[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

GT200000161A - Compuestos para el tratamiento de la isquemia. - Google Patents

Compuestos para el tratamiento de la isquemia.

Info

Publication number
GT200000161A
GT200000161A GT200000161A GT200000161A GT200000161A GT 200000161 A GT200000161 A GT 200000161A GT 200000161 A GT200000161 A GT 200000161A GT 200000161 A GT200000161 A GT 200000161A GT 200000161 A GT200000161 A GT 200000161A
Authority
GT
Guatemala
Prior art keywords
compounds
agonists
profarmacos
discussion
ischemia
Prior art date
Application number
GT200000161A
Other languages
English (en)
Inventor
Hiroko Masamune
Michael Paul Deninno
Robert William Scott
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200000161A publication Critical patent/GT200000161A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32Nitrogen atom
    • C07D473/34Nitrogen atom attached in position 6, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28Oxygen atom
    • C07D473/30Oxygen atom attached in position 6, e.g. hypoxanthine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Genetics & Genomics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

ESTA INVENCION SE REFIERE A COMPUESTOS DE LA FORMULA ADJUNTA, PROFARMACOS DE LOS MISMOS Y SALES FARMACEUTICAMENTE ACEPTABLES DE DICHOS COMPUESTOS Y DE DICHOS PROFARMACOS, EN LA QUE X = OXI, METILENO O TIO; Y = CH O N; Z = ES H, ALQUILO, TRIFLUOROMETILO O HALO; LAS DEMAS LETRAS REPRESENTAN UNA GRAN VARIEDAD DE SUSTITUYENTES QUE INDIVIDUAL O CONJUNTAMENTE FORMAN PARTE DE LAS CARACTERISTICAS DE ESTE INGREDIENTE ACTIVO Y DEBERAN COTEJARSE EN EL DOCUMENTO ORIGINAL, LOS COMPUESTOS SON AGONISTAS DE A3 UTILES PARA LA REDUCCION DE LESIONES DE TEJIDOS PRODUCIDAS POR ISQUEMIA O HIPOXIA DE LOS TEJIDOS. EL INVENTO REIVINDICA ADEMAS DEL PROCEDIMIENTO DE SINTESIS DE LOS DIFERENTES COMPUESTOS, LOS PROCEDIMIENTOS PARA USAR TALES AGONISTAS, Y COMPOSICIONES FARMACEUTICAS QUE CONTIENEN TALES AGONISTAS DE A3.
GT200000161A 1999-09-30 2000-09-28 Compuestos para el tratamiento de la isquemia. GT200000161A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15682899P 1999-09-30 1999-09-30

Publications (1)

Publication Number Publication Date
GT200000161A true GT200000161A (es) 2002-03-22

Family

ID=22561263

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200000161A GT200000161A (es) 1999-09-30 2000-09-28 Compuestos para el tratamiento de la isquemia.

Country Status (41)

