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HK1216886A1 - 調節劑和與其相關的方法 - Google Patents

調節劑和與其相關的方法

Info

Publication number
HK1216886A1
HK1216886A1 HK16104760.2A HK16104760A HK1216886A1 HK 1216886 A1 HK1216886 A1 HK 1216886A1 HK 16104760 A HK16104760 A HK 16104760A HK 1216886 A1 HK1216886 A1 HK 1216886A1
Authority
HK
Hong Kong
Prior art keywords
ship1
modulators
methods related
methods
ship1 modulators
Prior art date
Application number
HK16104760.2A
Other languages
English (en)
Inventor
F Mackenzie Lloyd
B Macrury Thomas
Harwig Curtis
Bogucki David
R Raymond Jeffery
D Pettigrew Jeremy
KHLEBNIKOV Vladimir
Shan Rudong
Original Assignee
Aquinox Pharmaceuticals (Canada) Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aquinox Pharmaceuticals (Canada) Inc filed Critical Aquinox Pharmaceuticals (Canada) Inc
Publication of HK1216886A1 publication Critical patent/HK1216886A1/zh

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
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    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
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    • A61K31/075—Ethers or acetals
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    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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    • C07C2602/14—All rings being cycloaliphatic
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WO2018126040A1 (en) 2016-12-28 2018-07-05 Aquinox Pharmaceuticals (Canada) Inc. Crystalline solid forms of (1s,3s,4r)-4-((3as,4r,5s,7as)-4- (aminomethyl)-7a-methyl-1-methyleneoctahydro-1h-inden-5-yl)-3- (hydroxymethyl)-4-methylcyclohexanol
CN107602496B (zh) * 2017-09-08 2020-10-13 南京农业大学 手性补身烷基杂环类化合物及其作为杀菌剂的用途
CN112533905A (zh) 2018-04-06 2021-03-19 塔罗制药公司 可用于治疗疼痛和炎症的茚衍生物
AU2019247453A1 (en) 2018-04-06 2020-10-22 Taro Pharmaceuticals Inc. Hexadecahydro-1H-cyclopenta[a]phenanthrene derivatives useful in treating pain and inflammation
WO2019195777A1 (en) 2018-04-06 2019-10-10 Aquinox Pharmaceuticals (Canada) Inc. Indene derivatives useful in treating pain and inflammation
CN116554063A (zh) * 2023-05-23 2023-08-08 江苏省农用激素工程技术研究中心有限公司 氟胺磺隆中间体的制备方法

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ES2327829T3 (es) * 2002-10-17 2009-11-04 The University Of British Columbia Moduladores de ship 1.
AU2004229598B2 (en) 2003-04-15 2011-01-20 Aquinox Pharmaceuticals (Canada) Inc. Indene derivatives as pharmaceutical agents
EP2035367A1 (en) 2006-06-21 2009-03-18 The University of British Columbia Ship 1 modulator prodrugs
RU2385863C2 (ru) 2008-04-21 2010-04-10 Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) (статус государственного учреждения) N-ЗАМЕЩЕННЫЕ (1S,4aR,5S)-МЕТИЛ-5-[2-(2'-ОКСО-2',5'-ДИГИДРО-1Н-ПИРРОЛ-3'-ИЛ)ЭТИЛ]-1,4a-ДИМЕТИЛ-6-МЕТИЛЕНДЕКАГИДРОНАФТАЛИН-1-КАРБОКСИЛАТЫ, ОБЛАДАЮЩИЕ ПРОТИВОСУДОРОЖНОЙ АКТИВНОСТЬЮ
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ES2594980T3 (es) 2010-08-20 2016-12-27 The University Of British Columbia Moduladores de SHIP1 y métodos relacionados
CN108752236A (zh) 2013-01-09 2018-11-06 阿奎诺克斯药物（加拿大）公司 Ship1调节剂和与其相关的方法
JP6407951B2 (ja) 2013-03-14 2018-10-17 アクイノックス ファーマシューティカルズ （カナダ） インコーポレイテッド Ｓｈｉｐ１モジュレーターおよびそれに関連する組成物および方法
KR20150130426A (ko) 2013-03-14 2015-11-23 에퀴녹스 파머수티칼스 (캐나다) 인코포레이티드 Ship1 조절제 및 그와 관련된 방법
US9944590B2 (en) 2015-06-26 2018-04-17 Aquinox Pharmaceuticals (Canada) Inc. Crystalline solid forms of the acetate salt of (1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexanol
WO2017127753A1 (en) 2016-01-20 2017-07-27 Aquinox Pharmaceuticals (Canada) Inc. Synthesis of a substituted indene derivative

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CA2896559A1 (en) 2014-07-17
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HK1216882A1 (zh) 2016-12-09
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