[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

HK1221747A1 - 基於 的定量成像和超分辨成像 - Google Patents

基於 的定量成像和超分辨成像

Info

Publication number
HK1221747A1
HK1221747A1 HK16109876.2A HK16109876A HK1221747A1 HK 1221747 A1 HK1221747 A1 HK 1221747A1 HK 16109876 A HK16109876 A HK 16109876A HK 1221747 A1 HK1221747 A1 HK 1221747A1
Authority
HK
Hong Kong
Prior art keywords
dna
imaging
super
quantitative
resolution
Prior art date
Application number
HK16109876.2A
Other languages
English (en)
Inventor
．容曼
．尹
．戴
．阿文戴諾
．韋爾斯坦恩
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52432405&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1221747(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Harvard College filed Critical Harvard College
Publication of HK1221747A1 publication Critical patent/HK1221747A1/zh

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6841—In situ hybridisation
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/20—Analysis of motion
    • G06T7/246—Analysis of motion using feature-based methods, e.g. the tracking of corners or segments
    • G06T7/248—Analysis of motion using feature-based methods, e.g. the tracking of corners or segments involving reference images or patches
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B45/00—ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/36—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Actinomyces; from Streptomyces (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Medical Informatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Engineering & Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Data Mining & Analysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Software Systems (AREA)
  • Artificial Intelligence (AREA)
  • Databases & Information Systems (AREA)
  • Evolutionary Computation (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Bioethics (AREA)
HK16109876.2A 2013-07-30 2016-08-17 基於 的定量成像和超分辨成像 HK1221747A1 (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361859891P 2013-07-30 2013-07-30
US201361884126P 2013-09-29 2013-09-29
US201461934759P 2014-02-01 2014-02-01
PCT/US2014/048977 WO2015017586A1 (en) 2013-07-30 2014-07-30 Quantitative dna-based imaging and super-resolution imaging

Publications (1)

Publication Number Publication Date
HK1221747A1 true HK1221747A1 (zh) 2017-06-09

Family

ID=52432405

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16109876.2A HK1221747A1 (zh) 2013-07-30 2016-08-17 基於 的定量成像和超分辨成像

Country Status (9)

