HRP20120278T1 - Polivalentni pripravak konjugata pneumokoknog polisaharida s proteinom - Google Patents
Polivalentni pripravak konjugata pneumokoknog polisaharida s proteinom Download PDFInfo
- Publication number
- HRP20120278T1 HRP20120278T1 HR20120278T HRP20120278T HRP20120278T1 HR P20120278 T1 HRP20120278 T1 HR P20120278T1 HR 20120278 T HR20120278 T HR 20120278T HR P20120278 T HRP20120278 T HR P20120278T HR P20120278 T1 HRP20120278 T1 HR P20120278T1
- Authority
- HR
- Croatia
- Prior art keywords
- adjuvant
- immunogenic preparation
- aluminum
- preparation according
- protein
- Prior art date
Links
- 230000002163 immunogen Effects 0.000 claims abstract 7
- 150000004676 glycans Chemical class 0.000 claims abstract 5
- 229920001282 polysaccharide Polymers 0.000 claims abstract 5
- 239000005017 polysaccharide Substances 0.000 claims abstract 5
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims abstract 4
- 102000014914 Carrier Proteins Human genes 0.000 claims abstract 3
- 108010078791 Carrier Proteins Proteins 0.000 claims abstract 3
- 241000193998 Streptococcus pneumoniae Species 0.000 claims abstract 2
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims abstract 2
- 239000002671 adjuvant Substances 0.000 claims 6
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical group [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 2
- 229910052782 aluminium Inorganic materials 0.000 claims 2
- 239000012669 liquid formulation Substances 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 1
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 229940074404 sodium succinate Drugs 0.000 claims 1
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 claims 1
- 239000008362 succinate buffer Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66960505P | 2005-04-08 | 2005-04-08 | |
PCT/US2006/012354 WO2006110381A1 (en) | 2005-04-08 | 2006-03-31 | Multivalent pneumococcal polysaccharide-protein conjugate composition |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20120278T1 true HRP20120278T1 (hr) | 2012-04-30 |
Family
ID=36709976
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20120278T HRP20120278T1 (hr) | 2005-04-08 | 2012-03-29 | Polivalentni pripravak konjugata pneumokoknog polisaharida s proteinom |
Country Status (29)
Country | Link |
---|---|
US (9) | US20060228380A1 (de) |
EP (9) | EP2425853A1 (de) |
JP (3) | JP4472770B2 (de) |
KR (11) | KR101730750B1 (de) |
CN (6) | CN108404126B (de) |
AR (2) | AR053354A1 (de) |
AT (1) | ATE548051T1 (de) |
AU (1) | AU2006235013B2 (de) |
BR (1) | BRPI0607025B8 (de) |
CA (4) | CA2878579C (de) |
CL (2) | CL2016000566A1 (de) |
CY (1) | CY1112777T1 (de) |
DK (1) | DK1868645T3 (de) |
ES (1) | ES2382048T3 (de) |
HK (3) | HK1120416A1 (de) |
HR (1) | HRP20120278T1 (de) |
IL (5) | IL308456A (de) |
ME (1) | ME01334B (de) |
MX (3) | MX358148B (de) |
MY (1) | MY145150A (de) |
NZ (1) | NZ562406A (de) |
PL (1) | PL1868645T3 (de) |
PT (1) | PT1868645E (de) |
RS (1) | RS52249B (de) |
SA (1) | SA06270323B1 (de) |
SI (1) | SI1868645T1 (de) |
TW (3) | TWI386222B (de) |
WO (1) | WO2006110381A1 (de) |
ZA (1) | ZA200709483B (de) |
Families Citing this family (138)
Publication number | Priority date | Publication date | Assignee | Title |
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US20070184072A1 (en) | 2005-04-08 | 2007-08-09 | Wyeth | Multivalent pneumococcal polysaccharide-protein conjugate composition |
US7709001B2 (en) * | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
US7955605B2 (en) * | 2005-04-08 | 2011-06-07 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
WO2006110381A1 (en) | 2005-04-08 | 2006-10-19 | Wyeth | Multivalent pneumococcal polysaccharide-protein conjugate composition |
PL1896065T5 (pl) * | 2005-06-27 | 2014-12-31 | Glaxosmithkline Biologicals Sa | Sposób wytwarzania szczepionek |
SI2384765T1 (sl) | 2005-12-22 | 2017-03-31 | Glaxosmithkline Biologicals S.A. | Streptococcus pneumoniae vakcina |
GB0607088D0 (en) * | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
AU2013200552B9 (en) * | 2006-04-07 | 2014-07-03 | Glaxosmithkline Biologicals S.A. | Conjugate vaccines |
AU2016204760A1 (en) * | 2006-04-26 | 2016-07-28 | Wyeth Llc | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
