HRP20120319T1 - Postupak za dobivanje dihidrokinazolina - Google Patents

Postupak za dobivanje dihidrokinazolina Download PDF

Info

Publication number: HRP20120319T1
Authority: HR; Croatia
Prior art keywords: compound; formula; image; trifluoromethyl; alkyl
Prior art date: 2005-06-15

Application number

HRP20120319TT

Other languages

English (en)

Croatian (hr)

Inventor

Goossen K�the

Kuhn Oliver

Berwe Mathias

Kr�ger Joachim

Militzer Hans-Christian

Original Assignee

Aicuris Gmbh & Co. Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-06-15

Filing date

2012-04-12

Publication date

2012-05-31

2012-04-12 Application filed by Aicuris Gmbh & Co. Kg filed Critical Aicuris Gmbh & Co. Kg

2012-05-31 Publication of HRP20120319T1 publication Critical patent/HRP20120319T1/hr

Links

238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 claims description 7
150000001875 compounds Chemical class 0.000 claims 30
125000000217 alkyl group Chemical group 0.000 claims 12
229910052736 halogen Inorganic materials 0.000 claims 10
150000002367 halogens Chemical class 0.000 claims 10
125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 9
125000003545 alkoxy group Chemical group 0.000 claims 9
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 9
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 9
229910052739 hydrogen Inorganic materials 0.000 claims 8
239000001257 hydrogen Substances 0.000 claims 8
125000004435 hydrogen atom Chemical group [H]* 0.000 claims 8
125000004414 alkyl thio group Chemical group 0.000 claims 7
-1 cyano, hydroxy, amino Chemical group 0.000 claims 7
125000001424 substituent group Chemical group 0.000 claims 6
125000004453 alkoxycarbonyl group Chemical group 0.000 claims 5
125000004448 alkyl carbonyl group Chemical group 0.000 claims 5
125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 5
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 4
125000003282 alkyl amino group Chemical group 0.000 claims 4
125000003118 aryl group Chemical group 0.000 claims 4
238000006243 chemical reaction Methods 0.000 claims 4
125000004093 cyano group Chemical group *C#N 0.000 claims 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
125000004432 carbon atom Chemical group C* 0.000 claims 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
CMIBUZBMZCBCAT-HOTGVXAUSA-N (2s,3s)-2,3-bis[(4-methylbenzoyl)oxy]butanedioic acid Chemical compound C1=CC(C)=CC=C1C(=O)O[C@H](C(O)=O)[C@@H](C(O)=O)OC(=O)C1=CC=C(C)C=C1 CMIBUZBMZCBCAT-HOTGVXAUSA-N 0.000 claims 2
WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical compound C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 claims 2
BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 claims 2
239000002253 acid Substances 0.000 claims 2
239000003054 catalyst Substances 0.000 claims 2
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
ZOBYBACEALCILX-UHFFFAOYSA-N methyl 2-[8-fluoro-3-[2-methoxy-5-(trifluoromethyl)phenyl]-2-oxo-1,4-dihydroquinazolin-4-yl]acetate Chemical compound O=C1NC2=C(F)C=CC=C2C(CC(=O)OC)N1C1=CC(C(F)(F)F)=CC=C1OC ZOBYBACEALCILX-UHFFFAOYSA-N 0.000 claims 2
229910052763 palladium Inorganic materials 0.000 claims 2
XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 claims 2
125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 2