Country Link
US (2) US20160161472A1 (zh)
EP (2) EP3027773B1 (zh)
JP (1) JP6475718B2 (zh)
KR (1) KR20160039229A (zh)
CN (1) CN105531377A (zh)
AU (1) AU2014296253A1 (zh)
CA (1) CA2919833A1 (zh)
HK (1) HK1221747A1 (zh)
WO (1) WO2015017586A1 (zh)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
KR102275006B1 (ko) 2013-03-11 2021-07-09 메소 스케일 테크놀러지즈, 엘엘시 다중화 어세이를 수행하기 위한 개선된 방법
KR20160039229A (ko) 2013-07-30 2016-04-08 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 정량적 dna-기반 영상화 및 초해상도 영상화
US9909167B2 (en) 2014-06-23 2018-03-06 The Board Of Trustees Of The Leland Stanford Junior University On-slide staining by primer extension
CN106715768B (zh) 2014-07-30 2020-06-16 哈佛学院院长及董事 用于测定核酸的系统和方法
CN107924473B (zh) * 2015-08-07 2021-11-23 哈佛学院院长及董事 蛋白质-蛋白质相互作用的超分辨成像
WO2017042695A1 (en) 2015-09-10 2017-03-16 King Abdullah University Of Science And Technology Conjugated polymer nanoparticles, methods of using, and methods of making
WO2017049136A1 (en) * 2015-09-18 2017-03-23 President And Fellows Of Harvard College Nucleic acid frameworks for structural determination
CN108603227A (zh) 2015-11-18 2018-09-28 卡利姆·U·米尔 超分辨率测序
DE102015016353A1 (de) 2015-12-16 2017-06-22 Horst Wochnowski PALM-Verfahren mit mehreren sich nur marginal voneinander unterscheidenden Fluorophoren
WO2017139354A1 (en) * 2016-02-10 2017-08-17 The Regents Of The University Of Michigan Detection of nucleic acids
WO2017189496A1 (en) * 2016-04-26 2017-11-02 Ultivue, Inc. Super-resolution fluorescence miscroscopy method using improved drift compensation markers
CN109071641A (zh) * 2016-04-26 2018-12-21 乌尔蒂维尤股份有限公司 具有衍射极限预览的超分辨率免疫荧光
EP3458858B1 (en) * 2016-05-15 2022-07-06 Ultivue, Inc. Multiplexed imaging using strand displacement
EP3465162A4 (en) * 2016-06-02 2020-03-25 Ultivue, Inc. COMPOSITIONS AND METHODS FOR ACCELERATING ANTIBODY EXCHANGE IMAGING
AU2017302300B2 (en) 2016-07-27 2023-08-17 The Board Of Trustees Of The Leland Stanford Junior University Highly-multiplexed fluorescent imaging
EP3290983A1 (de) * 2016-09-05 2018-03-07 Abberior Instruments GmbH Verfahren zum justieren eines laserscanning-fluoreszenzmikroskops und laserscanning-fluoreszenzmikroskop mit einer automatischen justiervorrichtung
ES2969671T3 (es) * 2016-11-08 2024-05-21 Harvard College Obtención de imágenes con multiplexación usando MERFISH, microscopía de expansión y tecnologías relacionadas
EP3551765A4 (en) 2016-12-09 2020-11-11 Ultivue, Inc. IMPROVED METHODS FOR MULTIPLEX IMAGING USING LABELED NUCLEIC ACID CONTRAST AGENTS
FI3929304T3 (fi) * 2016-12-16 2024-03-27 Aratome Llc Molekulaarin tunnistaminen käyttämällä ligatiovahvistusta
CA3037799A1 (en) * 2017-01-26 2018-08-02 Azure Biosystems, Inc. Devices and methods for imaging biomolecules
DE102017104736B9 (de) * 2017-03-07 2020-06-25 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren und Vorrichtung zum räumlichen Messen nanoskaliger Strukturen
CA3055565A1 (en) * 2017-03-08 2018-09-13 The Regents Of The University Of Michigan Analyte detection
CN117187346A (zh) 2017-03-31 2023-12-08 乌尔蒂维尤股份有限公司 Dna-抗原交换和扩增
US11788123B2 (en) 2017-05-26 2023-10-17 President And Fellows Of Harvard College Systems and methods for high-throughput image-based screening
