HK1164860A1 - 羧酰胺化合物及其使用方法 - Google Patents

羧酰胺化合物及其使用方法

Info

Publication number: HK1164860A1
Authority: HK; Hong Kong
Prior art keywords: methods; same; carboxamide compounds; carboxamide; compounds
Prior art date: 2009-01-28

Application number

HK12105538.4A

Other languages

English (en)

Inventor

Ihab S Darwish

Hui Hong

Rajinder Singh

Xiang Xu

Original Assignee

Rigel Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-01-28

Filing date

2012-06-07

Publication date

2012-09-28

2012-06-07 Application filed by Rigel Pharmaceuticals Inc filed Critical Rigel Pharmaceuticals Inc

2012-09-28 Publication of HK1164860A1 publication Critical patent/HK1164860A1/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N61/00—Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Dentistry (AREA)
Endocrinology (AREA)
Vascular Medicine (AREA)
Agronomy & Crop Science (AREA)
Pest Control & Pesticides (AREA)
Plant Pathology (AREA)
Emergency Medicine (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Environmental Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

HK12105538.4A 2009-01-28 2012-06-07 羧酰胺化合物及其使用方法 HK1164860A1 (zh)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US14798209P	2009-01-28	2009-01-28
PCT/US2010/022411 WO2010088392A1 (en)	2009-01-28	2010-01-28	Carboxamide compounds and methods for using the same

Publications (1)

Publication Number	Publication Date
HK1164860A1 true HK1164860A1 (zh)	2012-09-28

Family

ID=42061132

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK12105538.4A HK1164860A1 (zh)	2009-01-28	2012-06-07	羧酰胺化合物及其使用方法

Country Status (18)

Country	Link
US (2)	US8362235B2 (zh)
EP (1)	EP2391616B1 (zh)
JP (1)	JP5658688B2 (zh)
KR (1)	KR101693061B1 (zh)
CN (1)	CN102365275B (zh)
AU (1)	AU2010208247B2 (zh)
BR (1)	BRPI1007287B8 (zh)
CA (1)	CA2750835C (zh)
EA (1)	EA022083B1 (zh)
ES (1)	ES2581678T3 (zh)
HK (1)	HK1164860A1 (zh)
IL (1)	IL214203A (zh)
MX (1)	MX2011007639A (zh)
NZ (1)	NZ594556A (zh)
SG (1)	SG172974A1 (zh)
UA (1)	UA106600C2 (zh)
WO (1)	WO2010088392A1 (zh)
ZA (1)	ZA201105215B (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2722139C (en)	2008-04-23	2017-04-11	Rigel Pharmaceuticals, Inc.	Carboxamide compounds for the treatment of metabolic disorders
US8796254B2 (en)	2010-03-31	2014-08-05	Rigel Pharmaceuticals, Inc.	Methods for using carboxamide, sulfonamide and amine compounds
PT2598483T (pt)	2010-07-29	2020-10-12	Rigel Pharmaceuticals Inc	Compostos heterocíclicos de ativação de ampk e métodos de utilização dos mesmos
US9005909B2 (en)	2011-01-06	2015-04-14	Rigel Pharmaceuticals, Inc.	Whole blood assay for measuring AMPK activation
WO2013116491A1 (en)	2012-02-01	2013-08-08	Rigel Pharmaceuticals, Inc.	Carboxamide, sulfonamide and amine compounds and methods for using them
US8889730B2 (en)	2012-04-10	2014-11-18	Pfizer Inc.	Indole and indazole compounds that activate AMPK
EP2970177A1 (en)	2013-03-15	2016-01-20	Pfizer Inc.	Indole compounds that activate ampk
US20150087673A1 (en) *	2013-09-26	2015-03-26	Rigel Pharmaceuticals, Inc.	Methods for using and biomarkers for ampk-activating compounds
EP3053911B1 (en)	2013-09-30	2020-01-22	The University of Tokyo	Adiponectin receptor-activating compound
AU2019207887B2 (en)	2018-01-11	2024-05-23	Centaurus Therapeutics	Inhibitors of dihydroceramide desaturase for treating disease

