ATE255131T1
(de)
|
1991-06-14 |
2003-12-15 |
Genentech Inc |
Humanisierter heregulin antikörper
|
US6800738B1
(en)
|
1991-06-14 |
2004-10-05 |
Genentech, Inc. |
Method for making humanized antibodies
|
EP1745799B1
(en)
|
1998-03-04 |
2015-09-02 |
The Trustees of The University of Pennsylvania |
Compositions and methods of treating tumors
|
US6417168B1
(en)
|
1998-03-04 |
2002-07-09 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods of treating tumors
|
US6706721B1
(en)
|
1998-04-29 |
2004-03-16 |
Osi Pharmaceuticals, Inc. |
N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
|
WO2000074634A2
(en)
|
1999-06-03 |
2000-12-14 |
Au Jessie L S |
Methods and compositions for modulating cell proliferation and cell death
|
GB9925958D0
(en)
*
|
1999-11-02 |
1999-12-29 |
Bundred Nigel J |
Therapeutic use
|
US7087613B2
(en)
|
1999-11-11 |
2006-08-08 |
Osi Pharmaceuticals, Inc. |
Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
|
UA74803C2
(uk)
|
1999-11-11 |
2006-02-15 |
Осі Фармасьютікалз, Інк. |
Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
|
JP2004527456A
(ja)
*
|
2000-08-09 |
2004-09-09 |
イムクローン システムズ インコーポレイティド |
Egf受容体拮抗剤による過増殖性の疾患の治療
|
CU22979A1
(es)
*
|
2000-12-08 |
2004-09-09 |
Centro Inmunologia Molecular |
Combinación inmunoterapéutica para el tratamiento de tumores que sobre-expresan receptores con actividad quinasa en residuos de tirosina
|
AU2002239486A1
(en)
*
|
2000-12-08 |
2002-06-18 |
Uab Research Foundation |
Combination radiation therapy and chemotherapy in conjuction with administration of growth factor receptor antibody
|
US7081454B2
(en)
|
2001-03-28 |
2006-07-25 |
Bristol-Myers Squibb Co. |
Tyrosine kinase inhibitors
|
ES2362931T3
(es)
|
2002-03-04 |
2011-07-15 |
Imclone Llc |
Anticuerpos humanos específicos contra kdr y usos de los mismos.
|
DE60318561T2
(de)
*
|
2002-04-02 |
2009-01-08 |
Nerviano Medical Sciences S.R.L., Nerviano |
Kombinierte tumortherapie auf der basis von distamycin-acryloyl derivaten und radiotherapie
|
EP1506286B1
(en)
|
2002-05-24 |
2014-03-19 |
Merck Sharp & Dohme Corp. |
Neutralizing human anti-igfr antibody
|
WO2005016970A2
(en)
|
2003-05-01 |
2005-02-24 |
Imclone Systems Incorporated |
Fully human antibodies directed against the human insulin-like growth factor-1 receptor
|
JP2007500248A
(ja)
|
2003-06-09 |
2007-01-11 |
ワクサル,サムエル |
細胞外アンタゴニストおよび細胞内アンタゴニストによる受容体チロシンキナーゼの抑制方法
|
US7312215B2
(en)
|
2003-07-29 |
2007-12-25 |
Bristol-Myers Squibb Company |
Benzimidazole C-2 heterocycles as kinase inhibitors
|
CN1835975B
(zh)
|
2003-08-13 |
2012-11-21 |
辉瑞产品公司 |
经修饰的人类igf-1r抗体
|
CN1938428A
(zh)
|
2003-11-12 |
2007-03-28 |
先灵公司 |
多基因表达的质粒系统
|
PE20050928A1
(es)
|
2003-11-21 |
2005-11-08 |
Schering Corp |
Combinaciones terapeuticas de anticuerpo anti-igfr1
|
JP4734319B2
(ja)
|
2004-03-19 |
2011-07-27 |
イムクローン・リミテッド・ライアビリティ・カンパニー |
ヒト抗上皮成長因子受容体抗体
|
RU2006146612A
(ru)
|
2004-06-03 |
2008-07-20 |
Ф.Хоффманн-Ля Рош Аг (Ch) |
Лечение цисплатином и ингибитором рецептора эпидермального фактора роста (egfr)
|
JP2008521907A
(ja)
|
2004-12-03 |
2008-06-26 |
シェーリング コーポレイション |
抗igf1r治療について患者を予め選択するためのバイオマーカー
|
MY146381A
(en)
|
2004-12-22 |
2012-08-15 |
Amgen Inc |
Compositions and methods relating relating to anti-igf-1 receptor antibodies
|
KR101246504B1
(ko)
|
2005-06-17 |
2013-03-26 |
임클론 엘엘씨 |
항-PDGFRα 항체
|
ES2374450T3
(es)
|
2005-09-20 |
2012-02-16 |
OSI Pharmaceuticals, LLC |
Marcadores biológicos predictivos de respuesta anticancerígena para inhibidores de cinasa del receptor del factor de crecimiento 1 similar a insulina.
