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HK1246184A1 - 作為a7-烟碱乙酰膽碱受體激動劑的氨基苯並惡唑化合物 - Google Patents

作為a7-烟碱乙酰膽碱受體激動劑的氨基苯並惡唑化合物

Info

Publication number
HK1246184A1
HK1246184A1 HK18105734.0A HK18105734A HK1246184A1 HK 1246184 A1 HK1246184 A1 HK 1246184A1 HK 18105734 A HK18105734 A HK 18105734A HK 1246184 A1 HK1246184 A1 HK 1246184A1
Authority
HK
Hong Kong
Prior art keywords
agonists
nicotinic acetylcholine
acetylcholine receptors
aminobenzisoxazole compounds
aminobenzisoxazole
Prior art date
Application number
HK18105734.0A
Other languages
English (en)
Inventor
Raksha Acharya
Duane A Burnett
Matthew Gregory Bursavich
Andrew Simon Cook
Bryce Alden Harrison
Andrew J Mcriner
Original Assignee
Axovant Sciences Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axovant Sciences Gmbh filed Critical Axovant Sciences Gmbh
Publication of HK1246184A1 publication Critical patent/HK1246184A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK18105734.0A 2015-06-10 2018-05-03 作為a7-烟碱乙酰膽碱受體激動劑的氨基苯並惡唑化合物 HK1246184A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562173717P 2015-06-10 2015-06-10
PCT/US2016/036689 WO2016201096A1 (en) 2015-06-10 2016-06-09 Aminobenzisoxazole compounds as agonists of a7-nicotinic acetylcholine receptors

Publications (1)

Publication Number Publication Date
HK1246184A1 true HK1246184A1 (zh) 2018-09-07

Family

ID=57503923

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18105734.0A HK1246184A1 (zh) 2015-06-10 2018-05-03 作為a7-烟碱乙酰膽碱受體激動劑的氨基苯並惡唑化合物

Country Status (13)

Country Link
US (1) US10370370B2 (zh)
EP (1) EP3307269A4 (zh)
JP (1) JP2018516973A (zh)
KR (1) KR20180044256A (zh)
CN (1) CN107847494A (zh)
AU (1) AU2016274694A1 (zh)
CA (1) CA2988968A1 (zh)
HK (1) HK1246184A1 (zh)
IL (1) IL256226A (zh)
MX (1) MX2017016231A (zh)
NO (1) NO20180002A1 (zh)
RU (1) RU2017145964A (zh)
WO (1) WO2016201096A1 (zh)

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US10428062B2 (en) * 2015-08-12 2019-10-01 Axovant Sciences Gmbh Geminal substituted aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors
CN110105266A (zh) * 2018-02-01 2019-08-09 华中科技大学 一种特异性针对cyp2j2的小分子抗肿瘤药物的合成方法
CN110551147B (zh) * 2019-09-29 2021-11-26 蚌埠产品质量监督检验研究院 一种3-环丙基苯硼酸的合成方法
CN115003666A (zh) 2019-12-04 2022-09-02 先正达农作物保护股份公司 杀有害生物活性的稠合二环杂芳香族氨基化合物
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EP3909950A1 (en) 2020-05-13 2021-11-17 Basf Se Heterocyclic compounds for the control of invertebrate pests

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JP2018516973A (ja) 2018-06-28
US10370370B2 (en) 2019-08-06
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US20180134696A1 (en) 2018-05-17
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