HRP20030278B1 - Novel anticholinergic agents that can be used as medicaments and method for the production thereof - Google Patents
Novel anticholinergic agents that can be used as medicaments and method for the production thereofInfo
- Publication number
- HRP20030278B1 HRP20030278B1 HR20030278A HRP20030278A HRP20030278B1 HR P20030278 B1 HRP20030278 B1 HR P20030278B1 HR 20030278 A HR20030278 A HR 20030278A HR P20030278 A HRP20030278 A HR P20030278A HR P20030278 B1 HRP20030278 B1 HR P20030278B1
- Authority
- HR
- Croatia
- Prior art keywords
- fluorine
- ethyl
- methyl
- medicaments
- production
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Spojevi opće formule 1naznačeni time, daA predstavlja dvovalentan ostatak odabran iz skupine koju čineX- je anion s jednim negativnim nabojem, povoljno izabranim između klorida, bromida, metilsulfata, 4-toluensulfonata i metansulfonata; R1 i R2, jednaki ili različiti, predstavljaju skupinu izabranuizmeđu metil, etil, n-propil i izo-propil koji prema potrebi mogu biti supstituirani s hidroksi ilis fluorom; R3, R4, R5 i R6, jednaki ili različiti, predstavljaju vodik, metil, etil, etiloksi, metiloksi, hidroksi, fluor, klor, brom, CF3, CN ili NO2;R7 je metil, etil, metiloksi, etiloksi, -CH2-F, -CH2-CH2-F, -O-CH2-F, -O-CH2-CH2-F, -CH2-OH, -CH2-CH2-OH, -CF3, -CH2-OMe, -CH2-CH2-OMe, -CH2-OEt, -CH2-CH2-OEt, -O-COMe, -O-COEt, -O-COCF3, -O-COCF3, fluor, klor ili brom, prema potrebi u obliku pojedinačnih optičkih izomera, smjese pojedinačnih enantiomera ili njihovih racemata. Patent sadrži još 9patentnih zahtjeva.Compounds of general formula I wherein A represents a divalent residue selected from the group consisting of X- is a negatively charged anion preferably selected from chlorides, bromides, methylsulfate, 4-toluenesulfonate and methanesulfonate; R 1 and R 2, the same or different, represent a group selected from methyl, ethyl, n-propyl and iso-propyl which may be optionally substituted by hydroxy or fluorine; R3, R4, R5 and R6, the same or different, represent hydrogen, methyl, ethyl, ethyloxy, methyloxy, hydroxy, fluorine, chlorine, bromine, CF3, CN or NO2, R7 is methyl, ethyl, methyloxy, ethyloxy, -CH2- F, -CH2-CH2-F, -O-CH2-F, -O-CH2-CH2-F, -CH2-OH, -CH2-CH2-OH, -CF3, -CH2-OMe, -CH2-CH2- OMe, -CH2-OEt, -CH2-CH2-OEt, -O-COMe, -O-COEt, -O-COCF3, -O-COCF3, fluorine, chlorine or bromine, optionally in the form of individual optical isomers, mixtures of individual enantiomers or their racemates. The patent contains 9 more patent applications.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10050994A DE10050994A1 (en) | 2000-10-14 | 2000-10-14 | New diphenylalkanoic acid azabicyclooctane ester quaternary salts useful as anticholinergic agents, especially in treatment of asthma and chronic obstructive pulmonary disease |
| PCT/EP2001/011226 WO2002032899A1 (en) | 2000-10-14 | 2001-09-28 | Novel anticholinergic agents that can be used as medicaments and method for the production thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20030278A2 HRP20030278A2 (en) | 2005-02-28 |
| HRP20030278B1 true HRP20030278B1 (en) | 2006-02-28 |
Family
