HK1012190A1 - Substituted purine derivatives, processes for their preparation, their use, and compositions comprising them - Google Patents

Substituted purine derivatives, processes for their preparation, their use, and compositions comprising them

Info

Publication number: HK1012190A1
Authority: HK; Hong Kong
Prior art keywords: compositions; processes; preparation; purine derivatives; substituted purine
Prior art date: 1996-12-20

Application number

HK98113384A

Inventor

Anuschirwan Peyman

Jochen Knolle

Volkmar Wehner

Gerhard Breipohl

Jean-Francois Gourvest

Denis Carniato

Thomas Richard Gadek

Original Assignee

Hoechst Ag

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-20

Filing date

1998-12-15

Publication date

1999-07-30

1998-12-15 Application filed by Hoechst Ag, Genentech Inc filed Critical Hoechst Ag

1999-07-30 Publication of HK1012190A1 publication Critical patent/HK1012190A1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

HK98113384A 1996-12-20 1998-12-15 Substituted purine derivatives, processes for their preparation, their use, and compositions comprising them HK1012190A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19653646A DE19653646A1 (en)	1996-12-20	1996-12-20	Substituted purine derivatives, processes for their preparation, agents containing them and their use

Publications (1)

Publication Number	Publication Date
HK1012190A1 true HK1012190A1 (en)	1999-07-30

Family

ID=7815761

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK98113384A HK1012190A1 (en)	1996-12-20	1998-12-15	Substituted purine derivatives, processes for their preparation, their use, and compositions comprising them

Country Status (22)

Country	Link
EP (1)	EP0853084B1 (en)
JP (1)	JP4620190B2 (en)
KR (1)	KR19980064655A (en)
CN (2)	CN1495184A (en)
AR (1)	AR010700A1 (en)
AT (1)	ATE404562T1 (en)
AU (1)	AU728865B2 (en)
BR (1)	BR9706387A (en)
CA (1)	CA2225366C (en)
CZ (1)	CZ294437B6 (en)
DE (2)	DE19653646A1 (en)
HK (1)	HK1012190A1 (en)
HU (1)	HUP9702507A3 (en)
ID (1)	ID19254A (en)
IL (1)	IL122642A0 (en)
NO (1)	NO314583B1 (en)
NZ (1)	NZ329431A (en)
PL (1)	PL323969A1 (en)
RU (1)	RU2228335C2 (en)
TR (1)	TR199701647A2 (en)
TW (1)	TW523515B (en)
ZA (1)	ZA9711317B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4064059B2 (en)	1998-04-09	2008-03-19	明治製菓株式会社	Aminopiperidine derivatives as integrin αVβ3 antagonists
AU2209800A (en)	1998-12-23	2000-07-31	G.D. Searle & Co.	Method of using a matrix metalloproteinase inhibitor and radiation therapy as combination therapy in the treatment of neoplasia
JP3270834B2 (en)	1999-01-27	2002-04-02	ファイザー・プロダクツ・インク	Heteroaromatic bicyclic derivatives useful as anticancer agents
UA71945C2 (en)	1999-01-27	2005-01-17	Pfizer Prod Inc	Substituted bicyclic derivatives being used as anticancer agents
EP1065208A1 (en) *	1999-07-02	2001-01-03	Aventis Pharma Deutschland GmbH	Substituted purine derivatives as inhibitors of cell adhesion
EP1065207A1 (en)	1999-07-02	2001-01-03	Aventis Pharma Deutschland GmbH	Naphthyridine derivatives, processes for their preparation, their use, and pharmaceutical compositions comprising them
EP1209152A4 (en)	1999-08-05	2003-03-12	Meiji Seika Kaisha	Omega-amino-alpha-hydroxycarboxylic acid derivatives having integrin alpha v beta 3 antagonism
EP1176145A1 (en) *	2000-07-28	2002-01-30	Aventis Pharma Deutschland GmbH	Novel guanidino derivatives as inhibitors of cell adhesion
DE10042655A1 (en) *	2000-08-31	2002-03-14	Aventis Pharma Gmbh	Process for the preparation of inhibitors of cell adhesion
KR100438820B1 (en) *	2001-03-05	2004-07-05	삼성코닝 주식회사	Method for manufacturing compound semiconductor substrate of III-V group
CZ20033119A3 (en)	2001-04-24	2005-01-12	Merck Patent Gmbh	Combination therapy using anti-angiogenic agents and TNF alpha
FR2847254B1 (en) *	2002-11-19	2005-01-28	Aventis Pharma Sa	NOVEL VITRONECTIN RECEPTOR ANTAGONIST DERIVATIVES, PROCESS FOR PREPARING THEM, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS REFLECTING THEM
FR2870541B1 (en)	2004-05-18	2006-07-14	Proskelia Sas	ANTIGONISTIC PYRIMIDINE DERIVATIVES OF VITRONECTIN RECEPTOR
UA87854C2 (en)	2004-06-07	2009-08-25	Мерк Энд Ко., Инк.	N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
EP2335733B1 (en)	2006-01-18	2014-08-06	Merck Patent GmbH	Specific therapy using integrin ligands for treating cancer
KR20090108713A (en)	2007-01-18	2009-10-16	메르크 파텐트 게엠베하	Specific therapies and medicines for cancer treatment using integrin ligands
PL2206727T3 (en)	2007-10-11	2015-08-31	Daiichi Sankyo Co Ltd	ANTIBODY TARGETING OSTEOCLAST-RELATED PROTEIN Siglec-15
CA2705579A1 (en) *	2007-11-14	2009-05-22	Myriad Pharmaceuticals, Inc.	Therapeutic compounds and their use in treating diseases and disorders
EP3699277A1 (en)	2009-04-09	2020-08-26	Daiichi Sankyo Company, Limited	Anti-siglec-15 antibody
CN102448497A (en)	2009-05-25	2012-05-09	默克专利有限公司	Continuous administration of integrin ligands for treating cancer
CN103237813A (en)	2010-10-05	2013-08-07	第一三共株式会社	Antibody targeting osteoclast-elated protein Siglec-15
ES2660472T3 (en)	2012-03-30	2018-03-22	Daiichi Sankyo Company, Limited	Anti-Siglec-15 antibody modified with CDR
CN107312039B (en)	2012-08-30	2019-06-25	江苏豪森药业集团有限公司	A kind of preparation method of tenofovir prodrug
KR20160147007A (en)	2014-05-30	2016-12-21	화이자 인코포레이티드	Carbonitrile derivatives as selective androgen receptor modulators
WO2023275715A1 (en)	2021-06-30	2023-01-05	Pfizer Inc.	Metabolites of selective androgen receptor modulators

