HK1202538A1 - Heterocyclyl compounds as mek inhibitors mek - Google Patents

Heterocyclyl compounds as mek inhibitors mek

Info

Publication number: HK1202538A1
Authority: HK; Hong Kong
Prior art keywords: mek; heterocyclyl compounds; inhibitors; heterocyclyl; compounds
Prior art date: 2012-03-14

Application number

HK15103051.3A

Other languages

English (en)

Chinese (zh)

Inventor

Bhavesh Dave

Rakesh Kumar Banerjee

Samiron Phukan

Abhijit Datta Khoje

Rajkumar Hangarge

Jitendra Sambhaji Jadhav

Venkata P Palle

Rajender Kumar Kamboj

Original Assignee

Lupin Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-03-14

Filing date

2015-03-25

Publication date

2015-10-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47997632&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1202538(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2015-03-25 Application filed by Lupin Ltd filed Critical Lupin Ltd

2015-10-02 Publication of HK1202538A1 publication Critical patent/HK1202538A1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Oncology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Communicable Diseases (AREA)
Hematology (AREA)
Pathology (AREA)
Radiology & Medical Imaging (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Obesity (AREA)
Dermatology (AREA)
Psychiatry (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Transplantation (AREA)

HK15103051.3A 2012-03-14 2015-03-25 Heterocyclyl compounds as mek inhibitors mek HK1202538A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IN288KO2012		2012-03-14
PCT/IB2013/051908 WO2013136249A1 (en)	2012-03-14	2013-03-11	Heterocyclyl compounds as mek inhibitors

Publications (1)

Publication Number	Publication Date
HK1202538A1 true HK1202538A1 (en)	2015-10-02

Family

ID=47997632

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
HK15103051.3A HK1202538A1 (en)	2012-03-14	2015-03-25	Heterocyclyl compounds as mek inhibitors mek
HK15106571.7A HK1206020A1 (en)	2012-03-14	2015-07-09	Heterocyclyl compounds

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
HK15106571.7A HK1206020A1 (en)	2012-03-14	2015-07-09	Heterocyclyl compounds

Country Status (36)

