[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

GT200300075AA - COMPOUNDS THAT MODULATE PPAR ACTIVITY AND PROCEDURES FOR PREPARATION (FRACTIONARY PATENT NO. 1 OF APPLICATION NO. PI-20030075) - Google Patents

COMPOUNDS THAT MODULATE PPAR ACTIVITY AND PROCEDURES FOR PREPARATION (FRACTIONARY PATENT NO. 1 OF APPLICATION NO. PI-20030075)

Info

Publication number
GT200300075AA
GT200300075AA GT200300075AK GT200300075K GT200300075AA GT 200300075A A GT200300075A A GT 200300075AA GT 200300075A K GT200300075A K GT 200300075AK GT 200300075 K GT200300075 K GT 200300075K GT 200300075A A GT200300075A A GT 200300075AA
Authority
GT
Guatemala
Prior art keywords
compounds
procedures
therapy
preparation
fractionary
Prior art date
Application number
GT200300075AK
Other languages
Spanish (es)
Inventor
Gary Frederick Filzen
Bharat Kalidas Trivedi
Andrew George Geyer
Paul Charles Unangst
Larry Don Bratton
Bruce Jeffrey Auerbach
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of GT200300075AA publication Critical patent/GT200300075AA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/19—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C07C59/70—Ethers of hydroxy-acetic acid, e.g. substitutes on the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

LA INVENCIÓN SE REFIERE A COMPUESTOS QUE ALTERAN LA ACTIVIDAD DE PPAR. LA INVENCIÓN TAMBIÉN SE REFIERE A LAS SALES FARMACÉUTICAMENTE ACEPTABLES DE LOS COMPUESTOS, LAS COMPOSICIONES FARMACÉUTICAMENTE ACEPTABLES QUE COMPRENDEN LOS COMPUESTOS O SUS SALES, Y LOS PROCEDIMIENTOS DE UTILIZACIÓN DE ÉSTOS COMO AGENTES TERAPÉUTICOS PARA TRATAR O PREVENIR LA HIPERLIPIDEMIA, LA HIPERCOLESTEREMIA , LA OBESIDAD, LOS TRASTORNOS ALIMENTARIOS, LA HIPERGLUCEMIA, LA ATEROSCLEROSIS, LA HIPERTRIGLICERIDEMIA, LA HIPERINSULINEMIA Y LA DIABETES EN UN MAMÍFERO, ASÍ COM PROCEDIMIENTOS PARA SUPRIMIR EL APETITO Y MODULAR LOS NIVELES DE LEPTINA EN UN MAMÍFERO. LA PRESENTE INVENCIÓN SE REFIERE TAMBIÉN A PROCEDIMIENTOS PARA LA ELABORACIÓN DE LOS COMPUESTOS DESCRITOS.THE INVENTION REFERS TO COMPOUNDS THAT ALTER THE ACTIVITY OF PPAR. THE INVENTION ALSO REFERS TO THE PHARMACEUTICALLY ACCEPTABLE SALTS OF THE COMPOUNDS, THE PHARMACEUTICALLY ACCEPTABLE COMPOSITIONS THAT UNDERSTAND THE COMPOUNDS OR THEIR SALTS, AND THE PROCEDURES FOR USE OF THESE AS AGENTS THERAPY THREE-THREE-THREE-DAY HOPE, THERAPY THERAPY THERAPY THERAPY THERAPY THERAPY THERAPY THREE-DUTY, THE THREE-THREE-PIECES FOOD DISORDERS, HYPERGLUCEMIA, ATEROSCLEROSIS, HYPERTRIGLICERIDEMIA, HYPERINSULINEMIA AND DIABETES IN A MAMMERE, AS WELL AS PROCEDURES TO SUPPRESS THE APPETIZE AND MODULATE A LAMPHIN LEVEL. THIS INVENTION REFERS TO PROCEDURES FOR THE PREPARATION OF THE DESCRIBED COMPOUNDS.