JP7536450B2 (ja) 2017-06-05 2024-08-20 ベクトン・ディキンソン・アンド・カンパニー 単一細胞用のサンプルインデックス付加
US11331019B2 (en) 2017-08-07 2022-05-17 The Research Foundation For The State University Of New York Nanoparticle sensor having a nanofibrous membrane scaffold
CN107894411B (zh) * 2017-10-27 2020-06-02 上海纳米技术及应用国家工程研究中心有限公司 荧光精确定量dna折纸结构完整度的方法
GB2569283B (en) * 2017-12-05 2021-10-13 Continental Automotive Romania Srl Method and device for adaptively enhancing an output of a detector
EP3805405A1 (de) * 2017-12-14 2021-04-14 Ludwig-Maximilians-Universität München Einzelmolekülnachweis bzw. -quantifizierung durch dna-nanotechnologie in mikro-wells
CN107934531B (zh) * 2017-12-25 2024-04-16 福建上源生物科学技术有限公司 一种自动线虫挑选装置
KR20190108023A (ko) * 2018-03-13 2019-09-23 서울대학교산학협력단 초고감도 바이오마커 다중 검출 방법
US11682125B2 (en) * 2018-04-10 2023-06-20 Mgi Tech Co., Ltd. Fluorescence image registration method, gene sequencing instrument, and storage medium
CN109030434B (zh) * 2018-06-20 2021-08-27 天津大学 一种基于Android平台的真菌毒素含量检测方法
WO2020014036A1 (en) * 2018-07-09 2020-01-16 Ultivue, Inc. Methods for multicolor multiplex imaging
US20200058371A1 (en) * 2018-08-17 2020-02-20 Cellular Research, Inc. Aptamer barcoding
CN112567245A (zh) * 2018-08-28 2021-03-26 Jl美迪乐博斯公司 检测目标物质的方法和试剂盒
CN109255427A (zh) * 2018-08-30 2019-01-22 无锡城市职业技术学院 一种基于量子粒子群优化算法的分子对接计算方法
CN109371031A (zh) * 2018-11-23 2019-02-22 北京化工大学 一种特异性结合牛血清白蛋白核酸适配体的筛选方法
EP3670666A1 (en) 2018-12-20 2020-06-24 Freie Universität Berlin Method for optical imaging a target molecule in a sample, a protein-oligonuleotide conjugate for use in the method and a kit for carrying out the method
CN110364224B (zh) * 2018-12-29 2021-06-08 上海北昂医药科技股份有限公司 一种染色体分裂相定位排序方法
WO2020167920A1 (en) 2019-02-14 2020-08-20 Cellular Research, Inc. Hybrid targeted and whole transcriptome amplification
KR102513569B1 (ko) * 2019-03-19 2023-03-24 한국생명공학연구원 전사 시스템 기반 고감도 센서
CN110838134B (zh) * 2019-10-10 2020-09-29 北京海益同展信息科技有限公司 目标对象的统计方法、装置、计算机设备和存储介质
CN110746286B (zh) * 2019-11-04 2023-04-07 北京维德维康生物技术有限公司 一种丁香酚半抗原、人工抗原及其制备方法与应用
US11932901B2 (en) 2020-07-13 2024-03-19 Becton, Dickinson And Company Target enrichment using nucleic acid probes for scRNAseq
CN111830014B (zh) * 2020-08-04 2023-06-30 济南大学 一种基于聚苯胺吸附双链dna的传感器检测dna的方法
US11692217B2 (en) * 2020-11-11 2023-07-04 Nautilus Subsidiary, Inc. Affinity reagents having enhanced binding and detection characteristics
DE102020131047B4 (de) 2020-11-24 2024-08-22 Abberior Instruments Gmbh Verfahren und Vorrichtung zur Aufnahme nanoskopischer Bilder mehrfach gefärbter Proben
US20220252514A1 (en) * 2021-02-10 2022-08-11 Star Voltaic, LLC Fluorescent solid-state materials for optical calibration and methods thereof
CN113004885B (zh) * 2021-03-08 2024-06-11 光华临港工程应用技术研发(上海)有限公司 一种用于膨胀超分辨成像的dna纳米结构染料及其应用
EP4092414A1 (en) * 2021-05-19 2022-11-23 Leica Microsystems CMS GmbH Connector, marker and method for analysing biological samples
CN113281320B (zh) * 2021-06-07 2022-04-29 江南大学 一种基于荧光铜纳米粒子检测黄曲霉毒素b1的方法
GB202304755D0 (en) * 2023-03-30 2023-05-17 Univ Ramot Method of imaging biomolecules
CN116165187B (zh) * 2023-04-23 2023-08-29 深圳大学 一种基于基准标记物的漂移矫正与筛选方法及成像方法