Country	Link
US (5)	US9573944B2 (xx)
EP (2)	EP2834237B1 (xx)
JP (3)	JP6093384B2 (xx)
KR (4)	KR102240101B1 (xx)
CN (4)	CN104271577A (xx)
AP (2)	AP3859A (xx)
AU (4)	AU2013234009B2 (xx)
BR (1)	BR112014022713B1 (xx)
CA (2)	CA2865167C (xx)
CL (2)	CL2014002411A1 (xx)
CO (2)	CO7160029A2 (xx)
CR (2)	CR20140464A (xx)
CU (2)	CU24272B1 (xx)
DK (2)	DK2834237T3 (xx)
DO (2)	DOP2014000203A (xx)
EA (2)	EA028232B1 (xx)
ES (2)	ES2684517T3 (xx)
GE (2)	GEP201706671B (xx)
GT (2)	GT201400195A (xx)
HK (2)	HK1202538A1 (xx)
IL (2)	IL234560A (xx)
IN (2)	IN2014MN01755A (xx)
MA (2)	MA37405A1 (xx)
MX (3)	MX366426B (xx)
MY (2)	MY175950A (xx)
NI (2)	NI201400108A (xx)
NZ (2)	NZ629442A (xx)
PE (2)	PE20141974A1 (xx)
PH (2)	PH12014502040B1 (xx)
PL (1)	PL2834237T3 (xx)
SG (2)	SG11201405006PA (xx)
TN (2)	TN2014000356A1 (xx)
TR (1)	TR201811976T4 (xx)
UA (2)	UA114906C2 (xx)
WO (2)	WO2013136254A1 (xx)
ZA (1)	ZA201406186B (xx)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2012088266A2 (en)	2010-12-22	2012-06-28	Incyte Corporation	Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
DK2834237T3 (en)	2012-03-14	2018-08-27	Lupin Ltd	HETEROCYCLYL COMPOUNDS AS MEK INHITORS
PT3176170T (pt)	2012-06-13	2019-02-05	Incyte Holdings Corp	Compostos tricíclicos substituídos como inibidores de fgfr
WO2014026125A1 (en)	2012-08-10	2014-02-13	Incyte Corporation	Pyrazine derivatives as fgfr inhibitors
US9266892B2 (en)	2012-12-19	2016-02-23	Incyte Holdings Corporation	Fused pyrazoles as FGFR inhibitors
KR102469849B1 (ko)	2013-04-19	2022-11-23	인사이트 홀딩스 코포레이션	Fgfr 저해제로서 이환식 헤테로사이클
KR102222569B1 (ko) *	2013-10-25	2021-03-05	샹하이 헨그루이 파마수티컬 컴퍼니 리미티드	피리딘의 케톤 유도체의 제조 방법 및 제약 용도
WO2016009306A1 (en) *	2014-07-15	2016-01-21	Lupin Limited	Heterocyclyl compounds as mek inhibitors
WO2016035008A1 (en) *	2014-09-04	2016-03-10	Lupin Limited	Pyridopyrimidine derivatives as mek inhibitors
US10851105B2 (en)	2014-10-22	2020-12-01	Incyte Corporation	Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (fr)	2015-02-20	2017-12-26	Incyte Corp	Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
US9580423B2 (en)	2015-02-20	2017-02-28	Incyte Corporation	Bicyclic heterocycles as FGFR4 inhibitors
SG11201706287PA (en)	2015-02-20	2017-09-28	Incyte Corp	Bicyclic heterocycles as fgfr inhibitors
EP3878850A1 (en)	2016-12-22	2021-09-15	Boehringer Ingelheim International GmbH	Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors
AR111960A1 (es)	2017-05-26	2019-09-04	Incyte Corp	Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
RS64167B1 (sr)	2017-12-21	2023-05-31	Boehringer Ingelheim Int	Benzilamino supstituisani piridopirimidinoni i derivati kao sos1 inhibitori
PE20210920A1 (es)	2018-05-04	2021-05-19	Incyte Corp	Formas solidas de un inhibidor de fgfr y procesos para prepararlas
CN112566912A (zh)	2018-05-04	2021-03-26	因赛特公司	Fgfr抑制剂的盐
WO2020185532A1 (en)	2019-03-08	2020-09-17	Incyte Corporation	Methods of treating cancer with an fgfr inhibitor
BR112021018168B1 (pt)	2019-03-21	2023-11-28	Onxeo	Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer
CA3142239A1 (en)	2019-06-19	2020-12-24	Boehringer Ingelheim International Gmbh	Anticancer combination therapy
US11591329B2 (en)	2019-07-09	2023-02-28	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
MX2022001328A (es) *	2019-07-30	2022-05-20	Edvince Ab	Inhibidor de proteina quinasa quinasa activada por mitogeno (mek) para el tratamiento de apoplejia.
EP3797899A1 (de)	2019-09-27	2021-03-31	Primetals Technologies Austria GmbH	Vorrichtung und verfahren zum erkennen von einer bewegung eines körpers in einer industrieanlage
US12122767B2 (en)	2019-10-01	2024-10-22	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
TW202128685A (zh)	2019-10-14	2021-08-01	美商英塞特公司	作為ｆｇｆｒ抑制劑之雙環雜環
