GR68727B - - Google Patents
Info
- Publication number
- GR68727B GR68727B GR62114A GR800162114A GR68727B GR 68727 B GR68727 B GR 68727B GR 62114 A GR62114 A GR 62114A GR 800162114 A GR800162114 A GR 800162114A GR 68727 B GR68727 B GR 68727B
- Authority
- GR
- Greece
- Prior art keywords
- diones
- pyrroline
- inhibit
- hydroxy
- prevention
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/456—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/047,413 US4256758A (en) | 1979-06-11 | 1979-06-11 | 4-Substituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR68727B true GR68727B (el) | 1982-02-10 |
Family
ID=21948829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR62114A GR68727B (el) | 1979-06-11 | 1980-06-03 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4256758A (el) |
| EP (1) | EP0021228B1 (el) |
| JP (1) | JPS562962A (el) |
| AT (1) | ATE1501T1 (el) |
| DE (1) | DE3060801D1 (el) |
| DK (1) | DK249680A (el) |
| ES (1) | ES8105283A1 (el) |
| GR (1) | GR68727B (el) |
| IE (1) | IE49902B1 (el) |
| PT (1) | PT71368B (el) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4428959A (en) * | 1980-04-04 | 1984-01-31 | Merck & Co., Inc. | 4-Alkylsubstituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase |
| JPS5816528U (ja) * | 1981-07-25 | 1983-02-01 | 三菱重工業株式会社 | 液位計 |
| US4605663A (en) * | 1984-05-01 | 1986-08-12 | Merck & Co., Inc. | Use of substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones, for treatment of grey matter edema |
| US4604403A (en) * | 1984-05-01 | 1986-08-05 | Merck & Co., Inc. | Use of substituted-3(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones for treating grey matter edema |
| US4596821A (en) * | 1984-05-01 | 1986-06-24 | Merck & Co., Inc. | Treatment of gray matter edema with 3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones |
| US4605664A (en) * | 1984-05-01 | 1986-08-12 | Merck & Co., Inc. | Use of substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones for treatment of grey matter edema |
| US4634717A (en) * | 1984-05-01 | 1987-01-06 | Merck & Co., Inc. | Substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones, useful for treating persons with gray matter edema |
| ES2070914T3 (es) * | 1988-10-29 | 1995-06-16 | Cadbury Schweppes Plc | Agente tensioactivo. |
| US6353128B1 (en) * | 1996-12-03 | 2002-03-05 | Eli Lilly And Company | Phenyl acetamides as sPLA2 inhibitors |
| US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
| US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| US7279576B2 (en) | 2002-12-31 | 2007-10-09 | Deciphera Pharmaceuticals, Llc | Anti-cancer medicaments |
| US6903105B2 (en) * | 2003-02-19 | 2005-06-07 | Parion Sciences, Inc. | Sodium channel blockers |
| US20050090505A1 (en) * | 2003-08-18 | 2005-04-28 | Johnson Michael R. | Methods of reducing risk of infection from pathogens |
| US20090253714A1 (en) * | 2003-08-20 | 2009-10-08 | Johnson Michael R | Methods of reducing risk of infection from pathogens |
| US7745442B2 (en) * | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| CA2592118C (en) | 2004-12-23 | 2015-11-17 | Deciphera Pharmaceuticals, Llc | Urea derivatives as enzyme modulators |
| US20070021439A1 (en) * | 2005-07-25 | 2007-01-25 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers |
| US8188113B2 (en) | 2006-09-14 | 2012-05-29 | Deciphera Pharmaceuticals, Inc. | Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| US7790756B2 (en) | 2006-10-11 | 2010-09-07 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
| SG183054A1 (en) | 2007-04-20 | 2012-08-30 | Deciphera Pharmaceuticals Llc | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