GT200300075AK 2002-04-05 2003-04-01 COMPOUNDS THAT MODULATE PPAR ACTIVITY AND PROCEDURES FOR PREPARATION (FRACTIONARY PATENT NO. 1 OF APPLICATION NO. PI-20030075) GT200300075AA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37050802P 2002-04-05 2002-04-05
US38602602P 2002-06-05 2002-06-05

Publications (1)

Publication Number Publication Date
GT200300075AA true GT200300075AA (en) 2006-08-23

Family

ID=28794388

Family Applications (3)

Application Number Title Priority Date Filing Date
GT200300075BL GT200300075BA (en) 2002-04-05 2003-04-01 COMPOUNDS THAT MODULATE PPAR ACTIVITY AND PROCEDURES FOR THEIR PREPARATION (FRACTIONARY PATENT NO. 2 OF THE APPLICATION NO. PI-20030075)
GT200300075AK GT200300075AA (en) 2002-04-05 2003-04-01 COMPOUNDS THAT MODULATE PPAR ACTIVITY AND PROCEDURES FOR PREPARATION (FRACTIONARY PATENT NO. 1 OF APPLICATION NO. PI-20030075)
GT200300075A GT200300075A (en) 2002-04-05 2003-04-01 COMPOUNDS THAT MODULATE PPAR ACTIVITY AND PROCEDURES FOR PREPARATION

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GT200300075BL GT200300075BA (en) 2002-04-05 2003-04-01 COMPOUNDS THAT MODULATE PPAR ACTIVITY AND PROCEDURES FOR THEIR PREPARATION (FRACTIONARY PATENT NO. 2 OF THE APPLICATION NO. PI-20030075)

Family Applications After (1)

Application Number Title Priority Date Filing Date
GT200300075A GT200300075A (en) 2002-04-05 2003-04-01 COMPOUNDS THAT MODULATE PPAR ACTIVITY AND PROCEDURES FOR PREPARATION

Country Status (35)