US11566028B2 (en)	2019-10-16	2023-01-31	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
EP4054579A1 (en)	2019-11-08	2022-09-14	Institut National de la Santé et de la Recherche Médicale (INSERM)	Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
MX2022006691A (es)	2019-12-04	2022-09-19	Incyte Corp	Derivados de un inhibidor de receptores del factor de crecimiento de fibroblastos (fgfr).
EP4069696A1 (en)	2019-12-04	2022-10-12	Incyte Corporation	Tricyclic heterocycles as fgfr inhibitors
WO2021146424A1 (en)	2020-01-15	2021-07-22	Incyte Corporation	Bicyclic heterocycles as fgfr inhibitors
WO2021148581A1 (en)	2020-01-22	2021-07-29	Onxeo	Novel dbait molecule and its use
AU2021285032A1 (en)	2020-06-02	2022-12-08	Boehringer Ingelheim International Gmbh	Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
TWI825637B (zh)	2021-03-31	2023-12-11	美商輝瑞股份有限公司	啶－１，６（２ｈ，７ｈ）－二酮
US20240238294A1 (en)	2021-04-09	2024-07-18	Boehringer Ingelheim International Gmbh	Anticancer therapy
JP2024513575A (ja)	2021-04-12	2024-03-26	インサイト・コーポレイション	Ｆｇｆｒ阻害剤及びネクチン－４標的化剤を含む併用療法
AU2022258968A1 (en) *	2021-04-16	2023-10-19	Ikena Oncology, Inc.	Mek inhibitors and uses thereof
TW202313611A (zh)	2021-06-09	2023-04-01	美商英塞特公司	作為ｆｇｆｒ抑制劑之三環雜環
TW202340208A (zh)	2021-12-01	2023-10-16	德商百靈佳殷格翰國際股份有限公司	用於治療癌症之環狀2-胺基-3-氰基噻吩及衍生物
EP4441056A1 (en)	2021-12-01	2024-10-09	Boehringer Ingelheim International GmbH	Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
PE20241356A1 (es)	2021-12-01	2024-07-03	Boehringer Ingelheim Int	Tiofenos 2-amino-3-ciano anulados y derivados para el tratamiento del cancer
CN118591540A (zh)	2021-12-01	2024-09-03	勃林格殷格翰国际有限公司	包含环状2-氨基-3-氰基噻吩的kras降解化合物
WO2023099592A1 (en)	2021-12-01	2023-06-08	Boehringer Ingelheim International Gmbh	Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
CN114573582B (zh) *	2022-03-30	2023-06-16	沈阳药科大学	1,2,3,4-四氢吡啶并[2,3-d]嘧啶类化合物及其制备方法和应用
CN114573581B (zh) *	2022-03-30	2023-09-01	沈阳药科大学	5-取代氨基-1,3-二取代苯基吡啶并[2,3-d]嘧啶类化合物及其制备与应用
CN114456166B (zh) *	2022-03-30	2023-06-16	沈阳药科大学	5-取代氨基-3-甲基吡啶并[2,3-d]嘧啶类化合物及其制备与应用
CN114605408B (zh) *	2022-03-30	2023-06-16	沈阳药科大学	5-羟基-1,3-二取代苯基吡啶并[2,3-d]嘧啶类化合物及其制法和应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4235871A (en)	1978-02-24	1980-11-25	Papahadjopoulos Demetrios P	Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en)	1983-01-06	1985-02-26	Technology Unlimited, Inc.	Masking of liposomes from RES recognition
US5019369A (en)	1984-10-22	1991-05-28	Vestar, Inc.	Method of targeting tumors in humans
US4837028A (en)	1986-12-24	1989-06-06	Liposome Technology, Inc.	Liposomes with enhanced circulation time
UA72612C2 (en) *	2000-07-06	2005-03-15		Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells
US6825180B2 (en) *	2001-05-18	2004-11-30	Cell Therapeutics, Inc.	Pyridopyrimidine compounds and their uses
GB0129099D0 (en)	2001-12-05	2002-01-23	Astrazeneca Ab	Chemical compounds
CA2473026C (en) *	2002-01-22	2011-05-03	Warner-Lambert Company Llc	2-(pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-ones
US7235537B2 (en)	2002-03-13	2007-06-26	Array Biopharma, Inc.	N3 alkylated benzimidazole derivatives as MEK inhibitors
JP4869075B2 (ja)	2003-11-19	2012-02-01	アレイバイオファーマ、インコーポレイテッド	Ｍｅｋの複素環阻害剤及びその使用方法
US7378423B2 (en)	2004-06-11	2008-05-27	Japan Tobacco Inc.	Pyrimidine compound and medical use thereof
ES2297723T3 (es) *	2004-06-11	2008-05-01	Japan Tobacco, Inc.	Derivados de 5-amino-2,4,7-trioxo-3,4,7,8-tetrahidro-2h-pirido(2,3-d)pirimidina y compuestos relacioandos para el tratamiento de cancer.
EA201101533A1 (ru)	2009-04-21	2012-05-30	Новартис Аг	Гетероциклические соединения в качестве ингибиторов mek
DK2834237T3 (en) *	2012-03-14	2018-08-27	Lupin Ltd	HETEROCYCLYL COMPOUNDS AS MEK INHITORS

