US5420297A
(en)
*
|
1990-10-24 |
1995-05-30 |
Fujisawa Pharmaceutical Co., Ltd. |
Peptides having substance P antagonistic activity
|
US5610140A
(en)
*
|
1991-04-01 |
1997-03-11 |
Cortech, Inc. |
Bradykinin receptor antagonists with neurokinin receptor blocking activity
|
US5472978A
(en)
*
|
1991-07-05 |
1995-12-05 |
Merck Sharp & Dohme Ltd. |
Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
|
US5654400A
(en)
*
|
1991-10-04 |
1997-08-05 |
Fujisawa Pharmaceutical Co., Ltd. |
Process for making peptide compounds having tachykinin antagonistic activity
|
HUT70741A
(en)
*
|
1991-11-12 |
1995-10-30 |
Pfizer |
Acyclic ethylenediamine derivatives as substance p receptor antagonists
|
GB9200535D0
(en)
*
|
1992-01-10 |
1992-02-26 |
Fujisawa Pharmaceutical Co |
New compound
|
ES2153841T3
(es)
*
|
1992-08-13 |
2001-03-16 |
Warner Lambert Co |
Antagonistas de la taciquinina.
|
DK0610487T3
(da)
*
|
1992-09-03 |
2000-05-15 |
Boehringer Ingelheim Pharma |
Nye aminosyrederivater, fremgangsmåde til deres fremstilling og farmaceutiske præparater indeholdende disse forbindelser
|
DE4243496A1
(de)
*
|
1992-09-03 |
1994-03-10 |
Boehringer Ingelheim Kg |
Neue Dipeptidderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
|
FR2700472B1
(fr)
|
1993-01-19 |
1995-02-17 |
Rhone Poulenc Rorer Sa |
Association synergisante ayant un effet antagoniste des récepteurs NK1 et NK2.
|
WO1994020126A1
(en)
*
|
1993-03-03 |
1994-09-15 |
Fujisawa Pharmaceutical Co., Ltd. |
Use of peptides for the manufacture of a medicament
|
WO1995000536A1
(en)
*
|
1993-06-22 |
1995-01-05 |
Fujisawa Pharmaceutical Co., Ltd. |
Peptide compounds
|
EP0719561A4
(en)
*
|
1993-08-10 |
1997-07-30 |
Fujisawa Pharmaceutical Co |
Percutaneous absorbent preparation
|
WO1995011699A1
(en)
*
|
1993-10-29 |
1995-05-04 |
The Trustees Of Boston University |
Physiologically stable compositions of butyric acid, and butyric acid salts and derivatives as anti-neoplastic agents
|
US6403577B1
(en)
|
1993-11-17 |
2002-06-11 |
Eli Lilly And Company |
Hexamethyleneiminyl tachykinin receptor antagonists
|
ITFI940009A1
(it)
*
|
1994-01-19 |
1995-07-19 |
Menarini Farma Ind |
Antagonisti delle tachichinine, loro preparazione e formulazioni farmaceutiche che li contengono.
|
US5837687A
(en)
*
|
1994-03-17 |
1998-11-17 |
Fujirebio Inc. |
Azapeptide derivative
|
FR2719312B1
(fr)
*
|
1994-04-28 |
1996-06-14 |
Adir |
Nouveau pseudopeptides dérivés de neurokinines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
|
NZ285750A
(en)
*
|
1994-05-07 |
1998-08-26 |
Boehringer Ingelheim Int |
Neurokinin (tachykinin) antagonists
|
FR2728166A1
(fr)
|
1994-12-19 |
1996-06-21 |
Oreal |
Composition topique contenant un antagoniste de substance p
|
FR2728169A1
(fr)
|
1994-12-19 |
1996-06-21 |
Oreal |
Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
|
FR2728165A1
(fr)
|
1994-12-19 |
1996-06-21 |
Oreal |
Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
|
US5966295A
(en)
*
|
1994-12-27 |
1999-10-12 |
Autonics Corporation |
Convertible flush or exposure type terminal board of control device
|
FR2741262B1
(fr)
|
1995-11-20 |
1999-03-05 |
Oreal |
Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
|
GB9700597D0
(en)
*
|
1997-01-14 |
1997-03-05 |
Sandoz Pharma Uk |
Organic compounds
|
JP2001524960A
(ja)
*
|
1997-04-24 |
2001-12-04 |
メルク シヤープ エンド ドーム リミテツド |
摂食障害を治療するためのnk−1受容体拮抗薬の使用
|
EP1001764A4
(en)
*
|
1997-05-29 |
2005-08-24 |
Merck & Co Inc |
Heterocyclic amides as cell adhesion inhibitors
|
US6903075B1
(en)
|
1997-05-29 |
2005-06-07 |
Merck & Co., Inc. |
Heterocyclic amide compounds as cell adhesion inhibitors
|
CA2298777A1
(en)
*
|
1997-08-04 |
1999-02-18 |
Merck Sharp & Dohme Limited |
Use of nk-1 receptor antagonists for treating mania
|
GB9716457D0
(en)
*
|
1997-08-04 |
1997-10-08 |