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5889006A (en) *	1995-02-23	1999-03-30	Schering Corporation	Muscarinic antagonists
KR100579792B1 (ko) *	1998-05-13	2006-05-12	동화약품공업주식회사	신규 2,5-피리딘디카복실산 유도체
EP1319001A1 (en) *	2000-09-22	2003-06-18	Smithkline Beecham Plc	Pyrazolopyridines and pyrazolopyridazines as antidiabetics
TW200503994A (en) *	2003-01-24	2005-02-01	Novartis Ag	Organic compounds
CA2634235A1 (en) *	2005-12-21	2007-07-05	Schering Corporation	Combination of an h3 antagonist/inverse agonist and an appetite suppressant
DE602006021591D1 (de)	2006-12-11	2011-06-09	Genetics Co Inc	Aromatische 1,4-DI-Carboxylamide und deren Verwendung
EP2079694B1 (en)	2006-12-28	2017-03-01	Rigel Pharmaceuticals, Inc.	N-substituted-heterocycloalkyloxybenzamide compounds and methods of use
GB0706793D0 (en) *	2007-04-05	2007-05-16	Evotec Ag	Compounds
BRPI0820171B8 (pt)	2007-11-16	2021-05-25	Rigel Pharmaceuticals Inc	compostos de carboxamida, sulfonamida e amina para distúrbios metabólicos, composição farmacêutica, e, uso dos mesmos
US8129390B2 (en)	2007-12-12	2012-03-06	Rigel Pharmaceuticals, Inc.	Carboxamide, sulfonamide and amine compounds and methods for using the same
CA2722139C (en)	2008-04-23	2017-04-11	Rigel Pharmaceuticals, Inc.	Carboxamide compounds for the treatment of metabolic disorders
US8796254B2 (en)	2010-03-31	2014-08-05	Rigel Pharmaceuticals, Inc.	Methods for using carboxamide, sulfonamide and amine compounds

2010
- 2010-01-28 US US12/695,861 patent/US8362235B2/en active Active
- 2010-01-28 MX MX2011007639A patent/MX2011007639A/es active IP Right Grant
- 2010-01-28 EP EP10703206.2A patent/EP2391616B1/en active Active
- 2010-01-28 WO PCT/US2010/022411 patent/WO2010088392A1/en active Application Filing
- 2010-01-28 ES ES10703206.2T patent/ES2581678T3/es active Active
- 2010-01-28 JP JP2011548297A patent/JP5658688B2/ja not_active Expired - Fee Related
- 2010-01-28 KR KR1020117019811A patent/KR101693061B1/ko active IP Right Grant
- 2010-01-28 AU AU2010208247A patent/AU2010208247B2/en not_active Ceased
- 2010-01-28 CN CN201080015415.6A patent/CN102365275B/zh not_active Expired - Fee Related
- 2010-01-28 SG SG2011050861A patent/SG172974A1/en unknown
- 2010-01-28 NZ NZ594556A patent/NZ594556A/xx not_active IP Right Cessation
- 2010-01-28 CA CA2750835A patent/CA2750835C/en active Active
- 2010-01-28 UA UAA201110421A patent/UA106600C2/uk unknown
- 2010-01-28 EA EA201170979A patent/EA022083B1/ru not_active IP Right Cessation
- 2010-01-28 BR BRPI1007287A patent/BRPI1007287B8/pt not_active IP Right Cessation
2011
- 2011-07-14 ZA ZA2011/05215A patent/ZA201105215B/en unknown
- 2011-07-20 IL IL214203A patent/IL214203A/en active IP Right Grant
2012
- 2012-06-07 HK HK12105538.4A patent/HK1164860A1/zh not_active IP Right Cessation
- 2012-12-27 US US13/728,374 patent/US8846600B2/en active Active