2013
- 2013-03-11 DK DK13712929.2T patent/DK2834237T3/en active
- 2013-03-11 IN IN1755MUN2014 patent/IN2014MN01755A/en unknown
- 2013-03-11 MX MX2018003665A patent/MX366426B/es unknown
- 2013-03-11 CN CN201380023296.2A patent/CN104271577A/zh active Pending
- 2013-03-11 CN CN201710823363.9A patent/CN107698585A/zh active Pending
- 2013-03-11 ES ES13712929T patent/ES2684517T3/es active Active
- 2013-03-11 AU AU2013234009A patent/AU2013234009B2/en active Active
- 2013-03-11 GE GEAP201313595A patent/GEP201706671B/en unknown
- 2013-03-11 TR TR2018/11976T patent/TR201811976T4/tr unknown
- 2013-03-11 EA EA201491672A patent/EA028232B1/ru unknown
- 2013-03-11 PL PL13712929T patent/PL2834237T3/pl unknown
- 2013-03-11 KR KR1020197017334A patent/KR102240101B1/ko active IP Right Grant
- 2013-03-11 UA UAA201411011A patent/UA114906C2/uk unknown
- 2013-03-11 NZ NZ629442A patent/NZ629442A/en not_active IP Right Cessation
- 2013-03-11 IN IN1754MUN2014 patent/IN2014MN01754A/en unknown
- 2013-03-11 EP EP13712929.2A patent/EP2834237B1/en active Active
- 2013-03-11 CU CUP2014000110A patent/CU24272B1/xx unknown
- 2013-03-11 CA CA2865167A patent/CA2865167C/en not_active Expired - Fee Related
- 2013-03-11 CA CA2865164A patent/CA2865164C/en active Active
- 2013-03-11 BR BR112014022713-6A patent/BR112014022713B1/pt active IP Right Grant
- 2013-03-11 MX MX2014010928A patent/MX355474B/es active IP Right Grant
- 2013-03-11 MY MYPI2014002638A patent/MY175950A/en unknown
- 2013-03-11 GE GEAP201313596A patent/GEP201706774B/en unknown
- 2013-03-11 MA MA37405A patent/MA37405A1/fr unknown
- 2013-03-11 EA EA201491671A patent/EA029768B1/ru unknown
- 2013-03-11 ES ES13711973T patent/ES2741896T3/es active Active
- 2013-03-11 CU CUP2014000109A patent/CU24335B1/es unknown
- 2013-03-11 NZ NZ629432A patent/NZ629432A/en unknown
- 2013-03-11 US US14/385,106 patent/US9573944B2/en active Active
- 2013-03-11 UA UAA201411014A patent/UA114907C2/uk unknown
- 2013-03-11 AP AP2014008009A patent/AP3859A/en active
- 2013-03-11 DK DK13711973.1T patent/DK2834236T3/da active
- 2013-03-11 KR KR1020197024543A patent/KR102241111B1/ko active IP Right Grant
- 2013-03-11 KR KR1020147028556A patent/KR20140138910A/ko active Application Filing
- 2013-03-11 CN CN201810086896.8A patent/CN108383836B/zh active Active
- 2013-03-11 SG SG11201405006PA patent/SG11201405006PA/en unknown
- 2013-03-11 EP EP13711973.1A patent/EP2834236B1/en active Active
- 2013-03-11 JP JP2014561567A patent/JP6093384B2/ja active Active
- 2013-03-11 AU AU2013234014A patent/AU2013234014B2/en not_active Ceased
- 2013-03-11 CN CN201380014210.XA patent/CN104203947A/zh active Pending
