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GR900100280A - Aerosolized azole antifungals - Google Patents

Aerosolized azole antifungals

Info

Publication number
GR900100280A
GR900100280A GR900100280A GR900100280A GR900100280A GR 900100280 A GR900100280 A GR 900100280A GR 900100280 A GR900100280 A GR 900100280A GR 900100280 A GR900100280 A GR 900100280A GR 900100280 A GR900100280 A GR 900100280A
Authority
GR
Greece
Prior art keywords
antifungal
azole
inhalation
formulation
aerosolized
Prior art date
Application number
GR900100280A
Other languages
Greek (el)
Inventor
Campbell Samuel Thomas Dr Orr
Original Assignee
Fisons Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisons Plc filed Critical Fisons Plc
Publication of GR900100280A publication Critical patent/GR900100280A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Περιγράφονται φαρμακευτικές συνθέσεις οι οποίες περιέχουν σαν δραστικό συστατικό, ένα αντιμυκητικό σκεύασμα αζόλης υπό μορφήν κατάλληλη να χορηγηθεί δια εισπνοής. Τέτοια σκευάσματα περιλαμβάνουν πεπιεσμένα σκευάσματα αεροζόλης, μη-πεπιεσμένες συνθέσεις αεροζόλης και διαλύματα/εναιωρήματα τα οποία χρησιμοποιούνται με μια διάταξη εκνεφωτού. Επίσης περιγράφεται ένα λεπτομερές κονοποιημένο αντιμυκητικό σκεύασμα αζόλης και μέση διάμετρο μάζας εντός της περιοχής από 0.1 έως 10 μικρά και μια μέθοδο προφυλάξεως από μια μυκητική μόλυνσης των πνευμόνων η οποία περιλαμβάνει χορήγηση δια εισπνοής μιας θεραπευτικώς αποτελεσματικής ποσότητας ενός αντιμυκητικού σκευάσματος αζόλης σε ένα ασθενή ο οποίος έχει προδιάθεση σε μια τέτοια μόλυνση.ωPharmaceutical compositions are described which contain as active ingredient, an antifungal azole formulation in a form suitable for administration by inhalation. Such formulations include compressed aerosol formulations, non-compressed aerosol formulations, and solutions / suspensions used with a nebulizer device. Also described is a detailed powdered azole antifungal formulation with an average mass diameter in the range of 0.1 to 10 microns and a method of preventing a fungal infection of the lungs comprising administering by inhalation a therapeutically effective amount of an antifungal drug containing azo. predisposition to such an infection

GR900100280A 1989-04-12 1990-04-10 Aerosolized azole antifungals GR900100280A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898908250A GB8908250D0 (en) 1989-04-12 1989-04-12 Formulations

Publications (1)

Publication Number Publication Date
GR900100280A true GR900100280A (en) 1991-09-27

Family

ID=10654880

Family Applications (1)

Application Number Title Priority Date Filing Date
GR900100280A GR900100280A (en) 1989-04-12 1990-04-10 Aerosolized azole antifungals

Country Status (7)

