GB948090A - Improvements in or relating to tetracycline complexes - Google Patents
Improvements in or relating to tetracycline complexesInfo
- Publication number
- GB948090A GB948090A GB13299/61A GB1329961A GB948090A GB 948090 A GB948090 A GB 948090A GB 13299/61 A GB13299/61 A GB 13299/61A GB 1329961 A GB1329961 A GB 1329961A GB 948090 A GB948090 A GB 948090A
- Authority
- GB
- United Kingdom
- Prior art keywords
- aluminium
- cation
- calcium
- antibiotic
- magnesium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000004098 Tetracycline Substances 0.000 title 1
- 229960002180 tetracycline Drugs 0.000 title 1
- 229930101283 tetracycline Natural products 0.000 title 1
- 235000019364 tetracycline Nutrition 0.000 title 1
- 150000003522 tetracyclines Chemical class 0.000 title 1
- 150000001768 cations Chemical class 0.000 abstract 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 4
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 abstract 4
- 239000004411 aluminium Substances 0.000 abstract 4
- 229910052782 aluminium Inorganic materials 0.000 abstract 4
- 230000003115 biocidal effect Effects 0.000 abstract 4
- 239000011575 calcium Substances 0.000 abstract 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 3
- -1 aluminium ions Chemical class 0.000 abstract 3
- 239000007864 aqueous solution Substances 0.000 abstract 3
- 229910052791 calcium Inorganic materials 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 abstract 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 2
- 229910002651 NO3 Inorganic materials 0.000 abstract 2
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 2
- 239000000174 gluconic acid Substances 0.000 abstract 2
- 235000012208 gluconic acid Nutrition 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 229910052749 magnesium Inorganic materials 0.000 abstract 2
- 239000011777 magnesium Substances 0.000 abstract 2
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 2
- RMVMLZHPWMTQGK-SOUFLCLCSA-N (4s,4as,5as,6s,12ar)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1([C@H]2O)=CC=CC(O)=C1C(O)=C1[C@@H]2C[C@H]2[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]2(O)C1=O RMVMLZHPWMTQGK-SOUFLCLCSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 abstract 1
- FMTDIUIBLCQGJB-UHFFFAOYSA-N Demethylchlortetracyclin Natural products C1C2C(O)C3=C(Cl)C=CC(O)=C3C(=O)C2=C(O)C2(O)C1C(N(C)C)C(O)=C(C(N)=O)C2=O FMTDIUIBLCQGJB-UHFFFAOYSA-N 0.000 abstract 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 1
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 150000001399 aluminium compounds Chemical class 0.000 abstract 1
- 239000001164 aluminium sulphate Substances 0.000 abstract 1
- 235000011128 aluminium sulphate Nutrition 0.000 abstract 1
- 229910001424 calcium ion Inorganic materials 0.000 abstract 1
- FMTDIUIBLCQGJB-SEYHBJAFSA-N demeclocycline Chemical compound C1([C@@H](O)[C@H]2C3)=C(Cl)C=CC(O)=C1C(=O)C2=C(O)[C@@]1(O)[C@@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C1=O FMTDIUIBLCQGJB-SEYHBJAFSA-N 0.000 abstract 1
- JCSGAUKCDAVARS-UHFFFAOYSA-N demethyltetracycline Natural products CN(C1C(=C(C(C2(C(=C3C(C4=C(C=CC=C4C(C3CC12)O)O)=O)O)O)=O)C(=O)N)O)C JCSGAUKCDAVARS-UHFFFAOYSA-N 0.000 abstract 1
- BUACSMWVFUNQET-UHFFFAOYSA-H dialuminum;trisulfate;hydrate Chemical compound O.[Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O BUACSMWVFUNQET-UHFFFAOYSA-H 0.000 abstract 1
- HHFAWKCIHAUFRX-UHFFFAOYSA-N ethoxide Chemical compound CC[O-] HHFAWKCIHAUFRX-UHFFFAOYSA-N 0.000 abstract 1
- 235000012209 glucono delta-lactone Nutrition 0.000 abstract 1
- 239000000182 glucono-delta-lactone Substances 0.000 abstract 1
- 229960003681 gluconolactone Drugs 0.000 abstract 1
- 150000004679 hydroxides Chemical class 0.000 abstract 1
- 150000002681 magnesium compounds Chemical class 0.000 abstract 1
- 229910001425 magnesium ion Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- OGHBATFHNDZKSO-UHFFFAOYSA-N propan-2-olate Chemical compound CC(C)[O-] OGHBATFHNDZKSO-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to complexes of 6-demethyl tetracycline or 7-chloro- -6-demethyl tetracycline, aluminium, a cation selected from the cations of hydrogen, calcium and magnesium, and gluconic acid in the molar ratio of antibiotic to aluminium to cation to acid of not less than 1:1:1:1 and not greater than 1:6:9:28 save that when the cation is hydrogen the ratio of antibiotic to cation may be 1:28. These complexes are prepared by reacting the antibiotic or a salt thereof, an aluminium compound which furnishes aluminium ions in aqueous solution, gluconic acid or glucono-delta-lactone and, when the cation is not hydrogen, a calcium or magnesium compound which furnishes calcium or magnesium ions in aqueous solution so as to form said complex. Specified antibiotic salts are the hydrochloride, hydrobromide, nitrate, sulphate or an alkali or alkaline earth metal salt. The aluminium may be added as the ethoxide, isopropoxide, citrate, nitrate, lactrate, formate, chloride, sulphate or as potassium aluminium sulphate. The complex forming cations of calcium and magnesium may be added in the form of their oxides, hydroxides or water soluble salts. The complexes may be administered parenterally in aqueous solution.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2376360A | 1960-04-21 | 1960-04-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB948090A true GB948090A (en) | 1964-01-29 |
Family
ID=21817061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB13299/61A Expired GB948090A (en) | 1960-04-21 | 1961-04-13 | Improvements in or relating to tetracycline complexes |
Country Status (3)
| Country | Link |
|---|---|
| BE (1) | BE602878A (en) |
| FR (1) | FR1077M (en) |
| GB (1) | GB948090A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9084802B2 (en) | 2010-05-12 | 2015-07-21 | Rempex Pharmaceuticals, Inc. | Tetracycline compositions |
-
1961
- 1961-04-13 GB GB13299/61A patent/GB948090A/en not_active Expired
- 1961-04-18 FR FR859028A patent/FR1077M/en active Active
- 1961-04-21 BE BE602878A patent/BE602878A/en unknown
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9084802B2 (en) | 2010-05-12 | 2015-07-21 | Rempex Pharmaceuticals, Inc. | Tetracycline compositions |
| US9278105B2 (en) | 2010-05-12 | 2016-03-08 | Rempex Pharmaceuticals, Inc. | Tetracycline compositions |
| US9744179B2 (en) | 2010-05-12 | 2017-08-29 | Rempex Pharmaceuticals, Inc. | Tetracycline compositions |
| US11944634B2 (en) | 2010-05-12 | 2024-04-02 | Melinta Subsidiary Corp. | Tetracycline compositions |
| US12161656B2 (en) | 2010-05-12 | 2024-12-10 | Melinta Subsidiary Corp. | Tetracycline compositions |
Also Published As
| Publication number | Publication date |
|---|---|
| FR1077M (en) | 1962-01-22 |
| BE602878A (en) | 1961-10-23 |
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