- 2013-03-11 US US14/385,092 patent/US9428499B2/en active Active
- 2013-03-11 KR KR1020147028557A patent/KR20140138911A/ko not_active IP Right Cessation
- 2013-03-11 SG SG11201405007QA patent/SG11201405007QA/en unknown
- 2013-03-11 MX MX2014010925A patent/MX355526B/es active IP Right Grant
- 2013-03-11 MA MA37400A patent/MA37400B1/fr unknown
- 2013-03-11 JP JP2014561564A patent/JP6431770B2/ja active Active
- 2013-03-11 MY MYPI2014002639A patent/MY174188A/en unknown
- 2013-03-11 AP AP2014008008A patent/AP3834A/en active
- 2013-03-11 PE PE2014001400A patent/PE20141974A1/es active IP Right Grant
- 2013-03-11 WO PCT/IB2013/051915 patent/WO2013136254A1/en active Application Filing
- 2013-03-11 PE PE2014001399A patent/PE20141973A1/es active IP Right Grant
- 2013-03-11 WO PCT/IB2013/051908 patent/WO2013136249A1/en active Application Filing
2014
- 2014-08-18 TN TNP2014000356A patent/TN2014000356A1/fr unknown
- 2014-08-18 TN TNP2014000357A patent/TN2014000357A1/fr unknown
- 2014-08-22 ZA ZA2014/06186A patent/ZA201406186B/en unknown
- 2014-09-09 IL IL234560A patent/IL234560A/en active IP Right Grant
- 2014-09-09 IL IL234559A patent/IL234559A/en active IP Right Grant
- 2014-09-10 DO DO2014000203A patent/DOP2014000203A/es unknown
- 2014-09-10 DO DO2014000204A patent/DOP2014000204A/es unknown
- 2014-09-11 NI NI201400108A patent/NI201400108A/es unknown
- 2014-09-11 NI NI201400107A patent/NI201400107A/es unknown
- 2014-09-12 PH PH12014502040A patent/PH12014502040B1/en unknown
- 2014-09-12 GT GT201400195A patent/GT201400195A/es unknown
- 2014-09-12 CL CL2014002411A patent/CL2014002411A1/es unknown
- 2014-09-12 GT GT201400196A patent/GT201400196A/es unknown
- 2014-09-12 PH PH12014502041A patent/PH12014502041B1/en unknown
- 2014-09-12 CL CL2014002412A patent/CL2014002412A1/es unknown
- 2014-10-06 CO CO14221195A patent/CO7160029A2/es unknown
- 2014-10-06 CR CR20140464A patent/CR20140464A/es unknown
- 2014-10-06 CO CO14221191A patent/CO7170131A2/es unknown
- 2014-10-06 CR CR20140463A patent/CR20140463A/es unknown
2015
- 2015-03-25 HK HK15103051.3A patent/HK1202538A1/xx unknown
- 2015-07-09 HK HK15106571.7A patent/HK1206020A1/xx not_active IP Right Cessation
2016
- 2016-07-25 US US15/218,980 patent/US9555035B2/en active Active
- 2016-12-22 US US15/388,327 patent/US9969731B2/en active Active
2017
- 2017-01-06 US US15/400,627 patent/US9827247B2/en active Active
- 2017-01-25 AU AU2017200493A patent/AU2017200493B2/en active Active
2018
- 2018-04-12 AU AU2018202568A patent/AU2018202568B2/en active Active
- 2018-05-01 JP JP2018088389A patent/JP6630771B2/ja active Active

