HK1059083A1 - Prodrugs to nmda receptor ligands - Google Patents

Prodrugs to nmda receptor ligands

Info

Publication number: HK1059083A1
Authority: HK; Hong Kong
Prior art keywords: prodrugs; nmda receptor; receptor ligands; ligands; nmda
Prior art date: 2000-08-21

Application number

HK04101906A

Other languages

English (en)

Inventor

Alexander Alanine

Bernd Buettelamann

Holger Fishier

Marie-Paule Heitz Neidhart

Joerg Huwyler

Georg Jaeschke

Emmanuel Pinard

Rene Wyler

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-21

Filing date

2004-03-16

Publication date

2004-06-18

2004-03-16 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-06-18 Publication of HK1059083A1 publication Critical patent/HK1059083A1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

HK04101906A 2000-08-21 2004-03-16 Prodrugs to nmda receptor ligands HK1059083A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00117918		2000-08-21
PCT/EP2001/009561 WO2002016321A1 (en)	2000-08-21	2001-08-20	Prodrugs to nmda receptor ligands

Publications (1)

Publication Number	Publication Date
HK1059083A1 true HK1059083A1 (en)	2004-06-18

Family

ID=8169594

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK04101906A HK1059083A1 (en)	2000-08-21	2004-03-16	Prodrugs to nmda receptor ligands

Country Status (36)

Country	Link
US (1)	US6407235B1 (no)
EP (1)	EP1313703B1 (no)
JP (1)	JP4162991B2 (no)
KR (1)	KR100589991B1 (no)
CN (1)	CN1227230C (no)
AR (1)	AR030373A1 (no)
AT (1)	ATE386022T1 (no)
AU (2)	AU2001285894B2 (no)
BR (1)	BR0113348A (no)
CA (1)	CA2419279C (no)
CY (1)	CY1107937T1 (no)
CZ (1)	CZ303319B6 (no)
DE (1)	DE60132782T2 (no)
DK (1)	DK1313703T3 (no)
EC (1)	ECSP034489A (no)
EG (1)	EG24293A (no)
ES (1)	ES2299508T3 (no)
HK (1)	HK1059083A1 (no)
HR (1)	HRP20030125B1 (no)
HU (1)	HU229802B1 (no)
IL (1)	IL154254A0 (no)
JO (1)	JO2289B1 (no)
MA (1)	MA26947A1 (no)
MX (1)	MXPA03001311A (no)
MY (1)	MY136065A (no)
NO (1)	NO324941B1 (no)
NZ (1)	NZ523990A (no)
PA (1)	PA8525601A1 (no)
PE (1)	PE20020291A1 (no)
PL (1)	PL204215B1 (no)
PT (1)	PT1313703E (no)
RS (1)	RS51467B (no)
RU (1)	RU2272027C2 (no)
SI (1)	SI1313703T1 (no)
WO (1)	WO2002016321A1 (no)
ZA (1)	ZA200300894B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL365444A1 (en) *	2000-03-21	2005-01-10	The Procter & Gamble Company	Heterocyclic side chain containing, n-substituted metalloprotease inhibitors
US6713490B2 (en)	2002-04-26	2004-03-30	Pfizer, Inc.	3,4-dihydroquinolin-2(1H)-one compounds as NR2B receptor antagonists
JP2009521424A (ja) *	2005-12-19	2009-06-04	メチルジーンインコーポレイテッド	抗真菌剤の活性を増強するためのヒストンデアセチラーゼ阻害剤
US8796330B2 (en) *	2006-12-19	2014-08-05	Methylgene Inc.	Inhibitors of histone deacetylase and prodrugs thereof
JP2010513326A (ja)	2006-12-19	2010-04-30	メシルジーンインコーポレイテッド	ヒストンデアセチラーゼの阻害薬及びそのプロドラッグ
RS58991B1 (sr)	2013-11-05	2019-08-30	Astrazeneca Ab	Prolekovi nmda antagonista

