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HK1258304A1 - 優化抗cd3雙特異性抗體和其用途 - Google Patents

優化抗cd3雙特異性抗體和其用途

Info

Publication number
HK1258304A1
HK1258304A1 HK19100669.9A HK19100669A HK1258304A1 HK 1258304 A1 HK1258304 A1 HK 1258304A1 HK 19100669 A HK19100669 A HK 19100669A HK 1258304 A1 HK1258304 A1 HK 1258304A1
Authority
HK
Hong Kong
Prior art keywords
bispecific antibodies
optimized anti
optimized
bispecific
antibodies
Prior art date
Application number
HK19100669.9A
Other languages
English (en)
Inventor
Eric Smith
Lauric Haber
Robert Babb
Gang Chen
Douglas Macdonald
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of HK1258304A1 publication Critical patent/HK1258304A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK19100669.9A 2015-09-23 2019-01-15 優化抗cd3雙特異性抗體和其用途 HK1258304A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562222605P 2015-09-23 2015-09-23
PCT/US2016/053525 WO2017053856A1 (en) 2015-09-23 2016-09-23 Optimized anti-cd3 bispecific antibodies and uses thereof

Publications (1)

Publication Number Publication Date
HK1258304A1 true HK1258304A1 (zh) 2019-11-08

Family

ID=57130447

Family Applications (1)

Application Number Title Priority Date Filing Date
HK19100669.9A HK1258304A1 (zh) 2015-09-23 2019-01-15 優化抗cd3雙特異性抗體和其用途

Country Status (28)

Country Link
US (2) US20180355038A1 (zh)
EP (1) EP3353212B1 (zh)
JP (3) JP7023231B2 (zh)
KR (1) KR20180050412A (zh)
CN (1) CN108290951B (zh)
AU (1) AU2016325630B2 (zh)
BR (1) BR112018005445A2 (zh)
CA (1) CA2999385A1 (zh)
CY (1) CY1124944T1 (zh)
DK (1) DK3353212T3 (zh)
EA (1) EA201890785A1 (zh)
ES (1) ES2901133T3 (zh)
HK (1) HK1258304A1 (zh)
HR (1) HRP20220133T8 (zh)
HU (1) HUE057683T2 (zh)
IL (1) IL258036B (zh)
LT (1) LT3353212T (zh)
MA (1) MA42935B1 (zh)
MD (1) MD3353212T2 (zh)
MX (1) MX2018003403A (zh)
MY (1) MY195059A (zh)
PL (1) PL3353212T3 (zh)
PT (1) PT3353212T (zh)
RS (1) RS62859B1 (zh)
SI (1) SI3353212T1 (zh)
TW (2) TWI784917B (zh)
WO (1) WO2017053856A1 (zh)
ZA (1) ZA201801673B (zh)

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BR112018005445A2 (pt) 2018-10-09
JP7023231B2 (ja) 2022-02-21
US20180355038A1 (en) 2018-12-13
HRP20220133T8 (hr) 2022-05-13
CN108290951A (zh) 2018-07-17
AU2016325630A1 (en) 2018-04-26
MA42935A (fr) 2018-08-01
PL3353212T3 (pl) 2022-03-28
TW201726713A (zh) 2017-08-01
HUE057683T2 (hu) 2022-05-28
MA42935B1 (fr) 2022-02-28
EP3353212B1 (en) 2021-11-03
PT3353212T (pt) 2022-01-05
DK3353212T3 (da) 2021-12-20
KR20180050412A (ko) 2018-05-14
LT3353212T (lt) 2021-12-27
MY195059A (en) 2023-01-05
EA201890785A1 (ru) 2018-10-31
JP2018537516A (ja) 2018-12-20
JP2023154021A (ja) 2023-10-18
MX2018003403A (es) 2018-05-28
US20210253701A1 (en) 2021-08-19
TWI783914B (zh) 2022-11-21
IL258036B (en) 2022-09-01
CY1124944T1 (el) 2023-01-05
AU2016325630B2 (en) 2022-11-17
JP2022064886A (ja) 2022-04-26
ZA201801673B (en) 2022-12-21
RS62859B1 (sr) 2022-02-28
MD3353212T2 (ro) 2022-03-31
HRP20220133T1 (hr) 2022-04-15
CA2999385A1 (en) 2017-03-30
CN108290951B (zh) 2022-04-01
SI3353212T1 (sl) 2022-01-31
WO2017053856A1 (en) 2017-03-30
ES2901133T3 (es) 2022-03-21
TW202241514A (zh) 2022-11-01
EP3353212A1 (en) 2018-08-01
TWI784917B (zh) 2022-11-21
IL258036A (en) 2018-05-31

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