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5424413A (en) 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
US5681943A (en) 1993-04-12 1997-10-28 Northwestern University Method for covalently linking adjacent oligonucleotides
US7569341B2 (en) * 1994-01-31 2009-08-04 Trustees Of Boston University Nucleic acid directed immobilization arrays and methods of assembly
DE4421891C2 (de) 1994-06-23 1996-05-15 Helmut Prof Dr Med Feucht Verfahren zum Nachweis von komplementaktivierenden IgG-Antikörpern gegen HLA-DR-Antigene
US5491063A (en) 1994-09-01 1996-02-13 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
DE19709348C2 (de) 1996-05-29 1999-07-01 Schubert Walter Dr Md Automatisches Multi-Epitop-Ligand-Kartierungsverfahren
US6146828A (en) 1996-08-14 2000-11-14 Exact Laboratories, Inc. Methods for detecting differences in RNA expression levels and uses therefor
US6117631A (en) * 1996-10-29 2000-09-12 Polyprobe, Inc. Detection of antigens via oligonucleotide antibody conjugates
GB9622665D0 (en) * 1996-10-31 1997-01-08 Zeneca Ltd Methods
DE19717904A1 (de) 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
US7101672B2 (en) 1998-05-05 2006-09-05 Third Wave Technologies, Inc. Target-dependent reactions using structure-bridging oligonucleotides
US5888778A (en) 1997-06-16 1999-03-30 Exact Laboratories, Inc. High-throughput screening method for identification of genetic mutations or disease-causing microorganisms using segmented primers
US20100081134A1 (en) 1997-07-21 2010-04-01 Mirkin Chad A Bio-barcode based detection of target analytes
US6083486A (en) 1998-05-14 2000-07-04 The General Hospital Corporation Intramolecularly-quenched near infrared fluorescent probes
US7399844B2 (en) * 1998-07-09 2008-07-15 Agilent Technologies, Inc. Method and reagents for analyzing the nucleotide sequence of nucleic acids
WO2000003034A2 (en) 1998-07-10 2000-01-20 Chromagen, Inc. Novel polycyclic aromatic fluorogenic substrates for hydrolases
US6573043B1 (en) 1998-10-07 2003-06-03 Genentech, Inc. Tissue analysis and kits therefor
US6468785B1 (en) 1999-02-19 2002-10-22 New Mexico State University Technology Transfer Corporation Doped conducting polymers applications and methods
AU3567900A (en) 1999-03-30 2000-10-16 Solexa Ltd. Polynucleotide sequencing
EP1218543A2 (en) 1999-09-29 2002-07-03 Solexa Ltd. Polynucleotide sequencing
GB0002389D0 (en) 2000-02-02 2000-03-22 Solexa Ltd Molecular arrays
DE10014685B4 (de) 2000-03-24 2004-07-01 Schubert, Walter, Dr. Verfahren zur Identifizierung von zellspezifischen Zielstrukturen
US20020142310A1 (en) 2000-04-07 2002-10-03 Leif Andersson Variants of the human AMP-activated protein kinase gamma 3 subunit
WO2001086296A2 (en) 2000-05-05 2001-11-15 Agilix Corporation Highly multiplexed reporter carrier systems
EP1286705A2 (en) * 2000-06-01 2003-03-05 The Board Of Regents Of Oklahoma State University Bioconjugates of nanoparticles as radiopharmaceuticals
US6511809B2 (en) * 2000-06-13 2003-01-28 E. I. Du Pont De Nemours And Company Method for the detection of an analyte by means of a nucleic acid reporter
US6451588B1 (en) 2000-06-30 2002-09-17 Pe Corporation (Ny) Multipartite high-affinity nucleic acid probes
JP2004515752A (ja) 2000-09-15 2004-05-27 バイオジェネックス ラボラトリーズ ｉｎｓｉｔｕハイブリダイゼーションの向上
EP1356104A2 (en) 2000-10-06 2003-10-29 Nugen Technologies, Inc. Methods and probes for detection and/or quantification of nucleic acid sequences
US20030044353A1 (en) 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
US20050230255A1 (en) 2001-03-30 2005-10-20 Sumner Lloyd W Silver destaining method
US7219016B2 (en) 2001-04-20 2007-05-15 Yale University Systems and methods for automated analysis of cells and tissues
US20020173053A1 (en) 2001-04-27 2002-11-21 Bassam Damaj Multiple simultaneous antigen detection by immunohistochemistry