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4410822A1 (de)	1994-03-24	1995-09-28	Schering Ag	Neue Piperidin-Derivate
TW498067B (en)	1996-07-19	2002-08-11	Hoffmann La Roche	4-hydroxy-piperidine derivatives
TWI254043B (en)	1999-06-08	2006-05-01	Hoffmann La Roche	Ethanesulfonyl-piperidine derivatives having good affinity to N-methyl-D-aspartate (NMDA) receptor

2001
- 2001-08-16 US US09/931,431 patent/US6407235B1/en not_active Expired - Lifetime
- 2001-08-16 PA PA20018525601A patent/PA8525601A1/es unknown
- 2001-08-16 PE PE2001000820A patent/PE20020291A1/es not_active Application Discontinuation
- 2001-08-17 AR ARP010103939A patent/AR030373A1/es active IP Right Grant
- 2001-08-17 MY MYPI20013876A patent/MY136065A/en unknown
- 2001-08-19 JO JO2001136A patent/JO2289B1/en active
- 2001-08-20 AU AU2001285894A patent/AU2001285894B2/en not_active Ceased
- 2001-08-20 BR BR0113348-9A patent/BR0113348A/pt not_active Application Discontinuation
- 2001-08-20 CN CNB01814361XA patent/CN1227230C/zh not_active Expired - Fee Related
- 2001-08-20 AT AT01965201T patent/ATE386022T1/de active
- 2001-08-20 IL IL15425401A patent/IL154254A0/xx not_active IP Right Cessation
- 2001-08-20 HU HU0301548A patent/HU229802B1/hu not_active IP Right Cessation
- 2001-08-20 DE DE60132782T patent/DE60132782T2/de not_active Expired - Lifetime
- 2001-08-20 ES ES01965201T patent/ES2299508T3/es not_active Expired - Lifetime
- 2001-08-20 PL PL361387A patent/PL204215B1/pl unknown
- 2001-08-20 AU AU8589401A patent/AU8589401A/xx active Pending
- 2001-08-20 EG EG20010906A patent/EG24293A/xx active
- 2001-08-20 EP EP01965201A patent/EP1313703B1/en not_active Expired - Lifetime
- 2001-08-20 MX MXPA03001311A patent/MXPA03001311A/es active IP Right Grant
- 2001-08-20 KR KR1020037002485A patent/KR100589991B1/ko not_active IP Right Cessation
- 2001-08-20 WO PCT/EP2001/009561 patent/WO2002016321A1/en active IP Right Grant
- 2001-08-20 PT PT01965201T patent/PT1313703E/pt unknown
- 2001-08-20 NZ NZ523990A patent/NZ523990A/en not_active IP Right Cessation
- 2001-08-20 JP JP2002521197A patent/JP4162991B2/ja not_active Expired - Fee Related
- 2001-08-20 CZ CZ20030492A patent/CZ303319B6/cs not_active IP Right Cessation
- 2001-08-20 RS YUP-130/03A patent/RS51467B/sr unknown
- 2001-08-20 DK DK01965201T patent/DK1313703T3/da active
- 2001-08-20 CA CA002419279A patent/CA2419279C/en not_active Expired - Fee Related
- 2001-08-20 RU RU2003107572/04A patent/RU2272027C2/ru not_active IP Right Cessation
- 2001-08-20 SI SI200130812T patent/SI1313703T1/sl unknown
2003
- 2003-01-31 ZA ZA200300894A patent/ZA200300894B/en unknown
- 2003-02-19 NO NO20030781A patent/NO324941B1/no not_active IP Right Cessation
- 2003-02-20 HR HR20030125A patent/HRP20030125B1/xx not_active IP Right Cessation
- 2003-02-20 EC EC2003004489A patent/ECSP034489A/es unknown
- 2003-02-21 MA MA27052A patent/MA26947A1/fr unknown
2004
- 2004-03-16 HK HK04101906A patent/HK1059083A1/xx not_active IP Right Cessation
2008
- 2008-05-08 CY CY20081100485T patent/CY1107937T1/el unknown

