substituted with one or more Z substituents; R 3 is H or CH 3 ; R101 is: [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] [image] R 11 is H, C 1 -C 8 alkyl optionally substituted with one or more halogen atoms, C 3 -C 10 cycloalkyl or -(C 1 -C 4 alkyl)-C 3 -C 8 cycloalkyl; R 12 and R 18 are each independently H; C1-C8 alkyl optionally substituted with one or more halogen atoms; C2-C8 alkenyl; C2-C8 alkynyl; C3-C10 cycloalkyl; C5-C10 cycloalkenyl; -C1-C4 alkyl-C3-C8 cycloalkyl; -(C0-C4 alkyl)-C6-C14 aryl; or -(C0-C4 alkyl)- a 3- to 14-membered heterocyclic group, wherein the heterocyclic group contains at least one heteroatom selected from N, O, and S, wherein each of the cycloalkyl, cycloalkenyl, aryl, and heterocyclic groups is optionally substituted with one or multiple Z substituents; or R11 and R12, together with the nitrogen atom to which they are attached, can form a 4- to 14-membered heterocyclic group optionally substituted with one or more Z substituents; Z is independently OH, aryl, O-aryl, benzyl, O-benzyl, C1-C6 alkyl optionally substituted with one or more OH-groups or NH2-groups, C1-C6 alkyl optionally substituted with one or more halogen atoms, C1- C6 Alkoxy optionally substituted with one or more OH-groups or C1-C4 Alkoxy, NR18(SO2)R21, (SO2)NR19R21, (SO2)R21NR18C(O)R21, C(O)NR19R21, NR18C(O)NR19R21, NR18C (O)OR19, NR19R21, C(O)OR19, C(O)R19, SR19, OR19, oxo, CN, NO2, halogen or a 3- to 14-membered heterocyclic group, where the heterocyclic group contains at least one heteroatom selected from N , O and S; R 19 and R 21 are each independently H; C1-C8 alkyl; C3-C8 cycloalkyl; C1-C4 alkoxy-C1-C4 alkyl; (C0-C4 alkyl)-aryl optionally substituted with one or more groups selected from the following: C1-C6 alkyl, alkoxy and halogen; (C0-C4 alkyl)-3- to 14-membered heterocyclic group, wherein the heterocyclic group includes one or more heteroatoms selected from N, O, and S, optionally substituted with one or more groups selected from the following: halogen, oxo, C1-C6 alkyl and C(O)C1-C6 alkyl; (C0-C4 alkyl)-O-aryl optionally substituted with one or more groups selected from the following: C1-C6 alkyl, C1-C6 alkoxy and halogen; and (C0-C4 alkyl)-O-3- to 14-membered heterocyclic group, wherein the heterocyclic group includes one or more heteroatoms selected from N, O, and S, optionally substituted with one or more groups selected from the following: halogen, C1- C6 alkyl or C(O)C1-C6 alkyl; wherein the alkyl groups are optionally substituted with one or more halogen atoms, C1-C4 alkoxy, C(O)NH2, C(O)NHC1-C6 alkyl or C(O)N(C1-C6 alkyl)2; or R19 and R21, together with the nitrogen atom to which they are attached, form a 5- to 10-membered heterocyclic group, where the heterocyclic group includes one or more additional heteroatoms selected from N, O, and S, while the heterocyclic group is optionally substituted with one or more substituents selected from OH; halogen; aryl; a 5- to 10-membered heterocyclic group including one or more heteroatoms selected from N, O and S; S(O) 2 -aryl; S(O) 2 -C 1 -C 6 alkyl; C1-C6 alkyl optionally substituted with one or more halogen atoms; C1-C6 Alkoxy optionally substituted with one or more OH-groups or C1-C4 Alkoxy; and C(O)OC 1 -C 6 alkyl, wherein the aryl and heterocyclic substituent groups are themselves optionally substituted with the following: C 1 -C 6 alkyl, C 1 -C 6 haloalkyl or C 1 -C 6 alkoxy. 