HRP20130803T1 - Sredstva za vezanje sklerostina - Google Patents
Sredstva za vezanje sklerostina Download PDFInfo
- Publication number
- HRP20130803T1 HRP20130803T1 HRP20130803TT HRP20130803T HRP20130803T1 HR P20130803 T1 HRP20130803 T1 HR P20130803T1 HR P20130803T T HRP20130803T T HR P20130803TT HR P20130803 T HRP20130803 T HR P20130803T HR P20130803 T1 HRP20130803 T1 HR P20130803T1
- Authority
- HR
- Croatia
- Prior art keywords
- bone
- disease
- bone loss
- antibody
- sclerostin
- Prior art date
Links
- 102000019307 Sclerostin Human genes 0.000 title claims 25
- 108050006698 Sclerostin Proteins 0.000 title claims 25
- 239000011230 binding agent Substances 0.000 title 1
- 206010065687 Bone loss Diseases 0.000 claims 54
- 210000000988 bone and bone Anatomy 0.000 claims 20
- 238000000034 method Methods 0.000 claims 11
- 208000001132 Osteoporosis Diseases 0.000 claims 10
- 230000032683 aging Effects 0.000 claims 10
- 201000010099 disease Diseases 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 208000020084 Bone disease Diseases 0.000 claims 8
- 241000124008 Mammalia Species 0.000 claims 7
- 208000029725 Metabolic bone disease Diseases 0.000 claims 6
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 6
- 239000011707 mineral Substances 0.000 claims 6
- 230000011164 ossification Effects 0.000 claims 5
- 238000001356 surgical procedure Methods 0.000 claims 5
- 208000027414 Legg-Calve-Perthes disease Diseases 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 230000037118 bone strength Effects 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 210000003054 facial bone Anatomy 0.000 claims 4
- 230000035876 healing Effects 0.000 claims 4
- 208000027866 inflammatory disease Diseases 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 210000003625 skull Anatomy 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 239000007943 implant Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- 206010000599 Acromegaly Diseases 0.000 claims 2
- 208000007848 Alcoholism Diseases 0.000 claims 2
- 201000000736 Amenorrhea Diseases 0.000 claims 2
- 206010001928 Amenorrhoea Diseases 0.000 claims 2
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 2
- 208000010392 Bone Fractures Diseases 0.000 claims 2
- 206010006956 Calcium deficiency Diseases 0.000 claims 2
- 206010008723 Chondrodystrophy Diseases 0.000 claims 2
- 208000013725 Chronic Kidney Disease-Mineral and Bone disease Diseases 0.000 claims 2
- 201000000304 Cleidocranial dysplasia Diseases 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 208000013586 Complex regional pain syndrome type 1 Diseases 0.000 claims 2
- 102000012437 Copper-Transporting ATPases Human genes 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims 2
- 201000010374 Down Syndrome Diseases 0.000 claims 2
- 208000000088 Enchondromatosis Diseases 0.000 claims 2
- 208000024720 Fabry Disease Diseases 0.000 claims 2
- 206010017076 Fracture Diseases 0.000 claims 2
- 208000015872 Gaucher disease Diseases 0.000 claims 2
- 102000018997 Growth Hormone Human genes 0.000 claims 2
- 108010051696 Growth Hormone Proteins 0.000 claims 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 2
- 208000002972 Hepatolenticular Degeneration Diseases 0.000 claims 2
- 201000002980 Hyperparathyroidism Diseases 0.000 claims 2
- 206010020707 Hyperparathyroidism primary Diseases 0.000 claims 2
- 206010020850 Hyperthyroidism Diseases 0.000 claims 2
- 206010058359 Hypogonadism Diseases 0.000 claims 2
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 2
- 208000017670 Juvenile Paget disease Diseases 0.000 claims 2
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 2
- 208000017924 Klinefelter Syndrome Diseases 0.000 claims 2
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- 208000001826 Marfan syndrome Diseases 0.000 claims 2
- 208000008948 Menkes Kinky Hair Syndrome Diseases 0.000 claims 2
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- 208000003452 Multiple Hereditary Exostoses Diseases 0.000 claims 2
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- 230000001815 facial effect Effects 0.000 claims 2