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS4730696Y1 (en) *	1966-12-10	1972-09-13
JPS6396663A (en) *	1986-10-13	1988-04-27	Mita Ind Co Ltd	Electrostatic charge image developing toner
JPS6396553A (en) *	1986-10-14	1988-04-27	Sekisui Chem Co Ltd	Packing material
DE4129603A1 (en) *	1991-09-06	1993-03-11	Thomae Gmbh Dr K	CONDENSED 5-LOW HETEROCYCLES, METHOD FOR THE PRODUCTION THEREOF, AND MEDICAMENTS CONTAINING THESE COMPOUNDS
MX9207334A (en) *	1991-12-18	1993-08-01	Glaxo Inc	NUCLEIC ACIDS PEPTIDICS AND PHARMACEUTICAL FORMULATION CONTAINING THEM
FR2700337B1 (en) *	1993-01-11	1995-04-14	Lafon Labor	Imidazopyridine-2-one derivatives, their preparation process and their use in therapy.
US6133444A (en) *	1993-12-22	2000-10-17	Perseptive Biosystems, Inc.	Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
DE4405378A1 (en) *	1994-02-19	1995-08-24	Merck Patent Gmbh	Adhesion receptor antagonists
US5554746A (en) *	1994-05-16	1996-09-10	Isis Pharmaceuticals, Inc.	Lactam nucleic acids
US5929046A (en) *	1994-06-08	1999-07-27	Cancer Research Campaign Technology Limited	Pyrimidine and purine derivatives and their use in treating tumour cells
US5994361A (en) *	1994-06-22	1999-11-30	Biochem Pharma	Substituted purinyl derivatives with immunomodulating activity
PL318199A1 (en) *	1994-06-29	1997-05-26	Smithkline Beecham Corp	Antagonists of vitronectin receptors
US5525606A (en) *	1994-08-01	1996-06-11	The United States Of America As Represented By The Department Of Health And Human Services	Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines
WO1996020212A2 (en) *	1994-12-28	1996-07-04	Buchardt, Dorte	Peptide nucleic acid incorporating a chiral backbone
US5977061A (en) *	1995-04-21	1999-11-02	Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic	N6 - substituted nucleotide analagues and their use
JP2001518054A (en) *	1995-06-07	2001-10-09	パーセプティブバイオシステムズ，インコーポレーテッド	PNA-DNA chimera and PNA synthon for chimera synthesis
JPH1025294A (en) *	1996-03-26	1998-01-27	Akira Matsuda	Fused heterocyclic derivative, method for producing the same, and therapeutic agent for malignant tumor containing the same
CA2249598A1 (en) *	1996-03-26	1997-10-02	Paul Joseph Gilligan	Aryloxy- and arylthio-fused pyridines and pyrimidines and derivatives
GB9613021D0 (en) *	1996-06-21	1996-08-28	Pharmacia Spa	Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors
JP3306073B2 (en) *	1996-07-24	2002-07-24	ブヒャルト，ドルテ	Peptide nucleic acids with increased binding affinity, sequence specificity and solubility
US5866702A (en) *	1996-08-02	1999-02-02	Cv Therapeutics, Incorporation	Purine inhibitors of cyclin dependent kinase 2