7. Spoj prema zahtjevu 1, naznačen time, da je odabran od sljedećih: 3-amino-6-bromo-5-trifluorometil-piridin-2-karboksilna kiselina-(3,3,3-trifluoro-2-hidroksi-2-metil-propil)-amid; 3-amino-6-bromo-5-trifluorometil-piridin-2-karboksilna kiselina-(3,3,3-trifluoro-2-hidroksi-propil)-amid; 3-amino-6-bromo-5-trifluorometil-piridin-2-karboksilna kiselina-((S)-3,3,3- trifluoro-2-hidroksi-propil)-amid; 3-amino-6-bromo-5-trifluorometil-piridin-2-karboksilna kiselina-[(R)-1-(tetrahidro-furan-2-il)metil]-amid; 3-amino-6-bromo-5-trifluorometil-piridin-2-karboksilna kiselina-([1,3]dioksolan-2-ilmetil)-amid; 3-amino-6-bromo-5-trifluorometil-piridin-2-karboksilna kiselina-[(S)-1-(tetrahidrofuran-2-il)metil]-amid; 3-amino-6-bromo-5-trifluorometil-piridin-2-karboksilna kiselina-(tetrahidro-furan-2-ilmetil)-amid; 3-amino-6-bromo-5-trifluorometil-piridin-2-karboksilna kiselina-(2-metil-2-piperidin-1-il-propil)-amid; 3-amino-6-bromo-5-trifluorometil-piridin-2-karboksilna kiselina-(2-hidroksi-propil)-amid; 3-amino-6-bromo-5-trifluorometil-piridin-2-karboksilna kiselina-(2-hidroksi-2-metil-propil)-amid; 3-amino-6-bromo-5-trifluorometil-piridin-2-karboksilna kiselina-(2-metil-tetrahidrofuran-2-il-metil)-amid; 3-amino-6-bromo-5-trifluorometil-piridin-2-karboksilna kiselina-(2-metoksi-etil)-amid; 3-amino-6-bromo-5-trifluorometil-piridin-2-karboksilna kiselina-[2-(4-fluoro-fenil)-2-morfolin-4-il-etil]-amid; 3-amino-6-bromo-5-trifluorometil-piridin-2-karboksilna kiselina-(2-morfolin-4-il-2-fenil-etil)-amid; 3-amino-6-bromo-5-trifluorometil-piridin-2-karboksilna kiselina-(2-dimetilamino-2-fenil-etil)-amid; 3-amino-6-(4-fluoro-fenil)-5-trifluorometil-piridin-2-karboksilna kiselina-(3,3,3-trifluoro-2-hidroksi-2-metil-propil)-amid; 3-amino-5-trifluorometil-piridin-2-karboksilna kiselina-(3,3,3-trifluoro-2-hidroksi-2-metil-propil)-amid; 3-amino-6-(4-kloro-2-metiI-fenil)-5-trifluorometil-piridin-2-karboksilna kiselina-((R)-3,3,3-trifluoro-2-hidroksi-propil)-amid; 3-amino-6-bromo-5-trifluorometil-piridin-2-karboksilna kiselina-(3,3,3-trifluoro-2-hidroksi-2-trifluorometil-propil)-amid; 5-amino-6'-metil-3-trifluorometil-[2,3']bipiridinil-6-karboksilna kiselina-(3,3,3-trifluoro-2-hidroksi-2-metil-propil)-amid; 3-amino-6-bromo-5-trifluorometil-piridin-2-karboksilna kiselina-((R)-3,3,3-trifluoro-2-hidroksi-2-metil-propil)-amid; 3-amino-6-bromo-5-trifluorometil-piridin-2-karboksilna kiselina-((S)-3,3,3-trifluoro-2-hidroksi-2-metil-propil)-amid; 3-amino-6-metoksi-5-trifluorometil-piridin-2-karboksilna kiselina-(3,3,3-trifluoro-2-hidroksi-2-metil-propil)-amid; 3-amino-6-(4-fluoro-fenil)-5-trifluorometil-piridin-2-kaxboksilna kiselina-((S)-3,3,3-trifluoro-2-hidroksi-2-metil-propil)-amid; 3-amino-6-(4-fluoro-feniI)-5-trifluorometil-piridin-2-karboksilna kiselina-((R)-3,3,3-trifluoro-2-hidroksi-2-metil-propil)-amid; 3-amino-6-(2,4-dikloro-fenil)-5-trifluorometiI-piridin-2-karboksilna kiselina-(3,3,3-trifluoro-2-hidroksi-2-metil-propil)-amid; 3-amino-6-(4-fluoro-fenil)-5-trifluorometil-piridin-2-karboksilna kiselina-(2-hidroksi-2-metil-propil)-amid; 