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HK1083096A1 - Casr antagonist casr - Google Patents

Casr antagonist casr

Info

Publication number
HK1083096A1
HK1083096A1 HK06105438.3A HK06105438A HK1083096A1 HK 1083096 A1 HK1083096 A1 HK 1083096A1 HK 06105438 A HK06105438 A HK 06105438A HK 1083096 A1 HK1083096 A1 HK 1083096A1
Authority
HK
Hong Kong
Prior art keywords
casr
antagonist
casr antagonist
antagonist casr
Prior art date
Application number
HK06105438.3A
Other languages
English (en)
Inventor
Yuko Shinagawa
Teruhiko Inoue
Toshihiro Kiguchi
Taku Ikenogami
Naoki Ogawa
Kenji Fukuda
Takashi Nakagawa
Masanori Shindo
Yuki Soejima
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of HK1083096A1 publication Critical patent/HK1083096A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79Acids; Esters
    • C07D213/80Acids; Esters in position 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/44Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)
HK06105438.3A 2003-04-23 2006-05-10 Casr antagonist casr HK1083096A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003119131 2003-04-23
PCT/JP2004/005886 WO2004094362A1 (fr) 2003-04-23 2004-04-23 Antagoniste de casr

Publications (1)

Publication Number Publication Date
HK1083096A1 true HK1083096A1 (en) 2006-06-23

Family

ID=33308093

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06105438.3A HK1083096A1 (en) 2003-04-23 2006-05-10 Casr antagonist casr

Country Status (31)

Country Link
US (4) US7304174B2 (fr)
EP (3) EP2189439A3 (fr)
JP (1) JP3751312B2 (fr)
KR (1) KR100696927B1 (fr)
CN (2) CN100577633C (fr)
AR (1) AR044075A1 (fr)
AT (1) ATE452121T1 (fr)
AU (1) AU2004232604C1 (fr)
BR (1) BRPI0407097A (fr)
CA (1) CA2513738C (fr)
CL (1) CL2004000868A1 (fr)
CO (1) CO5640091A2 (fr)
CY (1) CY1109880T1 (fr)
DE (1) DE602004024668D1 (fr)
DK (1) DK1619180T3 (fr)
ES (1) ES2337576T3 (fr)
HK (1) HK1083096A1 (fr)
HR (1) HRP20100042T1 (fr)
IL (1) IL169575A (fr)
MX (1) MXPA05007609A (fr)
MY (1) MY138734A (fr)
NO (1) NO20054868L (fr)
NZ (1) NZ541188A (fr)
PE (1) PE20050460A1 (fr)
PL (1) PL1619180T3 (fr)
PT (1) PT1619180E (fr)
RU (1) RU2315036C2 (fr)
SI (1) SI1619180T1 (fr)
TW (1) TWI329628B (fr)
WO (1) WO2004094362A1 (fr)
ZA (1) ZA200505587B (fr)