Also Published As

Publication number	Publication date
NZ629432A (en)	2017-01-27
US9827247B2 (en)	2017-11-28
PL2834237T3 (pl)	2018-11-30
ES2684517T3 (es)	2018-10-03
JP2015509975A (ja)	2015-04-02
GT201400195A (es)	2017-11-09
NZ629442A (en)	2016-12-23
US20170101408A1 (en)	2017-04-13
CU24335B1 (es)	2018-04-03
US9969731B2 (en)	2018-05-15
TR201811976T4 (tr)	2018-09-21
EP2834236B1 (en)	2019-05-22
AU2013234014A1 (en)	2014-09-25
AP2014008008A0 (en)	2014-10-31
KR20190100472A (ko)	2019-08-28
CN107698585A (zh)	2018-02-16
UA114906C2 (uk)	2017-08-28
AP3859A (en)	2016-10-31
DK2834237T3 (en)	2018-08-27
WO2013136249A1 (en)	2013-09-19
MA37400A1 (fr)	2016-05-31
IN2014MN01754A (xx)	2015-07-03
BR112014022713A2 (xx)	2017-06-20
MY174188A (en)	2020-03-12
MA37405A1 (fr)	2016-03-31
AU2018202568A1 (en)	2018-05-10
AU2013234014B2 (en)	2017-02-02
US20160331753A1 (en)	2016-11-17
KR20140138911A (ko)	2014-12-04
JP2018115215A (ja)	2018-07-26
BR112014022713B1 (pt)	2021-09-08
JP6093384B2 (ja)	2017-03-08
TN2014000357A1 (en)	2015-12-21
PH12014502040A1 (en)	2014-11-24
JP6630771B2 (ja)	2020-01-15
CN108383836B (zh)	2021-11-12
ZA201406186B (en)	2016-06-29
MX355526B (es)	2018-04-20
SG11201405006PA (en)	2014-10-30
UA114907C2 (uk)	2017-08-28
MY175950A (en)	2020-07-16
TN2014000356A1 (en)	2015-12-21
MX366426B (es)	2019-07-08
JP2015514056A (ja)	2015-05-18
EP2834237A1 (en)	2015-02-11
CO7160029A2 (es)	2015-01-15
EA201491672A1 (ru)	2014-12-30
PE20141974A1 (es)	2014-12-12
AU2017200493A1 (en)	2017-02-16
EA029768B1 (ru)	2018-05-31
CL2014002412A1 (es)	2015-03-06
AU2013234009B2 (en)	2016-10-27
WO2013136254A1 (en)	2013-09-19
US9573944B2 (en)	2017-02-21
NI201400107A (es)	2014-11-26
ES2741896T3 (es)	2020-02-12
US20150299186A1 (en)	2015-10-22
CN104271577A (zh)	2015-01-07
KR102241111B1 (ko)	2021-04-15
SG11201405007QA (en)	2014-10-30
MA37400B1 (fr)	2019-11-29
IN2014MN01755A (xx)	2015-07-03
CA2865164C (en)	2021-06-08
US9555035B2 (en)	2017-01-31
US20170112840A1 (en)	2017-04-27
CA2865167A1 (en)	2013-09-19
PH12014502040B1 (en)	2014-11-24
AP3834A (en)	2016-09-30
US20150133424A1 (en)	2015-05-14
KR20190073597A (ko)	2019-06-26
AP2014008009A0 (en)	2014-10-31
EP2834237B1 (en)	2018-06-06
IL234560A (en)	2017-06-29
KR102240101B1 (ko)	2021-04-14
DOP2014000203A (es)	2015-02-15
CO7170131A2 (es)	2015-01-28
AU2017200493B2 (en)	2018-03-29
CN108383836A (zh)	2018-08-10
EP2834236A1 (en)	2015-02-11
GEP201706774B (en)	2017-11-27
EA028232B1 (ru)	2017-10-31
US9428499B2 (en)	2016-08-30
CR20140463A (es)	2014-11-28
MX2014010928A (es)	2015-04-10
AU2018202568B2 (en)	2019-05-09
MX2014010925A (es)	2015-04-10
DK2834236T3 (da)	2019-08-26
CU24272B1 (es)	2017-08-08
PE20141973A1 (es)	2014-12-12
EA201491671A1 (ru)	2014-12-30
AU2013234009A1 (en)	2014-09-25
DOP2014000204A (es)	2015-02-15
KR20140138910A (ko)	2014-12-04
CU20140110A7 (es)	2014-11-27
CU20140109A7 (es)	2014-11-27
HK1206020A1 (en)	2015-12-31
GT201400196A (es)	2017-09-28
PH12014502041A1 (en)	2014-11-24
GEP201706671B (en)	2017-05-25
NI201400108A (es)	2014-11-28
PH12014502041B1 (en)	2014-11-24
MX355474B (es)	2018-04-16
CR20140464A (es)	2014-11-28
CA2865167C (en)	2019-08-06
CA2865164A1 (en)	2013-09-19
JP6431770B2 (ja)	2018-11-28
CN104203947A (zh)	2014-12-10
CL2014002411A1 (es)	2015-04-06
IL234559A (en)	2017-06-29

Publication	Publication Date	Title
AP3859A (en)	2016-10-31	Heterocyclyl compounds as MEK inhibitors
HK1211921A1 (en)	2016-06-03	Inhibitor compounds
HK1197063A1 (en)	2015-01-02	Heterocyclyl aminoimidazopyridazines
HK1208442A1 (en)	2016-03-04	Substituted pyrrolopyrimidinylamino-benzothiazolones as mknk kinase inhibitors mknk
HK1248702A1 (zh)	2018-10-19	取代的吡咯烷-2-甲酰胺
HK1200830A1 (en)	2015-08-14	Substituted pyrrolidine-2-carboxamides -2-
HK1207366A1 (en)	2016-01-29	Thiadiazolidinediones as gsk-3 inhibitors gsk-3
HK1206724A1 (en)	2016-01-15	Substituted benzothienopyrimidines
HK1210178A1 (en)	2016-04-15	Substituted pyridopyrazines as syk inhibitors syk
GB201214842D0 (en)	2012-10-03	Content tracker
HK1209422A1 (en)	2016-04-01	Fbxo3 inhibitors fbxo3
EP2934541A4 (en)	2016-08-03	NORIBOGAINE SUBSTITUTE
GB201202368D0 (en)	2012-03-28	Tracking method
HK1206022A1 (zh)	2015-12-31	取代的咪唑並噠嗪
GB201211019D0 (en)	2012-08-01	Inhibitor compounds
EP2929742A4 (en)	2015-12-23	TRACKING DEVICE