HK1047749B - 叔丁基-(7-甲基-咪唑[1，2-a]吡啶-3-基)-胺衍生物 - Google Patents

叔丁基-(7-甲基-咪唑[1，2-a]吡啶-3-基)-胺衍生物

Info

Publication number: HK1047749B
Authority: HK; Hong Kong
Prior art keywords: imidazo; pyridine; tert; butyl; methyl
Prior art date: 1999-10-08

Application number

HK02109385.2A

Other languages

English (en)

Other versions

HK1047749A1 (en

Inventor

Maul Corinna

Sundermann Bernd

Hennies Hagen-Heinrich

Schneider Johannes

Gerlach Matthias

Original Assignee

Gruenenthal Chemie

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-08

Filing date

2002-12-28

Publication date

2003-08-22

2002-12-28 Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie

2003-03-07 Publication of HK1047749A1 publication Critical patent/HK1047749A1/xx

2003-08-22 Publication of HK1047749B publication Critical patent/HK1047749B/zh

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Psychology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Communicable Diseases (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Oncology (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

HK02109385.2A 1999-10-08 2002-12-28 叔丁基-(7-甲基-咪唑[1，2-a]吡啶-3-基)-胺衍生物 HK1047749B (zh)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19948434A DE19948434A1 (de)	1999-10-08	1999-10-08	Substanzbibliothek enthaltend bicyclische Imidazo-5-amine und/oder bicyclische Imidazo-3-amine
PCT/EP2000/009791 WO2001027109A2 (de)	1999-10-08	2000-10-06	Tert.-butyl-(7-methyl-imidazo[1,2-a]pyridin-3-yl)-amin-derivate

Publications (2)

Publication Number	Publication Date
HK1047749A1 HK1047749A1 (en)	2003-03-07
HK1047749B true HK1047749B (zh)	2003-08-22

Family

ID=7924888

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK02109385.2A HK1047749B (zh)	1999-10-08	2002-12-28	叔丁基-(7-甲基-咪唑[1，2-a]吡啶-3-基)-胺衍生物

Country Status (28)

Country	Link
US (1)	US6703404B2 (zh)
EP (1)	EP1218378B1 (zh)
JP (1)	JP2003511450A (zh)
KR (1)	KR100793619B1 (zh)
CN (1)	CN1208336C (zh)
AR (2)	AR025960A1 (zh)
AT (1)	ATE238304T1 (zh)
AU (2)	AU7419900A (zh)
BR (1)	BR0014827A (zh)
CA (1)	CA2386804A1 (zh)
CO (2)	CO5210861A1 (zh)
CZ (1)	CZ20021241A3 (zh)
DE (2)	DE19948434A1 (zh)
DK (1)	DK1218378T3 (zh)
ES (1)	ES2198355T3 (zh)
HK (1)	HK1047749B (zh)
HU (1)	HUP0203545A3 (zh)
IL (3)	IL148997A0 (zh)
MX (1)	MXPA02003546A (zh)
NO (1)	NO20021564L (zh)
NZ (1)	NZ518438A (zh)
PE (2)	PE20010632A1 (zh)
PL (1)	PL355109A1 (zh)
PT (1)	PT1218378E (zh)
RU (1)	RU2002110281A (zh)
SK (1)	SK4622002A3 (zh)
WO (2)	WO2001027119A2 (zh)
ZA (2)	ZA200203579B (zh)