3-amino-6-metoksi-5-trifluorometil-piridin-2-karboksilna kiselina-(3,3,3-trifluoro-2-hidroksi-propil)-amid; S-amino-6'-metil-3-trifluorometil-[2,3']bipiridinil-6-karboksilna kiselina-(3,3,3-trifluoro-2-hidroksi-2-trifluorometil-propil)-amid; 5-amino-6'-metil-3-trifluorometil-[2,3']bipiridinil-6-karboksilna kiselina-(3,3,3-trifluoro-2-hidroksi-2-metil-propil)-amid; 3-amino-5,6-bis-trifluorometil-piridin-2-karboksilna kiselina-((S)-3,3,3-trifluoro-2-hidroksi-2-metil-propil)-amid; 3-amino-5,6-bis-trifluorometil-piridin-2-karboksilna kiselina-((R)-3,3,3-trifluoro-2-hidroksi-2-metil-propil)-amid; 3-amino-6-metoksi-5-trifluorometil-piridin-2-karboksilna kiselina-((S)-3,3,3-trifluoro-2-hidroksi-2-metil-propil)-amid; 3-amino-6-metoksi-5-trifluorometil-piridin-2-karboksilna kiselina-((R)-3,3,3-trifluoro-2-hidroksi-2-metil-propil)-amid; metil 3-(3-amino-6-bromo-5-(trifluorometil)pikolinamido)propanoat; 3-amino-6-(oksazol-2-il)-N-(3,3,3-trifluoro-2-hidroksi-2-metilpropil)-5-(trifluorometil)pikolinamid; 3-amino-6-bromo-N-(3,3,3-trifluoro-2-metoksi-2-metilpropil)-5-(trifluorometil)pikolinamid; 3-amino-N-(2-hidroksi-3-metil-2-(trifluorometil)butil)-6-metoksi-5-(trifluorometil)pikolinamid; 3-amino-6-ciklopropil-N-(3,3,3-trifluoro-2-hidroksi-2-metilpropil)-5-(trifluorometil)pikolinamid; 3-amino-6-metoksi-N-(3,3,3-trifluoro-2-hidroksi-2-(trifluorometil)propil)-5-(trifluorometil)pikolinamid; 5-amino-N-(3,3,3-trifluoro-2-hidroksi-2-metilpropil)-3-(trifluorometil)-2,4'-bipiridin-6-karboksamid; 3-amino-6-bromo-5-trifluorometil-piridin-2-karboksilna kiselina-(3-metil-2-okso-butil)-amid; 3-amino-6-(1-metil-1H-pirazol-4-il)-N-(3,3,3-trifluoro-2-hidroksi-2-metilpropil)-5-(trifluorometil)pikolinamid; (S)-3-amino-6-etoksi-N-(3,3,3-trifluoro-2-hidroksi-2-metilpropil)-5-(trifluorometil)pikolinamid; 3-amino-6-(pirolidin-1-il)-N-(3,3,3-trifluoro-2-hidroksi-2-metilpropil)-5-(trifluorometil)pikolinamid; 3-amino-N-(2-amino-3,3,3-trifluoro-2-metilpropil)-6-metoksi-5-(trifluorometil)pikolinamid; i 3-amino-6-metoksi-N-(3,3,3-trifluoro-2-(4-metoksibenzilamino)-2-metilpropil)-5-(trifluorometil)pikolinamid; ili njegova farmaceutski prihvatljiva sol.7. The compound according to claim 1, characterized in that it is selected from the following: 3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid-(3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-amide; 3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid-(3,3,3-trifluoro-2-hydroxy-propyl)-amide; 3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid-((S)-3,3,3-trifluoro-2-hydroxy-propyl)-amide; 3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid-[(R)-1-(tetrahydro-furan-2-yl)methyl]-amide; 3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid-([1,3]dioxolan-2-ylmethyl)-amide; 3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid-[(S)-1-(tetrahydrofuran-2-yl)methyl]-amide; 3-amino-6-bromo-5-trifluoromethyl-pyridin-2-carboxylic acid-(tetrahydro-furan-2-ylmethyl)-amide; 3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid-(2-methyl-2-piperidin-1-yl-propyl)-amide; 3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid-(2-hydroxy-propyl)-amide; 3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid-(2-hydroxy-2-methyl-propyl)-amide; 