US7473767B2 (en) * 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
WO2003008968A2 (en) 2001-07-19 2003-01-30 Signet Laboratories, Inc. Human tissue specific drug screening procedure
EP2980222A1 (en) 2001-09-24 2016-02-03 One Lambda, Inc. Diagnostic probe detection system
US8323903B2 (en) 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
WO2003061711A2 (en) 2002-01-16 2003-07-31 Visen Medical, Inc. Chromophore probes for optical imaging
US20040018495A1 (en) * 2002-07-24 2004-01-29 Xing-Xiang Li Microparticle based signal amplification for the detection of analytes
US7122319B2 (en) 2002-12-18 2006-10-17 Monogram Biosciences, Inc Multiplexed immunohistochemical assays using molecular tags
EP1615948B1 (en) 2003-04-18 2015-04-01 Becton Dickinson and Company Immuno-amplification
WO2005017485A2 (en) 2003-05-22 2005-02-24 Agdia, Inc. Multiplex enzyme-linked immunosorbent assay for detecting multiple analytes
US7279280B2 (en) 2003-09-25 2007-10-09 Mgp Biotech, Inc. Apparatus and method for detecting genetic mutations and single nucleotide polymorphisms
US20050095595A1 (en) 2003-10-29 2005-05-05 Pittaro Richard J. Methods and systems for improving of polymer analysis
WO2005047468A2 (en) * 2003-11-06 2005-05-26 University Of Nevada, Reno Improved methods for detecting and measuring specific nucleic acid sequences
US20050287578A1 (en) 2004-06-28 2005-12-29 Exagen Diagnostics, Inc. Methods for RNA fluorescence in situ hybridization
US8153363B2 (en) 2005-01-13 2012-04-10 Progenika Biopharma S.A. Methods and products for in vitro genotyping
US7727721B2 (en) * 2005-03-08 2010-06-01 California Institute Of Technology Hybridization chain reaction amplification for in situ imaging
US20060204999A1 (en) 2005-03-14 2006-09-14 Stephen Macevicz Detecting molecular complexes
US8956857B2 (en) 2005-06-06 2015-02-17 Mediomics, Llc Three-component biosensors for detecting macromolecules and other analytes
US7795009B2 (en) 2005-06-15 2010-09-14 Saint Louis University Three-component biosensors for detecting macromolecules and other analytes
US20070048759A1 (en) 2005-06-10 2007-03-01 Dan Luo Detection of target molecules with labeled nucleic acid detection molecules
US7842793B2 (en) 2005-06-14 2010-11-30 The California Institute Of Technology Methods of making nucleic acid nanostructures
US7494776B2 (en) 2005-07-07 2009-02-24 Beckman Coulter, Inc. Labeled complementary oligonucleotides to detect oligonucleotide-linked ligands
US20070259345A1 (en) 2006-05-03 2007-11-08 Agilent Technologies, Inc. Target determination using compound probes
US20080004185A1 (en) * 2006-06-12 2008-01-03 Antara Biosciences Inc. Three dimensional array
US7838302B2 (en) * 2006-08-07 2010-11-23 President And Fellows Of Harvard College Sub-diffraction limit image resolution and other imaging techniques
US7741045B2 (en) 2006-11-16 2010-06-22 General Electric Company Sequential analysis of biological samples
US20080242560A1 (en) 2006-11-21 2008-10-02 Gunderson Kevin L Methods for generating amplified nucleic acid arrays
US9217151B2 (en) 2007-05-16 2015-12-22 California Institute Of Technology Versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways
US8481714B2 (en) 2007-11-19 2013-07-09 Japan Advanced Institute Of Science And Technology Light-responsive artificial nucleotide having photo-crosslinking ability
US8309306B2 (en) 2008-11-12 2012-11-13 Nodality, Inc. Detection composition
CN102317779A (zh) 2008-11-21 2012-01-11 圣路易大学 检测目标物多个表位的生物感应器
DE102008062372B3 (de) * 2008-12-17 2010-06-17 Medizinische Hochschule Hannover Nachweiskonjugat und Verfahren zur Analyse
WO2010111494A1 (en) * 2009-03-25 2010-09-30 Georgia Tech Research Corporation Single molecule sensitive probes for detecting rna