1996
- 1996-12-20 DE DE19653646A patent/DE19653646A1/en not_active Withdrawn
1997
- 1997-12-12 EP EP97121930A patent/EP0853084B1/en not_active Expired - Lifetime
- 1997-12-12 DE DE59712958T patent/DE59712958D1/en not_active Expired - Lifetime
- 1997-12-12 AT AT97121930T patent/ATE404562T1/en not_active IP Right Cessation
- 1997-12-17 BR BR9706387-8A patent/BR9706387A/en not_active Application Discontinuation
- 1997-12-17 ZA ZA9711317A patent/ZA9711317B/en unknown
- 1997-12-18 NZ NZ329431A patent/NZ329431A/en unknown
- 1997-12-18 AR ARP970105996A patent/AR010700A1/en unknown
- 1997-12-18 TR TR97/01647A patent/TR199701647A2/en unknown
- 1997-12-18 CZ CZ19974114A patent/CZ294437B6/en not_active IP Right Cessation
- 1997-12-18 ID IDP973919A patent/ID19254A/en unknown
- 1997-12-18 IL IL12264297A patent/IL122642A0/en unknown
- 1997-12-18 AU AU48466/97A patent/AU728865B2/en not_active Ceased
- 1997-12-19 RU RU97121235/04A patent/RU2228335C2/en not_active IP Right Cessation
- 1997-12-19 CN CNA031009328A patent/CN1495184A/en active Pending
- 1997-12-19 CN CN97107287A patent/CN1101816C/en not_active Expired - Fee Related
- 1997-12-19 NO NO19975977A patent/NO314583B1/en unknown
- 1997-12-19 CA CA002225366A patent/CA2225366C/en not_active Expired - Lifetime
- 1997-12-19 HU HU9702507A patent/HUP9702507A3/en unknown
- 1997-12-20 KR KR1019970073883A patent/KR19980064655A/en not_active Application Discontinuation
- 1997-12-20 PL PL97323969A patent/PL323969A1/en unknown
- 1997-12-22 JP JP36553097A patent/JP4620190B2/en not_active Expired - Lifetime
1998
- 1998-02-11 TW TW086119133A patent/TW523515B/en not_active IP Right Cessation
- 1998-12-15 HK HK98113384A patent/HK1012190A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
HU9702507D0 (en)	1998-03-02
CN1101816C (en)	2003-02-19
RU2228335C2 (en)	2004-05-10
TR199701647A3 (en)	1998-07-21
KR19980064655A (en)	1998-10-07
ID19254A (en)	1998-06-28
IL122642A0 (en)	1998-08-16
DE19653646A1 (en)	1998-06-25
EP0853084A2 (en)	1998-07-15
CN1495184A (en)	2004-05-12
NZ329431A (en)	2000-01-28
CN1193623A (en)	1998-09-23
HUP9702507A2 (en)	1999-05-28
PL323969A1 (en)	1998-06-22
NO975977L (en)	1998-06-22
ATE404562T1 (en)	2008-08-15
MX9710277A (en)	1998-10-31
TW523515B (en)	2003-03-11
NO314583B1 (en)	2003-04-14
HUP9702507A3 (en)	1999-12-28
JPH10182645A (en)	1998-07-07
AU728865B2 (en)	2001-01-18
CA2225366C (en)	2006-10-10
CZ294437B6 (en)	2005-01-12
EP0853084B1 (en)	2008-08-13
DE59712958D1 (en)	2008-09-25
TR199701647A2 (en)	1998-07-21
AR010700A1 (en)	2000-06-28
NO975977D0 (en)	1997-12-19
AU4846697A (en)	1998-06-25
CA2225366A1 (en)	1998-06-20
JP4620190B2 (en)	2011-01-26
BR9706387A (en)	2000-03-14
EP0853084A3 (en)	1998-09-09
CZ411497A3 (en)	1998-07-15
ZA9711317B (en)	1998-06-22

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Legal Events

Date	Code	Title	Description
2004-12-15	PF	Patent in force
2007-07-27	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20061219