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HK1064370A1 - N-formyl hydroxylamine compounds as inhibitors of pdf - Google Patents

N-formyl hydroxylamine compounds as inhibitors of pdf

Info

Publication number
HK1064370A1
HK1064370A1 HK04107013A HK04107013A HK1064370A1 HK 1064370 A1 HK1064370 A1 HK 1064370A1 HK 04107013 A HK04107013 A HK 04107013A HK 04107013 A HK04107013 A HK 04107013A HK 1064370 A1 HK1064370 A1 HK 1064370A1
Authority
HK
Hong Kong
Prior art keywords
pdf
inhibitors
hydroxylamine compounds
formyl hydroxylamine
formyl
Prior art date
Application number
HK04107013A
Other languages
English (en)
Inventor
Dinesh V Patel
Zhengyu Yuan
Rakesh K Jain
Salvador Garcia Alvarez
Jeffrey Jacobs
Original Assignee
Vicuron Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vicuron Pharm Inc filed Critical Vicuron Pharm Inc
Publication of HK1064370A1 publication Critical patent/HK1064370A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK04107013A 2001-06-15 2004-09-14 N-formyl hydroxylamine compounds as inhibitors of pdf HK1064370A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29841901P 2001-06-15 2001-06-15
US36031302P 2002-02-27 2002-02-27
PCT/EP2002/006604 WO2002102790A1 (en) 2001-06-15 2002-06-14 N-formyl hydroxylamine compounds as inhibitors of pdf

Publications (1)

Publication Number Publication Date
HK1064370A1 true HK1064370A1 (en) 2005-01-28

Family

ID=26970649

Family Applications (1)

Application Number Title Priority Date Filing Date
HK04107013A HK1064370A1 (en) 2001-06-15 2004-09-14 N-formyl hydroxylamine compounds as inhibitors of pdf

Country Status (31)

Country Link
US (1) US7148242B2 (xx)
EP (1) EP1401828B1 (xx)
JP (1) JP4361365B2 (xx)
KR (2) KR20060014083A (xx)
CN (1) CN1511152A (xx)
AR (1) AR036053A1 (xx)
AT (1) ATE323081T1 (xx)
AU (1) AU2002321062B2 (xx)
BR (1) BR0210377A (xx)
CA (1) CA2448526A1 (xx)
CO (1) CO5640131A2 (xx)
CY (1) CY1105085T1 (xx)
CZ (1) CZ20033388A3 (xx)
DE (1) DE60210612T2 (xx)
DK (1) DK1401828T3 (xx)
ES (1) ES2262824T3 (xx)
HK (1) HK1064370A1 (xx)
HU (1) HUP0400208A3 (xx)
IL (1) IL158770A0 (xx)
MX (1) MXPA03011628A (xx)
MY (1) MY138619A (xx)
NO (1) NO327420B1 (xx)
NZ (1) NZ529489A (xx)
PE (1) PE20030100A1 (xx)
PL (1) PL364476A1 (xx)
PT (1) PT1401828E (xx)
RU (1) RU2325386C2 (xx)
SI (1) SI1401828T1 (xx)
SK (1) SK15242003A3 (xx)
WO (1) WO2002102790A1 (xx)
ZA (1) ZA200308379B (xx)

