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HK1004396A1 - Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders - Google Patents

Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders Download PDF

Info

Publication number
HK1004396A1
HK1004396A1 HK98103657A HK98103657A HK1004396A1 HK 1004396 A1 HK1004396 A1 HK 1004396A1 HK 98103657 A HK98103657 A HK 98103657A HK 98103657 A HK98103657 A HK 98103657A HK 1004396 A1 HK1004396 A1 HK 1004396A1
Authority
HK
Hong Kong
Prior art keywords
compound
tetrahydrofuran
trans
fluorophenyl
solution
Prior art date
Application number
HK98103657A
Other languages
English (en)
Chinese (zh)
Other versions
HK1004396B (en
Inventor
蔡雄
G‧格雷瓦尔
S‧于松
A‧弗拉
R‧斯坎内尔
T‧比富兹
钱长耕
Original Assignee
千年药品公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/265,656 external-priority patent/US5792776A/en
Priority claimed from US08/390,641 external-priority patent/US6201016B1/en
Priority claimed from US08/454,600 external-priority patent/US5750565A/en
Priority claimed from US08/454,748 external-priority patent/US5703093A/en
Application filed by 千年药品公司 filed Critical 千年药品公司
Publication of HK1004396A1 publication Critical patent/HK1004396A1/xx
Publication of HK1004396B publication Critical patent/HK1004396B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK98103657.1A 1994-06-27 1995-06-27 Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders HK1004396B (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US08/265,656 1994-06-27
US08/265,656 US5792776A (en) 1994-06-27 1994-06-27 Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US08/390,641 1995-02-17
US08/390,641 US6201016B1 (en) 1994-06-27 1995-02-17 Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US08/454,600 US5750565A (en) 1995-05-25 1995-05-25 Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US08/454,600 1995-05-31
US08/454,748 US5703093A (en) 1995-05-31 1995-05-31 Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US08/454,748 1995-05-31
PCT/US1995/008213 WO1996000212A1 (en) 1994-06-27 1995-06-27 Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders

Publications (2)

Publication Number Publication Date
HK1004396A1 true HK1004396A1 (en) 1998-11-27
HK1004396B HK1004396B (en) 2005-01-14

Family

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Also Published As

Publication number Publication date
PL317873A1 (en) 1997-04-28
NO965569L (no) 1997-02-17
WO1996000212A1 (en) 1996-01-04
EE9600184A (et) 1997-06-16
EP0770064B1 (en) 2003-11-05
EP0770064A4 (en) 1998-01-14
HU9603611D0 (en) 1997-02-28
FI965123A7 (fi) 1997-02-26
AU703756B2 (en) 1999-04-01
CA2194064A1 (en) 1996-01-04
RU2190607C2 (ru) 2002-10-10
HUT77773A (hu) 1998-08-28
DE69532077T2 (de) 2004-09-02
FI965123A0 (fi) 1996-12-19
EP0770064A1 (en) 1997-05-02
NO965569D0 (no) 1996-12-23
CA2194064C (en) 2009-03-17
CZ372096A3 (cs) 1998-04-15
BR9508196A (pt) 1997-09-02
AU2914295A (en) 1996-01-19
KR100276570B1 (ko) 2001-02-01
CN1163610A (zh) 1997-10-29
ATE253564T1 (de) 2003-11-15
MX9606635A (es) 1997-12-31
CN1151125C (zh) 2004-05-26
DE69532077D1 (de) 2003-12-11

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Legal Events

Date Code Title Description
AS Change of ownership

Owner name: MILLENNIUM PHARMACEUTICALS, INC.

Free format text: FORMER OWNER(S): CYTOMED, INC

PE Patent expired

Effective date: 20150626