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GB868880A - ª--amino acetophenone derivatives - Google Patents

ª--amino acetophenone derivatives

Info

Publication number
GB868880A
GB868880A GB18966/59A GB1896659A GB868880A GB 868880 A GB868880 A GB 868880A GB 18966/59 A GB18966/59 A GB 18966/59A GB 1896659 A GB1896659 A GB 1896659A GB 868880 A GB868880 A GB 868880A
Authority
GB
United Kingdom
Prior art keywords
group
hydrogen
formula
acid addition
nitro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB18966/59A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Philips Gloeilampenfabrieken NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philips Gloeilampenfabrieken NV filed Critical Philips Gloeilampenfabrieken NV
Publication of GB868880A publication Critical patent/GB868880A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises amino-acetophenones of the formula: <FORM:0868880/IV (b)/1> and acid addition salts thereof, wherein R3 is hydrogen or an alkyl group of 1-6 carbon atoms, such as a tertiary butyl group, and their preparation by reducing a nitro compound of the formula: <FORM:0868880/IV (b)/2> wherein R4 is hydrogen or a benzyl group and when R4 is benzyl, subsequently splitting off the group or groups by catalytic hydrogenation. The products are used pharmaceutically, suitably as acid addition salts such as hydrohalides, sulphates, citrates, acetates or phosphates. Nitro-acetophenones used as starting materials in the above process are made by condensing 2-hydroxy (or benzyloxy)-5-nitro-O -haloacetophenone with an amine NHR3R4. Specification 809,791 is referred to.ALSO:Pharmaceutical preparations suitable for oral or parenteral administration having antivirus activity comprise an amino-acetophenone of the formula <FORM:0868880/VI/1> or an organic or inorganic acid addition salt thereof (see Group IV (b)), wherein R3 is hydrogen or an alkyl group of 1 to 6 carbon atoms, and a solid or liquid inert diluent or solvent. The preparations suitably may contain 0.5 to 5% by weight of active compound. Specification 809,791 is referred to.
GB18966/59A 1958-06-06 1959-06-03 ª--amino acetophenone derivatives Expired GB868880A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL868880X 1958-06-06

Publications (1)

Publication Number Publication Date
GB868880A true GB868880A (en) 1961-05-25

Family

ID=19849341

Family Applications (1)

Application Number Title Priority Date Filing Date
GB18966/59A Expired GB868880A (en) 1958-06-06 1959-06-03 ª--amino acetophenone derivatives

Country Status (1)

Country Link
GB (1) GB868880A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008109624A2 (en) * 2007-03-05 2008-09-12 Benz Research And Development Corp. Light filters comprising a naturally occurring chromophore and derivatives thereof

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008109624A2 (en) * 2007-03-05 2008-09-12 Benz Research And Development Corp. Light filters comprising a naturally occurring chromophore and derivatives thereof
WO2008109624A3 (en) * 2007-03-05 2009-01-15 Benz Res & Dev Corp Light filters comprising a naturally occurring chromophore and derivatives thereof
US8026326B2 (en) 2007-03-05 2011-09-27 Benz Research And Development Corp. Light filters comprising a naturally occurring chromophore and derivatives thereof
US8618323B2 (en) 2007-03-05 2013-12-31 Benz Research And Development Corporation Light filters comprising a naturally occurring chromophore and derivatives thereof
EP2535747A3 (en) * 2007-03-05 2016-06-22 Benz Research and Development Corporation Light filters comprising a naturally occurring chromophore and derivates thereof

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