|
EP1940881B1
(en)
*
|
2005-10-11 |
2016-11-30 |
Amgen Research (Munich) GmbH |
Compositions comprising cross-species-specific antibodies and uses thereof
|
TW200812615A
(en)
|
2006-03-22 |
2008-03-16 |
Hoffmann La Roche |
Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2
|
ES2392630T3
(es)
|
2006-08-21 |
2012-12-12 |
F. Hoffmann-La Roche Ag |
Terapia antitumoral con anticuerpos anti-VEGF
|
BRPI0808055A2
(pt)
|
2007-02-16 |
2013-07-30 |
Merrimack Pharmaceuticals Inc |
anticorpo monoclonal isolado ou porÇço do mesmo que se liga ao antÍgeno, composiÇço, Ácido nucleico isolado, vetor de expressço, cÉlula hospedeira, hibridoma, kit, uso de um anticorpo monoclonal isolado ou porÇço do mesmo que se liga ao antÍgeno, mÉtodo para diagnosticar um cÂncer associado com erbb3 em um paciente, e, anticorpo
|
WO2008119566A2
(en)
*
|
2007-04-03 |
2008-10-09 |
Micromet Ag |
Cross-species-specific bispecific binders
|
BRPI0816458A2
(pt)
|
2007-09-05 |
2013-03-12 |
Hoffmann La Roche |
terapia combinada com anticorpos anti-cd20 tipo i e tipo ii
|
US20090098118A1
(en)
|
2007-10-15 |
2009-04-16 |
Thomas Friess |
Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent
|
AR071891A1
(es)
|
2008-05-30 |
2010-07-21 |
Imclone Llc |
Anticuerpos humanos anti-flt3 (receptor tirosina cinasa 3 tipo fms humano)
|
CA2732658A1
(en)
|
2008-08-15 |
2010-02-18 |
Merrimack Pharmaceuticals, Inc. |
Methods and systems for predicting response of cells to a therapeutic agent
|
EP2400985A2
(en)
|
2009-02-25 |
2012-01-04 |
OSI Pharmaceuticals, LLC |
Combination of an either an anti-igf-1r antibody or an igf binding protein and a small molecule igf-1r kinase inhibitor
|
WO2010099137A2
(en)
|
2009-02-26 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
In situ methods for monitoring the emt status of tumor cells in vivo
|
WO2010107968A1
(en)
|
2009-03-18 |
2010-09-23 |
Osi Pharmaceuticals, Inc. |
Combination cancer therapy comprising administration of an egfr inhibitor and an igf-1r inhibitor
|
TWI461211B
(zh)
|
2009-03-20 |
2014-11-21 |
Genentech Inc |
抗-her抗體
|
EP2236139A1
(en)
|
2009-03-31 |
2010-10-06 |
F. Hoffmann-La Roche AG |
Combination therapy of erlotinib with an anti-IGF-1R antibody, which does not inhibit binding of insulin to the insulin receptor
|
AR075982A1
(es)
|
2009-03-31 |
2011-05-11 |
Roche Glycart Ag |
Terapia de combinacion de un anticuerpo afucosilado y una o mas de las citoquinas seleccionadas de gm- csf humano, m -csf humano y/o il-3 humano y composicion
|
TWI409079B
(zh)
|
2009-08-14 |
2013-09-21 |
Roche Glycart Ag |
非典型岩藻醣化cd20抗體與苯達莫斯汀(bendamustine)之組合療法
|
AR077867A1
(es)
|
2009-08-14 |
2011-09-28 |
Roche Glycart Ag |
Terapia combinatoria de un anticuerpo cd20 afucosilado con fludarabina y/o mitoxantrona
|
AR078161A1
(es)
|
2009-09-11 |
2011-10-19 |
Hoffmann La Roche |
Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento.
