HK1194733A1 - 製備 -酰基- -苯基磺酰基脯氨酰胺衍生物的方法及中間體 - Google Patents
製備 -酰基- -苯基磺酰基脯氨酰胺衍生物的方法及中間體Info
- Publication number
- HK1194733A1 HK1194733A1 HK14108048.9A HK14108048A HK1194733A1 HK 1194733 A1 HK1194733 A1 HK 1194733A1 HK 14108048 A HK14108048 A HK 14108048A HK 1194733 A1 HK1194733 A1 HK 1194733A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- phenylsulfonylprolinamide
- intermediates
- acyl
- derivatives
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11188728 | 2011-11-11 | ||
PCT/EP2012/072078 WO2013068434A1 (en) | 2011-11-11 | 2012-11-08 | Process for the preparation of 1-acyl-4-phenylsulfonylprolinamide derivatives and new intermediates |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1194733A1 true HK1194733A1 (zh) | 2014-10-24 |
Family
ID=47143910
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK14108048.9A HK1194733A1 (zh) | 2011-11-11 | 2014-08-06 | 製備 -酰基- -苯基磺酰基脯氨酰胺衍生物的方法及中間體 |
Country Status (22)
Country | Link |
---|---|
US (1) | US8796471B2 (zh) |
EP (1) | EP2776392B1 (zh) |
JP (1) | JP5852254B2 (zh) |
KR (1) | KR101620769B1 (zh) |
CN (1) | CN103930400B (zh) |
AR (1) | AR088816A1 (zh) |
AU (1) | AU2012334123B2 (zh) |
BR (1) | BR112014011248B1 (zh) |
CA (1) | CA2853877C (zh) |
DK (1) | DK2776392T3 (zh) |
ES (1) | ES2582643T3 (zh) |
HK (1) | HK1194733A1 (zh) |
HU (1) | HUE029182T2 (zh) |
IL (1) | IL232424A (zh) |
MX (1) | MX339996B (zh) |
MY (1) | MY167569A (zh) |
PL (1) | PL2776392T3 (zh) |
RU (1) | RU2615997C2 (zh) |
SG (1) | SG11201402030VA (zh) |
SI (1) | SI2776392T1 (zh) |
WO (1) | WO2013068434A1 (zh) |
ZA (1) | ZA201403152B (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103333094B (zh) * | 2013-06-19 | 2015-05-13 | 广东肇庆星湖生物科技股份有限公司 | 一种脯氨酸结晶精制的工艺方法 |
WO2016034602A1 (en) * | 2014-09-05 | 2016-03-10 | F. Hoffmann-La Roche Ag | Solid forms of (2s,4r)-4-[4-(1-methyl-1h-pyrazol-4-yl)-2-trifluoromethyl-benzenesulfonyl]-1-(1-trifluoromethyl-cyclopropanecarbonyl)-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide |
LT3419970T (lt) * | 2016-02-26 | 2020-03-10 | F. Hoffmann-La Roche Ag | Nauji pirolidino dariniai |
CN111574422B (zh) * | 2017-01-24 | 2023-09-08 | 安斯泰来制药株式会社 | 苯基二氟甲基取代脯氨酰胺化合物 |
TWI846731B (zh) * | 2018-09-18 | 2024-07-01 | 瑞士商赫孚孟拉羅股份公司 | 組織蛋白酶(cathepsin)S抑制劑之對抗抗藥抗體形成之用途 |
EP3725769A1 (en) * | 2019-04-17 | 2020-10-21 | Newron Pharmaceuticals S.p.A. | Process for the production of substituted 2-[2-(phenyl) ethylamino]alkaneamide derivatives |
CN111825582B (zh) * | 2020-08-12 | 2022-04-08 | 江西理工大学 | 一种以芳基磺酰氯为硫源合成β-硫代羰基化合物的方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4394599A (en) * | 1998-09-09 | 2000-03-27 | Nippon Fine Chemical Co., Ltd. | Process for the preparation of aromatic sulfur compounds |
CN101475517B (zh) * | 2009-01-15 | 2012-08-15 | 河南大学 | 一种对称的含二硫键化合物的制备方法 |