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US20070155819A1 (en) * 2004-02-06 2007-07-05 Marquis Robert W Jr Calcilytic compounds
CN101437490A (zh) * 2006-04-20 2009-05-20 安美基公司 稳定乳液配方
WO2008121386A2 (fr) 2007-03-30 2008-10-09 Amgen Inc. Procédés de traitement de troubles intestinaux
WO2009148052A1 (fr) * 2008-06-05 2009-12-10 旭化成ファーマ株式会社 Composé de sulfonamide et son application
JP5628687B2 (ja) 2008-12-24 2014-11-19 第一三共株式会社 インダニル化合物
CA2748249C (fr) 2008-12-24 2013-07-02 Daiichi Sankyo Company, Limited Composes amine cycliques
WO2010103429A1 (fr) * 2009-03-10 2010-09-16 Pfizer Inc. Dérivés de l'acide 1,1-(diméthyl-éthylamino)-2-hydroxy-propoxy]-éthyl}-3-méthyl-biphényl-4-carboxylique utiles en tant qu'antagonistes des récepteurs du calcium
WO2010104882A1 (fr) 2009-03-10 2010-09-16 Amgen Inc. Procédés de modulation de la motilité des spermatozoïdes
PE20120520A1 (es) * 2009-03-26 2012-05-14 Japan Tobacco Inc Proceso para producir compuesto de acido carboxilico
WO2010113860A1 (fr) * 2009-03-31 2010-10-07 第一三共株式会社 Composé biphényle-amine cyclique
WO2010136035A2 (fr) 2009-05-27 2010-12-02 Leo Pharma A/S Composés inédits modulant les récepteurs du calcium et leur utilisation pharmaceutique
WO2010136037A1 (fr) 2009-05-27 2010-12-02 Leo Pharma A/S Nouveaux composés modulant le récepteur sensible au calcium, et leur utilisation pharmaceutique
CN103228619A (zh) 2010-11-26 2013-07-31 利奥制药有限公司 钙传感受体活性化合物
JP2014500882A (ja) 2010-11-26 2014-01-16 レオ ファーマ アクティーゼルスカブ カルシウム感知受容体活性化合物
RU2013128968A (ru) 2010-11-26 2015-01-10 Лео Фарма А/С Соединения, активные в отношении кальций-чувствительного рецептора
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CN104583177B (zh) * 2012-08-27 2016-09-07 卢平亚特兰蒂斯控股有限公司 作为钙敏感受体调节剂的芳基烷基胺化合物
MX2018015464A (es) 2016-06-13 2019-05-27 Syneurx Int Taiwan Corp Uso de benzoato de litio para tratar trastornos del sistema nervioso central.
TW202122410A (zh) * 2019-12-09 2021-06-16 大陸商北京拓界生物醫藥科技有限公司 鈣敏感受體激動劑化合物及其應用
US20220040112A1 (en) 2020-08-04 2022-02-10 Calcilytix Therapeutics, Inc. Formulations of triphenyl calcilytic compounds
WO2022060987A1 (fr) 2020-09-18 2022-03-24 Calcilytix Therapeutics, Inc. Composés triphényl calcilytiques destinés au traitement de l'hypocalcémie autosomique dominante de type 1 (adh1)
WO2024220796A1 (fr) 2023-04-21 2024-10-24 Calcilytix Therapeutics, Inc. Traitement de l'hypoparathyroïdie à l'aide de composés triphényle calcilytiques

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Also Published As

Publication number Publication date
NZ541188A (en) 2008-01-31
SI1619180T1 (sl) 2010-04-30
MY138734A (en) 2009-07-31
US7304174B2 (en) 2007-12-04
EP2308828A3 (fr) 2013-05-22
IL169575A0 (en) 2007-07-04
JPWO2004094362A1 (ja) 2006-07-13
JP3751312B2 (ja) 2006-03-01
ES2337576T3 (es) 2010-04-27
RU2005123985A (ru) 2006-01-27
EP2308828A2 (fr) 2011-04-13
PL1619180T3 (pl) 2010-05-31
IL169575A (en) 2011-07-31
US20120301552A1 (en) 2012-11-29
PE20050460A1 (es) 2005-07-08
CA2513738A1 (fr) 2004-11-04
DK1619180T3 (da) 2010-03-29
EP2189439A2 (fr) 2010-05-26
CY1109880T1 (el) 2014-09-10
PT1619180E (pt) 2009-12-29
AU2004232604A8 (en) 2004-11-04
EP2189439A3 (fr) 2011-05-04
AU2004232604B2 (en) 2007-09-13
BRPI0407097A (pt) 2006-01-24
TW200505823A (en) 2005-02-16
TWI329628B (en) 2010-09-01
CO5640091A2 (es) 2006-05-31
HRP20100042T1 (hr) 2010-02-28
AR044075A1 (es) 2005-08-24
AU2004232604C1 (en) 2008-06-05
WO2004094362A1 (fr) 2004-11-04
NO20054868D0 (no) 2005-10-21
AU2004232604B8 (en) 2004-11-04
NO20054868L (no) 2005-12-20
EP1619180A1 (fr) 2006-01-25
CN1741984A (zh) 2006-03-01
ATE452121T1 (de) 2010-01-15
RU2315036C2 (ru) 2008-01-20
US20050032796A1 (en) 2005-02-10
US20080255042A1 (en) 2008-10-16
KR100696927B1 (ko) 2007-03-20
KR20050094047A (ko) 2005-09-26
EP1619180B1 (fr) 2009-12-16
MXPA05007609A (es) 2005-09-30
ZA200505587B (en) 2006-09-27
CA2513738C (fr) 2010-04-06
CL2004000868A1 (es) 2005-01-21
EP1619180A4 (fr) 2006-05-24
US20090326058A1 (en) 2009-12-31
AU2004232604A1 (en) 2004-11-04
CN100577633C (zh) 2010-01-06
CN101723921A (zh) 2010-06-09
DE602004024668D1 (de) 2010-01-28

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