Also Published As

Publication number	Publication date
US8846600B2 (en)	2014-09-30
US8362235B2 (en)	2013-01-29
EA022083B1 (ru)	2015-10-30
CN102365275A (zh)	2012-02-29
UA106600C2 (uk)	2014-09-25
ZA201105215B (en)	2012-09-26
MX2011007639A (es)	2011-09-15
WO2010088392A1 (en)	2010-08-05
IL214203A0 (en)	2011-08-31
CA2750835C (en)	2018-09-04
NZ594556A (en)	2013-11-29
JP2012516349A (ja)	2012-07-19
EP2391616B1 (en)	2016-03-30
AU2010208247A1 (en)	2011-08-11
BRPI1007287B8 (pt)	2021-05-25
BRPI1007287B1 (pt)	2021-03-09
CA2750835A1 (en)	2010-08-05
US20100190802A1 (en)	2010-07-29
CN102365275B (zh)	2014-09-24
ES2581678T3 (es)	2016-09-06
US20130131078A1 (en)	2013-05-23
EA201170979A1 (ru)	2012-02-28
AU2010208247B2 (en)	2015-06-18
KR101693061B1 (ko)	2017-01-04
SG172974A1 (en)	2011-08-29
JP5658688B2 (ja)	2015-01-28
KR20110119755A (ko)	2011-11-02
EP2391616A1 (en)	2011-12-07
IL214203A (en)	2015-01-29

Publication	Publication Date	Title
IL244197A0 (en)	2016-04-21	Antibodies against cd100 and methods of using them
ZA201401833B (en)	2014-09-25	Ampk-activating heterocyclic compounds and methods for using the same
HK1196358A1 (zh)	2014-12-12	取代的吡啶- -酮和噠嗪- -酮
ZA201303499B (en)	2015-03-25	Specific diarylhydantoin and diarylthiohydantion compounds
EP2456757A4 (en)	2012-12-19	HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME
EP2416657A4 (en)	2012-09-05	COMPOUNDS COMPRISING SUBSTITUTED DI-ARYLHYDANTOIDS AND DI-ARYLTHIOHYDANTOINES AND METHODS OF USE THEREOF
IL220939A0 (en)	2012-09-24	Compounds and methods
EP2523664A4 (en)	2013-06-26	COMPOUNDS AND METHODS
EP2308884A4 (en)	2011-11-09	PROCESS FOR THE PREPARATION OF HETEROSUBSTITUTED ALKYLHALOHYDROSILANE AND ITS USE
HK1164860A1 (zh)	2012-09-28	羧酰胺化合物及其使用方法
IL220812A0 (en)	2012-08-30	Compounds and methods
EP2523560A4 (en)	2013-07-03	CONNECTIONS AND METHODS
HK1212698A1 (zh)	2016-06-17	噻唑基和噁唑基異喹哪啶以及它們的使用方法
IL243809A0 (en)	2016-04-21	Process for the production of γ-ketosulfide compound and γ-ketosulfide compounds
IL205308A0 (en)	2010-12-30	Compounds and methods
EP2470022A4 (en)	2014-08-06	COMPOUNDS AND METHODS
GB201004450D0 (en)	2010-05-05	Compounds and methods relating thereto
GB0903348D0 (en)	2009-04-08	Compounds and methods relating thereto
GB0907249D0 (en)	2009-06-10	New process and new compounds
GB0807655D0 (en)	2008-06-04	Med time
GB201002028D0 (en)	2010-03-24	Ts 15
GB201008248D0 (en)	2010-06-30	Ts 23
GB201008537D0 (en)	2010-07-07	Ts 25
GB201002063D0 (en)	2010-03-24	Ts 14
GB201002265D0 (en)	2010-03-31	Ts 16

Legal Events

Date	Code	Title	Description
2023-08-25	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20230201