WO2010121918A1 (en) * | 2009-04-20 | 2010-10-28 | F. Hoffmann-La Roche Ag | Proline derivatives as cathepsin inhibitors |
-
2012
- 2012-11-08 SI SI201230621A patent/SI2776392T1/sl unknown
- 2012-11-08 RU RU2014122116A patent/RU2615997C2/ru active
- 2012-11-08 PL PL12783216.0T patent/PL2776392T3/pl unknown
- 2012-11-08 AU AU2012334123A patent/AU2012334123B2/en not_active Ceased
- 2012-11-08 WO PCT/EP2012/072078 patent/WO2013068434A1/en active Application Filing
- 2012-11-08 CA CA2853877A patent/CA2853877C/en active Active
- 2012-11-08 BR BR112014011248-7A patent/BR112014011248B1/pt not_active IP Right Cessation
- 2012-11-08 US US13/671,586 patent/US8796471B2/en active Active
- 2012-11-08 MY MYPI2014701188A patent/MY167569A/en unknown
- 2012-11-08 EP EP12783216.0A patent/EP2776392B1/en active Active
- 2012-11-08 HU HUE12783216A patent/HUE029182T2/en unknown
- 2012-11-08 ES ES12783216.0T patent/ES2582643T3/es active Active
- 2012-11-08 JP JP2014540444A patent/JP5852254B2/ja active Active
- 2012-11-08 KR KR1020147015454A patent/KR101620769B1/ko active IP Right Grant
- 2012-11-08 MX MX2014005689A patent/MX339996B/es active IP Right Grant
- 2012-11-08 SG SG11201402030VA patent/SG11201402030VA/en unknown
- 2012-11-08 CN CN201280055223.7A patent/CN103930400B/zh active Active
- 2012-11-08 DK DK12783216.0T patent/DK2776392T3/en active
- 2012-11-09 AR ARP120104226A patent/AR088816A1/es unknown
-
2014
- 2014-04-30 ZA ZA2014/03152A patent/ZA201403152B/en unknown
- 2014-05-01 IL IL232424A patent/IL232424A/en active IP Right Grant
- 2014-08-06 HK HK14108048.9A patent/HK1194733A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP2776392A1 (en) | 2014-09-17 |
PL2776392T3 (pl) | 2016-11-30 |
EP2776392B1 (en) | 2016-05-18 |
SG11201402030VA (en) | 2014-06-27 |
US8796471B2 (en) | 2014-08-05 |
MX339996B (es) | 2016-06-21 |
MX2014005689A (es) | 2014-08-08 |
RU2615997C2 (ru) | 2017-04-12 |
KR20140098123A (ko) | 2014-08-07 |
US20130123512A1 (en) | 2013-05-16 |
DK2776392T3 (en) | 2016-07-04 |
MY167569A (en) | 2018-09-20 |
IL232424A (en) | 2017-01-31 |
CA2853877C (en) | 2019-10-01 |
ZA201403152B (en) | 2015-07-29 |
CN103930400A (zh) | 2014-07-16 |
BR112014011248B1 (pt) | 2020-11-17 |
AR088816A1 (es) | 2014-07-10 |
IL232424A0 (en) | 2014-06-30 |
AU2012334123B2 (en) | 2016-12-15 |
JP2014532740A (ja) | 2014-12-08 |
BR112014011248A2 (pt) | 2017-05-09 |
CN103930400B (zh) | 2016-04-20 |
RU2014122116A (ru) | 2015-12-20 |
ES2582643T3 (es) | 2016-09-14 |
KR101620769B1 (ko) | 2016-05-12 |
JP5852254B2 (ja) | 2016-02-03 |
CA2853877A1 (en) | 2013-05-16 |
WO2013068434A1 (en) | 2013-05-16 |
AU2012334123A1 (en) | 2014-05-01 |
NZ623851A (en) | 2015-06-26 |
SI2776392T1 (sl) | 2016-08-31 |
HUE029182T2 (en) | 2017-02-28 |
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