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- 239000003862 glucocorticoid Substances 0.000 claims 2
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- 229960002897 heparin Drugs 0.000 claims 2
- 229920000669 heparin Polymers 0.000 claims 2
- 238000001794 hormone therapy Methods 0.000 claims 2
- 208000011111 hypophosphatemic rickets Diseases 0.000 claims 2
- 230000004968 inflammatory condition Effects 0.000 claims 2
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- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
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- 150000003431 steroids Chemical class 0.000 claims 2
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- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 210000001835 viscera Anatomy 0.000 claims 2
- 208000000103 Anorexia Nervosa Diseases 0.000 claims 1
- 101100454808 Caenorhabditis elegans lgg-2 gene Proteins 0.000 claims 1
- 238000009007 Diagnostic Kit Methods 0.000 claims 1
- 101000711796 Homo sapiens Sclerostin Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
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- 208000030136 Marchiafava-Bignami Disease Diseases 0.000 claims 1
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- 206010030295 Oligomenorrhoea Diseases 0.000 claims 1
- 206010031243 Osteogenesis imperfecta Diseases 0.000 claims 1
- 208000024799 Thyroid disease Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 208000022531 anorexia Diseases 0.000 claims 1
- 230000033558 biomineral tissue development Effects 0.000 claims 1
- 230000014461 bone development Effects 0.000 claims 1
- 230000008468 bone growth Effects 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 239000013599 cloning vector Substances 0.000 claims 1
- 206010061428 decreased appetite Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 238000002474 experimental method Methods 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 230000012010 growth Effects 0.000 claims 1
- 102000058171 human SOST Human genes 0.000 claims 1
- 208000003532 hypothyroidism Diseases 0.000 claims 1
- 230000002989 hypothyroidism Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
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- 239000000203 mixture Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 1
- 208000021510 thyroid gland disease Diseases 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
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Claims (33)
1. Protutijelo za vezanje sklerostina, naznačeno time, da sadržava sljedeće CDR odsječke:
CDR-H1: DYNMH (SEQ ID NO:245);
CDR-H2: EINPNSGGAGYNQKFKG (SEQ ID NO:246);
CDR-H3: LGYDDIYDDWYFDV (SEQ ID NO:247);
CDR-L1: RASQDISNYLN (SEQ ID NO:78);
CDR-L2: YTSRLLS (SEQ ID NO:79); and
CDR-L3: QQGDTLPYT (SEQ ID N0:80).
2. Protutijelo za vezanje sklerostina iz patentnog zahtjeva 1, naznačeno time, da sadržava teški lanac koji sadrži polipeptidni odsječak s najmanje 85 % identiteta s odsječkom SEQ ID NO: 378.
3. Protutijelo za vezanje sklerostina iz patentnog zahtjeva 1 ili 2, naznačeno time, da sadrži laki lanac koji sadrži polipeptidni odsječak s najmanje 85% identiteta s odsječkom SEQ ID NO: 376.
4. Protutijelo za vezanje sklerostina iz bilo kojeg patentnog zahtjeva 1 do 3, naznačeno time, da sadrži i teški lanac koji sadrži polipeptidni odsječak s najmanje 85% identiteta s odsječkom SEQ ID NO: 378 i laki lanac koji sadrži polipeptidni odsječak s najmanje 85% identiteta s odsječkom SEQ ID NO: 376.
5. Protutijelo za vezanje sklerostina iz bilo kojeg patentnog zahtjeva 1 do 4, naznačeno time, da sadržava laki lanac i/ili konstantnu regiju teškog lanca.
6. Protutijelo za vezanje sklerostina iz patentnog zahtjeva 5, naznačeno time, da je to protutijelo IgG.
7. Protutijelo za vezanje sklerostina iz patentnog zahtjeva 5, naznačeno time, da sadržava humani lgG4 ili konstantnu regiju humanog lgG2.
8. Protutijelo za vezanje sklerostina iz patentnog zahtjeva 1, naznačeno time, da ima teške lance SEQ ID NO: 137 i lake lance SEQ ID NO: 133.
9. Protutijelo za vezanje sklerostina iz patentnog zahtjeva 1, naznačeno time, da ima teške lance SEQ ID NO: 145 ili 392 i lake lance SEQ ID NO: 141.
