GR1003359B - Liposomic niflumic acid-new transdermal anti-inflammatory medicine - Google Patents
Liposomic niflumic acid-new transdermal anti-inflammatory medicineInfo
- Publication number
- GR1003359B GR1003359B GR980100469A GR980100469A GR1003359B GR 1003359 B GR1003359 B GR 1003359B GR 980100469 A GR980100469 A GR 980100469A GR 980100469 A GR980100469 A GR 980100469A GR 1003359 B GR1003359 B GR 1003359B
- Authority
- GR
- Greece
- Prior art keywords
- encapsulated
- medecine
- liposomes
- niflumic acid
- encapsulation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
- A61K9/1278—Post-loading, e.g. by ion or pH gradient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention relates to the encapsulation of the niflumic acid in liposomes for creating a new transdermal non steroid anti-inflamatory preparation. Various pharmaceutical molecules are encapsulated in liposomes (spherical lipid constructions), by techniques such as the active transfer or the encapsulation of the medecine in lipid double-layers. The aim of this technology is to improve the pharmacokinetic properties of said molecules, and increase the selectivity of the medecines concerning the tissues as well as their absorption by the skin. The niflumic acid and its esters are encapsulated in liposomes of different lipid composition by the aforementioned techniques with the purpose of improving the efficiency of the drastic substance. Furthermore, the physico-chemical characteristics of the liposomal suspension with or without the encapsulated medecine, such as size, stability in diverse preservation conditions as to the temperature and the moisture, are measured. The process continues with the shaping in cream of the liposomal suspension with or without the encapsulated medecine as well as with the stability study of the final pharmacoceutical form. The final product is, finally, tested for its permeability, in vitro, on the human skin and, in vivo, for its efficienfy, following precise protocols.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR98100469 | 1998-12-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR1003359B true GR1003359B (en) | 2000-04-10 |
Family
ID=10943556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR980100469A GR1003359B (en) | 1998-12-24 | 1998-12-24 | Liposomic niflumic acid-new transdermal anti-inflammatory medicine |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1140089A1 (en) |
| JP (1) | JP2002533394A (en) |
| KR (1) | KR20010089889A (en) |
| CN (1) | CN1331592A (en) |
| AU (1) | AU1673400A (en) |
| BR (1) | BR9917006A (en) |
| CA (1) | CA2357765A1 (en) |
| CZ (1) | CZ20012240A3 (en) |
| GR (1) | GR1003359B (en) |
| HU (1) | HUP0104853A3 (en) |
| IL (1) | IL143499A0 (en) |
| IS (1) | IS5964A (en) |
| MX (1) | MXPA01006462A (en) |
| NO (1) | NO20013015D0 (en) |
| PL (1) | PL349344A1 (en) |
| SK (1) | SK7962001A3 (en) |
| WO (1) | WO2000038681A1 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100367932C (en) * | 2002-11-26 | 2008-02-13 | 吉里德科学公司 | Method of drug loading in liposomes by gradient |
| BRPI0409663A (en) * | 2003-04-25 | 2006-04-18 | Penn State Res Found | method and system for the systemic delivery of growth arresting lipid-derived bioactive compounds |
| US20050255154A1 (en) | 2004-05-11 | 2005-11-17 | Lena Pereswetoff-Morath | Method and composition for treating rhinitis |
| JP4791082B2 (en) * | 2005-05-30 | 2011-10-12 | 株式会社クラレ | Liposomes and topical skin preparations containing the same |
| JP4931369B2 (en) * | 2005-05-31 | 2012-05-16 | ポーラ化成工業株式会社 | Liposomes and therapeutic compositions containing the same |
| PL1888033T3 (en) | 2005-06-09 | 2014-09-30 | Meda Ab | Method and composition for treating inflammatory disorders |