| WO2010051373A1 (en) | 2008-10-29 | 2010-05-06 | Deciphera Pharmaceuticals, Llc | Cyclopropane amides and analogs exhibiting anti-cancer and anti-proliferative activities |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| SI2931713T1 (sl) | 2012-12-17 | 2017-03-31 | Parion Sciences, Inc. | Derivati kloro-pirazin karboksamida uporabni za zdravljenje bolezni favoriziranih z nezadostno hidracijo sluznice |
| MX2015007797A (es) | 2012-12-17 | 2015-10-05 | Parion Sciences Inc | Compuestos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil) carbamimidoil) pirazin-2-carboxamida. |
| DE102013213217A1 (de) | 2013-07-05 | 2015-01-08 | Bayerische Motoren Werke Aktiengesellschaft | Schließbaugruppe für einen Gepäckkoffer |
| US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
| WO2017100268A1 (en) * | 2015-12-07 | 2017-06-15 | Wake Forest University Health Sciences | Combinations for the treatment of kidney stones |
| CN107805209B (zh) * | 2016-09-09 | 2020-11-10 | 中国石化扬子石油化工有限公司 | 一种对二乙酰苯酰胺化制备2-(4-氨基甲酰基甲基-苯基)-乙酰胺的方法 |
| CN118557737A (zh) | 2018-01-31 | 2024-08-30 | 德西费拉制药有限责任公司 | 治疗胃肠道间质瘤的组合疗法 |
| SG11202007287XA (en) | 2018-01-31 | 2020-08-28 | Deciphera Pharmaceuticals Llc | Combination therapy for the treatment of mastocytosis |
| CA3150433A1 (en) | 2019-08-12 | 2021-02-18 | Deciphera Pharmaceuticals, Llc | Ripretinib for treating gastrointestinal stromal tumors |
| TW202122082A (zh) | 2019-08-12 | 2021-06-16 | 美商迪賽孚爾製藥有限公司 | 治療胃腸道基質瘤方法 |
| DK4084778T3 (da) | 2019-12-30 | 2023-12-11 | Deciphera Pharmaceuticals Llc | Amorfe kinaseinhibitorformuleringer og fremgangsmåder til anvendelse deraf |
| KR20220123058A (ko) | 2019-12-30 | 2022-09-05 | 데시페라 파마슈티칼스, 엘엘씨. | 1-(4-브로모-5-(1-에틸-7-(메틸아미노)-2-옥소-1,2-디히드로-1,6-나프티리딘-3-일)-2-플루오로페닐)-3-페닐우레아의 조성물 |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3184475A (en) * | 1961-09-15 | 1965-05-18 | Monsanto Co | Maleimides, maleamides and fumaramides |
| US3183245A (en) * | 1963-01-04 | 1965-05-11 | Parke Davis & Co | Process for the production of alpha-methyl-alpha-phenyl-beta-ethylsuccinimide |
| DE1445664A1 (de) * | 1963-07-04 | 1969-11-27 | Klinke Desitin Werk | Verfahren zur Herstellung von alpha,alpha-disubstituierten Succinimiden |
| CH445487A (de) * | 1963-08-05 | 1967-10-31 | Calanda Stiftung | Verfahren zur Darstellung cyclischer Imide |
| US3340263A (en) * | 1964-02-14 | 1967-09-05 | Ciba Geigy Corp | Amino-pyrroles |
| US3317390A (en) * | 1965-07-27 | 1967-05-02 | American Cyanamid Co | Compositions having cns depressant activity |
-
1979
- 1979-06-11 US US06/047,413 patent/US4256758A/en not_active Expired - Lifetime
-
1980
- 1980-06-03 GR GR62114A patent/GR68727B/el unknown
- 1980-06-09 PT PT71368A patent/PT71368B/pt unknown
- 1980-06-09 IE IE1178/80A patent/IE49902B1/en unknown
- 1980-06-10 EP EP80103216A patent/EP0021228B1/en not_active Expired
- 1980-06-10 DE DE8080103216T patent/DE3060801D1/de not_active Expired
- 1980-06-10 AT AT80103216T patent/ATE1501T1/de active
- 1980-06-10 ES ES492310A patent/ES8105283A1/es not_active Expired
- 1980-06-10 DK DK249680A patent/DK249680A/da not_active Application Discontinuation
- 1980-06-11 JP JP7790580A patent/JPS562962A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| PT71368A (en) | 1980-07-01 |
| EP0021228A1 (en) | 1981-01-07 |
| ES492310A0 (es) | 1981-05-16 |
| EP0021228B1 (en) | 1982-09-01 |
| ATE1501T1 (de) | 1982-09-15 |
| ES8105283A1 (es) | 1981-05-16 |
| US4256758A (en) | 1981-03-17 |
| DE3060801D1 (en) | 1982-10-28 |
| JPS562962A (en) | 1981-01-13 |
| PT71368B (en) | 1981-10-21 |
| IE49902B1 (en) | 1986-01-08 |
| IE801178L (en) | 1980-12-11 |
| DK249680A (da) | 1980-12-12 |
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