3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid-(2-methyl-tetrahydrofuran-2-yl-methyl)-amide; 3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid-(2-methoxy-ethyl)-amide; 3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid-[2-(4-fluoro-phenyl)-2-morpholin-4-yl-ethyl]-amide; 3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid-(2-morpholin-4-yl-2-phenyl-ethyl)-amide; 3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid-(2-dimethylamino-2-phenyl-ethyl)-amide; 3-amino-6-(4-fluoro-phenyl)-5-trifluoromethyl-pyridine-2-carboxylic acid-(3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-amide; 3-amino-5-trifluoromethyl-pyridine-2-carboxylic acid-(3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-amide; 3-amino-6-(4-chloro-2-methyl-phenyl)-5-trifluoromethyl-pyridine-2-carboxylic acid-((R)-3,3,3-trifluoro-2-hydroxy-propyl)-amide ; 3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid-(3,3,3-trifluoro-2-hydroxy-2-trifluoromethyl-propyl)-amide; 5-amino-6'-methyl-3-trifluoromethyl-[2,3']bipyridinyl-6-carboxylic acid-(3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-amide; 3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid-((R)-3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-amide; 3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid-((S)-3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-amide; 3-amino-6-methoxy-5-trifluoromethyl-pyridine-2-carboxylic acid-(3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-amide; 3-amino-6-(4-fluoro-phenyl)-5-trifluoromethyl-pyridine-2-carboxylic acid-((S)-3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-amide ; 3-amino-6-(4-fluoro-phenyl)-5-trifluoromethyl-pyridine-2-carboxylic acid-((R)-3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-amide ; 3-amino-6-(2,4-dichloro-phenyl)-5-trifluoromethyl-pyridine-2-carboxylic acid-(3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-amide; 3-amino-6-(4-fluoro-phenyl)-5-trifluoromethyl-pyridine-2-carboxylic acid-(2-hydroxy-2-methyl-propyl)-amide; 3-amino-6-methoxy-5-trifluoromethyl-pyridine-2-carboxylic acid-(3,3,3-trifluoro-2-hydroxy-propyl)-amide; S-amino-6'-methyl-3-trifluoromethyl-[2,3']bipyridinyl-6-carboxylic acid-(3,3,3-trifluoro-2-hydroxy-2-trifluoromethyl-propyl)-amide; 5-amino-6'-methyl-3-trifluoromethyl-[2,3']bipyridinyl-6-carboxylic acid-(3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-amide; 3-amino-5,6-bis-trifluoromethyl-pyridine-2-carboxylic acid-((S)-3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-amide; 3-amino-5,6-bis-trifluoromethyl-pyridine-2-carboxylic acid-((R)-3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-amide; 3-amino-6-methoxy-5-trifluoromethyl-pyridine-2-carboxylic acid-((S)-3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-amide; 3-amino-6-methoxy-5-trifluoromethyl-pyridine-2-carboxylic acid-((R)-3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-amide; methyl 3-(3-amino-6-bromo-5-(trifluoromethyl)picolinamido)propanoate; 3-amino-6-(oxazol-2-yl)-N-(3,3,3-trifluoro-2-hydroxy-2-methylpropyl)-5-(trifluoromethyl)picolinamide; 3-amino-6-bromo-N-(3,3,3-trifluoro-2-methoxy-2-methylpropyl)-5-(trifluoromethyl)picolinamide; 3-amino-N-(2-hydroxy-3-methyl-2-(trifluoromethyl)butyl)-6-methoxy-5-(trifluoromethyl)picolinamide; 