HRP20140981T4 - Viskoelastični gelovi kao nova punila - Google Patents
Viskoelastični gelovi kao nova punila Download PDFInfo
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- HRP20140981T4 HRP20140981T4 HRP20140981TT HRP20140981T HRP20140981T4 HR P20140981 T4 HRP20140981 T4 HR P20140981T4 HR P20140981T T HRP20140981T T HR P20140981TT HR P20140981 T HRP20140981 T HR P20140981T HR P20140981 T4 HRP20140981 T4 HR P20140981T4
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- hbc
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- temperature
- solution
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- 239000000945 filler Substances 0.000 title 1
- 239000000499 gel Substances 0.000 title 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 8
- 229920002674 hyaluronan Polymers 0.000 claims 8
- 229960003160 hyaluronic acid Drugs 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 238000002156 mixing Methods 0.000 claims 6
- 239000000243 solution Substances 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- 230000036571 hydration Effects 0.000 claims 3
- 238000006703 hydration reaction Methods 0.000 claims 3
- SHKUUQIDMUMQQK-UHFFFAOYSA-N 2-[4-(oxiran-2-ylmethoxy)butoxymethyl]oxirane Chemical compound C1OC1COCCCCOCC1CO1 SHKUUQIDMUMQQK-UHFFFAOYSA-N 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 239000012670 alkaline solution Substances 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 238000007865 diluting Methods 0.000 claims 2
- 239000006185 dispersion Substances 0.000 claims 2
- 238000004090 dissolution Methods 0.000 claims 2
- 238000001125 extrusion Methods 0.000 claims 2
- 238000011049 filling Methods 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 230000007935 neutral effect Effects 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- 238000010979 pH adjustment Methods 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 230000001954 sterilising effect Effects 0.000 claims 2
- 238000004659 sterilization and disinfection Methods 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 238000000265 homogenisation Methods 0.000 claims 1
- 230000014759 maintenance of location Effects 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000008363 phosphate buffer Substances 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 239000012266 salt solution Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000001291 vacuum drying Methods 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/005—Processes for mixing polymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/12—Powdering or granulating
- C08J3/14—Powdering or granulating by precipitation from solutions
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
- C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (4)
1. Postupak miješanja ACP s HBC koji je proveden u postupku koji obuhvaća sljedeće korake:
a. otapanje u alkalnoj otopini diepoksida BDDE u stehiometrijskom omjeru od 2.5 do 25% u molovima prema ponavljajućim jedinicama hialuronske kiseline, nakon čega slijedi
b. disperzija hialuronske kiseline (HA) u otopini navedenoj u paragrafu a), pri sobnoj temperaturi,
c. poticanje reakcije aktivacijom toplinom, zagrijavanjem otopine navedene u paragrafu b) pri temperaturi između 35 i 55 °C kroz između 2 i 36 sati,
d. ekstruzija dobivene mase preko metalnog sita da se čestice smanje na veličinu od približno 600 µm.
e. hidratacija dobivenog gela razrijeđivanjem vodom 3 do 20 puta,
f. podešavanje pH vodenom otopinom HCl do neutralnog,
g. taloženje organskim otapalom topljivim u vodi do dobivanja produkta u obliku praška,
h. pranje organskim otapalima koji sadrže vodu,
i. sušenje u vakuumu da se otapalo eliminira i njegov sadržaj bude ispod 400 ppm te nastane praškasti HBC,
pri čemu postupak miješanja obuhvaća sljedeće korake:
j. miješanje praškastog ACP s praškastim HBC u ACP: HBC omjer je između 90:10 i 10:90,
k. hidratacija otopinom soli ili fosfatnim puferom, tako da ukupna koncentracija HA bude između 12 i 27 mg/mL,
l. ekstruzija pri temperaturi između 25 i 65 °C kroz sito veličine otvora između 50 i 500 µm,
m. punjenje injekcije,
n. sterilizacija toplinom sa zasićenom vodenom parom pri temperaturi između 120 i 124 °C najmanje 10 minuta.
2. Postupak miješanja ACP s HBC koji je proveden u postupku koji obuhvaća sljedeće korake:
a. otapanje u alkalnoj otopini diepoksida BDDE u stehiometrijskom omjeru od 2.5 do 25% u molovima prema ponavljajućim jedinicama hialuronske kiseline, nakon čega slijedi
b. disperzija hialuronske kiseline (HA) u otopini navedenoj u paragrafu a), pri sobnoj temperaturi,
c. poticanje reakcije aktivacije toplinom, zagrijavanjem otopine navedene u paragrafu b) pri temperaturi između 35 i 55 °C kroz između 2 i 36 sati,
d. podešavanje pH vodenom otopinom HCl do neutralnog,
e. hidratacija dobivenog gela razrijeđivanjem vodom 3 do 20 puta,
pri čemu postupak miješanja obuhvaća sljedeće korake:
f. miješanje ACP u obliku praška ili gela i HBC u obliku gela u omjeru između 90:10 i 10:90,
g. usitnjavanje i homogenizajcija prolaskom kroz filter s koeficijentom retencije usitnjene tvari između 25 i 150 µm,
h. punjenje injekcije,
i. sterilizacija toplinom sa zasićenom vodenom parom pri temperaturi između 120 i 124 °C najmanje 10 minuta.