Country Link
EP (1) EP1216257B1 (es)
JP (1) JP2003510331A (es)
KR (1) KR100481605B1 (es)
CN (1) CN1374967A (es)
AP (1) AP2002002458A0 (es)
AR (1) AR029887A1 (es)
AT (1) ATE312117T1 (es)
AU (1) AU778185B2 (es)
BG (1) BG106636A (es)
BR (1) BR0014384A (es)
CA (1) CA2386079A1 (es)
CO (1) CO5180581A1 (es)
CR (1) CR6592A (es)
CZ (1) CZ20021020A3 (es)
DE (1) DE60024649D1 (es)
EA (1) EA005422B1 (es)
EC (1) ECSP003682A (es)
EE (1) EE200200172A (es)
GE (1) GEP20043241B (es)
GT (1) GT200000161A (es)
HK (1) HK1049011A1 (es)
HR (1) HRP20020253A2 (es)
HU (1) HUP0202807A3 (es)
IL (1) IL148222A0 (es)
IS (1) IS6286A (es)
MA (1) MA26822A1 (es)
MX (1) MXPA02003308A (es)
MY (1) MY133996A (es)
NO (1) NO20021474L (es)
NZ (1) NZ517177A (es)
OA (1) OA12021A (es)
PA (1) PA8503301A1 (es)
PE (1) PE20010696A1 (es)
PL (1) PL357371A1 (es)
SK (1) SK4182002A3 (es)
TN (1) TNSN00191A1 (es)
TR (1) TR200200843T2 (es)
UA (1) UA73525C2 (es)
WO (1) WO2001023399A1 (es)
YU (1) YU23102A (es)
ZA (1) ZA200202461B (es)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6803457B1 (en) 1999-09-30 2004-10-12 Pfizer, Inc. Compounds for the treatment of ischemia
EP1241176A1 (en) * 2001-03-16 2002-09-18 Pfizer Products Inc. Purine derivatives for the treatment of ischemia
WO2003039528A1 (en) * 2001-11-02 2003-05-15 Aventis Pharmaceuticals Inc. Pharmaceutical composition comprising an adenosine a1/a2 agonist and a sodium hydrogen exchanger inhibitor
US7414036B2 (en) 2002-01-25 2008-08-19 Muscagen Limited Compounds useful as A3 adenosine receptor agonists
WO2003088978A1 (en) 2002-04-18 2003-10-30 Cv Therapeutics, Inc. Method of treating arrhythmias comprising administration of an a1 adenosine agonist with a beta blocker, calcium channel blocker or a cardiac glycoside
AR044519A1 (es) 2003-05-02 2005-09-14 Novartis Ag Derivados de piridin-tiazol amina y de pirimidin-tiazol amina
JP2007513082A (ja) * 2003-11-10 2007-05-24 シエーリング アクチエンゲゼルシャフト Ccr−5アンタゴニストとして有用なベンジルエーテルアミン化合物
GB0401334D0 (en) 2004-01-21 2004-02-25 Novartis Ag Organic compounds
CN101132802A (zh) 2004-03-24 2008-02-27 法斯根有限责任公司 通过药理学抑制amp-活化的蛋白激酶的神经保护的新方法
EA011097B1 (ru) 2004-05-07 2008-12-30 Янссен Фармацевтика Н.В. Производные пирролидин-2-она и пиперидин-2-она, используемые в качестве ингибиторов 11-бета-гидроксистероид-дегидрогеназы
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
ES2432113T3 (es) * 2004-07-28 2013-11-29 Can-Fite Biopharma Ltd. Agonistas del receptor de adenosina A3 para el tratamiento de trastornos del ojo seco, incluido el síndrome de Sjogren
CA2576255A1 (en) * 2004-08-09 2006-02-16 Universite Catholique De Louvain Use of agonists and antagonists of beta-adrenoceptors for treating arterial diseases
DE602005017159D1 (de) 2004-08-30 2009-11-26 Janssen Pharmaceutica Nv Oxysteroid-dehydrogenase-inhibitoren
DE602005018509D1 (de) * 2004-08-30 2010-02-04 Janssen Pharmaceutica Nv N-2-adamantanyl-2-phenoxy-acetamid-derivate als 11-betahydroxysteroid-dehydrogenase-hemmer
ES2334246T3 (es) 2004-08-30 2010-03-08 Janssen Pharmaceutica Nv Derivados triciclos de adamantilamida como inhibidores de la 11-beta-hidroxiesteroide-deshidrogenasa.
GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
GB0426164D0 (en) 2004-11-29 2004-12-29 Novartis Ag Organic compounds
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
US7910708B2 (en) 2005-10-21 2011-03-22 Novartis Ag Anti-IL13 human antibodies
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