Merck Sharp & Dohme |
Therapeutic agents
|
CA2298779A1
(en)
*
|
1997-08-04 |
1999-02-18 |
Merck Sharp & Dohme Limited |
Use of nk-1 receptor antagonists for treating aggressive behaviour disorders
|
GB9716463D0
(en)
*
|
1997-08-04 |
1997-10-08 |
Merck Sharp & Dohme |
Therapeutic agents
|
EP1046650A4
(en)
*
|
1997-12-22 |
2001-12-19 |
Ono Pharmaceutical Co |
PEPTIDES, PROCESS FOR ASSAYING HUMAN PEPSINOGEN II OR HUMAN PEPSIN II, AND ASSAY KIT
|
WO1999040883A2
(en)
*
|
1998-02-11 |
1999-08-19 |
Faller Douglas V |
Compositions and methods for the treatment of cystic fibrosis
|
WO1999064395A1
(en)
*
|
1998-06-11 |
1999-12-16 |
Merck & Co., Inc. |
Heterocyclic amide compounds as cell adhesion inhibitors
|
GB9816897D0
(en)
*
|
1998-08-04 |
1998-09-30 |
Merck Sharp & Dohme |
Therapeutic use
|
US6300341B1
(en)
|
1998-09-30 |
2001-10-09 |
The Procter & Gamble Co. |
2-substituted heterocyclic sulfonamides
|
US6307049B1
(en)
|
1998-09-30 |
2001-10-23 |
The Procter & Gamble Co. |
Heterocyclic 2-substituted ketoamides
|
AU2180600A
(en)
*
|
1998-12-18 |
2000-07-12 |
Warner-Lambert Company |
Non-peptide nk1 receptors antagonists
|
EP1158996A4
(en)
|
1999-02-18 |
2005-01-12 |
Kaken Pharma Co Ltd |
NEW AMID DERIVATIVES AS GROWTH HORMONE SECRETION CONVEYORS
|
JP4907818B2
(ja)
|
1999-11-03 |
2012-04-04 |
エーエムアール テクノロジー インコーポレイテッド |
アリールおよびヘテロアリール置換テトラヒドロイソキノリン、ならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを阻止するためのそれらの使用
|
US7163949B1
(en)
|
1999-11-03 |
2007-01-16 |
Amr Technology, Inc. |
4-phenyl substituted tetrahydroisoquinolines and use thereof
|
WO2002004455A2
(en)
|
2000-07-11 |
2002-01-17 |
Albany Molecular Research, Inc |
4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
|
KR100960802B1
(ko)
|
2003-03-08 |
2010-06-01 |
주식회사유한양행 |
씨형 간염바이러스 감염 치료용 엔에스3 프로테아제 억제제
|
UA84050C2
(xx)
|
2004-01-30 |
2008-09-10 |
Медивир Аб |
Інгібітори серин-протеази ns-3 hcv$ингибиторы серин-протеазы ns-3 hcv
|
ZA200701232B
(en)
|
2004-07-15 |
2008-08-27 |
Amr Technology Inc |
Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
|
ATE550019T1
(de)
|
2005-05-17 |
2012-04-15 |
Merck Sharp & Dohme |
Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs
|
EA019115B1
(ru)
|
2005-07-15 |
2014-01-30 |
Олбани Молекьюлар Рисерч, Инк. |
Арил- и гетероарилзамещенные тетрагидробензазепины и их применение для блокировки обратного захвата норэпинефрина, допамина и серотонина
|
PE20070211A1
(es)
|
2005-07-29 |
2007-05-12 |
Medivir Ab |
Compuestos macrociclicos como inhibidores del virus de hepatitis c
|
GB0603041D0
(en)
|
2006-02-15 |
2006-03-29 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
US20110218176A1
(en)
|
2006-11-01 |
2011-09-08 |
Barbara Brooke Jennings-Spring |
Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
|
EP2336120B1
(en)
|
2007-01-10 |
2014-07-16 |
MSD Italia S.r.l. |
Combinations containing amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
|
WO2008090117A1
(en)
|
2007-01-24 |
2008-07-31 |
Glaxo Group Limited |
Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1
|
WO2009002495A1
(en)
|
2007-06-27 |
2008-12-31 |
Merck & Co., Inc. |
4-carboxybenzylamino derivatives as histone deacetylase inhibitors
|
AR071997A1
(es)
|
2008-06-04 |
2010-07-28 |
Bristol Myers Squibb Co |
Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
|
US9156812B2
(en)
|
2008-06-04 |
2015-10-13 |
Bristol-Myers Squibb Company |
Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
|
UA105182C2
(ru)
|
2008-07-03 |
2014-04-25 |
Ньюрексон, Інк. |
Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
|
WO2010105112A1
(en)
*
|
2009-03-11 |
2010-09-16 |
Hemaquest Pharmaceuticals, Inc. |
Detection of short-chain fatty acids in biological samples
|
MX2011009700A
(es)
|
2009-03-17 |
2011-12-08 |
Daiichi Sankyo Co Ltd |
Derivado de amida.
