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HK1208217A1 - Pyrrolobenzodiazepines - Google Patents

Pyrrolobenzodiazepines

Info

Publication number
HK1208217A1
HK1208217A1 HK15108789.1A HK15108789A HK1208217A1 HK 1208217 A1 HK1208217 A1 HK 1208217A1 HK 15108789 A HK15108789 A HK 15108789A HK 1208217 A1 HK1208217 A1 HK 1208217A1
Authority
HK
Hong Kong
Prior art keywords
pyrrolobenzodiazepines
Prior art date
Application number
HK15108789.1A
Other languages
English (en)
Chinese (zh)
Inventor
Philip Wilson Howard
David Edwin Thurston
Khondaker Mirazur Rahman
Peter William Taylor
Original Assignee
Ucl Business Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucl Business Plc filed Critical Ucl Business Plc
Publication of HK1208217A1 publication Critical patent/HK1208217A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK15108789.1A 2012-04-30 2015-09-09 Pyrrolobenzodiazepines HK1208217A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261640316P 2012-04-30 2012-04-30
PCT/GB2013/051097 WO2013164592A1 (en) 2012-04-30 2013-04-30 Pyrrolobenzodiazepines

Publications (1)

Publication Number Publication Date
HK1208217A1 true HK1208217A1 (en) 2016-02-26

Family

ID=48289484

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15108789.1A HK1208217A1 (en) 2012-04-30 2015-09-09 Pyrrolobenzodiazepines

Country Status (14)

Country Link
US (1) US9321774B2 (ko)
EP (1) EP2855481A1 (ko)
JP (1) JP6125614B2 (ko)
KR (1) KR101960130B1 (ko)
CN (1) CN104540827B (ko)
AU (1) AU2013255612B2 (ko)
BR (1) BR112014027190B1 (ko)
CA (1) CA2872205C (ko)
HK (1) HK1208217A1 (ko)
IN (1) IN2014MN02175A (ko)
MX (1) MX2014013144A (ko)
NZ (1) NZ701478A (ko)
WO (1) WO2013164592A1 (ko)
ZA (1) ZA201408043B (ko)

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SG11201400770SA (en) 2011-09-20 2014-04-28 Spirogen Sarl Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates
US9399073B2 (en) 2011-10-14 2016-07-26 Seattle Genetics, Inc. Pyrrolobenzodiazepines
BR112014009055B1 (pt) 2011-10-14 2021-12-14 Seattle Genetics, Inc. Compostos pirrolobenzodiazepinas, conjugados alvos, ligante de fármaco e uso dos ditos conjugados para tratar uma doença proliferativa
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CN108164551A (zh) 2011-10-14 2018-06-15 西雅图基因公司 吡咯并苯并二氮杂卓和靶向结合物
US9745303B2 (en) 2012-10-12 2017-08-29 Medimmune Limited Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
MX364329B (es) 2012-10-12 2019-04-23 Medimmune Ltd Conjugados del anticuerpo pirrolobenzodiazepina.
KR20150083994A (ko) 2012-10-12 2015-07-21 스피로즌 살 피롤로벤조디아제핀 및 그의 컨주게이트
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EP2935268B2 (en) 2012-12-21 2021-02-17 MedImmune Limited Pyrrolobenzodiazepines and conjugates thereof
WO2014096365A1 (en) 2012-12-21 2014-06-26 Spirogen Sàrl Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases
CA2904044C (en) 2013-03-13 2020-03-31 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
EP2968596B1 (en) 2013-03-13 2019-03-06 Medimmune Limited Pyrrolobenzodiazepines and conjugates thereof
GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
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US10780096B2 (en) 2014-11-25 2020-09-22 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
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EP3458069B1 (en) 2016-05-18 2023-07-05 Mersana Therapeutics, Inc. Pyrrolobenzodiazepines and conjugates thereof
EP3475284B1 (en) * 2016-06-24 2022-11-02 Mersana Therapeutics, Inc. Pyrrolobenzodiazepines and conjugates thereof
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ES2871001T3 (es) 2017-02-08 2021-10-28 Adc Therapeutics Sa Conjugados de pirrolobenzodiazepinas y anticuerpos
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
JP2020517609A (ja) 2017-04-18 2020-06-18 メディミューン リミテッド ピロロベンゾジアゼピン複合体
BR112019021880A2 (pt) 2017-04-20 2020-06-02 Adc Therapeutics Sa Terapia de combinação com conjugado anticorpo anti-axl-droga
UA127900C2 (uk) 2017-06-14 2024-02-07 Ейдісі Терапьютікс Са Схема дозування для введення adc до cd19
RS62928B1 (sr) 2017-08-18 2022-03-31 Medimmune Ltd Konjugati pirolobenzodiazepina
CA3126646A1 (en) 2017-09-29 2019-04-04 Daiichi Sankyo Company, Limited Antibody-pyrrolobenzodiazepine derivative conjugate
EP3717021A1 (en) 2017-11-27 2020-10-07 Mersana Therapeutics, Inc. Pyrrolobenzodiazepine antibody conjugates
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
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GB2597532A (en) 2020-07-28 2022-02-02 Femtogenix Ltd Cytotoxic compounds
WO2024127332A1 (en) 2022-12-14 2024-06-20 Pheon Therapeutics Ltd Cytotoxic compounds

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GB0819095D0 (en) 2008-10-17 2008-11-26 Spirogen Ltd Pyrrolobenzodiazepines

Also Published As

Publication number Publication date
MX2014013144A (es) 2015-05-11
JP2015516987A (ja) 2015-06-18
CN104540827A (zh) 2015-04-22
BR112014027190A2 (pt) 2017-06-27
AU2013255612B2 (en) 2017-06-22
WO2013164592A1 (en) 2013-11-07
JP6125614B2 (ja) 2017-05-10
CA2872205A1 (en) 2013-11-07
KR20150014935A (ko) 2015-02-09
NZ701478A (en) 2016-08-26
CA2872205C (en) 2020-07-21
US9321774B2 (en) 2016-04-26
KR101960130B1 (ko) 2019-03-19
ZA201408043B (en) 2017-08-30
CN104540827B (zh) 2018-03-23
US20150126495A1 (en) 2015-05-07
AU2013255612A1 (en) 2014-11-20
IN2014MN02175A (ko) 2015-08-28
EP2855481A1 (en) 2015-04-08
BR112014027190B1 (pt) 2020-03-03

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