10. Protutijelo za vezanje sklerostina iz bilo kojeg patentnog zahtjeva 1 do 4, naznačeno time, da je navedeno protutijelo fragment protutijela za vezanje sklerostina fragment koji sadržava šest CDR-ova iz patentnog zahtjeva 1.
11. Protutijelo za vezanje sklerostina iz bilo kojeg patentnog zahtjeva 1 do 9, naznačeno time, da je to tijelo cjelovito protutijelo.
12. Protutijelo za vezanje sklerostina iz patentnog zahtjeva 10, naznačeno time, da je navedeno protutijelo fragment F(ab’)2, Fab, Fab’ ili Fv.
13. Protutijelo za vezanje sklerostina iz bilo kojeg patentnog zahtjeva 1 do 7, naznačeno time, daje to humanizirano protutijelo ili kimerično protutijelo.
14. Protutijelo za vezanje sklerostina iz bilo kojeg od prethodnih patentnih zahtjeva, naznačeno time, da navedeno protutijelo ima disocijacijsku konstantu za humani sklerostin izmjerenu površinskom plazmonskom rezonancijom manjom od ili jednakom 1 × 10-9 M, manjom od ili jednakom 1 × 10-10M, manjom od ili jednakom 1 × 10-11M ili manjom od ili jednakom 1 ×10-12 M.
15. Protutijelo za vezanje sklerostina iz bilo kojeg od prethodnih patentnih zahtjeva, naznačeno time, da su na njega vezani jedna ili više efektorskih ili reporterskih molekula.
16. Protutijelo za vezanje sklerostina iz bilo kojeg od prethodnih patentnih zahtjeva, naznačeno time, da navedeno protutijelo može povećati najmanje jednu od koštanih formacija, mineralnu gustoću kosti, količinu minerala u kosti, koštanu masu, kvalitetu kosti i čvrstinu kosti u sisavca.
17. Protutijelo za vezanje sklerostina iz bilo kojeg od prethodnih patentnih zahtjeva, naznačeno time, da navedeno protutijelo može blokirati inhibicijski učinak sklerostina u pokusu mineralizacije na staničnoj razini.
18. Izolirani polinukleotidni odsječak, naznačen time, da je kodirajuće protutijelo za vezanje sklerostina iz bilo kojeg od patentnih zahtjeva 1 do 17.
19. Vektor kloniranja ili ekspresije, naznačeno time, da sadrži jedan ili više polinukleotidnih odsječaka u skladu s patentnim zahtjevom 18.
20. Vektor iz patentnog zahtjeva 19, naznačeno time, da vektor sadrži najmanje jedan odsječak iz SEQ ID NO: 134, 136, 138, 140, 142, 144, 146, 148 i 379.
21. Stanica domaćina, naznačena time, da sadrži jedan ili više vektora za kloniranje ili ekspresiju u skladu s patentnim zahtjevom 19 ili patentnim zahtjevom 20.
22. Postupak za proizvodnju protutijela za vezanje sklerostina iz bilo kojeg patentnog zahtjeva 1 do 17, naznačen time, da se sastoji od uzgajanja stanice domaćina iz patentnog zahtjeva 21 i izoliranja protutijela za vezanje sklerostina.
23. Farmaceutski pripravak koji sadrži protutijelo za vezanje sklerostina iz bilo kojeg patentnog zahtjeva 1 do 17, naznačen time, da je u kombinaciji s jednim ili više farmaceutski prihvatljivih ekscipijensa, razblaživača i nosača.
24. Farmaceutski pripravak iz patentnog zahtjeva 23, naznačen time, da dodatno sadrži druge djelatne sastojke.
25. Protutijelo za vezanje sklerostina iz bilo kojeg patentnog zahtjeva 1 do 17 ili farmaceutski pripravak iz patentnog zahtjeva 23 ili patentnog zahtjeva 24, naznačeno time, da je za uporabu u postupku liječenja poremećaja kosti povezane s najmanje jednom niskom koštanom formacijom, niskom mineralnom koštanom gustoćom, niskim sadržajem minerala u kosti, niskom koštanom masom, niskom kvalitetom kosti i niskom čvrstinom kosti u sisavca, gdje se postupak sastoji od primjene na subjekta kojem je potreban tretman određene količine rečenog protutijela dovoljnog za povećanje najmanje jedne koštane formacije, mineralne gustoće kosti, mineralnog sadržaja kosti, koštane mase, kvalitete kosti i čvrstoće kosti.