Country Link
US (4) US6875780B2 (en)
EP (1) EP1494989A2 (en)
JP (2) JP3816922B2 (en)
KR (1) KR100687166B1 (en)
CN (1) CN1649820A (en)
AP (1) AP1772A (en)
AR (1) AR039239A1 (en)
AU (1) AU2003212578A1 (en)
BR (1) BR0309169A (en)
CA (1) CA2481246C (en)
CO (1) CO5640080A2 (en)
DO (1) DOP2003000620A (en)
EA (2) EA200700969A1 (en)
GE (1) GEP20074244B (en)
GT (3) GT200300075BA (en)
HN (1) HN2003000113A (en)
HR (1) HRP20040916A2 (en)
IL (1) IL164015A0 (en)
IS (1) IS7429A (en)
MA (1) MA27189A1 (en)
MX (1) MXPA04009727A (en)
MY (1) MY134199A (en)
NI (1) NI200300042A (en)
NO (1) NO20044795L (en)
NZ (1) NZ554477A (en)
OA (1) OA12859A (en)
PA (1) PA8570701A1 (en)
PE (1) PE20040307A1 (en)
PL (1) PL373651A1 (en)
RS (1) RS82904A (en)
TN (1) TNSN04191A1 (en)
TW (1) TWI249522B (en)
UA (1) UA76838C2 (en)
UY (1) UY27749A1 (en)
WO (1) WO2003084916A2 (en)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7517884B2 (en) * 1998-03-30 2009-04-14 Kalypsys Inc. Sulfonyl-substituted bicyclic compounds as modulators of PPAR
GB0029974D0 (en) * 2000-12-08 2001-01-24 Glaxo Group Ltd Chemical compounds
BR0212512A (en) 2001-09-14 2004-10-26 Tularik Inc Compound, pharmaceutical composition and methods for treating a disorder, condition or disease, raising hdl cholesterol levels, reducing triglyceride levels, treating diabetes, decreasing insulin resistance or lowering blood pressure and modulating ppardelta
US6833380B2 (en) 2002-03-07 2004-12-21 Warner-Lambert Company, Llc Compounds that modulate PPAR activity and methods of preparation
BR0305570A (en) * 2002-06-24 2004-09-28 Sugatsune Kogyo Storage device or umbrella holder and lock used on it
EP1583746A1 (en) * 2003-01-06 2005-10-12 Eli Lilly And Company A pyrazole derivative as ppar modulator
US7244763B2 (en) * 2003-04-17 2007-07-17 Warner Lambert Company Llc Compounds that modulate PPAR activity and methods of preparation
EP1630152A4 (en) * 2003-05-30 2009-09-23 Takeda Pharmaceutical Condensed ring compound
ES2328581T3 (en) 2003-09-19 2009-11-16 Janssen Pharmaceutica Nv ACIDS 4 - ((FHENOXIALQUIL) UNCLE) -PHENOXYACETICS AND ANALOGS.
JP2007509921A (en) * 2003-10-28 2007-04-19 ドクター・レディーズ・ラボラトリーズ・リミテッド Novel compounds and their use in medicine: methods for preparing them and pharmaceutical compositions containing them
JP2007527416A (en) 2003-10-31 2007-09-27 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Phenoxyacetic acid derivatives useful as peroxisome proliferator-activated receptor (PPAR) dual agonists
CA2543247A1 (en) * 2003-11-05 2005-06-02 F. Hoffmann-La Roche Ag Benzannelated compounds as ppar activators
WO2005049573A1 (en) * 2003-11-05 2005-06-02 F. Hoffmann-La Roche Ag Phenyl derivatives as ppar agonists
WO2005049606A1 (en) * 2003-11-05 2005-06-02 F. Hoffmann-La Roche Ag Heteroaryl derivatives as ppar activators
WO2005054213A1 (en) * 2003-12-02 2005-06-16 Shionogi & Co., Ltd. Isoxazole derivative having agonistic activity against peroxisome proliferator-activated receptor
EP1706386A1 (en) * 2003-12-22 2006-10-04 Eli Lilly And Company Bicyclic derivatives as ppar modulators
US7507832B2 (en) 2003-12-22 2009-03-24 Eli Lilly And Company Triazole PPAR modulators
TW200523247A (en) * 2003-12-25 2005-07-16 Takeda Pharmaceutical 3-(4-benzyloxyphenyl) propanoic acid derivatives
GB0403148D0 (en) * 2004-02-12 2004-03-17 Smithkline Beecham Corp Chemical compounds
ES2433466T3 (en) * 2004-02-27 2013-12-11 Amgen, Inc Compounds, pharmaceutical compositions and methods for use in the treatment of metabolic disorders
WO2005085235A1 (en) * 2004-03-09 2005-09-15 F. Hoffmann-La Roche Ag Pyrazolyl indolyl derivatives as ppar activators
US7119214B2 (en) * 2004-04-13 2006-10-10 Cephalon France Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
JP4981662B2 (en) * 2004-05-05 2012-07-25 ハイ・ポイント・ファーマスーティカルズ、エルエルシー New compounds, their preparation and use
ES2352085T3 (en) * 2004-05-05 2011-02-15 High Point Pharmaceuticals, Llc NEW COMPOUNDS, THEIR PREPARATION AND USE.
ATE475642T1 (en) * 2004-05-05 2010-08-15 High Point Pharmaceuticals Llc PHENOXYACETIC ACID DERIVATIVES AS PPAR AGONISTS
BRPI0511099A (en) * 2004-05-14 2007-12-26 Irm Llc compounds and compositions as modulators of ppar
CN1980894A (en) 2004-05-14 2007-06-13 Irm责任有限公司 Compounds and compositions as PPAR modulators
JP2008500328A (en) * 2004-05-25 2008-01-10 ファイザー・プロダクツ・インク New use
WO2005115384A2 (en) * 2004-05-25 2005-12-08 Metabolex, Inc. Bicyclic, substituted triazoles as modulators of ppar and methods of their preparation
CN1997633A (en) * 2004-05-25 2007-07-11 麦它波莱克斯股份有限公司 Substituted triazoles as modulators of PPAR and methods of their preparation
AU2005259579A1 (en) * 2004-07-01 2006-01-12 F. Hoffmann-La Roche Ag Phenyl derivatives comprising an acetylene group
US7622491B2 (en) * 2004-08-13 2009-11-24 Metabolex Inc. Modulators of PPAR and methods of their preparation
MY145712A (en) * 2004-09-15 2012-03-30 Janssen Pharmaceutica Nv 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs
HUE039584T2 (en) 2004-10-29 2019-01-28 Kalypsys Inc Sulfonyl-substituted bicyclic compounds as modulators of ppar
US20070190079A1 (en) * 2004-10-29 2007-08-16 Kalypsys, Inc. Methods for the selective modulation of ppar
BRPI0518300A2 (en) * 2004-11-23 2008-11-11 Warner Lambert Co 7- (2h-pyrazol-3-yl) -3,5-dihydroxyheptanoic acid derivatives as hmg co-reductase inhibitors for the treatment of lipidemia
US7465804B2 (en) * 2005-05-20 2008-12-16 Amgen Inc. Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders
US7943669B2 (en) * 2005-06-30 2011-05-17 High Point Pharmaceuticals, Llc Phenoxy acetic acids as PPAR delta activators
KR20080042170A (en) * 2005-09-07 2008-05-14 플렉시콘, 인코퍼레이티드 Ppar active compounds
JO3006B1 (en) * 2005-09-14 2016-09-05 Janssen Pharmaceutica Nv Novel Lysine Salts of 4-((Phenoxy Alkyl)Thio)-Phenoxy Acetic Acid Derivatives
WO2007033002A1 (en) * 2005-09-14 2007-03-22 Amgen Inc. Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
DK1940815T3 (en) * 2005-10-25 2018-11-05 Kalypsys Inc SALTS OF MODULATORS OF PPAR AND PROCEDURES FOR TREATMENT OF SUBSTITUTE DISEASES
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
CN103224477A (en) 2005-12-22 2013-07-31 高点制药有限责任公司 Phenoxy acetic acids as PPAR delta activators
CN101007798B (en) * 2006-01-24 2011-01-26 中国人民解放军军事医学科学院毒物药物研究所 Benzodioxole derivatives and their preparation method and medicinal uses
CA2645719A1 (en) * 2006-03-09 2007-09-13 High Point Pharmaceuticals, Llc Compounds that modulate ppar activity, their preparation and use
US8383660B2 (en) 2006-03-10 2013-02-26 Pfizer Inc. Dibenzyl amine compounds and derivatives
AU2007225208A1 (en) * 2006-03-14 2007-09-20 Amgen Inc. Bicyclic carboxylic acid derivatives useful for treating metabolic disorders
UY30288A1 (en) * 2006-04-18 2007-08-31 Janssen Pharmaceutica Nv DERIVATIVES OF BENZOAZEPIN-OXI-ACETIC ACID AS PPAR-DELTA AGONISTS USED TO INCREASE HDL-C. REDUCE LDL-C AND REDUCE CHOLESTEROL
US20070249519A1 (en) * 2006-04-20 2007-10-25 Kalypsys, Inc. Methods for the upregulation of glut4 via modulation of ppar delta in adipose tissue and for the treatment of disease
AR060937A1 (en) * 2006-05-16 2008-07-23 Kalypsys Inc SUBSTITUTED BICYCLIC COMPOUNDS WITH SULFONYL AS PPAR MODULATORS
US7714008B2 (en) 2006-09-07 2010-05-11 Amgen Inc. Heterocyclic GPR40 modulators
CA2662242C (en) * 2006-09-07 2012-06-12 Amgen Inc. Benzo-fused compounds for use in treating metabolic disorders
ES2382009T3 (en) 2006-12-01 2012-06-04 Bristol-Myers Squibb Company N - ((3-Benzyl) -2,2- (bis-phenyl -) - propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
CA2669639A1 (en) 2006-12-02 2008-06-05 Seoul National University Industry Foundation Aryl compounds as ppar ligands and their use
WO2008091863A1 (en) 2007-01-23 2008-07-31 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis
EP2129667A2 (en) * 2007-02-23 2009-12-09 Eli Lilly And Company Peroxisome proliferator activated receptor modulators
AU2008226844A1 (en) * 2007-03-13 2008-09-18 Merck Sharp & Dohme Corp. Inhibitors of janus kinases and/or 3-phosphoinositide-dependent protein kinase-1
CA2683751C (en) * 2007-04-16 2013-01-08 Amgen Inc. Substituted biphenyl phenoxy-, thiophenyl- and aminophenylpropanoic acid gpr40 modulators
EP2184277B1 (en) * 2007-07-25 2015-07-01 Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China Aryl pyrimidine derivatives, preparation methods and pharmaceutical uses thereof
CN102083783A (en) 2007-10-10 2011-06-01 安姆根有限公司 Substituted biphenyl GPR40 modulators
AU2008338963A1 (en) * 2007-12-13 2009-06-25 Sri International PPAR-delta ligands and methods of their use
CA2716352C (en) * 2008-03-06 2013-05-28 Amgen Inc. Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders
EP2310371B1 (en) 2008-05-26 2013-05-15 Genfit Ppar agonist compounds and preparation and uses thereof for treating diabetes and/or dyslipidemia
WO2010018547A1 (en) * 2008-08-13 2010-02-18 Pfizer Inc. Aminoquinoline compounds
AU2009303475B2 (en) * 2008-10-15 2012-09-13 Amgen Inc. Spirocyclic GPR40 modulators
WO2012178142A1 (en) * 2011-06-23 2012-12-27 Metabolic Solutions Development Company, Llc Ppar-sparing compounds and combinations fort the treatment of diabetes and other metabolic diseases
KR20150036407A (en) * 2012-07-06 2015-04-07 메르크 파텐트 게엠베하 Bimesogenic compounds and mesogenic media
BR112015026513A2 (en) 2013-04-17 2017-07-25 Pfizer n-piperidin-3-ylbenzamide derivatives to treat cardiovascular disease
US9487493B2 (en) 2013-09-09 2016-11-08 Vtv Therapeutics Llc Use of a PPAR-delta agonist for treating muscle atrophy
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
CN106831437B (en) * 2016-02-03 2019-06-21 华中师范大学 Ester type compound and its preparation method and application containing nitroethenyl group
UY37806A (en) 2017-07-11 2020-01-31 Vertex Pharma CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS
WO2019058393A1 (en) 2017-09-22 2019-03-28 Jubilant Biosys Limited Heterocyclic compounds as pad inhibitors
FI3697785T3 (en) 2017-10-18 2023-04-03 Jubilant Epipad LLC Imidazo-pyridine compounds as pad inhibitors
US11629135B2 (en) 2017-11-06 2023-04-18 Jubilant Prodell Llc Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation
WO2019102494A1 (en) 2017-11-24 2019-05-31 Jubilant Biosys Limited Heterocyclic compounds as prmt5 inhibitors
SG11202008950PA (en) 2018-03-13 2020-10-29 Jubilant Prodel LLC Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation
MX2021008533A (en) 2019-01-18 2021-08-19 Astrazeneca Ab Pcsk9 inhibitors and methods of use thereof.
CA3145378A1 (en) * 2019-06-28 2020-12-30 Sumitomo Chemical Company, Limited Acrylate derivative, use and production intermediate compound of the same
CN112824394B (en) * 2019-11-21 2024-08-13 中国科学院上海药物研究所 PPARs-FXR multi-target small molecule agonist and preparation method and application thereof
IL300000A (en) 2020-07-22 2023-03-01 Reneo Pharmaceuticals Inc Crystalline ppar-delta agonist
WO2023147309A1 (en) 2022-01-25 2023-08-03 Reneo Pharmaceuticals, Inc. Use of ppar-delta agonists in the treatment of disease