HYPQVNLUKMOLIV-UHFFFAOYSA-N 1-(2-bromo-6-fluorophenyl)-3-[2-methoxy-5-(trifluoromethyl)phenyl]urea Chemical compound COC1=CC=C(C(F)(F)F)C=C1NC(=O)NC1=C(F)C=CC=C1Br HYPQVNLUKMOLIV-UHFFFAOYSA-N 0.000 claims 1
ISELQDXAOGXIAD-UHFFFAOYSA-N 1-(2-fluorophenyl)-3-[2-methoxy-5-(trifluoromethyl)phenyl]urea Chemical compound COC1=CC=C(C(F)(F)F)C=C1NC(=O)NC1=CC=CC=C1F ISELQDXAOGXIAD-UHFFFAOYSA-N 0.000 claims 1
PZIBVWUXWNYTNL-UHFFFAOYSA-N 1-(3-methoxyphenyl)piperazine Chemical compound COC1=CC=CC(N2CCNCC2)=C1 PZIBVWUXWNYTNL-UHFFFAOYSA-N 0.000 claims 1
FWYSMLBETOMXAG-UHFFFAOYSA-N 2-[8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-4h-quinazolin-4-yl]acetic acid Chemical compound COC1=CC=CC(N2CCN(CC2)C=2N(C(CC(O)=O)C3=CC=CC(F)=C3N=2)C=2C(=CC=C(C=2)C(F)(F)F)OC)=C1 FWYSMLBETOMXAG-UHFFFAOYSA-N 0.000 claims 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
125000004471 alkyl aminosulfonyl group Chemical group 0.000 claims 1
125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
238000010931 ester hydrolysis Methods 0.000 claims 1
150000002148 esters Chemical class 0.000 claims 1
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
238000002955 isolation Methods 0.000 claims 1
XBEUBXLFZSRSFE-RMKNXTFCSA-N methyl (e)-3-[3-fluoro-2-[[2-methoxy-5-(trifluoromethyl)phenyl]carbamoylamino]phenyl]prop-2-enoate Chemical compound COC(=O)\C=C\C1=CC=CC(F)=C1NC(=O)NC1=CC(C(F)(F)F)=CC=C1OC XBEUBXLFZSRSFE-RMKNXTFCSA-N 0.000 claims 1
DDWYVVLPVLTZIN-DEOSSOPVSA-N methyl 2-[(4s)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-4h-quinazolin-4-yl]acetate Chemical class C=1C(C(F)(F)F)=CC=C(OC)C=1N([C@H](C1=CC=CC(F)=C1N=1)CC(=O)OC)C=1N(CC1)CCN1C1=CC=CC(OC)=C1 DDWYVVLPVLTZIN-DEOSSOPVSA-N 0.000 claims 1
DDWYVVLPVLTZIN-UHFFFAOYSA-N methyl 2-[8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-4h-quinazolin-4-yl]acetate Chemical compound N=1C2=C(F)C=CC=C2C(CC(=O)OC)N(C=2C(=CC=C(C=2)C(F)(F)F)OC)C=1N(CC1)CCN1C1=CC=CC(OC)=C1 DDWYVVLPVLTZIN-UHFFFAOYSA-N 0.000 claims 1
239000007800 oxidant agent Substances 0.000 claims 1
UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 claims 1
FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 claims 1
125000004193 piperazinyl group Chemical group 0.000 claims 1
150000003254 radicals Chemical group 0.000 claims 1
238000000926 separation method Methods 0.000 claims 1
241000701022 Cytomegalovirus Species 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
NTURVSFTOYPGON-UHFFFAOYSA-N Dihydroquinazoline Chemical compound C1=CC=C2C=NCNC2=C1 NTURVSFTOYPGON-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Oncology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

HRP20120319TT 2005-06-15 2012-04-12 Postupak za dobivanje dihidrokinazolina HRP20120319T1 (hr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE102005027517A DE102005027517A1 (de)	2005-06-15	2005-06-15	Verfahren zur Herstellung von Dihydrochinazolinen
PCT/EP2006/005298 WO2006133822A1 (de)	2005-06-15	2006-06-02	Verfahren zur herstellung von dihydrochinazolinen

Publications (1)

Publication Number	Publication Date
HRP20120319T1 true HRP20120319T1 (hr)	2012-05-31

Family

ID=36764739

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HRP20120319TT HRP20120319T1 (hr)	2005-06-15	2012-04-12	Postupak za dobivanje dihidrokinazolina

Country Status (24)