26. Protutijelo ili farmaceutski pripravak u skladu s patentnim zahtjevom 25 za rečenu uporabu, naznačeno time, da je koštani poremećaj osteopenija, osteoporoza, gubitak kosti ili nenormalni rast ili razvoj kosti uslijed najmanje jedne od ahondroplazije, kleidokranijalne disostoze, enhondromatoze, fibrozne displazije, Gaucherove bolesti, hipofosfatemičnog rahitisa, Marfanovog sindroma, višestruke nasljedne egzostoze, neurofibromatoze, nesavršene osteogeneza, osteopoikilozisa, sklerotične lezije, pseudoartroze, piogenog osteomijelitisa, parodontne bolesti, gubitka kosti kao posljedica uzimanja protu-epileptičnog lijeka, primarne i sekundarne hiperparatiroidoze, sličnih sindroma hiperparatiroidoze, gubitka kosti uslijed bestežinskog stanja, osteoporoze u muškaraca, gubitka kosti nakon menopauze, osteoartritisa, bubrežne osteodistrofije, infiltracijskog poremećaja kosti, gubitak oralne kosti, osteonekroze čeljusti, juvenilne Pagetove bolesti, meloreostoze, metaboličke bolesti kostiju, mastocitoze, srpaste anemije/bolesti, gubitka kosti povezane s u sad kom, gubitka kosti usljed usadka bubrega, sistemskog lupusa eritematozusa, ankiloznog spondilitisa, epilepsije, juvenilnog artritisa, talasemije, mukopoiisaharidoze, Fabryjeve bolesti, Turnerovog sindroma, Downovog sindroma, Klinefelterovog sindroma, lepre, Perthesove bolesti, adolescentske idiopatske skolioze, početne infantilne više-sustavne upalne bolesti, Winchesterovog sindroma, Menkesove bolesti, Wilsonove bolesti, ishemične koštane bolesti (poput Legg-Calve-Perthesove bolesti, regionalne migratorne osteoporoze), anemičnih stanja, stanja uzrokovanih steroidima, gubitka kosti izazvane glukokortikoidima, gubitka kosti izazvane heparinom, poremećaja koštane srži, skorbuta, pothranjenosti, nedostatka kalcija, alkoholizma, kronične bolesti jetre, stanja poslije menopauze, kroničnih upalnih stanja, reumatoidnog artritisa, upalne bolesti unutarnjih organa, ulceroznog kolitisa, upalnog kolitisa, Crohnove bolesti, oligomenoreje, amenoreje, trudnoće, diajbetes melitusa, hipertiroidizma, oboljenja štitnjače, paratiroidnih poremećaja, Cushingove bolesti, akromegalije, hipogonadizma, imobilizacije ili neuporabe, sindroma refleksne simpatetičke distrofije, regionalne osteoporoze, osteomalacije, gubitka kosti povezane sa zamjenom zgloba, gubitka kosti povezane HIV-om, gubitka kosti povezane s hormonom rasta, gubitka kosti povezane s cističnom fibrozom, gubitka kosti povezane s kemoterapijom, gubitka kosti izazvane tumorom, gubitka kosti povezane s karcinomom, gubitka kosti zbog ablativne hormonske terapije, višestrukog mijeloma, gubitka kosti izazvane uzimanjem lijekova, anoreksija nervoza, gubitak kostiju lica uslijed bolesti, gubitak kranijalne kosti uslijed bolesti, gubitak čeljusne kosti uslijed bolesti, gubitak kosti lubanje uslijed bolesti, gubitka kosti kao posljedica starenja, gubitka kosti lica kao posljedica starenja, gubitka kranijanle kosti kao posljedica starenja, gubitka čeljusne kosti kao posljedica starenja, gubitka kosti lubanje kao posljedica starenja i gubitka uslijed putovanja u svemir.