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3526235A1 (en) 1984-11-16 1986-05-22 Bayer Ag, 5090 Leverkusen LIQUID CRYSTAL COMPOSITIONS
DE4002374C2 (en) 1990-01-27 1999-04-15 Merck Patent Gmbh Partially fluorinated compounds and their use as a component of liquid crystalline media
DE4222565A1 (en) 1992-07-09 1994-01-13 Hoechst Ag Meta-substituted six-membered aromatics for use in liquid-crystal mixtures
JP3187611B2 (en) 1993-05-17 2001-07-11 キヤノン株式会社 Liquid crystal compound, liquid crystal composition containing the same, liquid crystal element having the same, display method and display device using them
HUT75028A (en) 1994-08-04 1997-03-28 Sumitomo Chemical Co Dihalopropene compounds, insecticidal/acaricidal agents containing same, and intermediates for their production
JPH09194418A (en) 1996-01-18 1997-07-29 Sumitomo Chem Co Ltd Dihalopropene compound, its use and its production intermediate
WO1997028149A1 (en) 1996-02-02 1997-08-07 Merck & Co., Inc. Method for raising hdl cholesterol levels
AU708055B2 (en) 1996-02-02 1999-07-29 Merck & Co., Inc. Heterocyclic derivatives as antidiabetic and antiobesity agents
WO1998007699A1 (en) 1996-08-19 1998-02-26 Japan Tobacco Inc. Propionic acid derivatives and applications thereof
ATE451346T1 (en) 1998-03-10 2009-12-15 Ono Pharmaceutical Co CARBOXYLIC ACID DERIVATIVES AND MEDICATIONS THAT CONTAIN THEM AS THE ACTIVE INGREDIENTS
GB9914977D0 (en) 1999-06-25 1999-08-25 Glaxo Group Ltd Chemical compounds
AU7073400A (en) 1999-08-27 2001-03-26 Eli Lilly And Company Biaryl-oxa(thia)zole derivatives and their use as ppars modulators
AU7962200A (en) * 1999-10-29 2001-05-14 Wakunaga Pharmaceutical Co., Ltd Novel indole derivatives and drugs containing the same as the active ingredient
GB0031107D0 (en) 2000-12-20 2001-01-31 Glaxo Group Ltd Chemical compounds
GB0031109D0 (en) 2000-12-20 2001-01-31 Glaxo Group Ltd Chemical compounds
GB0111523D0 (en) 2001-05-11 2001-07-04 Glaxo Group Ltd Chemical compounds
HUP0400268A2 (en) 2001-06-07 2004-07-28 Eli Lilly And Co. Modulators of peroxisome proliferator activated receptors (ppar), their use and pharmaceutical compositions containing them
BR0212512A (en) 2001-09-14 2004-10-26 Tularik Inc Compound, pharmaceutical composition and methods for treating a disorder, condition or disease, raising hdl cholesterol levels, reducing triglyceride levels, treating diabetes, decreasing insulin resistance or lowering blood pressure and modulating ppardelta
US20030207924A1 (en) 2002-03-07 2003-11-06 Xue-Min Cheng Compounds that modulate PPAR activity and methods of preparation
US6867224B2 (en) 2002-03-07 2005-03-15 Warner-Lambert Company Compounds that modulate PPAR activity and methods of preparation
US6833380B2 (en) 2002-03-07 2004-12-21 Warner-Lambert Company, Llc Compounds that modulate PPAR activity and methods of preparation