3-amino-6-cyclopropyl-N-(3,3,3-trifluoro-2-hydroxy-2-methylpropyl)-5-(trifluoromethyl)picolinamide; 3-amino-6-methoxy-N-(3,3,3-trifluoro-2-hydroxy-2-(trifluoromethyl)propyl)-5-(trifluoromethyl)picolinamide; 5-amino-N-(3,3,3-trifluoro-2-hydroxy-2-methylpropyl)-3-(trifluoromethyl)-2,4'-bipyridine-6-carboxamide; 3-amino-6-bromo-5-trifluoromethyl-pyridine-2-carboxylic acid-(3-methyl-2-oxo-butyl)-amide; 3-amino-6-(1-methyl-1H-pyrazol-4-yl)-N-(3,3,3-trifluoro-2-hydroxy-2-methylpropyl)-5-(trifluoromethyl)picolinamide; (S)-3-amino-6-ethoxy-N-(3,3,3-trifluoro-2-hydroxy-2-methylpropyl)-5-(trifluoromethyl)picolinamide; 3-amino-6-(pyrrolidin-1-yl)-N-(3,3,3-trifluoro-2-hydroxy-2-methylpropyl)-5-(trifluoromethyl)picolinamide; 3-amino-N-(2-amino-3,3,3-trifluoro-2-methylpropyl)-6-methoxy-5-(trifluoromethyl)picolinamide; and 3-amino-6-methoxy-N-(3,3,3-trifluoro-2-(4-methoxybenzylamino)-2-methylpropyl)-5-(trifluoromethyl)picolinamide; or a pharmaceutically acceptable salt thereof. 8. Spoj prema zahtjevu 7, naznačen time, da je to: 3-amino-6-metoksi-5-trifluorometil-piridin-2-karboksilna kiselina-((S)-3,3,3-trifluoro-2-hidroksi-2-metil-propil)-amid, ili njegova farmaceutski prihvatljiva sol.8. Compound according to claim 7, characterized in that it is: 3-amino-6-methoxy-5-trifluoromethyl-pyridine-2-carboxylic acid-((S)-3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-amide, or a pharmaceutically acceptable salt thereof. 9. Spoj prema zahtjevu 7, naznačen time, da je to: 3-amino-6-metoksi-5-trifluorometil-piridin-2-karboksilna kiselina-((R)-3,3,3-trifluoro-2-hidroksi-2-metil-propil)-amid, ili njegova farmaceutski prihvatljiva sol.9. Compound according to claim 7, characterized in that it is: 3-amino-6-methoxy-5-trifluoromethyl-pyridine-2-carboxylic acid-((R)-3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-amide, or a pharmaceutically acceptable salt thereof. 10. Spoj prema zahtjevu 7, naznačen time, da je to: 3-amino-6-(4-fluoro-fenil)-5-trifluorometil-piridin-2-karboksilna kiselina-(3,3,3-trifluoro-2-hidroksi-2-metil-propil)-amid, ili njegova farmaceutski prihvatljiva sol.10. Compound according to claim 7, characterized in that it is: 3-amino-6-(4-fluoro-phenyl)-5-trifluoromethyl-pyridine-2-carboxylic acid-(3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-amide, or a pharmaceutically acceptable salt thereof. 11. Spoj prema zahtjevu 7, naznačen time, da je to: 3-amino-5,6-bis-trifluorometil-piridin-2-karboksilna kiselina-((S)-(3,3,3-trifluoro-2-hidroksi-2-metil-propil)-amid, ili njegova farmaceutski prihvatljiva sol.11. Compound according to claim 7, characterized in that it is: 3-amino-5,6-bis-trifluoromethyl-pyridine-2-carboxylic acid-((S)-(3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-amide, or a pharmaceutically acceptable salt thereof. 12. Spoj prema zahtjevu 7, naznačen time, da je to: 3-amino-5,6-bis-trifluorometil-piridin-2-karboksilna kiselina-((R)-(3,3,3-trifluoro-2-hidroksi-2-metil-propil)-amid, ili njegova farmaceutski prihvatljiva sol.12. Compound according to claim 7, characterized in that it is: 3-amino-5,6-bis-trifluoromethyl-pyridine-2-carboxylic acid-((R)-(3,3,3-trifluoro-2-hydroxy-2-methyl-propyl)-amide, or a pharmaceutically acceptable salt thereof. 