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GT200900292A - "inhibidores de cinasa p70 s6" - Google Patents

"inhibidores de cinasa p70 s6"

Info

Publication number
GT200900292A
GT200900292A GT200900292A GT200900292A GT200900292A GT 200900292 A GT200900292 A GT 200900292A GT 200900292 A GT200900292 A GT 200900292A GT 200900292 A GT200900292 A GT 200900292A GT 200900292 A GT200900292 A GT 200900292A
Authority
GT
Guatemala
Prior art keywords
kinase inhibitors
inhibitors
methods
pharmaceutical formulations
invention refers
Prior art date
Application number
GT200900292A
Other languages
English (en)
Inventor
Robert Dean Dally
Jianping Huang
Sojan Joseph
Timothy Alan Shepherd
Christian L Holst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200900292A publication Critical patent/GT200900292A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A INHIBIDORES DE CINASA P70 6 Y FORMULACIONES FARMACÉUTICAS QUE LOS COMPRENDEN Y MÉTODOS PARA SU USO.
GT200900292A 2007-05-11 2009-11-10 "inhibidores de cinasa p70 s6" GT200900292A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91733107P 2007-05-11 2007-05-11

Publications (1)

Publication Number Publication Date
GT200900292A true GT200900292A (es) 2011-06-24

Family

ID=39765082

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200900292A GT200900292A (es) 2007-05-11 2009-11-10 "inhibidores de cinasa p70 s6"

Country Status (34)

Country Link
US (2) US8093383B2 (es)
EP (1) EP2148880B1 (es)
JP (1) JP5503532B2 (es)
KR (1) KR101088219B1 (es)
CN (1) CN101679439B (es)
AR (1) AR066344A1 (es)
AU (1) AU2008251692B2 (es)
BR (1) BRPI0811212A2 (es)
CA (1) CA2687265C (es)
CL (1) CL2008001230A1 (es)
CO (1) CO6241109A2 (es)
CR (1) CR11106A (es)
DK (1) DK2148880T3 (es)
DO (1) DOP2009000257A (es)
EA (1) EA016445B1 (es)
EC (1) ECSP099721A (es)
ES (1) ES2483726T3 (es)
GT (1) GT200900292A (es)
HK (1) HK1140767A1 (es)
HR (1) HRP20140611T1 (es)
IL (1) IL201564A (es)
MA (1) MA31433B1 (es)
MX (1) MX2009012075A (es)
MY (1) MY154898A (es)
NZ (1) NZ580423A (es)
PE (1) PE20090887A1 (es)
PL (1) PL2148880T3 (es)
PT (1) PT2148880E (es)
RS (1) RS53451B (es)
SI (1) SI2148880T1 (es)
TN (1) TN2009000446A1 (es)
TW (1) TWI423805B (es)
UA (1) UA99284C2 (es)
WO (1) WO2008140947A1 (es)