Also Published As

Publication number Publication date
CA2481246A1 (en) 2003-10-16
UY27749A1 (en) 2003-11-28
US20050113440A1 (en) 2005-05-26
IS7429A (en) 2004-08-30
EA200401153A1 (en) 2005-04-28
WO2003084916A3 (en) 2003-12-24
US20050153996A1 (en) 2005-07-14
EA009518B1 (en) 2008-02-28
JP2006151985A (en) 2006-06-15
JP3816922B2 (en) 2006-08-30
TNSN04191A1 (en) 2007-03-12
HN2003000113A (en) 2004-05-05
EP1494989A2 (en) 2005-01-12
US6875780B2 (en) 2005-04-05
US6964983B2 (en) 2005-11-15
CN1649820A (en) 2005-08-03
NO20044795L (en) 2004-11-04
GT200300075BA (en) 2006-08-23
UA76838C2 (en) 2006-09-15
AP2004003135A0 (en) 2004-09-30
HRP20040916A2 (en) 2004-12-31
US6939875B2 (en) 2005-09-06
AP1772A (en) 2007-08-27
IL164015A0 (en) 2005-12-18
MA27189A1 (en) 2005-01-03
KR100687166B1 (en) 2007-02-28
GEP20074244B (en) 2007-11-26
USRE39916E1 (en) 2007-11-06
JP2005521741A (en) 2005-07-21
TW200403220A (en) 2004-03-01
RS82904A (en) 2007-02-05
CO5640080A2 (en) 2006-05-31
PA8570701A1 (en) 2003-12-19
OA12859A (en) 2006-09-15
BR0309169A (en) 2005-01-25
KR20040105842A (en) 2004-12-16
PL373651A1 (en) 2005-09-05
DOP2003000620A (en) 2003-10-15
MXPA04009727A (en) 2005-01-11
PE20040307A1 (en) 2004-05-19
WO2003084916A2 (en) 2003-10-16
TWI249522B (en) 2006-02-21
NI200300042A (en) 2005-11-01
US20030225158A1 (en) 2003-12-04
NZ554477A (en) 2008-09-26
CA2481246C (en) 2008-07-22
MY134199A (en) 2007-11-30
AU2003212578A1 (en) 2003-10-20
AR039239A1 (en) 2005-02-16
EA200700969A1 (en) 2008-02-28
GT200300075A (en) 2004-02-12