27. Protutijelo ili farmaceutski pripravak iz patentnog zahtjeva 25 za rečenu uporabu, naznačeno time, da je koštani poremećaj osteoporoza.
28. Protutijelo iz bilo kojeg patentnog zahtjeva 1 do 17 ili farmaceutski pripravak iz patentnog zahtjeva 23 ili 24, naznačeno time, da je za uporabu u postupku poboljšanja ishoda kod sisavca koji prolazi jednu ili više ortopedskih procedura, zubnih procedura, operacija usatka, zamjene zgloba, presađivanja kosti, kozmetičke operacije kosti i reparacije poput liječenja loma, zacjeljivanja bez srastanja, zakašnjelog zacjeljivanja i rekonstrukcije lica, rečeni postupak se sastoji od primjene rečenog protutijela ili pripravka na rečenog sisavca prije, tijekom i/ili nakon rečene procedure, zamjene, grafta, operacije ili popravka.
29. Dijagnostički pribor, naznačeno time, da sadrži protutijelo iz bilo kojeg patentnog zahtjeva 1 do 17.
30. Uporaba protutijela iz bilo kojeg patentnog zahtjeva 1 do 17, naznačena time, da je za proizvodnju lijeka za liječenje bolesti kostiju povezanih s najmanje jednom niskom koštanom formacijom, niskom mineralnom gustoćom kosti, niskim mineralnim sadržajem kosti, niskom koštanom masom, niskom kvalitetom kosti i niskom koštanom čvrstoćom u sisavca.
31. Uporaba iz patentnog zahtjeva 30, naznačeno time, da je koštani poremećaj osteopenija, osteoporoza, gubitak kosti ili nenormalni rast ili uslijed najmanje jedne od ahondroplazije, kleidokranijalne disostoze, enhondromatoze, fibrozne displazije, Gaucherove bolesti, hipofosfatemičnog rahitisa, Marfanovog sindroma, višestruke nasljedne egzostoze, neurofibromatoze, nesavršene osteogeneza, osteopoikilozisa, sklerotične lezije, pseudoartroze, piogenog osteomijelitisa, parodontne bolesti, gubitka kosti kao posljedica uzimanja protu-epileptičnog lijeka, primarne i sekundarne hiperparatiroidoze, sličnih sindroma hiperparatiroidoze, gubitka kosti uslijed bestežinskog stanja, osteoporoze u muškaraca, gubitka kosti nakon menopauze, osteoartritisa, bubrežne osteodistrofije, infi11racijskog poremećaja kosti, gubitak oralnih kostiju, osteonekroze čeljusti, juvenilne Pagetove bolesti, meloreostoze, metaboličke bolesti kostiju, mastocitoze, srpaste anemije/bolesti, gubitka kosti povezane s usatkom, gubitka kosti uslijed usatka bubrega, sistemskog lupusa eritematozusa, ankiloznog spondilitisa, epilepsije, juvenilnog artritisa, talasemije, mukopofisaharidoze, Fabryjeve bolesti, Turnerovog sindroma, Downovog sindroma, Klinefelterovog sindroma, lepre, Perthesove bolesti, adolescentske idiopatske skolioze, početne infantilne više-sustavne upalne bolesti, Winchesterovog sindroma, Menkesove bolesti, Wilsonove bolesti, ishemične koštane bolesti (poput Legg-Calve-Perthesove bolesti, regionalne migratorne osteoporoze), anemičnih stanja, stanja uzrokovanih steroidima, gubitka kosti izazvane glukokortikoidima, gubitka kosti izazvane heparinom, poremećaja koštane srži, skorbuta, pothranjenosti, nedostatka kalcija, alkoholizma, kronične bolesti jetre, stanja poslije menopauze, kroničnih upalnih stanja, reumatoidnog artritisa, upalne bolesti unutarnjih organa, ulceroznog kolitisa, upalnog kolitisa, Crohnove bolesti, oligomenoheje, amenoreje, trudnoće, dijabetesa melitusa, hipertiroidizma, oboljenja štitnjače, paratiroidnih poremećaja, Cushingove bolesti, akromegalije, hipogonadizma, imobilizacije ili neuporabe, sindroma refleksne simpatetičke distrofije, regionalne osteoporoze, osteomalacije, gubitka kosti povezane sa zamjenom zgloba, gubitka kosti povezane HlV-om, gubitka kosti povezane s hormonom rasta, gubitka kosti povezane s cističnom fibrozom, gubitka kosti povezane s kemoterapijom, gubitka kosti izazvane tumorom, gubitka kosti povezane s karcinomom, gubitka kosti zbog ablativne hormonske terapije, višestrukog mijeloma, gubitka kosti izazvane uzimanjem lijekova, anoreksija nervoza, gubitak kostiju lica uslijed bolesti, gubitak kranijalne kosti uslijed bolesti, gubitak čeljusne kosti uslijed bolesti, gubitak kosti lubanje uslijed bolesti, gubitka kosti kao posljedica starenja, gubitka kosti lica kao posljedica starenja, gubitka kranijanle kosti kao posljedica starenja, gubitka čeljusne kosti kao posljedica starenja, gubitka kosti lubanje kao posljedica starenja i gubitka uslijed putovanja u svemir.
