HRP20041150B1 - Method for the inhibition of atrophy or for treatment or prevention of atrophy-related symptoms in women - Google Patents
Method for the inhibition of atrophy or for treatment or prevention of atrophy-related symptoms in womenInfo
- Publication number
- HRP20041150B1 HRP20041150B1 HR20041150A HRP20041150A HRP20041150B1 HR P20041150 B1 HRP20041150 B1 HR P20041150B1 HR 20041150 A HR20041150 A HR 20041150A HR P20041150 A HRP20041150 A HR P20041150A HR P20041150 B1 HRP20041150 B1 HR P20041150B1
- Authority
- HR
- Croatia
- Prior art keywords
- toremifene
- tore
- urgency
- atrophy
- urinary
- Prior art date
Links
- 208000024891 symptom Diseases 0.000 title abstract 3
- 206010003694 Atrophy Diseases 0.000 title 2
- 230000037444 atrophy Effects 0.000 title 2
- 230000005764 inhibitory process Effects 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- XFCLJVABOIYOMF-QPLCGJKRSA-N toremifene Chemical compound C1=CC(OCCN(C)C)=CC=C1C(\C=1C=CC=CC=1)=C(\CCCl)C1=CC=CC=C1 XFCLJVABOIYOMF-QPLCGJKRSA-N 0.000 abstract 4
- 229960005026 toremifene Drugs 0.000 abstract 4
- 208000003251 Pruritus Diseases 0.000 abstract 2
- 206010046543 Urinary incontinence Diseases 0.000 abstract 2
- 206010071018 Urogenital atrophy Diseases 0.000 abstract 2
- 206010011985 Decubitus ulcer Diseases 0.000 abstract 1
- 208000032843 Hemorrhage Diseases 0.000 abstract 1
- 206010021639 Incontinence Diseases 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 208000004210 Pressure Ulcer Diseases 0.000 abstract 1
- 206010064921 Urinary tract inflammation Diseases 0.000 abstract 1
- 208000034158 bleeding Diseases 0.000 abstract 1
- 230000000740 bleeding effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000028659 discharge Diseases 0.000 abstract 1
- 206010013990 dysuria Diseases 0.000 abstract 1
- 208000006750 hematuria Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000007794 irritation Effects 0.000 abstract 1
- 230000007803 itching Effects 0.000 abstract 1
- 201000005630 leukorrhea Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 230000027939 micturition Effects 0.000 abstract 1
- 206010029446 nocturia Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001568 sexual effect Effects 0.000 abstract 1
- 230000002485 urinary effect Effects 0.000 abstract 1
- 208000019206 urinary tract infection Diseases 0.000 abstract 1
- 206010046901 vaginal discharge Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38590402P | 2002-06-06 | 2002-06-06 | |
PCT/FI2003/000369 WO2003103649A1 (en) | 2002-06-06 | 2003-05-14 | Method for the inhibition of atrophy or for treatment or prevention of atrophy-related symptoms in women |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP20041150A2 HRP20041150A2 (en) | 2006-03-31 |
HRP20041150B1 true HRP20041150B1 (en) | 2007-06-30 |
Family
ID=29736123
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20041150A HRP20041150B1 (en) | 2002-06-06 | 2004-12-02 | Method for the inhibition of atrophy or for treatment or prevention of atrophy-related symptoms in women |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP1509215B1 (no) |
JP (1) | JP4362442B2 (no) |
KR (1) | KR100991157B1 (no) |
CN (2) | CN101406464A (no) |
AT (1) | ATE344025T1 (no) |
AU (1) | AU2003227790B2 (no) |
BR (1) | BR0311613A (no) |
CA (1) | CA2484542C (no) |
CY (1) | CY1105787T1 (no) |
DE (1) | DE60309465T2 (no) |
DK (1) | DK1509215T3 (no) |
ES (1) | ES2270025T3 (no) |
HR (1) | HRP20041150B1 (no) |
IL (1) | IL164528A (no) |
MX (1) | MXPA04012220A (no) |
NO (3) | NO334090B1 (no) |
NZ (1) | NZ536118A (no) |
PL (1) | PL214242B1 (no) |
PT (1) | PT1509215E (no) |
RU (1) | RU2317816C2 (no) |
SI (1) | SI1509215T1 (no) |
UA (1) | UA79797C2 (no) |
WO (1) | WO2003103649A1 (no) |
ZA (1) | ZA200408321B (no) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8236861B2 (en) | 2004-02-13 | 2012-08-07 | Hormos Medical Corporation | Method for enhancing the bioavailablity of ospemifene |