Country	Link
US (3)	US8084604B2 (sl)
EP (1)	EP1893587B1 (sl)
JP (1)	JP5114391B2 (sl)
KR (1)	KR101355229B1 (sl)
CN (2)	CN101213180B (sl)
AT (1)	ATE542803T1 (sl)
AU (1)	AU2006257415B2 (sl)
BR (1)	BRPI0613277B1 (sl)
CA (1)	CA2611927C (sl)
DE (1)	DE102005027517A1 (sl)
DK (1)	DK1893587T3 (sl)
ES (1)	ES2383989T3 (sl)
HK (1)	HK1116185A1 (sl)
HR (1)	HRP20120319T1 (sl)
IL (1)	IL187586A (sl)
MX (1)	MX2007016040A (sl)
NO (1)	NO340521B1 (sl)
NZ (1)	NZ564325A (sl)
PL (1)	PL1893587T3 (sl)
PT (1)	PT1893587E (sl)
RU (1)	RU2419617C2 (sl)
SI (1)	SI1893587T1 (sl)
WO (1)	WO2006133822A1 (sl)
ZA (1)	ZA200710481B (sl)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10319612A1 (de)	2003-05-02	2004-11-18	Bayer Healthcare Ag	Substituierte Dihydrochinazoline
DE10305785A1 (de) *	2003-02-12	2004-08-26	Bayer Healthcare Ag	Dihydrochinazoline
DE10320780A1 (de) *	2003-05-09	2005-01-20	Bayer Healthcare Ag	Heterocyclyl-substituierte Dihydrochinazoline
DE10352499A1 (de) *	2003-11-11	2005-06-09	Bayer Healthcare Ag	Substituierte Dihydrochinazoline II
DE102004022672A1 (de) *	2004-05-07	2005-11-24	Bayer Healthcare Ag	Substituierte Azachinazoline
DE102005027517A1 (de)	2005-06-15	2006-12-21	Bayer Healthcare Ag	Verfahren zur Herstellung von Dihydrochinazolinen
DE102012101680A1 (de) *	2012-02-29	2013-08-29	Aicuris Gmbh & Co. Kg	Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat
DE102012101659A1 (de)	2012-02-29	2013-08-29	Aicuris Gmbh & Co. Kg	Salze eines Dihydrochinazolinderivats
DE102012101673A1 (de)	2012-02-29	2013-08-29	Aicuris Gmbh & Co. Kg	Salze eines Dihydrochinazolinderivats
CN103232400B (zh) *	2013-04-26	2015-01-21	苏州大学	一种制备喹唑啉-2-硫酮的方法
HUE043721T2 (hu)	2013-06-19	2019-09-30	Aicuris Anti Infective Cures Gmbh	Amorf letermovir és szilárd gyógyászati készítményei orális adagolásra
WO2015088931A1 (en) *	2013-12-12	2015-06-18	Merck Sharp & Dohme Corp.	Process for making substituted quinazoline compounds
WO2016109360A1 (en) *	2014-12-29	2016-07-07	Auspex Pharmaceuticals, Inc.	Dihydroquinazoline inhibitors of viral terminase
WO2017091453A1 (en) *	2015-11-24	2017-06-01	Merck Sharp & Dohme Corp.	Novel processes for making substituted quinazoline compounds using hydrogen bonding catalysts
CN111024861A (zh) *	2019-12-31	2020-04-17	山东省药学科学院	一种莱特莫韦及含莱特莫韦的制剂中有关物质的检测方法
AR121440A1 (es)	2020-02-27	2022-06-08	Aic246 Gmbh & Co Kg	Un método de preparación de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio monohidrato, dicho compuesto y el uso del mismo para el tratamiento de infecciones virales
UY39097A (es)	2020-02-27	2021-09-30	Aic246 Gmbh & Co Kg	Sal de potasio del ácido 2-[(4s)-8-fluoro-2-[4-(3- metoxifenil)piperazin-1-il]-3-[2-metoxi-5- (trifluorometil)fenil]-4h-quinazolin-4-il]acético
EP3906929A1 (en)	2020-05-08	2021-11-10	AiCuris GmbH & Co. KG	Letermovir for use in the prevention and the treatment of coronavirus infections
IT202000017617A1 (it) *	2020-07-21	2022-01-21	Olon Spa	Procedimento per la preparazione di un intermedio utilizzato nella sintesi del letermovir
CA3189271A1 (en)	2020-08-17	2022-02-24	Girij Pal Singh	A precipitation process for amorphous letermovir
CN115403528A (zh) *	2021-05-27	2022-11-29	南京正大天晴制药有限公司	无定形3,4-二氢喹唑啉衍生物的制备方法
WO2023185597A1 (zh) *	2022-04-01	2023-10-05	上海迪赛诺化学制药有限公司	莱特莫韦中间体及其制备方法
CN115322157B (zh) *	2022-06-02	2023-12-05	浙江车头制药股份有限公司	来特莫韦中间体化合物及其制备方法和应用
CN115677539B (zh) *	2022-11-01	2023-10-24	南京工业大学	一种温和条件下钴催化脲基导向芳烃的高选择性单烯基化的方法