|
US8691825B2
(en)
|
2009-04-01 |
2014-04-08 |
Merck Sharp & Dohme Corp. |
Inhibitors of AKT activity
|
AU2010247735B2
(en)
|
2009-05-12 |
2015-07-16 |
Albany Molecular Research, Inc. |
Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydroisoquinoline and use thereof
|
MX2011011901A
(es)
|
2009-05-12 |
2012-01-20 |
Albany Molecular Res Inc |
Tetrahidroisoquinolinas aril, heteroaril, y heterociclo sustituidas y uso de las mismas.
|
AU2010247763B2
(en)
|
2009-05-12 |
2015-12-24 |
Albany Molecular Research, Inc. |
7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof
|
US20110086869A1
(en)
|
2009-09-24 |
2011-04-14 |
The Trustees Of Boston University |
Methods for treating viral disorders
|
AU2010307198C9
(en)
|
2009-10-14 |
2014-02-13 |
Merck Sharp & Dohme Corp. |
Substituted piperidines that increase p53 activity and the uses thereof
|
WO2011072086A1
(en)
|
2009-12-08 |
2011-06-16 |
Hemaquest Pharmaceuticals, Inc. |
Methods and low dose regimens for treating red blood cell disorders
|
US20110245154A1
(en)
|
2010-03-11 |
2011-10-06 |
Hemaquest Pharmaceuticals, Inc. |
Methods and Compositions for Treating Viral or Virally-Induced Conditions
|
WO2012018754A2
(en)
|
2010-08-02 |
2012-02-09 |
Merck Sharp & Dohme Corp. |
RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
DK2606134T3
(da)
|
2010-08-17 |
2019-07-22 |
Sirna Therapeutics Inc |
RNA-Interferens-formidlet inhibering af hepatitis-B-virus (HBV)-genekspression ved hjælp af kort interfererende nukleinsyre (siNA)
|
US8883801B2
(en)
|
2010-08-23 |
2014-11-11 |
Merck Sharp & Dohme Corp. |
Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
|
EP2613782B1
(en)
|
2010-09-01 |
2016-11-02 |
Merck Sharp & Dohme Corp. |
Indazole derivatives useful as erk inhibitors
|
WO2012036997A1
(en)
|
2010-09-16 |
2012-03-22 |
Schering Corporation |
Fused pyrazole derivatives as novel erk inhibitors
|
US9260471B2
(en)
|
2010-10-29 |
2016-02-16 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
|
WO2012087772A1
(en)
|
2010-12-21 |
2012-06-28 |
Schering Corporation |
Indazole derivatives useful as erk inhibitors
|
CA2833009A1
(en)
|
2011-04-21 |
2012-10-26 |
Merck Sharp & Dohme Corp. |
Insulin-like growth factor-1 receptor inhibitors
|
WO2013063214A1
(en)
|
2011-10-27 |
2013-05-02 |
Merck Sharp & Dohme Corp. |
Novel compounds that are erk inhibitors
|
EP3453762B1
(en)
|
2012-05-02 |
2021-04-21 |
Sirna Therapeutics, Inc. |
Short interfering nucleic acid (sina) compositions
|
MX2015004041A
(es)
|
2012-09-28 |
2015-07-06 |
Merck Sharp & Dohme |
Compuestos novedosos que son inhibidores de erk.
|
DK2925888T3
(en)
|
2012-11-28 |
2017-12-18 |
Merck Sharp & Dohme |
COMPOSITIONS AND METHODS OF CANCER TREATMENT
|
BR112015013611A2
(pt)
|
2012-12-20 |
2017-11-14 |
Merck Sharp & Dohme |
composto, e, composição farmacêutica
|
WO2014120748A1
(en)
|
2013-01-30 |
2014-08-07 |
Merck Sharp & Dohme Corp. |
2,6,7,8 substituted purines as hdm2 inhibitors
|
WO2015034925A1
(en)
|
2013-09-03 |
2015-03-12 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
US10975084B2
(en)
|
2016-10-12 |
2021-04-13 |
Merck Sharp & Dohme Corp. |
KDM5 inhibitors
|
US11098059B2
(en)
|
2017-11-08 |
2021-08-24 |
Merck Sharp & Dohme Corp. |
PRMT5 inhibitors
|
US10947234B2
(en)
|
2017-11-08 |
2021-03-16 |
Merck Sharp & Dohme Corp. |
PRMT5 inhibitors
|
US11993602B2
(en)
|
2018-08-07 |
2024-05-28 |
Merck Sharp & Dohme Llc |
PRMT5 inhibitors
|
EP3833667B1
(en)
|
2018-08-07 |
2024-03-13 |
Merck Sharp & Dohme LLC |
Prmt5 inhibitors
|
EP3976198A4
(en)
|
2019-05-31 |
2023-07-19 |
Viracta Subsidiary, Inc. |
METHODS OF TREATMENT OF VIRAL ASSOCIATED CANCER WITH HISTONE DEACETYLASE INHIBITORS
|