MX2009003185A (es) 2006-09-29 2009-04-03 Novartis Ag Pirazolopirimidinas como inhibidores de lipido cinasa pi3k.
CA2667962A1 (en) 2006-10-30 2008-05-08 Novartis Ag Heterocyclic compounds as antiinflammatory agents
ES2442930T3 (es) 2008-01-11 2014-02-14 Novartis Ag Pirimidinas como inhibidores de cinasas
PL2391366T3 (pl) 2009-01-29 2013-04-30 Novartis Ag Podstawione benzimidazole do leczenia gwiaździaków
US9199102B2 (en) 2009-07-21 2015-12-01 Oradin Pharmaceutical Ltd. A3 adenosine receptor ligands for modulation of pigmentation
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
EP2464649A1 (en) 2009-08-12 2012-06-20 Novartis AG Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation
MX2012002066A (es) 2009-08-17 2012-03-29 Intellikine Inc Compuestos heterociclicos y usos de los mismos.
KR20120089463A (ko) 2009-08-20 2012-08-10 노파르티스 아게 헤테로시클릭 옥심 화합물
US8637516B2 (en) 2010-09-09 2014-01-28 Irm Llc Compounds and compositions as TRK inhibitors
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
WO2012107500A1 (en) 2011-02-10 2012-08-16 Novartis Ag [1, 2, 4] triazolo [4, 3 -b] pyridazine compounds as inhibitors of the c-met tyrosine kinase
EP2678016B1 (en) 2011-02-23 2016-08-10 Intellikine, LLC Heterocyclic compounds and uses thereof
MX2013009767A (es) 2011-02-25 2013-10-01 Irm Llc Compuestos y composiciones como inhibidores de trk.
JP5957526B2 (ja) 2011-09-15 2016-07-27 ノバルティス アーゲー チロシンキナーゼとしての6−置換3−(キノリン−6−イルチオ)−[1,2,4]トリアゾロ[4,3−a]ピラジン
US20130209543A1 (en) 2011-11-23 2013-08-15 Intellikine Llc Enhanced treatment regimens using mtor inhibitors
EP3964513A1 (en) 2012-04-03 2022-03-09 Novartis AG Combination products with tyrosine kinase inhibitors and their use
CN109512805B (zh) 2012-05-08 2021-12-31 埃罗米克斯公司 用于治疗水通道蛋白介导的疾病的化合物
RU2559776C2 (ru) * 2012-08-20 2015-08-10 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" Фармацевтические композиции для лечения цереброваскулярных расстройств и способы их изготовления
CA2906542A1 (en) 2013-03-15 2014-09-25 Intellikine, Llc Combination of kinase inhibitors and uses thereof
CN112402434A (zh) 2013-11-06 2021-02-26 埃罗米克斯公司 新配方
TW201605450A (zh) 2013-12-03 2016-02-16 諾華公司 Mdm2抑制劑與BRAF抑制劑之組合及其用途
RU2611339C2 (ru) * 2014-02-17 2017-02-21 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" Фармацевтические композиции с пролонгированным высвобождением для лечения цереброваскулярных расстройств
WO2016011658A1 (en) 2014-07-25 2016-01-28 Novartis Ag Combination therapy
BR112017001695A2 (pt) 2014-07-31 2017-11-21 Novartis Ag terapia de combinação
RU2582961C1 (ru) * 2015-03-04 2016-04-27 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" Фармацевтические композиции в жидких лекарственных формах для лечения цереброваскулярных расстройств и способы их изготовления
RU2712150C1 (ru) * 2019-08-22 2020-01-24 Общество с ограниченной ответственностью "ЦЕНТР ТРАНСФЕРА БИОТЕХНОЛОГИЙ ОКА-Биотех" ПРИМЕНЕНИЕ ТЕТРААЦЕТИЛИРОВАННОГО 5-АМИНО-4-КАРБАМОИЛИМИДАЗОЛИЛ-1-β-D-РИБОФУРАНОЗИДА В КАЧЕСТВЕ ИНГИБИТОРА ПРОТЕИНКИНАЗЫ Cδ
TW202140550A (zh) 2020-01-29 2021-11-01 瑞士商諾華公司 使用抗tslp抗體治療炎性或阻塞性氣道疾病之方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK62692D0 (es) * 1992-05-14 1992-05-14 Novo Nordisk As
TW336938B (en) * 1992-05-21 1998-07-21 Pfizer Calcium channel blocking polypeptides from filistata hibernalis
AU7331094A (en) * 1993-07-13 1995-02-13 United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The A3 adenosine receptor agonists

