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HK1168102A1 - Process for the preparation of a compound useful as an inhibitor of tafia - Google Patents

Process for the preparation of a compound useful as an inhibitor of tafia

Info

Publication number
HK1168102A1
HK1168102A1 HK12108882.0A HK12108882A HK1168102A1 HK 1168102 A1 HK1168102 A1 HK 1168102A1 HK 12108882 A HK12108882 A HK 12108882A HK 1168102 A1 HK1168102 A1 HK 1168102A1
Authority
HK
Hong Kong
Prior art keywords
preparation
tafia
inhibitor
compound useful
compound
Prior art date
Application number
HK12108882.0A
Inventor
Kai Rossen
Volker Kraft
Hermut Wehlan
Antony Bigot
Veronique Crocq-Stuerga
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of HK1168102A1 publication Critical patent/HK1168102A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

The present invention relates to a process for the preparation of a compound of the formula I, which comprises reacting a compound of the formula IV with an oxalic acid diester and to novel intermediate compounds used therein.
HK12108882.0A 2009-05-15 2012-09-12 Process for the preparation of a compound useful as an inhibitor of tafia HK1168102A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09290366 2009-05-15
PCT/EP2010/056426 WO2010130718A1 (en) 2009-05-15 2010-05-11 Process for the preparation of a compound useful as an inhibitor of tafia

Publications (1)

Publication Number Publication Date
HK1168102A1 true HK1168102A1 (en) 2012-12-21

Family

ID=41259362

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12108882.0A HK1168102A1 (en) 2009-05-15 2012-09-12 Process for the preparation of a compound useful as an inhibitor of tafia

Country Status (23)

Country Link
US (1) US8865906B2 (en)
EP (1) EP2430002B1 (en)
JP (1) JP5706397B2 (en)
KR (1) KR20120016651A (en)
CN (1) CN102459192B (en)
AU (1) AU2010247431B2 (en)
BR (1) BRPI1010571A2 (en)
CA (1) CA2760748A1 (en)
CY (1) CY1114493T1 (en)
DK (1) DK2430002T3 (en)
ES (1) ES2431068T3 (en)
HK (1) HK1168102A1 (en)
HR (1) HRP20130881T1 (en)
IL (1) IL216202A (en)
MX (1) MX2011011849A (en)
MY (1) MY157304A (en)
PL (1) PL2430002T3 (en)
PT (1) PT2430002E (en)
RS (1) RS52963B (en)
RU (1) RU2538506C2 (en)
SG (1) SG176558A1 (en)
SI (1) SI2430002T1 (en)
WO (1) WO2010130718A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5807006B2 (en) * 2010-03-18 2015-11-10 第一三共株式会社 Imidazole derivatives substituted with cycloalkyl groups
EP2548872B1 (en) * 2010-03-18 2016-09-28 Daiichi Sankyo Company, Limited Cyclopropanecarboxylic acid derivative
AU2011328263A1 (en) * 2010-11-11 2013-05-30 Sanofi Process for the preparation of 3-(6-amino-pyridin-3yl)-2-acrylic acid derivatives
US9102657B2 (en) 2011-11-25 2015-08-11 Sanofi Sodium salt of (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1H-imidazol-4-yl)-propionic acid
US9145385B2 (en) 2011-11-25 2015-09-29 Sanofi Crystalline salts of R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexy1-1H-imidazol-4-yl)-propionic acid
EP2805705B1 (en) 2013-05-23 2016-11-09 IP Gesellschaft für Management mbH Packaging with one or more administration units comprising a sodium salt of (R)-3-[6-amino-pyridin-3-yl]-2-(1-cyclohexyl-1 H-imidazol-4-yl)-propionic acid
ES2965478T3 (en) * 2017-03-01 2024-04-15 Boehringer Ingelheim Int Transition metal-catalyzed protodecarboxylation of alpha-halo-acrylic acid derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4216218A (en) * 1979-02-23 1980-08-05 American Hoechst Corporation Antidepressant and analgesic 4-aryloxy- and 4-arylthio-3-phenylpiperidines
IT1177017B (en) * 1984-10-22 1987-08-26 Ravizza Spa PROCESS FOR THE PREPARATION OF 2 (4-FLUROPHENYL) ALPHA-METHYL-5-BENZOX AZOLOACETIC ACID
FR2693192B1 (en) * 1992-07-02 1994-08-12 Rhone Poulenc Agrochimie Derivatives of 2-imidazoline-5-ones and 2-imidazoline-5-thiones fungicides.
CN1170822C (en) * 1998-12-24 2004-10-13 藤泽药品工业株式会社 Imidazole compounds and medicinal use thereof
US8710232B2 (en) 2004-04-22 2014-04-29 Sanofi-Aventis Deutschland Gmbh Imidazole derivatives used as TAFIa inhibitors
DE102004020186A1 (en) * 2004-04-22 2005-11-17 Aventis Pharma Deutschland Gmbh Heterocyclyl acetic acids as inhibitors of TAFla

Also Published As

Publication number Publication date
HRP20130881T1 (en) 2013-10-25
RU2538506C2 (en) 2015-01-10
CY1114493T1 (en) 2016-10-05
SI2430002T1 (en) 2013-10-30
IL216202A0 (en) 2012-01-31
EP2430002A1 (en) 2012-03-21
AU2010247431B2 (en) 2015-02-19
US8865906B2 (en) 2014-10-21
MY157304A (en) 2016-05-31
WO2010130718A1 (en) 2010-11-18
CA2760748A1 (en) 2010-11-18
JP2012526763A (en) 2012-11-01
MX2011011849A (en) 2011-12-08
CN102459192A (en) 2012-05-16
CN102459192B (en) 2015-06-24
KR20120016651A (en) 2012-02-24
PT2430002E (en) 2013-09-11
PL2430002T3 (en) 2013-12-31
BRPI1010571A2 (en) 2019-09-24
US20120245358A1 (en) 2012-09-27
RS52963B (en) 2014-02-28
EP2430002B1 (en) 2013-07-24
AU2010247431A1 (en) 2011-12-01
IL216202A (en) 2015-07-30
ES2431068T3 (en) 2013-11-25
DK2430002T3 (en) 2013-11-04
SG176558A1 (en) 2012-01-30
JP5706397B2 (en) 2015-04-22
RU2011151044A (en) 2013-06-20

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20170511