GB933715A - Substituted phenylalanines and manufacture thereof - Google Patents
Substituted phenylalanines and manufacture thereofInfo
- Publication number
- GB933715A GB933715A GB3585159A GB3585159A GB933715A GB 933715 A GB933715 A GB 933715A GB 3585159 A GB3585159 A GB 3585159A GB 3585159 A GB3585159 A GB 3585159A GB 933715 A GB933715 A GB 933715A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- hydrogen
- alkali metal
- metal ion
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of the general formula <FORM:0933715/IV(a)/1> (wherein R represents hydrogen, an alkali metal ion or a C1-4 alkyl group, X represents a formyl or acetyl group, and Y is a radical found in attachment to the a -carbon atom of a known naturally occurring a -amino acid containing only one amino group and carbon, hydrogen and oxygen as the only other elements), and the preparation thereof by reacting a compound of the formula <FORM:0933715/IV(a)/2> with a mixed anhydride derived from an acid <FORM:0933715/IV(a)/3> and a C1-4 alkyl ester of chloroformic acid, or with an azide <FORM:0933715/IV(a)/4> Partial racemization occurs with the first method, giving a mixture of diastereoisomers (also comprised by the invention), but not with the second method. When R in the final product is to be hydrogen it should be an alkali metal ion in the starting material, the acid being liberated from the resulting salt. Pharmaceutical preparations comprise the foregoing compounds and a pharmaceutically acceptable carrier. Specification 750,155 is referred to.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3585159A GB933715A (en) | 1959-10-22 | 1959-10-22 | Substituted phenylalanines and manufacture thereof |
| CH1184360A CH396933A (en) | 1959-10-22 | 1960-10-22 | Process for the preparation of therapeutically active derivatives of p-di- (2-chloroetyl) -aminophenylalanine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3585159A GB933715A (en) | 1959-10-22 | 1959-10-22 | Substituted phenylalanines and manufacture thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB933715A true GB933715A (en) | 1963-08-14 |
Family
ID=10382222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3585159A Expired GB933715A (en) | 1959-10-22 | 1959-10-22 | Substituted phenylalanines and manufacture thereof |
Country Status (2)
| Country | Link |
|---|---|
| CH (1) | CH396933A (en) |
| GB (1) | GB933715A (en) |
-
1959
- 1959-10-22 GB GB3585159A patent/GB933715A/en not_active Expired
-
1960
- 1960-10-22 CH CH1184360A patent/CH396933A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH396933A (en) | 1965-08-15 |
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