AU2012216628B9 (en) * | 2006-04-26 | 2021-10-21 | Wyeth Llc | Novel Formulations which Stabilize and Inhibit Precipitation of Immunogenic Compositions |
TW200806315A (en) | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
US8808707B1 (en) | 2006-05-08 | 2014-08-19 | Wyeth Llc | Pneumococcal dosing regimen |
WO2008118752A2 (en) | 2007-03-23 | 2008-10-02 | Wyeth | Shortened purification process for the production of capsular streptococcus pneumoniae polysaccharides |
EP2155244B1 (de) * | 2007-04-23 | 2017-03-22 | Serum Institute of India Private Limited | Antigene polysaccharide und verfahren zu ihrer herstellung |
PE20090212A1 (es) * | 2007-05-02 | 2009-03-30 | Glaxosmithkline Biolog Sa | Kit de vacuna para la inmunizacion primaria |
MX2009013949A (es) * | 2007-06-26 | 2010-05-24 | Glaxosmithkline Biolog Sa | Vacuna que comprende conjugados de polisacárido capsular de streptococcus pneumoniae. |
GB0713880D0 (en) * | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
GB0818453D0 (en) * | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
WO2009106085A1 (en) * | 2008-02-28 | 2009-09-03 | Nordic Vaccine A/S | Vaccine compositions comprising saccharide antigens |
WO2009143413A1 (en) * | 2008-05-22 | 2009-11-26 | Children'smedical Center Corporation | Synergistic immunogenic fusion protein-polysaccharide conjugate |
GB0822634D0 (en) | 2008-12-11 | 2009-01-21 | Novartis Ag | Meningitis vaccines |
WO2010080484A1 (en) * | 2008-12-18 | 2010-07-15 | Wyeth Llc | Method for controlling streptococcus pneumoniae polysaccharide molecular weight using carbon |
PT2379734T (pt) | 2008-12-18 | 2018-04-27 | Wyeth Llc | Método para o controlo da massa molecular do polissacárido do serotipo 19a de streptococcus pneumoniae |
LT2411048T (lt) | 2009-03-24 | 2020-06-25 | Glaxosmithkline Biologicals Sa | Adjuvantinį meningokokinį faktorių h surišantis baltymas |
WO2010109324A1 (en) | 2009-03-24 | 2010-09-30 | Novartis Ag | Combinations of meningococcal factor h binding protein and pneumococcal saccharide conjugates |
BRPI1014494A2 (pt) * | 2009-04-30 | 2016-08-02 | Coley Pharm Group Inc | vacina pneumocócica e usos da mesma |
TW201136603A (en) * | 2010-02-09 | 2011-11-01 | Merck Sharp & Amp Dohme Corp | 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition |
CN101785857B (zh) * | 2010-03-05 | 2012-09-26 | 成都安特金生物技术有限公司 | 一种新的肺炎球菌结合疫苗及其制备方法 |
GB201003924D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Immunogenic composition |
GB201003922D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Conjugation process |
WO2011148382A1 (en) | 2010-05-28 | 2011-12-01 | Biological E Limited | An improved process for the purification of capsular polysaccharides of haemophilus influenza - b, neisseria meningitis such as serotypes a, c, y and w-135, and other similar related capsular polysaccharides produced from both gram negative and gram positive microorganisms using aluminium phosphate with alcohol. |
HUE048398T2 (hu) | 2010-06-04 | 2020-07-28 | Wyeth Llc | Vakcinakészítmények |
AU2011268507B2 (en) | 2010-06-25 | 2014-08-14 | Novartis Ag | Combinations of meningococcal factor H binding proteins |
TR201811280T4 (tr) | 2011-03-02 | 2018-08-27 | Glaxosmithkline Biologicals Sa | Düşük antijen ve/ veya adjuvan dozları olan karma aşılar. |
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MX2009013949A (es) | 2007-06-26 | 2010-05-24 | Glaxosmithkline Biolog Sa | Vacuna que comprende conjugados de polisacárido capsular de streptococcus pneumoniae. |
SG188813A1 (en) | 2007-12-24 | 2013-04-30 | Id Biomedical Corp Quebec | Recombinant rsv antigens |
TW201136603A (en) | 2010-02-09 | 2011-11-01 | Merck Sharp & Amp Dohme Corp | 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition |
KR102057217B1 (ko) | 2012-06-20 | 2020-01-22 | 에스케이바이오사이언스 주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
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KR20140075196A (ko) | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
CN106102770B (zh) | 2014-01-21 | 2022-03-22 | 辉瑞公司 | 包含缀合荚膜糖抗原的免疫原性组合物及其用途 |
JP2020514326A (ja) * | 2017-02-24 | 2020-05-21 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | 肺炎連鎖球菌多糖−タンパク質コンジュゲートの免疫原性の増強 |
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