Family Cites Families (15)

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US5854245A (en) *	1996-06-28	1998-12-29	Merck & Co., Inc.	Fibrinogen receptor antagonists
CA2321153A1 (en)	1998-02-17	1999-08-19	Timothy D. Cushing	Anti-viral pyrimidine derivatives
US6730682B2 (en) *	2000-07-12	2004-05-04	Pharmacia & Upjohn Company	Heterocycle carboxamides as antiviral agents
AU2001283955B2 (en) *	2000-07-31	2006-05-18	F. Hoffmann-La Roche Ag	Piperazine derivatives
EP1201765A3 (en)	2000-10-16	2003-08-27	Axxima Pharmaceuticals Aktiengesellschaft	Cellular kinases involved in cytomegalovirus infection and their inhibition
DE10251914A1 (de)	2002-11-08	2004-05-19	Bayer Ag	Substituierte Chinazoline
DE10319612A1 (de) *	2003-05-02	2004-11-18	Bayer Healthcare Ag	Substituierte Dihydrochinazoline
DE10305785A1 (de) *	2003-02-12	2004-08-26	Bayer Healthcare Ag	Dihydrochinazoline
DE10320780A1 (de)	2003-05-09	2005-01-20	Bayer Healthcare Ag	Heterocyclyl-substituierte Dihydrochinazoline
DE10352499A1 (de) *	2003-11-11	2005-06-09	Bayer Healthcare Ag	Substituierte Dihydrochinazoline II
KR100610731B1 (ko) *	2004-02-24	2006-08-09	한국과학기술연구원	Ｔ-형 칼슘 채널 차단제로서 유용한 ３,４-디히드로퀴나졸린유도체 및 그의 제조 방법
DE102004022672A1 (de) *	2004-05-07	2005-11-24	Bayer Healthcare Ag	Substituierte Azachinazoline
BRPI0607306A2 (pt) *	2005-01-25	2009-08-25	Prolexys Pharmaceuticals Inc	derivados de quinoxalina como agentes anti-tumor
DE102005027517A1 (de)	2005-06-15	2006-12-21	Bayer Healthcare Ag	Verfahren zur Herstellung von Dihydrochinazolinen
CA2614443C (en) *	2005-07-21	2011-03-22	F. Hoffmann-La Roche Ag	Pyrido [2,3-d] pyrimidine-2,4-diamine compounds as ptp1b inhibitors