3. Postupak kako je prijavljen u patentnom zahtjevu 1 ili 2, naznačen time da HA koja se koristi za prirpavu HBC i ACP derivata ima prosječnu molekularnu masu između 400 i 3x106 Da, preferiranije između 1x105 Da i 1x106 Da, još preferiranije između 200000 i 1x106 Da.
4. Postupak kako je prijavljen u patentnom zahtjevu 2, naznačen time da maseni omjer ACP:HBC iznosi 25:75.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITPD2009A000246A IT1395392B1 (it) | 2009-08-27 | 2009-08-27 | Geli viscoelastici come nuovi filler |
| EP10750046.4A EP2470230B2 (en) | 2009-08-27 | 2010-08-25 | Viscoelastic gels as novel fillers |
| PCT/EP2010/005161 WO2011023355A2 (en) | 2009-08-27 | 2010-08-25 | Viscoelastic gels as novel fillers |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| HRP20140981T1 HRP20140981T1 (en) | 2014-11-21 |
| HRP20140981T8 HRP20140981T8 (en) | 2015-01-16 |
| HRP20140981T2 HRP20140981T2 (hr) | 2016-05-06 |
| HRP20140981T4 true HRP20140981T4 (hr) | 2022-08-19 |
Family
ID=42046298
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20140981TT HRP20140981T4 (hr) | 2009-08-27 | 2010-08-25 | Viskoelastični gelovi kao nova punila |
| HRP20160196T HRP20160196T1 (hr) | 2009-08-27 | 2016-02-25 | Viskoelastični gelovi kao nova punila |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20160196T HRP20160196T1 (hr) | 2009-08-27 | 2016-02-25 | Viskoelastični gelovi kao nova punila |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8846640B2 (hr) |
| EP (2) | EP2470230B2 (hr) |
| JP (1) | JP5976537B2 (hr) |
| KR (1) | KR101749660B1 (hr) |
| CN (2) | CN104623730B (hr) |
| AU (1) | AU2010288937B2 (hr) |
| BR (1) | BR112012004157B8 (hr) |
| CA (2) | CA2995957C (hr) |
| CY (2) | CY1115628T1 (hr) |
| DK (2) | DK2470230T4 (hr) |
| ES (2) | ES2563160T3 (hr) |
| HK (2) | HK1172850A1 (hr) |
| HR (2) | HRP20140981T4 (hr) |
| HU (1) | HUE026830T2 (hr) |
| IT (1) | IT1395392B1 (hr) |
| MX (1) | MX2012002364A (hr) |
| PL (2) | PL2772273T3 (hr) |
| PT (1) | PT2470230E (hr) |
| RU (2) | RU2543329C2 (hr) |
| SI (2) | SI2470230T2 (hr) |
| SM (1) | SMT201600062B (hr) |
| WO (1) | WO2011023355A2 (hr) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2818184B1 (en) | 2007-11-16 | 2018-10-31 | Allergan, Inc. | Compositions and methods for treating Purpura |
| US8394782B2 (en) | 2007-11-30 | 2013-03-12 | Allergan, Inc. | Polysaccharide gel formulation having increased longevity |
| US8450475B2 (en) | 2008-08-04 | 2013-05-28 | Allergan, Inc. | Hyaluronic acid-based gels including lidocaine |
| CA2735173C (en) | 2008-09-02 | 2017-01-10 | Tautona Group Lp | Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof |
| US20110172180A1 (en) | 2010-01-13 | 2011-07-14 | Allergan Industrie. Sas | Heat stable hyaluronic acid compositions for dermatological use |
| CA2792729C (en) | 2010-03-12 | 2016-06-28 | Allergan Industrie, Sas | Fluid compositions for improving skin conditions |
| CA2794254C (en) | 2010-03-22 | 2018-09-04 | Allergan, Inc. | Polysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation |
| US9005605B2 (en) | 2010-08-19 | 2015-04-14 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| US8883139B2 (en) | 2010-08-19 | 2014-11-11 | Allergan Inc. | Compositions and soft tissue replacement methods |
| US8889123B2 (en) | 2010-08-19 | 2014-11-18 | Allergan, Inc. | Compositions and soft tissue replacement methods |
| FR2968305B1 (fr) | 2010-12-06 | 2014-02-28 | Teoxane | Procede de preparation d'un gel reticule |
| US9408797B2 (en) | 2011-06-03 | 2016-08-09 | Allergan, Inc. | Dermal filler compositions for fine line treatment |
| US9393263B2 (en) | 2011-06-03 | 2016-07-19 | Allergan, Inc. | Dermal filler compositions including antioxidants |
| US20130096081A1 (en) | 2011-06-03 | 2013-04-18 | Allergan, Inc. | Dermal filler compositions |
| ES2738208T3 (es) | 2011-06-03 | 2020-01-20 | Allergan Ind Sas | Composiciones de relleno dérmico que incluyen antioxidantes |
| PT2742070T (pt) * | 2011-08-10 | 2021-11-22 | Glycores 2000 Srl | Hialuronato de baixo peso molecular reticulado, resistente à degradação |
| US20130244943A1 (en) | 2011-09-06 | 2013-09-19 | Allergan, Inc. | Hyaluronic acid-collagen matrices for dermal filling and volumizing applications |
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