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1999
- 1999-10-08 DE DE19948434A patent/DE19948434A1/de not_active Withdrawn
2000
- 2000-09-18 AU AU74199/00A patent/AU7419900A/en not_active Abandoned
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- 2000-09-18 WO PCT/EP2000/009098 patent/WO2001027119A2/de active Application Filing
- 2000-10-02 CO CO00074640A patent/CO5210861A1/es not_active Application Discontinuation
- 2000-10-05 AR ARP000105251A patent/AR025960A1/es not_active Application Discontinuation
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- 2000-10-06 ES ES00969439T patent/ES2198355T3/es not_active Expired - Lifetime
- 2000-10-06 PL PL00355109A patent/PL355109A1/xx not_active IP Right Cessation
- 2000-10-06 PT PT00969439T patent/PT1218378E/pt unknown
- 2000-10-06 AU AU79153/00A patent/AU780526B2/en not_active Ceased
- 2000-10-06 EP EP00969439A patent/EP1218378B1/de not_active Expired - Lifetime
- 2000-10-06 DK DK00969439T patent/DK1218378T3/da active
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- 2000-10-06 KR KR1020027004518A patent/KR100793619B1/ko not_active IP Right Cessation
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- 2000-10-06 RU RU2002110281/04A patent/RU2002110281A/ru not_active Application Discontinuation
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2002
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Publication number	Publication date
KR100793619B1 (ko)	2008-01-11
US20030022914A1 (en)	2003-01-30
AR025959A1 (es)	2002-12-26
NO20021564D0 (no)	2002-04-03
DE50001911D1 (de)	2003-05-28
ZA200203581B (en)	2004-02-25
CN1208336C (zh)	2005-06-29
IL148999A (en)	2007-03-08
US6703404B2 (en)	2004-03-09
EP1218378B1 (de)	2003-04-23
CN1407983A (zh)	2003-04-02
CA2386804A1 (en)	2001-04-19
WO2001027109A3 (de)	2001-09-20
WO2001027119A2 (de)	2001-04-19
HUP0203545A3 (en)	2004-07-28
AU7915300A (en)	2001-04-23
PL355109A1 (en)	2004-04-05
RU2002110281A (ru)	2003-12-20
ES2198355T3 (es)	2004-02-01
SK4622002A3 (en)	2002-09-10
BR0014827A (pt)	2003-07-08
JP2003511450A (ja)	2003-03-25
ATE238304T1 (de)	2003-05-15
DK1218378T3 (da)	2003-07-21
ZA200203579B (en)	2003-10-29
AU780526B2 (en)	2005-03-24
NZ518438A (en)	2004-08-27
PE20010632A1 (es)	2001-07-07
IL148999A0 (en)	2002-11-10
CO5251429A1 (es)	2003-02-28
WO2001027119A3 (de)	2001-10-11
CZ20021241A3 (cs)	2002-08-14
NO20021564L (no)	2002-06-04
AU7419900A (en)	2001-04-23
IL148997A0 (en)	2002-11-10
CO5210861A1 (es)	2002-10-30
KR20020069003A (ko)	2002-08-28
WO2001027109A2 (de)	2001-04-19
HK1047749A1 (en)	2003-03-07
HUP0203545A2 (hu)	2003-02-28
DE19948434A1 (de)	2001-06-07
AR025960A1 (es)	2002-12-26
PT1218378E (pt)	2003-09-30
PE20010706A1 (es)	2001-08-13
MXPA02003546A (es)	2002-09-18
EP1218378A2 (de)	2002-07-03

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HK1047749A1 (en)	2003-03-07	Tert.-butyl-(7-methyl-imidazo[1,2-a]pyridine-3-yl)-amine derivatives
IL147752A0 (en)	2002-08-14	Imidazo[1,2-a] pyridine and pyrazolo [2,3-a] pyridine derivatives
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HUP0301614A3 (en)	2005-02-28	Pyrido[2,3-d]pyrimidini and pyrimido[4,5-d]pyrimidini nucleosides
IL147770A0 (en)	2002-08-14	8-phenyl-6,9-dihydro-[1,2,4] triazolo[3,4-i] purin-5-one derivatives
HU9801587D0 (en)	1998-09-28	5h-thiazolo[3,2-a]pyrimidine derivatives
AU2002251546A1 (en)	2003-04-17	Pyrazolo[1,5-A]pyridines and medicines containing the same
ZA200110536B (en)	2003-03-24	1,2,3,4,5,6-hexahydroazepino [4,5-b]indoles containing arylsulfones at the 9-position.
HUP0102117A2 (hu)	2001-12-28	Imidazo[1,2-a]piridin-származékok és ezeket tartalmazó gyógyászati készítmények
PL349364A1 (en)	2002-07-15	Use of pyridazino[4,5-b
HUP0102981A3 (en)	2002-10-28	Pyrrolo[1,2-a]pyrazine derivatives and pharmaceutical compositions thereof
PL349341A1 (en)	2002-07-15	Imidazo[4,5-c]-pyridine-4-on-derivatives
AU6831500A (en)	2001-02-19	1h-pirido[3, 4-b]indol-1-one derivatives
HUP0003692A3 (en)	2002-10-28	Pyrimido[4,5-b]indolyl-alkanecarboxamide derivatives
ZA985120B (en)	1999-12-13	3-Substituted pyrido[3',4':4,5]thieno[2,3-d]pyrimidine derivatives, their preparation and use.
SI1218378T1 (en)	2003-08-31	Tert.-butyl-(7-methyl-imidazo(1,2-a)pyridine-3-yl)-amine derivatives
IL147128A0 (en)	2002-08-14	DITHIEPINO [6,5-b]PYRIDINES, AND RELATED COMPOSITIONS AND METHODS
PL371201A1 (en)	2005-06-13	3-heteroaryl-3,5-dihydro-4-oxo-4h-pyridazino[4,5-b]indole-1-carboxamide derivatives, their preparation and therapeutic use
ZA9811642B (en)	1999-06-24	Pyrido 1,2,4-thiadiazine derivatives their preparation and use
AU2002224115A1 (en)	2002-06-11	1,4,5,6-tetrahydroimidazo(4,5-d)diazepine derivatives or salts thereof
PL352760A1 (en)	2003-09-08	Oxathiepino[6,5-b
ZA200202763B (en)	2003-06-25	Pyrazolo [4,3-D] pyrimidine derivatives.
PL325356A1 (en)	1999-09-27	Novel derivative 2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-carboxylic pyrolydinamide

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2004-12-15	PF	Patent in force
2014-05-02	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20131006