US9677125B2 (en) 2009-10-21 2017-06-13 General Electric Company Detection of plurality of targets in biological samples
WO2011056864A1 (en) 2009-11-05 2011-05-12 Anaptysbio, Inc. Methods of generating improved antigen-binding agents using chain shuffling and optionally somatic hypermutation
WO2012003330A2 (en) 2010-06-30 2012-01-05 Stratos Genomics, Inc Multiplexed identification of nucleic acid sequences
US20120004132A1 (en) 2010-07-02 2012-01-05 Affymetrix, Inc. Detection of Nucleic Acids and Proteins
WO2012051386A2 (en) 2010-10-14 2012-04-19 Meso Scale Technologies, Llc Reagent storage in an assay device
US10024796B2 (en) 2010-10-29 2018-07-17 President And Fellows Of Harvard College Nucleic acid nanostructure barcode probes
US20120258881A1 (en) 2010-11-22 2012-10-11 The University Of Chicago Methods and/or Use of Oligonucleotide Conjugates for Assays and Microscopy/Imaging Detections
US20120178081A1 (en) 2010-12-31 2012-07-12 Affymetrix. Inc. Methods of Labeling Cells, Labeled Cells, and uses Thereof
US8946389B2 (en) * 2011-04-25 2015-02-03 University Of Washington Compositions and methods for multiplex biomarker profiling
WO2013010023A2 (en) * 2011-07-13 2013-01-17 Aperio Technologies, Inc. Standardizing fluorescence microscopy systems
EP2737356A1 (en) * 2011-07-25 2014-06-04 Mad City Labs, Inc. Active-feedback positional drift correction in a microscope image using a fiduciary element held on a nanopositioning stage
US9115394B2 (en) 2011-12-22 2015-08-25 Roche Molecular Systems, Inc. Methods and reagents for reducing non-specific amplification
WO2014028538A2 (en) 2012-08-13 2014-02-20 William Marsh Rice University Multiplexed in situ molecular analyses and programmable molecular probes for regulated signal amplification
US10584381B2 (en) * 2012-08-14 2020-03-10 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9975916B2 (en) 2012-11-06 2018-05-22 President And Fellows Of Harvard College Compositions and methods relating to complex nucleic acid nanostructures
EP2920320B1 (en) 2012-11-14 2016-12-28 Olink Bioscience AB Rca reporter probes and their use in detecting nucleic acid molecules
KR102275006B1 (ko) 2013-03-11 2021-07-09 메소 스케일 테크놀러지즈, 엘엘시 다중화 어세이를 수행하기 위한 개선된 방법
US8933261B2 (en) * 2013-03-14 2015-01-13 Andrei POLUKHTIN Benzophenone-based chromophoric crosslinkers and reagents for incorporation of biotin or other haptens into macromolecules
WO2014145620A2 (en) 2013-03-15 2014-09-18 The Broad Institute, Inc. Novel hybridization probes and uses thereof
KR20160039229A (ko) 2013-07-30 2016-04-08 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 정량적 dna-기반 영상화 및 초해상도 영상화
WO2015070037A2 (en) 2013-11-08 2015-05-14 Prognosys Biosciences, Inc. Polynucleotide conjugates and methods for analyte detection
CA2938082A1 (en) 2013-12-15 2015-06-18 President And Fellows Of Harvard College Methods and compositions relating to optical super-resolution patterning
WO2015138231A1 (en) 2014-03-08 2015-09-17 President And Fellows Of Harvard College Nucleic acid polyhedra from self-assembled vertex-containing fixed-angle nucleic acid structures
KR102313982B1 (ko) 2014-03-11 2021-10-18 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 프로그램가능한 핵산 프로브를 이용한 고처리량 고도 다중 영상화
US20160033411A1 (en) 2014-07-29 2016-02-04 President And Fellows Of Harvard College Methods and compositions relating to storm-based patterning
SG11201703693UA (en) 2014-11-11 2017-06-29 Illumina Cambridge Ltd Methods and arrays for producing and sequencing monoclonal clusters of nucleic acid
US10006917B2 (en) 2014-12-15 2018-06-26 President And Fellows Of Harvard College Methods and compositions relating to super-resolution imaging and modification
CN107924473B (zh) 2015-08-07 2021-11-23 哈佛学院院长及董事 蛋白质-蛋白质相互作用的超分辨成像
CN112567245A (zh) 2018-08-28 2021-03-26 Jl美迪乐博斯公司 检测目标物质的方法和试剂盒