| US20120028335A1 (en) | 2010-07-28 | 2012-02-02 | Life Technologies Corporation | Anti-viral azide-containing compounds |
| EP2598128B1 (en) | 2010-07-28 | 2018-03-28 | Life Technologies Corporation | Anti- viral azide-containing compounds |
| US9890361B2 (en) | 2012-01-26 | 2018-02-13 | Life Technologies Corporation | Methods for increasing the infectivity of viruses utilizing alkyne-modified fatty acids |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4528193A (en) * | 1978-12-27 | 1985-07-09 | A. Natterman & Cie. Gmbh | Inflammation-preventing pharmaceutical composition of oral administration |
| EP0225162A2 (en) * | 1985-11-27 | 1987-06-10 | Ethicon, Inc. | Inhibition of post-surgical adhesion formation by the topical administration of non-steroidal anti-inflammatory drug |
| EP0249561A2 (en) * | 1986-06-12 | 1987-12-16 | The Liposome Company, Inc. | Compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs |
| WO1996032930A1 (en) * | 1995-04-18 | 1996-10-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Liposome drug-loading method and composition |
-
1998
- 1998-12-24 GR GR980100469A patent/GR1003359B/en not_active IP Right Cessation
-
1999
- 1999-12-22 BR BR9917006-0A patent/BR9917006A/en not_active Application Discontinuation
- 1999-12-22 HU HU0104853A patent/HUP0104853A3/en unknown
- 1999-12-22 EP EP99959605A patent/EP1140089A1/en not_active Withdrawn
- 1999-12-22 AU AU16734/00A patent/AU1673400A/en not_active Abandoned
- 1999-12-22 KR KR1020017008144A patent/KR20010089889A/en not_active Application Discontinuation
- 1999-12-22 MX MXPA01006462A patent/MXPA01006462A/en unknown
- 1999-12-22 CN CN99814948A patent/CN1331592A/en active Pending
- 1999-12-22 CZ CZ20012240A patent/CZ20012240A3/en unknown
- 1999-12-22 WO PCT/GR1999/000048 patent/WO2000038681A1/en not_active Application Discontinuation
- 1999-12-22 CA CA002357765A patent/CA2357765A1/en not_active Abandoned
- 1999-12-22 IL IL14349999A patent/IL143499A0/en unknown
- 1999-12-22 JP JP2000590635A patent/JP2002533394A/en active Pending
- 1999-12-22 SK SK796-2001A patent/SK7962001A3/en unknown
- 1999-12-22 PL PL99349344A patent/PL349344A1/en not_active Application Discontinuation
-
2001
- 2001-06-08 IS IS5964A patent/IS5964A/en unknown
- 2001-06-18 NO NO20013015A patent/NO20013015D0/en not_active Application Discontinuation
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4528193A (en) * | 1978-12-27 | 1985-07-09 | A. Natterman & Cie. Gmbh | Inflammation-preventing pharmaceutical composition of oral administration |
| EP0225162A2 (en) * | 1985-11-27 | 1987-06-10 | Ethicon, Inc. | Inhibition of post-surgical adhesion formation by the topical administration of non-steroidal anti-inflammatory drug |
| EP0249561A2 (en) * | 1986-06-12 | 1987-12-16 | The Liposome Company, Inc. | Compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs |
| WO1996032930A1 (en) * | 1995-04-18 | 1996-10-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Liposome drug-loading method and composition |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2357765A1 (en) | 2000-07-06 |
| PL349344A1 (en) | 2002-07-15 |
| NO20013015L (en) | 2001-06-18 |
| HUP0104853A3 (en) | 2003-05-28 |
| NO20013015D0 (en) | 2001-06-18 |
| IS5964A (en) | 2001-06-08 |
| IL143499A0 (en) | 2002-04-21 |
| JP2002533394A (en) | 2002-10-08 |
| EP1140089A1 (en) | 2001-10-10 |
| CZ20012240A3 (en) | 2001-11-14 |
| SK7962001A3 (en) | 2002-02-05 |
| HUP0104853A2 (en) | 2002-05-29 |
| WO2000038681A1 (en) | 2000-07-06 |
| AU1673400A (en) | 2000-07-31 |
| CN1331592A (en) | 2002-01-16 |
| KR20010089889A (en) | 2001-10-12 |
| BR9917006A (en) | 2001-10-30 |
| MXPA01006462A (en) | 2002-06-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ML | Lapse due to non-payment of fees |