Similar Documents

Publication Publication Date Title
GT200300075AA (en) COMPOUNDS THAT MODULATE PPAR ACTIVITY AND PROCEDURES FOR PREPARATION (FRACTIONARY PATENT NO. 1 OF APPLICATION NO. PI-20030075)
PA8567801A1 (en) COMPOUNDS THAT MODULATE THE ACTIVITY OF PPAR
ECSP045004A (en) INHIBITORS OF THE 17BETA-HYDROXIESTEROID DEHYDROGENASE TYPE 3 FOR THE TREATMENT OF DEPENDING ANDROGEN DISEASES
PA8568701A1 (en) COMPOUNDS THAT MODULATE THE ACTIVITY OF PPAR
PA8575401A1 (en) DERIVATIVES OF BENZOCONDENSED HETEROARILAMIDE OF USEFUL TIENOPIRIDINS AS THERAPEUTIC AGENTS, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THE SAME AND METHODS FOR USE
PA8568601A1 (en) COMPOUNDS THAT MODULATE THE ACTIVITY OF PPAR
DK1723144T3 (en) Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
AR038047A1 (en) THERAPEUTIC AGENTS
CR8497A (en) DERIVATIVES OF AZEPINOINDOL AS PHARMACEUTICAL AGENTS
SV2004001691A (en) NEW DERIVATIVES OF AROMATIC FLUOROGLYCOSIDS, MEDICINES CONTAINING COMPOUNDS AND THEIR USES
CR9667A (en) BENZAMIDA DERIVATIVES AND USES RELATED TO THE SAME
UY29182A1 (en) "DERIVATIVES OF REPLACED BENCENOSULPHONAMIDS, COMPOSITIONS THAT CONTAIN THEM, PREPARATION PROCEDURES AND APPLICATIONS"
CR8858A (en) SULFAMATE AND SULFAMIDE DERIVATIVES FOR THE TREATMENT OF EPILEPSY AND RELATED DISORDERS
UY27300A1 (en) NEW DERIVATIVES OF QUINOLINA
AR028810A1 (en) DERIVATIVES OF ARILPIPERAZINIL-CICLOHEXIL INDOL, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM AND THE USE OF THE SAME FOR THE MANUFACTURE OF MEDICINES FOR THE TREATMENT OF DEPRESSION
ECSP066392A (en)
HN2005000255A (en) USED PIRROLOTRIAZINE DERIVATIVES TO TREAT HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS
DK1694318T3 (en) (S) -2-N-propylamino-5-hydroxytetraline as D3 agonist therapeutic
UY29790A1 (en) DIARILOIMIDAZOLA-4-CARBOXAMID SALTS, COMPOSITIONS THAT CONTAIN THEM, PREPARATION PROCESSES AND APPLICATIONS
HN2003000063A (en) NICOTINAMIDE DERIVATIVES AND A COMBINATION TIOTROPIO SALT FOR THE TREATMENT OF DISEASES.
UY28098A1 (en) USEFUL ANILINOPIRAZOL DERIVATIVES IN THE TREATMENT OF DIABETES
CO5611124A2 (en) BENZOFURAN DERIVATIVES SUBSTITUTED USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS
ECSP088250A (en) DERIVATIVES OF PIRAZOL AS THERAPEUTIC AGENTS
DOP2006000287A (en) PIPERIDINE DERIVATIVES
ECSP055985A (en) ACID DERIVATIVES 3-METHYL-2- (3- (2-PHENYL-OXAZOL-4-ILMETOXI) -CICLOHEXANOCARBONIL-AMINOBUTÍRICO AND RELATED COMPOUNDS AS PPAR MODULATORS FOR THE TREATMENT OF TYPE 2 DIABETES AND ATEROSCLEROSIS