Country Link
EP (1) EP0467916A1 (en)
JP (1) JPH04504419A (en)
CA (1) CA2014401A1 (en)
GB (1) GB8908250D0 (en)
GR (1) GR900100280A (en)
PT (1) PT93739A (en)
WO (1) WO1990011754A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0536235T3 (en) * 1990-06-29 1997-04-14 Fisons Plc Pressurized aerosol preparations
DE69231991T2 (en) * 1991-06-10 2002-04-04 Schering Corp., Kenilworth Chlorofluorocarbon free aerosol formulations
IT1253711B (en) * 1991-12-17 1995-08-23 Alfa Wassermann Spa VAGINAL PHARMACEUTICAL FORMULATIONS CONTAINING RIFAXIMIN AND THEIR USE IN THE TREATMENT OF VAGINAL INFECTIONS
US7101534B1 (en) 1991-12-18 2006-09-05 3M Innovative Properties Company Suspension aerosol formulations
ES2158859T3 (en) * 1992-03-18 2001-09-16 Janssen Pharmaceutica Nv STEREOISOMEROS ITRACONAZOL AND SAPERCONAZOL.
AU6096094A (en) * 1993-01-27 1994-08-15 Georgetown University Method and composition employing (2r,4s) itraconazole
DE4323636A1 (en) * 1993-07-15 1995-01-19 Hoechst Ag Pharmaceutical preparations from coated, poorly water-soluble pharmaceutical substances for inhalation pharmaceutical forms and processes for their preparation
JP2875140B2 (en) * 1993-08-16 1999-03-24 明治製菓株式会社 Anti-MRSA composition
NL1006103C2 (en) * 1997-05-21 1998-11-25 Nutricia Nv Powder-based skin spray.
JP4100868B2 (en) 1997-12-09 2008-06-11 ザ・グッドイヤー・タイヤ・アンド・ラバー・カンパニー Pneumatic tire with antenna for radio frequency band transponder
US6485743B1 (en) 1997-12-31 2002-11-26 Choongwae Pharma Corporation Method and composition of an oral preparation of itraconazole
US6086376A (en) * 1998-01-30 2000-07-11 Rtp Pharma Inc. Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant
CA2432319A1 (en) 2000-12-21 2002-07-18 Nektar Therapeutics Pulmonary delivery of polyene antifungal agents
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
WO2006026502A1 (en) * 2004-08-27 2006-03-09 The Dow Chemical Company Enhanced delivery of drug compositions to treat life threatening infections
DK2120875T3 (en) 2007-02-11 2018-10-22 Map Pharmaceuticals Inc METHOD OF THERAPEUTIC ADMINISTRATION OF DHE TO POSSIBLE QUICK PREVENTION OF MIGRANE AT THE MINIMUM OF THE SIDE EFFECT PROFILE
WO2008124131A1 (en) * 2007-04-05 2008-10-16 The John Hopkins University Antifungal agents as neuroprotectants
PE20091778A1 (en) * 2008-04-15 2009-11-13 Schering Corp HIGH DENSITY COMPOSITIONS CONTAINING POSACONAZOLE AND FORMULATIONS THAT INCLUDE IT
EP2601973A1 (en) 2011-12-09 2013-06-12 Laboratoires SMB SA Dry powder formulation of azole derivative for inhalation
WO2014106727A1 (en) 2013-01-03 2014-07-10 Vectura Limited Inhaler and formulation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0156508A1 (en) * 1984-02-23 1985-10-02 Ortho Pharmaceutical Corporation Antifungal aerosol solution
EP0320002A1 (en) * 1987-12-10 1989-06-14 Kyorin Seiyaku Kabushiki Kaisha Inhalant

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0156508A1 (en) * 1984-02-23 1985-10-02 Ortho Pharmaceutical Corporation Antifungal aerosol solution
EP0320002A1 (en) * 1987-12-10 1989-06-14 Kyorin Seiyaku Kabushiki Kaisha Inhalant

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BIOLOGICAL ABSTRACTS, vol. 74, no. 3, 1987, abstract no. 15685, Biological Abstract, Inc., Philadelphia, PA, US; W.V.R. SHELLOW: "2 Percent miconazole nitrate powder in aerosol spray form: Efficacy in treating tinea pedis", & J. INT. MED. RES. 10(1): 28-31 *
BIOLOGICAL ABSTRACTS, vol. 88, no. 10, 1989, abstract no. 105355, Biological Abstracts, Inc., Philadelphia, PA, US; J. VAN CUTSEM et al.: "The treatment of experimental aspergillosis with enilconazole and itraconazole", & BULL. SOC. FR. MYCOL. MED. 18(1): 55-60 *
CLAIMS SEARCHED: ALL *

Also Published As

Publication number Publication date
EP0467916A1 (en) 1992-01-29
PT93739A (en) 1990-11-20
JPH04504419A (en) 1992-08-06
GB8908250D0 (en) 1989-05-24
WO1990011754A1 (en) 1990-10-18
CA2014401A1 (en) 1990-10-12

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