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KR101945061B1 (ko) 2010-07-29 2019-02-01 메르크 파텐트 게엠베하 시클릭 아민 아자헤테로시클릭 카르복사미드
EA023821B1 (ru) 2010-11-24 2016-07-29 Мерк Патент Гмбх Хиназолинкарбоксамидазетидины, их применение в лечении гиперпролиферативных заболеваний и содержащие их композиции
RS56486B1 (sr) 2011-09-12 2018-01-31 Merck Patent Gmbh Aminopirimidin derivati za upotrebu kao modulatori aktivnosti kinaza
KR101995605B1 (ko) * 2011-09-12 2019-07-02 메르크 파텐트 게엠베하 키나아제 활성의 조절 인자로서 새로운 이미다졸 아민
CN104981247A (zh) 2012-09-06 2015-10-14 普莱希科公司 用于激酶调节的化合物和方法及其适应症
AU2013203714B2 (en) 2012-10-18 2015-12-03 Signal Pharmaceuticals, Llc Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
US9580443B2 (en) 2012-11-16 2017-02-28 Merck Patent Gmbh Heterocyclic derivatives as modulators of kinase activity
ES2656096T3 (es) 2012-11-16 2018-02-23 Merck Patent Gmbh Nuevos derivados de imidazol-piperidinilo como moduladores de la actividad de quinasa
CN105793254B (zh) 2012-11-29 2020-10-23 默克专利有限公司 氮杂喹唑啉羧酰胺衍生物
SG11201505999VA (en) * 2013-03-11 2015-08-28 Merck Patent Gmbh 6-[4-(1 h-imidazol-2-yl)piperidin-1 -yl]pyrimidin-4-amine derivatives as modulators of kinase activity
TW201527300A (zh) 2013-04-17 2015-07-16 Signal Pharm Llc 關於１－乙基－７－（２－甲基－６－（１Ｈ－１，２，４－三唑－３－基）吡啶－３－基）－３，４－二氫吡并［２，３－ｂ］吡－２（１Ｈ）－酮之醫藥調配物、方法、固態型式及使用方法
JP6382949B2 (ja) 2013-04-17 2018-08-29 シグナル ファーマシューティカルズ，エルエルシー 癌を治療するためのｔｏｒキナーゼ阻害剤及び５−置換キナゾリノン化合物を含む組合せ療法
KR102242505B1 (ko) 2013-04-17 2021-04-20 시그날 파마소티칼 엘엘씨 암 치료용 tor 키나제 억제제 및 시티딘 유사체를 포함하는 병용 요법
EP2986298A1 (en) 2013-04-17 2016-02-24 Signal Pharmaceuticals, LLC Treatment of cancer with dihydropyrazino-pyrazines
MX2015014455A (es) 2013-04-17 2016-07-21 Signal Pharm Llc Terapia de combinacion que comprende un inhibidor de tor cinasa y n-(3-(5-fluoro-2-(4-(2-metoxietoxi)fenilamino)pirimidin-4-ilamino )fenil)acrilamida para tratar cancer.
NZ629469A (en) 2013-04-17 2017-05-26 Signal Pharm Llc Methods for treating cancer using dihydropyrazino-pyrazine compound combination therapy
JP6382945B2 (ja) 2013-04-17 2018-08-29 シグナル ファーマシューティカルズ，エルエルシー ジヒドロピラジノ−ピラジンによる癌治療
NZ629486A (en) 2013-05-29 2017-11-24 Signal Pharm Llc Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use
WO2015134536A1 (en) * 2014-03-04 2015-09-11 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
ES2768900T3 (es) 2014-04-03 2020-06-24 Merck Patent Gmbh Combinaciones de agentes terapéuticos contra cáncer
US9512129B2 (en) 2014-04-16 2016-12-06 Signal Pharmaceuticals, Llc Solid forms comprising 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one and a coformer
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WO2016040078A1 (en) * 2014-09-10 2016-03-17 Eli Lilly And Company Substituted phenyl imidazolyl piperidyl compounds as p70s6k1 inhibitors
WO2016164641A1 (en) 2015-04-08 2016-10-13 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
CN106187899B (zh) * 2016-06-28 2019-07-16 绍兴文理学院 一种氟代氮杂芳烃的合成方法
EA202090103A1 (ru) 2017-06-22 2020-04-24 Селджин Корпорейшн Лечение гепатоцеллюлярной карциномы, которая характеризуется вирусной инфекцией гепатита b
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Also Published As

Publication number Publication date
ES2483726T3 (es) 2014-08-07
TWI423805B (zh) 2014-01-21
PE20090887A1 (es) 2009-07-13
MA31433B1 (fr) 2010-06-01
MY154898A (en) 2015-08-28
EP2148880B1 (en) 2014-05-28
CO6241109A2 (es) 2011-01-20
BRPI0811212A2 (pt) 2014-10-29
AU2008251692A1 (en) 2008-11-20
TW200848053A (en) 2008-12-16
MX2009012075A (es) 2009-11-19
ECSP099721A (es) 2009-12-28
IL201564A0 (en) 2010-05-31
IL201564A (en) 2014-08-31
HK1140767A1 (en) 2010-10-22
KR20100005710A (ko) 2010-01-15
JP2010526814A (ja) 2010-08-05
TN2009000446A1 (en) 2011-03-31
CL2008001230A1 (es) 2009-05-22
KR101088219B1 (ko) 2011-11-30
EP2148880A1 (en) 2010-02-03
US20090163714A1 (en) 2009-06-25
CR11106A (es) 2010-04-12
US20120071490A1 (en) 2012-03-22
CN101679439B (zh) 2013-09-11
US8093383B2 (en) 2012-01-10
JP5503532B2 (ja) 2014-05-28
EA016445B1 (ru) 2012-05-30
CA2687265C (en) 2012-12-04
AR066344A1 (es) 2009-08-12
EA200971051A1 (ru) 2010-06-30
AU2008251692B2 (en) 2012-10-11
UA99284C2 (ru) 2012-08-10
WO2008140947A1 (en) 2008-11-20
CN101679439A (zh) 2010-03-24
PT2148880E (pt) 2014-08-28
DK2148880T3 (da) 2014-06-16
SI2148880T1 (sl) 2014-07-31
CA2687265A1 (en) 2008-11-20
PL2148880T3 (pl) 2014-10-31
HRP20140611T1 (hr) 2014-08-15
RS53451B (en) 2014-12-31
NZ580423A (en) 2012-02-24
DOP2009000257A (es) 2010-03-31

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