2005
- 2005-06-15 DE DE102005027517A patent/DE102005027517A1/de not_active Withdrawn
2006
- 2006-06-02 DK DK06743106.4T patent/DK1893587T3/da active
- 2006-06-02 PT PT06743106T patent/PT1893587E/pt unknown
- 2006-06-02 AU AU2006257415A patent/AU2006257415B2/en active Active
- 2006-06-02 CN CN2006800211044A patent/CN101213180B/zh active Active
- 2006-06-02 PL PL06743106T patent/PL1893587T3/pl unknown
- 2006-06-02 JP JP2008516173A patent/JP5114391B2/ja active Active
- 2006-06-02 WO PCT/EP2006/005298 patent/WO2006133822A1/de active Application Filing
- 2006-06-02 RU RU2007147955/04A patent/RU2419617C2/ru active
- 2006-06-02 ES ES06743106T patent/ES2383989T3/es active Active
- 2006-06-02 NZ NZ564325A patent/NZ564325A/en unknown
- 2006-06-02 MX MX2007016040A patent/MX2007016040A/es active IP Right Grant
- 2006-06-02 US US11/922,280 patent/US8084604B2/en active Active
- 2006-06-02 EP EP06743106A patent/EP1893587B1/de active Active
- 2006-06-02 SI SI200631321T patent/SI1893587T1/sl unknown
- 2006-06-02 ZA ZA200710481A patent/ZA200710481B/xx unknown
- 2006-06-02 BR BRPI0613277-4A patent/BRPI0613277B1/pt active IP Right Grant
- 2006-06-02 CN CN2010102197919A patent/CN101863843B/zh active Active
- 2006-06-02 CA CA2611927A patent/CA2611927C/en active Active
- 2006-06-02 AT AT06743106T patent/ATE542803T1/de active
- 2006-06-02 KR KR1020087000996A patent/KR101355229B1/ko active IP Right Grant
2007
- 2007-11-22 IL IL187586A patent/IL187586A/en active IP Right Grant
2008
- 2008-01-08 NO NO20080129A patent/NO340521B1/no unknown
- 2008-08-28 HK HK08109596.1A patent/HK1116185A1/xx unknown
2011
- 2011-11-30 US US13/308,418 patent/US8372972B2/en active Active
2012
- 2012-04-12 HR HRP20120319TT patent/HRP20120319T1/hr unknown
- 2012-11-01 US US13/666,704 patent/US8816075B2/en active Active

Also Published As

Publication number	Publication date
US8372972B2 (en)	2013-02-12
RU2419617C2 (ru)	2011-05-27
BRPI0613277A2 (pt)	2010-12-28
ATE542803T1 (de)	2012-02-15
JP2008543797A (ja)	2008-12-04
NZ564325A (en)	2010-11-26
KR101355229B1 (ko)	2014-01-27
DE102005027517A1 (de)	2006-12-21
EP1893587A1 (de)	2008-03-05
WO2006133822A1 (de)	2006-12-21
SI1893587T1 (sl)	2012-10-30
US8084604B2 (en)	2011-12-27
MX2007016040A (es)	2008-03-10
AU2006257415A1 (en)	2006-12-21
NO340521B1 (no)	2017-05-02
CN101863843B (zh)	2013-03-27
PT1893587E (pt)	2012-05-07
BRPI0613277B1 (pt)	2022-01-25
US8816075B2 (en)	2014-08-26
RU2007147955A (ru)	2009-07-20
IL187586A0 (en)	2008-03-20
KR20080031278A (ko)	2008-04-08
US20130066073A1 (en)	2013-03-14
PL1893587T3 (pl)	2012-06-29
ES2383989T3 (es)	2012-06-28
IL187586A (en)	2013-07-31
AU2006257415B2 (en)	2011-11-24
CN101213180B (zh)	2011-09-07
CN101863843A (zh)	2010-10-20
CA2611927A1 (en)	2006-12-21
US20090221822A1 (en)	2009-09-03
NO20080129L (no)	2008-01-08
DK1893587T3 (da)	2012-05-07
EP1893587B1 (de)	2012-01-25
HK1116185A1 (en)	2008-12-19
JP5114391B2 (ja)	2013-01-09
CA2611927C (en)	2013-10-22
US20120130072A1 (en)	2012-05-24
CN101213180A (zh)	2008-07-02
ZA200710481B (en)	2009-08-26

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