32. Uporaba iz patentnog zahtjeva 30, naznačena time, da je koštani poremećaj osteoporoza.
33. Uporaba protutijela iz bilo kojeg patentnog zahtjeva 1 do 17, naznačena time, da je za proizvodnju lijeka za poboljšanje ishoda u sisavca koji prolazi jednu ili više ortopedskih procedura, zubnih procedura, operacija usatka, zamjene zgloba, presađivanja kosti, kozmetičke operacije kosti i reparacije poput liječenja loma, zacjeljivanja bez srastanja, zakašnjelog zacjeljivanja i rekonstrukcije lica, rečeni postupak se sastoji od primjene rečenog protutijela ili pripravka na rečenog sisavca prije, tijekom i/ili nakon rečene procedure, zamjene, grafta, operacije ili popravka.
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| US67758305P | 2005-05-03 | 2005-05-03 | |
| US77684706P | 2006-02-24 | 2006-02-24 | |
| US78224406P | 2006-03-13 | 2006-03-13 | |
| US79264506P | 2006-04-17 | 2006-04-17 | |
| US11/411,003 US7592429B2 (en) | 2005-05-03 | 2006-04-25 | Sclerostin-binding antibody |
| PCT/US2006/016441 WO2006119107A2 (en) | 2005-05-03 | 2006-04-28 | Sclerostin binding agents |
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| HRP20211904TT HRP20211904T1 (hr) | 2005-05-03 | 2006-04-28 | Sklerostin vezujuća sredstva |
| HRP20130803TT HRP20130803T1 (hr) | 2005-05-03 | 2013-08-22 | Sredstva za vezanje sklerostina |
| HRP20150597TT HRP20150597T1 (hr) | 2005-05-03 | 2015-06-03 | Sredstva ta vezivanje sklerostina |
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| US20040009535A1 (en) * | 1998-11-27 | 2004-01-15 | Celltech R&D, Inc. | Compositions and methods for increasing bone mineralization |
| MX343200B (es) * | 1998-11-27 | 2016-10-19 | Ucb Pharma Sa | Composiciones y metodos para aumentar la mineralizacion ósea. |
| US7799523B2 (en) | 2002-04-03 | 2010-09-21 | Celltech R & D, Inc. | Association of polymorphisms in the SOST gene region with bone mineral density |
| WO2003106657A2 (en) * | 2002-06-14 | 2003-12-24 | Stowers Institute For Medical Research | Wise/sost nucleic acid sequences and amino acid sequences |
| US7893218B2 (en) | 2003-06-16 | 2011-02-22 | Stowers Institute For Medical Research | Antibodies that specifically bind SOST peptides |
| US7585501B2 (en) | 2002-06-14 | 2009-09-08 | Stowers Institute For Medical Research | Compositions and methods for treating kidney disease |
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| UY35148A (es) * | 2012-11-21 | 2014-05-30 | Amgen Inc | Immunoglobulinas heterodiméricas |
| MX2020010092A (es) * | 2018-03-30 | 2020-10-28 | Amgen Inc | Variantes de anticuerpo c-terminales. |
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