US8642079B2 (en) | 2004-02-23 | 2014-02-04 | Hormos Medical Corporation | Solid formulations of ospemifene |
WO2005105052A1 (en) * | 2004-05-04 | 2005-11-10 | Hormos Medical Ltd. | Novel oral formulations of ospemifene |
US8758821B2 (en) | 2004-05-04 | 2014-06-24 | Hormos Medical Ltd. | Oral formulations of ospemifene |
CA2654152A1 (en) | 2006-06-02 | 2007-12-13 | Pear Tree Women's Health Care | Method of treating atrophic vaginitis |
SI2518039T1 (sl) | 2007-02-14 | 2015-02-27 | Forendo Pharma Ltd. | Postopek za pripravo terapevtsko dragocenih derivatov trifenilbutena |
US7504530B2 (en) | 2007-02-14 | 2009-03-17 | Hormos Medical Ltd. | Methods for the preparation of fispemifene from ospemifene |
US9321712B2 (en) | 2012-10-19 | 2016-04-26 | Fermion Oy | Process for the preparation of ospemifene |
KR102052133B1 (ko) | 2017-08-10 | 2019-12-05 | 고려대학교 산학협력단 | 당 부가된 오스페미펜, 이의 제조방법 및 이를 유효성분으로 함유하는 약학적 조성물 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5352699A (en) * | 1992-04-30 | 1994-10-04 | University Of Massachusetts Medical Center | Use of retinioc acid to treat vaginal atrophy |
US5461064A (en) * | 1993-12-21 | 1995-10-24 | Eli Lilly And Company | Methods of inhibiting atrophy of the skin and vagina |
US5747059A (en) * | 1996-01-11 | 1998-05-05 | Novo Nordisk A/S | Atrophy of skin/mucous membrane |
JP2003520817A (ja) * | 2000-01-28 | 2003-07-08 | エンドルシェルシェ, インコーポレイテッド. | エストロゲンと組み合わせた選択的エストロゲン受容体モジュレータ |
US20010034340A1 (en) * | 2000-03-20 | 2001-10-25 | American Home Products Corporation | Hormone replacement therapy |
US6245819B1 (en) * | 2000-07-21 | 2001-06-12 | Hormos Medical Oy, Ltd. | Method for the treatment of vaginal dryness and sexual dysfunction in women during or after the menopause |
-
2003
- 2003-05-14 MX MXPA04012220A patent/MXPA04012220A/es active IP Right Grant
- 2003-05-14 JP JP2004510768A patent/JP4362442B2/ja not_active Expired - Lifetime
- 2003-05-14 CA CA2484542A patent/CA2484542C/en not_active Expired - Lifetime
- 2003-05-14 SI SI200330601T patent/SI1509215T1/sl unknown
- 2003-05-14 UA UAA200500144A patent/UA79797C2/uk unknown
- 2003-05-14 WO PCT/FI2003/000369 patent/WO2003103649A1/en active IP Right Grant
- 2003-05-14 BR BR0311613-1A patent/BR0311613A/pt not_active Application Discontinuation
- 2003-05-14 DK DK03725238T patent/DK1509215T3/da active
- 2003-05-14 CN CNA2008101733358A patent/CN101406464A/zh active Pending
- 2003-05-14 AU AU2003227790A patent/AU2003227790B2/en not_active Expired
- 2003-05-14 PT PT03725238T patent/PT1509215E/pt unknown
- 2003-05-14 NZ NZ536118A patent/NZ536118A/en not_active IP Right Cessation
- 2003-05-14 EP EP03725238A patent/EP1509215B1/en not_active Expired - Lifetime
- 2003-05-14 PL PL372758A patent/PL214242B1/pl unknown
- 2003-05-14 KR KR1020047019843A patent/KR100991157B1/ko active IP Right Grant
- 2003-05-14 DE DE60309465T patent/DE60309465T2/de not_active Expired - Lifetime
- 2003-05-14 CN CNB038128780A patent/CN100448437C/zh not_active Expired - Lifetime
- 2003-05-14 ES ES03725238T patent/ES2270025T3/es not_active Expired - Lifetime
- 2003-05-14 RU RU2004138571/14A patent/RU2317816C2/ru active
- 2003-05-14 AT AT03725238T patent/ATE344025T1/de active
-
2004
- 2004-10-12 IL IL164528A patent/IL164528A/en active IP Right Grant
- 2004-10-14 ZA ZA200408321A patent/ZA200408321B/en unknown
- 2004-10-22 NO NO20044568A patent/NO334090B1/no not_active IP Right Cessation
- 2004-12-02 HR HR20041150A patent/HRP20041150B1/xx not_active IP Right Cessation
-
2006
- 2006-11-15 CY CY20061101664T patent/CY1105787T1/el unknown
-
2013
- 2013-09-04 NO NO20131189A patent/NO336612B1/no not_active IP Right Cessation
-
2015
- 2015-04-22 NO NO20150487A patent/NO339194B1/no not_active IP Right Cessation
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