|
JP2013527748A
(ja)
|
2010-03-03 |
2013-07-04 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
インスリン様増殖因子1受容体キナーゼ阻害剤に対する抗癌反応の予測に役立つ生物学的マーカー
|
CA2783665A1
(en)
|
2010-03-03 |
2011-09-09 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
|
EP2859893A1
(en)
|
2010-03-11 |
2015-04-15 |
Merrimack Pharmaceuticals, Inc. |
Use of ERBB3 inhibitors in the treatment of triple negative and basal-like breast cancers
|
BR112012026707A2
(pt)
|
2010-04-27 |
2017-03-14 |
Roche Glycart Ag |
uso de um anticorpo anti-cd20 afucosilado, composição que compreende um anticorpo anti-cd20 afucosilado e método de tratamento de pacientes que sofrem de câncer por meio da administração de um anticorpo anti-cd20 afucosilado
|
TW201208703A
(en)
|
2010-08-17 |
2012-03-01 |
Roche Glycart Ag |
Combination therapy of an afucosylated CD20 antibody with an anti-VEGF antibody
|
TW201302793A
(zh)
|
2010-09-03 |
2013-01-16 |
Glaxo Group Ltd |
新穎之抗原結合蛋白
|
WO2012080389A1
(en)
|
2010-12-16 |
2012-06-21 |
Roche Glycart Ag |
Combination therapy of an afucosylated cd20 antibody with a mdm2 inhibitor
|
JP2014510265A
(ja)
|
2011-02-02 |
2014-04-24 |
アムジェン インコーポレイテッド |
Igf−1rの阻害に関する方法および組成物
|
WO2012116040A1
(en)
|
2011-02-22 |
2012-08-30 |
OSI Pharmaceuticals, LLC |
Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors in hepatocellular carcinoma
|
WO2012129145A1
(en)
|
2011-03-18 |
2012-09-27 |
OSI Pharmaceuticals, LLC |
Nscle combination therapy
|
JP5908972B2
(ja)
|
2011-04-07 |
2016-04-26 |
アムジエン・インコーポレーテツド |
新規な抗原結合タンパク質
|
EP2702173A1
(en)
|
2011-04-25 |
2014-03-05 |
OSI Pharmaceuticals, LLC |
Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment
|
ES2723827T3
(es)
|
2011-11-11 |
2019-09-02 |
Univ Duke |
Terapia de combinación de fármacos para el tratamiento de tumores sólidos
|
US20130302274A1
(en)
|
2011-11-25 |
2013-11-14 |
Roche Glycart Ag |
Combination therapy
|
CN108404129A
(zh)
|
2012-02-23 |
2018-08-17 |
第三共欧洲有限公司 |
用于调节放射敏感性的her3抑制剂
|
AR090263A1
(es)
|
2012-03-08 |
2014-10-29 |
Hoffmann La Roche |
Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
EP3919079A1
(en)
|
2012-09-07 |
2021-12-08 |
Genentech, Inc. |
Combination therapy of a type ii anti-cd20 antibody with a selective bcl-2 inhibitor
|
US9180185B2
(en)
|
2013-01-11 |
2015-11-10 |
Hoffman-La Roche Inc. |
Combination therapy of anti-HER3 antibodies
|
WO2015100459A2
(en)
|
2013-12-27 |
2015-07-02 |
Merrimack Pharmaceuticals, Inc. |
Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies
|
BR112016021383A2
(pt)
|
2014-03-24 |
2017-10-03 |
Genentech Inc |
Método para identificar um paciente com câncer que é susceptível ou menos susceptível a responder ao tratamento com um antagonista de cmet, método para identificar um paciente apresentando câncer previamente tratado, método para determinar a expressão do biomarcador hgf, antagonista anti-c-met e seu uso, kit de diagnóstico e seu método de preparo
|
US10184006B2
(en)
|
2015-06-04 |
2019-01-22 |
Merrimack Pharmaceuticals, Inc. |
Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors
|
JP6910339B2
(ja)
|
2015-07-07 |
2021-07-28 |
ジェネンテック, インコーポレイテッド |
抗her2抗体−薬物複合体とbcl−2阻害剤の併用療法
|
CN108601752A
(zh)
|
2015-12-03 |
2018-09-28 |
安吉奥斯医药品有限公司 |
用于治疗mtap缺失型癌症的mat2a抑制剂
|
EP3405194A1
(en)
|
2016-01-18 |
2018-11-28 |
Institut National de la Sante et de la Recherche Medicale (INSERM) |
The use of a temporary inhibitor of p53 for preventing or reducing cancer relapse
|
CN116333130A
(zh)
|
2016-05-24 |
2023-06-27 |
英斯梅德股份有限公司 |
抗体及其制备方法
|
CN110891608A
(zh)
|
2017-07-26 |
2020-03-17 |
豪夫迈·罗氏有限公司 |
用BET抑制剂和Bcl-2抑制剂进行的组合疗法
|
CN110869391A
(zh)
|
2017-07-26 |
2020-03-06 |
豪夫迈·罗氏有限公司 |
用BET抑制剂,Bcl-2抑制剂和抗CD20抗体的组合疗法
|
WO2019062755A1
(en)
*
|
2017-09-29 |
2019-04-04 |
Wuxi Biologics (Shanghai) Co., Ltd. |
BISPECIFIC ANTIBODIES DIRECTED AGAINST EGFR AND PD-1
|
EP3781139A1
(en)
|
2018-04-18 |
2021-02-24 |
F. Hoffmann-La Roche AG |
Combination therapy with a bet inhibitor and a proteasome inhibitor
|
WO2020234445A1
(en)
|
2019-05-23 |
2020-11-26 |
F. Hoffmann-La Roche Ag |
Combination therapy with a bet inhibitor and a bcl-2 inhibitor
|
WO2021155006A1
(en)
|
2020-01-31 |
2021-08-05 |
Les Laboratoires Servier Sas |
Inhibitors of cyclin-dependent kinases and uses thereof
|