Also Published As

Publication number	Publication date
JP2004506715A (ja)	2004-03-04
SI1313703T1 (sl)	2008-06-30
PL361387A1 (en)	2004-10-04
HRP20030125B1 (en)	2011-07-31
US6407235B1 (en)	2002-06-18
MA26947A1 (fr)	2004-12-20
DE60132782T2 (de)	2009-02-05
ES2299508T3 (es)	2008-06-01
CN1447793A (zh)	2003-10-08
CZ303319B6 (cs)	2012-08-01
ATE386022T1 (de)	2008-03-15
EP1313703A1 (en)	2003-05-28
KR20030022417A (ko)	2003-03-15
CA2419279A1 (en)	2002-02-28
MXPA03001311A (es)	2003-06-30
NO20030781D0 (no)	2003-02-19
RS51467B (sr)	2011-04-30
HRP20030125A2 (en)	2005-02-28
EG24293A (en)	2009-01-08
MY136065A (en)	2008-08-29
PE20020291A1 (es)	2002-04-17
KR100589991B1 (ko)	2006-06-15
EP1313703B1 (en)	2008-02-13
RU2272027C2 (ru)	2006-03-20
WO2002016321A1 (en)	2002-02-28
AU2001285894B2 (en)	2006-06-15
HU229802B1 (hu)	2014-07-28
HUP0301548A3 (en)	2010-03-29
CA2419279C (en)	2008-10-14
JP4162991B2 (ja)	2008-10-08
DE60132782D1 (de)	2008-03-27
ECSP034489A (es)	2003-03-31
ZA200300894B (en)	2004-04-30
NO20030781L (no)	2003-02-19
YU13003A (sh)	2006-05-25
CN1227230C (zh)	2005-11-16
AR030373A1 (es)	2003-08-20
US20020040037A1 (en)	2002-04-04
DK1313703T3 (da)	2008-05-19
AU8589401A (en)	2002-03-04
NZ523990A (en)	2004-09-24
BR0113348A (pt)	2003-07-08
PL204215B1 (pl)	2009-12-31
PA8525601A1 (es)	2002-04-25
JO2289B1 (en)	2005-09-12
HUP0301548A2 (hu)	2003-08-28
CZ2003492A3 (cs)	2004-01-14
IL154254A0 (en)	2003-09-17
CY1107937T1 (el)	2013-09-04
NO324941B1 (no)	2008-01-07
PT1313703E (pt)	2008-03-25

Publication	Publication Date	Title
IL153884A0 (en)	2003-07-31	Capsaicin receptor ligands
AU3092901A (en)	2001-08-27	Aniline-derived ligands for the thyroid receptor
AU9631301A (en)	2002-04-08	Melanocortin receptor ligands
IL152781A0 (en)	2003-06-24	Melanocortin receptor ligands
GB0302292D0 (en)	2003-03-05	A means for applying images to other images
IL157031A0 (en)	2004-02-08	Thyroid receptor ligands
AU1702102A (en)	2002-05-27	Device for connecting to each other three flat elements
AU4439801A (en)	2001-10-23	Pyrazolo-triazine derivatives as ligands for gaba receptors
GB0010161D0 (en)	2000-06-14	Novel phosphine compounds
EG24293A (en)	2009-01-08	Prodrugs to NMDA receptor ligands
AU3167402A (en)	2002-06-24	Aminotriazolopyridiine derivatives as adenosine receptor ligands
EP1343494A4 (en)	2005-08-03	PROMOTERS TETRAPARTATES
GB0012054D0 (en)	2000-07-12	Ligands
GB0000474D0 (en)	2000-03-01	Receptor
AU1252102A (en)	2002-05-21	Receptor
AU143874S (en)	2001-05-15	A fondue set
AU144173S (en)	2001-06-07	A fondue set
TW439713U (en)	2001-06-07	Pedal structure for baby-stroller
SI1261613T1 (en)	2004-12-31	Gastro-specific prodrugs
GB2362332B (en)	2003-12-03	Improvements relating to crackers
GB0010767D0 (en)	2000-06-28	Twinfill flask
AU144172S (en)	2001-06-07	A flask
GB0030689D0 (en)	2001-01-31	Synthesis
GB0017055D0 (en)	2000-08-30	Synthesis
GB0026477D0 (en)	2000-12-13	Improvements relating to back supports

Legal Events

Date	Code	Title	Description
2016-03-18	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20150820