Also Published As

Publication number Publication date
EP3027773A4 (en) 2017-03-01
US11536715B2 (en) 2022-12-27
JP6475718B2 (ja) 2019-02-27
EP3027773A1 (en) 2016-06-08
EP3696277B1 (en) 2023-01-25
EP3696277A2 (en) 2020-08-19
JP2016532689A (ja) 2016-10-20
KR20160039229A (ko) 2016-04-08
EP3696277A3 (en) 2020-10-21
US20200064340A1 (en) 2020-02-27
EP3027773B1 (en) 2020-03-25
AU2014296253A1 (en) 2016-02-04
WO2015017586A1 (en) 2015-02-05
CA2919833A1 (en) 2015-02-05
US20160161472A1 (en) 2016-06-09
CN105531377A (zh) 2016-04-27

Similar Documents

Publication Publication Date Title
HK1221747A1 (zh) 基於 的定量成像和超分辨成像
IL269693A (en) Oligonucleotide probes and their uses
IL276106A (en) Garp-binding proteins and their uses
IL254402B (en) Oligonucleotide probes and their uses
EP2971280A4 (en) BIOSENSOR MICROARRAY COMPOSITIONS AND METHOD
HK1219503A1 (zh) 用於核酸測序的方法和組合物
EP3008181A4 (en) METHOD AND COMPOSITIONS FOR TARGETED DNA MODIFICATION
SG11201605896WA (en) Dihydropyrimidine compounds and their application in pharmaceuticals
ZA201507314B (en) Refractory batch and use thereof
EP3027775A4 (en) Dna sequencing and epigenome analysis
EP2924608A4 (en) METHOD AND DEVICE FOR IMAGING BIOLOGICAL ELEMENTS
IL245839A0 (en) Inhibitors of rna polymerase i and use of preparations containing them for treatment
HRP20182063T1 (hr) Gen otpornosti na rizomaniju
EP2918681A4 (en) FERTILITY GENE AND USES THEREOF
GB201314302D0 (en) Probe and sample exchange mechanism
SG11201602291TA (en) Nucleic acid biomarker and use thereof
SG11201507949YA (en) Biological sample processing
EP2978862A4 (en) DOUBLE-SINGLE ANTISOND COMPOSITIONS FOR DNA AND RNA DETECTION
EP2902488A4 (en) MODIFIED DNA POLYMERASE
GB201320066D0 (en) Biological products
GB201315748D0 (en) Biological methods and materials for use therein
HK1215408A1 (zh) 纖蛋白蛋白變體及相應的核酸序列
GB2522743B (en) Laboratory mixer
EP3078747A4 (en) Peanut-binding nucleic acid molecule and use thereof
EP2855704A4 (en) NUCLEIC ACID AMPLIFICATION AND USE THEREOF