ID=7659808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20030278A HRP20030278B1 (en) | 2000-10-14 | 2003-04-11 | Novel anticholinergic agents that can be used as medicaments and method for the production thereof |
Country Status (38)
| Country | Link |
|---|---|
| EP (2) | EP1382606A3 (en) |
| JP (2) | JP4109106B2 (en) |
| KR (1) | KR100830359B1 (en) |
| CN (1) | CN1275962C (en) |
| AR (1) | AR035589A1 (en) |
| AT (1) | ATE259805T1 (en) |
| AU (2) | AU1397502A (en) |
| BG (1) | BG66225B1 (en) |
| BR (1) | BR0114635A (en) |
| CA (1) | CA2425557C (en) |
| DE (2) | DE10050994A1 (en) |
| DK (1) | DK1325001T3 (en) |
| EA (1) | EA005816B1 (en) |
| EC (1) | ECSP034542A (en) |
| EE (1) | EE05179B1 (en) |
| ES (1) | ES2215147T3 (en) |
| HK (1) | HK1060566A1 (en) |
| HR (1) | HRP20030278B1 (en) |
| HU (1) | HUP0301203A3 (en) |
| IL (2) | IL155334A0 (en) |
| ME (1) | MEP39908A (en) |
| MX (1) | MXPA03003160A (en) |
| MY (1) | MY127144A (en) |
| NO (1) | NO328207B1 (en) |
| NZ (1) | NZ525836A (en) |
| PE (1) | PE20020433A1 (en) |
| PL (1) | PL207311B1 (en) |
| PT (1) | PT1325001E (en) |
| RS (1) | RS50464B (en) |
| SA (1) | SA01220414B1 (en) |
| SI (1) | SI1325001T1 (en) |
| SK (1) | SK287138B6 (en) |
| TR (1) | TR200400376T4 (en) |
| TW (1) | TWI306098B (en) |
| UA (1) | UA73804C2 (en) |
| UY (1) | UY26958A1 (en) |
| WO (1) | WO2002032899A1 (en) |
| ZA (1) | ZA200302914B (en) |
Families Citing this family (79)
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| US7417051B2 (en) | 2002-04-12 | 2008-08-26 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments comprising betamimetics and a novel anticholinergic |
| DE10256317A1 (en) * | 2002-04-12 | 2003-10-23 | Boehringer Ingelheim Pharma | Synergistic medicaments used for treating inflammaSynergistic medicaments used for treating inflammatory or obstructive respiratory tract diseases, cotory or obstructive respiratory tract diseases, contain quaternized scopine ester anticholinergic agntain quaternized scopine ester anticholinergic agent and beta-mimetic agent e.g. salmeterol salt ent and beta-mimetic agent e.g. salmeterol salt |
| CN1646527A (en) * | 2002-04-12 | 2005-07-27 | 贝林格尔英格海姆法玛两合公司 | Medicaments containing BETAMIMETICS drugs and a novel anticholinesterase drug |
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| US10716907B2 (en) | 2014-05-07 | 2020-07-21 | Boehringer Ingelheim International Gmbh | Nebulizer |
| EP3603640A1 (en) | 2014-06-18 | 2020-02-05 | Boehringer Ingelheim Vetmedica GmbH | Muscarinic antagonists and combinations thereof for the treatment of airway disease in horses |
| WO2017040772A1 (en) * | 2015-09-04 | 2017-03-09 | Janssen Pharmaceutica Nv | Therapeutic compounds and synthesis |
| CN113292574B (en) * | 2020-02-21 | 2022-05-03 | 四川大学 | Chiral polycyclic tropane compounds, preparation method and application thereof |
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| DE4003270A1 (en) * | 1990-02-03 | 1991-08-08 | Boehringer Ingelheim Kg | NEW SPEED GASES AND THEIR USE IN MEDICINE PREPARATIONS |
| DE4108393A1 (en) * | 1991-03-15 | 1992-09-17 | Boehringer Ingelheim Kg | NEW ESTERS BI-AND TRICYCLIC AMINO ALCOHOLS, THEIR PREPARATION AND THEIR USE IN MEDICINAL PRODUCTS |
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