Also Published As

Publication number Publication date
MXPA02003308A (es) 2002-10-04
BG106636A (bg) 2003-01-31
BR0014384A (pt) 2002-07-02
AU778185B2 (en) 2004-11-18
JP2003510331A (ja) 2003-03-18
DE60024649D1 (de) 2006-01-12
IL148222A0 (en) 2002-09-12
OA12021A (en) 2006-04-19
TR200200843T2 (tr) 2002-07-22
CR6592A (es) 2004-02-23
CO5180581A1 (es) 2002-07-30
EA005422B1 (ru) 2005-02-24
WO2001023399A1 (en) 2001-04-05
ATE312117T1 (de) 2005-12-15
GEP20043241B (en) 2004-05-25
HUP0202807A3 (en) 2005-02-28
ZA200202461B (en) 2003-05-28
YU23102A (sh) 2006-01-16
MA26822A1 (fr) 2004-12-20
TNSN00191A1 (fr) 2005-11-10
AR029887A1 (es) 2003-07-23
EP1216257A1 (en) 2002-06-26
NO20021474D0 (no) 2002-03-25
HUP0202807A2 (hu) 2002-12-28
SK4182002A3 (en) 2003-04-01
PL357371A1 (en) 2004-07-26
EP1216257B1 (en) 2005-12-07
IS6286A (is) 2002-02-26
KR100481605B1 (ko) 2005-04-08
NZ517177A (en) 2003-10-31
HK1049011A1 (zh) 2003-04-25
CN1374967A (zh) 2002-10-16
UA73525C2 (en) 2005-08-15
AP2002002458A0 (en) 2002-06-30
MY133996A (en) 2007-11-30
ECSP003682A (es) 2002-04-23
CZ20021020A3 (cs) 2003-04-16
KR20020034206A (ko) 2002-05-08
NO20021474L (no) 2002-05-22
CA2386079A1 (en) 2001-04-05
EE200200172A (et) 2003-06-16
PA8503301A1 (es) 2003-06-30
HRP20020253A2 (en) 2004-04-30
EA200200316A1 (ru) 2002-08-29
PE20010696A1 (es) 2001-07-05
AU7035200A (en) 2001-04-30

Similar Documents

Publication Publication Date Title
GT200000161A (es) Compuestos para el tratamiento de la isquemia.
AR029634A1 (es) Compuestos derivados heterociclicos utiles como agentes anticancerosos, composicion farmaceutica y procedimiento de tratamiento
UY26872A1 (es) Derivados de la 4- fenil piridina
PA8591701A1 (es) Derivados de pirrolopirimidina
PA8442001A1 (es) Derivados de pirimidina biciclica condensada
GT200000005A (es) Derivados biciclicos sustituidos utiles como agentes contra el cancer.
CO4810375A1 (es) Derivados de 9-amino-3-ceto eritromicina
AR126701A1 (es) Derivados de n-ciclopropilpirido[4,3-d]pirimidin-4-amina y usos de los mismos
AR054347A1 (es) Combinaciones terapeuticas para el tratamiento o la prevencion de la depresion
AR048039A1 (es) Profarmacos de piperazina y agentes antivirales de piperidina sustituidos
PA8489501A1 (es) Antibioticos cetolidos
PA8507601A1 (es) Nuevos derivados de benzoimidazol utiles como agentes antiproliferativos
UY27350A1 (es) Azaindoles
PA8547701A1 (es) Nucleosidos 4 substituidos.
PA8580301A1 (es) Nuevos derivados de benzoimidazol utiles como agentes antiproliferativos
CR7069A (es) Derivados de pirazol para el tratamiento de vih
SV2002000504A (es) Derivados biciclicos sustituidos para el tratamiento del crecimiento celular anormal ref.pc10760/20205/bb
ECSP066643A (es) PIRIDO [2,3-d] PIRIMIDINA-2,4-DIAMINAS COMO INHIBIDORES DE PDE 2
PA8593101A1 (es) Composiciones para el tratamiento de crecimiento celular anormal
AR040925A1 (es) Compuestos de pirazol utiles como inhibidores de proteinquinasa
CO5271715A1 (es) 7-aza-indolin-2-onas sustituidas en 4 y su uso como inhibidores de proteiuna quinasa
AR028810A1 (es) Derivados de arilpiperazinil-ciclohexil indol, composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de medicamentos para el tratamiento de la depresion
UY26635A1 (es) Métodos sinérgicos y composiciones para el tratamiento del cáncer
PA8559501A1 (es) Formulaciones farmaceuticas de 5,7,14-triazatetraciclo[10.3.1.02,11.04,9]-hexadeca-2(11),3,5,7,9-pentaeno
PA8451801A1 (es) Derivados de la 9-oxima eritromicina