13. Spoj ili njegova farmaceutski prihvatljiva sol, prema bilo kojem od zahtjeva 1 do 12, naznačen/a time, da se upotrebljava kao farmaceutsko sredstvo.13. The compound or its pharmaceutically acceptable salt, according to any one of claims 1 to 12, characterized in that it is used as a pharmaceutical agent. 14. Spoj ili njegova farmaceutski prihvatljiva sol, prema bilo kojem od zahtjeva 1 do 12, naznačena time, da se upotrebljava u liječenju upalne ili opstrukcijske bolesti dišnih puteva ili stanja kojima pogoduje mukozna hidratacija.14. The compound or its pharmaceutically acceptable salt, according to any one of claims 1 to 12, characterized in that it is used in the treatment of inflammatory or obstructive diseases of the respiratory tract or conditions favored by mucosal hydration. 15. Spoj ili njegova farmaceutski prihvatljiva sol, prema bilo kojem od zahtjeva 1 do 12, naznačen/a time, da se upotrebljava u liječenju cistične fibroze.15. The compound or its pharmaceutically acceptable salt, according to any one of claims 1 to 12, characterized in that it is used in the treatment of cystic fibrosis. 16. Uporaba spoja ili njegove farmaceutski prihvatljive soli, prema bilo kojem od zahtjeva 1 do 12, naznačena time, da je za proizvodnju lijeka koji se upotrebljava u liječenju upalne ili opstrukcijske bolesti dišnih puteva ili stanja kojima pogoduje mukozna hidratacija.16. The use of the compound or its pharmaceutically acceptable salt, according to any one of claims 1 to 12, characterized in that it is for the production of a drug used in the treatment of inflammatory or obstructive diseases of the respiratory tract or conditions favored by mucosal hydration. 17. Farmaceutski sastav, naznačen time, da obuhvaća spoj ili njegovu farmaceutski prihvatljivu sol, prema bilo kojem od zahtjeva 1 do 12, i jedno ili više farmaceutski prihvatljivih pomoćnih sredstava.17. Pharmaceutical composition, characterized in that it comprises a compound or its pharmaceutically acceptable salt, according to any one of claims 1 to 12, and one or more pharmaceutically acceptable excipients. 18. Farmaceutska kombinacija, naznačena time, da obuhvaća: prvi djelatni sastojak koji sadrži spoj ili njegovu farmaceutski prihvatljivu sol, prema bilo kojem od zahtjeva 1 do 12, i drugi djelatni sastojak odabran od sljedećih: osmotska sredstva, ENaC-blokatori, protuupalna sredstva, bronhodilatorna sredstva, antihistaminska sredstva, antitusivna sredstva, antibiotici i ljekovite DNase-supstance, pri čemu prvi i drugi djelatni sastojci mogu biti u istom ili u drugačijem farmaceutskom sastavu.18. Pharmaceutical combination, characterized in that it includes: the first active ingredient comprising a compound or a pharmaceutically acceptable salt thereof, according to any one of claims 1 to 12, and second active ingredient selected from the following: osmotic agents, ENaC-blockers, anti-inflammatory agents, bronchodilators, antihistamines, antitussive agents, antibiotics and medicinal DNase-substances, whereby the first and second active ingredients can be in the same or different pharmaceutical composition.
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