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Publication number Priority date Publication date Assignee Title
PT1406893E (pt) * 2001-06-15 2007-07-12 Vicuron Pharm Inc Compostos bicíclicos de pirrolidina
GB0208579D0 (en) * 2002-04-13 2002-05-22 British Biotech Pharm Antibacterial agents
DK1542968T3 (da) * 2002-09-19 2009-04-20 Novartis Ag Fremgangsmåde til fremstilling af mellemforbindelser
PL379008A1 (pl) * 2003-02-21 2006-06-26 Novartis Ag Chemiczny sposób wytwarzania związków pośrednich do otrzymywania związków N-formylohydroksyloaminowych
TW200427458A (en) * 2003-04-02 2004-12-16 Novartis Ag Crystalline N-formyl hydroxylamine compounds
KR20060026445A (ko) * 2003-06-26 2006-03-23 노파르티스 아게 특정 항박테리아성 ｎ-포르밀 히드록실아민의 제조에유용한 중간체의 제조 방법
KR100527624B1 (ko) * 2003-08-21 2005-11-22 한기종 질소에 포밀기를 갖는 아민유도체의 새로운 제조방법
CN1976703A (zh) * 2004-06-30 2007-06-06 诺瓦提斯公司 通过使用外排泵抑制剂增加肽脱甲酰基酶抑制剂敏感性的方法
US20080161249A1 (en) 2004-11-17 2008-07-03 Smithkline Beecham Corporation Use of Novel Antibacterial Compounds
GT200600196A (es) * 2005-05-23 2007-01-15 Compuestos n-formil de hidroxilamina
RU2007148233A (ru) 2005-06-07 2009-07-20 Новартис АГ (CH) Ингибиторы 4 пептиддеформилазы (pdf)
DE102005026231A1 (de) * 2005-06-07 2006-12-14 Origenis Ag Peptid-Deformylase (PDF) Inhibitoren 3
SG133452A1 (en) * 2005-12-30 2007-07-30 Novartis Ag Peptide deformylase inhibitors for treatment of mycobacterial and other parasitic diseases
CA2643267A1 (en) * 2006-03-03 2007-09-20 Novartis Ag N-formyl hydroxylamine compounds
CN101328155B (zh) * 2007-06-20 2010-11-03 上海医药工业研究院 噁唑烷衍生物及其制备方法和应用
CN101434570B (zh) * 2007-11-16 2011-02-02 上海医药工业研究院 吡咯烷衍生物及其制备方法和应用
CN101584694B (zh) * 2009-06-15 2011-01-12 华东师范大学 含2,5-二氢吡咯的肽脱甲酰基酶抑制剂及合成方法
AU2010291212A1 (en) * 2009-09-04 2012-02-23 Novartis Ag Heteroaryl compounds as kinase inhibitors
CA2789189A1 (en) 2010-03-10 2011-09-15 Ingenium Pharmaceuticals Gmbh Inhibitors of protein kinases
JP5825086B2 (ja) 2011-12-19 2015-12-02 住友化学株式会社 α−置換−β−アミノ酸エステル誘導体不斉加水分解酵素
US9512084B2 (en) 2013-11-29 2016-12-06 Novartis Ag Amino pyrimidine derivatives
WO2016164580A1 (en) 2015-04-07 2016-10-13 Novartis Ag Combination of chimeric antigen receptor therapy and amino pyrimidine derivatives
JP7001898B2 (ja) * 2016-05-11 2022-01-20 グアンドン・ヘボ・ファーマシューティカル・カンパニー・リミテッド スピロ３員環、スピロ５員環系ペプチドデホルミラーゼ阻害剤および抗菌と抗腫瘍におけるその使用

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Also Published As

Publication number Publication date
RU2325386C2 (ru) 2008-05-27
CO5640131A2 (es) 2006-05-31
KR100589544B1 (ko) 2006-06-15
ES2262824T3 (es) 2006-12-01
EP1401828B1 (en) 2006-04-12
HUP0400208A3 (en) 2008-10-28
NO20035571D0 (no) 2003-12-12
BR0210377A (pt) 2004-08-10
NO20035571L (no) 2004-02-16
CN1511152A (zh) 2004-07-07
HUP0400208A2 (hu) 2004-06-28
NZ529489A (en) 2005-10-28
DE60210612T2 (de) 2006-09-21
US20030045479A1 (en) 2003-03-06
ATE323081T1 (de) 2006-04-15
JP2005502606A (ja) 2005-01-27
US7148242B2 (en) 2006-12-12
JP4361365B2 (ja) 2009-11-11
SI1401828T1 (sl) 2006-10-31
NO327420B1 (no) 2009-06-29
MY138619A (en) 2009-07-31
CZ20033388A3 (en) 2004-03-17
IL158770A0 (en) 2004-05-12
CY1105085T1 (el) 2009-11-04
PT1401828E (pt) 2006-08-31
RU2003137565A (ru) 2005-05-27
AR036053A1 (es) 2004-08-04
ZA200308379B (en) 2004-05-21
MXPA03011628A (es) 2005-03-07
PE20030100A1 (es) 2003-03-28
KR20040010721A (ko) 2004-01-31
DK1401828T3 (da) 2006-07-31
EP1401828A1 (en) 2004-03-31
SK15242003A3 (sk) 2004-07-07
KR20060014083A (ko) 2006-02-14
AU2002321062B2 (en) 2006-02-02
DE60210612D1 (de) 2006-05-24
PL364476A1 (en) 2004-12-13
WO2002102790A1 (en) 2002-12-27
CA2448526A1 (en) 2002-12-27

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20100614