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GB8501889D0 - Heterocyclic compounds - Google Patents

Heterocyclic compounds

Info

Publication number
GB8501889D0
GB8501889D0 GB858501889A GB8501889A GB8501889D0 GB 8501889 D0 GB8501889 D0 GB 8501889D0 GB 858501889 A GB858501889 A GB 858501889A GB 8501889 A GB8501889 A GB 8501889A GB 8501889 D0 GB8501889 D0 GB 8501889D0
Authority
GB
United Kingdom
Prior art keywords
heterocyclic compounds
heterocyclic
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB858501889A
Other versions
GB2153821A (en
GB2153821B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848401888A external-priority patent/GB8401888D0/en
Priority claimed from GB848425959A external-priority patent/GB8425959D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of GB8501889D0 publication Critical patent/GB8501889D0/en
Publication of GB2153821A publication Critical patent/GB2153821A/en
Application granted granted Critical
Publication of GB2153821B publication Critical patent/GB2153821B/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/80[b, c]- or [b, d]-condensed
    • C07D209/82Carbazoles; Hydrogenated carbazoles
    • C07D209/88Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
GB08501889A 1984-01-25 1985-01-25 3-imidazolylmethyl-1,2,3,9-tetrahydro-4h-carbazol-4-one derivatives Expired GB2153821B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848401888A GB8401888D0 (en) 1984-01-25 1984-01-25 Heterocyclic compounds
GB848425959A GB8425959D0 (en) 1984-10-15 1984-10-15 Heterocyclic compounds

Publications (3)

Publication Number Publication Date
GB8501889D0 true GB8501889D0 (en) 1985-02-27
GB2153821A GB2153821A (en) 1985-08-29
GB2153821B GB2153821B (en) 1988-01-20

Family

ID=26287221

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08501889A Expired GB2153821B (en) 1984-01-25 1985-01-25 3-imidazolylmethyl-1,2,3,9-tetrahydro-4h-carbazol-4-one derivatives

Country Status (29)

Country Link
KR (1) KR920003064B1 (en)
AT (1) AT392276B (en)
AU (1) AU579132B2 (en)
BE (1) BE901576A (en)
CA (1) CA1252793A (en)
CH (1) CH664152A5 (en)
CY (1) CY1479A (en)
CZ (1) CZ404391A3 (en)
DE (2) DE3502508A1 (en)
DK (1) DK169521B1 (en)
ES (3) ES8609309A1 (en)
FI (1) FI84349C (en)
FR (1) FR2561244B1 (en)
GB (1) GB2153821B (en)
GR (1) GR850219B (en)
HK (1) HK33189A (en)
HU (1) HU193592B (en)
IE (1) IE57809B1 (en)
IL (1) IL74165A (en)
IT (1) IT1182150B (en)
LU (2) LU88268I2 (en)
NL (2) NL190373C (en)
NO (2) NO164025C (en)
NZ (1) NZ210940A (en)
PH (1) PH22672A (en)
PT (1) PT79890B (en)
SE (1) SE460359B (en)
SG (1) SG7089G (en)
SK (1) SK277923B6 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5470868A (en) 1991-06-26 1995-11-28 Sepracor Inc. Methods for treating emesis and nausea using optically pure R(+) ondansetron
CN115611864A (en) * 2022-11-01 2023-01-17 常州兰陵制药有限公司 A kind of ondansetron compound and its preparation method and application

Families Citing this family (77)

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US4695578A (en) * 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
DE3680123D1 (en) * 1985-01-23 1991-08-14 Glaxo Group Ltd Tetrahydrocarbazolonderivate.
DE3689974T2 (en) * 1985-03-14 1994-11-03 Beecham Group Plc Medicines to treat emesis.
GB8516083D0 (en) * 1985-06-25 1985-07-31 Glaxo Group Ltd Heterocyclic compounds
US5578628A (en) * 1985-06-25 1996-11-26 Glaxo Group Limited Medicaments for the treatment of nausea and vomiting
GB8518742D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
US5204356A (en) * 1985-07-24 1993-04-20 Glaxo Group Limited Treatment of anxiety
GB8518658D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Medicaments
GB8518741D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8518745D0 (en) 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8617994D0 (en) * 1986-07-23 1986-08-28 Glaxo Group Ltd Heterocyclic compounds
NL8701682A (en) * 1986-07-30 1988-02-16 Sandoz Ag METHOD FOR THE THERAPEUTIC USE OF SEROTONIN ANTAGONISTS, ACTIVE COMPOUNDS AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS
AT396870B (en) * 1986-08-07 1993-12-27 Sandoz Ag Process for the production of a pharmaceutical formulation for the nasal administration of serotonin antagonists
GB8623819D0 (en) * 1986-10-03 1986-11-05 Glaxo Group Ltd Heterocyclic compounds
DE3777805D1 (en) * 1986-11-21 1992-04-30 Glaxo Group Ltd MEDICINES FOR TREATING OR PREVENTING THE WITHDRAWAL SYNDROME.
GB8627909D0 (en) * 1986-11-21 1986-12-31 Glaxo Group Ltd Medicaments
GR871809B (en) * 1986-11-28 1988-03-07 Glaxo Group Ltd Process for the preparation of tricyclic ketones
GB8812002D0 (en) * 1988-05-20 1988-06-22 Glaxo Group Ltd Chemical compounds
US5202343A (en) * 1986-11-28 1993-04-13 Glaxo Group Limited Tricyclic ketones useful as HT3 -receptor antagonists
GB8628475D0 (en) * 1986-11-28 1987-01-07 Glaxo Group Ltd Medicaments
US4973594A (en) * 1986-12-17 1990-11-27 Glaxo Group Limited Medicaments
US5200414A (en) * 1986-12-17 1993-04-06 Glaxo Group Limited Methods for the treatment of cognitive disorders
ES2052585T3 (en) * 1986-12-17 1994-07-16 Glaxo Group Ltd USE OF KETONIC DERIVATIVES IN THE TREATMENT OF COGNITIVE DISORDERS.
US5190954A (en) * 1986-12-17 1993-03-02 Glaxo Group Limited Methods for the treatment of cognitive disorders
GB8630071D0 (en) * 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
GB8630079D0 (en) * 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
EP0291172B1 (en) * 1987-04-14 1992-11-19 Glaxo Group Limited Ketone derivatives
DE3874229T2 (en) * 1987-06-16 1993-03-25 British Tech Group USE OF DIOXOPIPERIDINE DERIVATIVES FOR PRODUCING A TOPICAL PREPARATION AS AN ANALGETIC.
DE3822792C2 (en) * 1987-07-11 1997-11-27 Sandoz Ag New use of 5HT¶3¶ antagonists
GB8723157D0 (en) * 1987-10-02 1987-11-04 Beecham Group Plc Compounds
JPH01258673A (en) * 1987-10-22 1989-10-16 Glaxo Group Ltd Ketone derivative
CA1304082C (en) * 1987-10-22 1992-06-23 Tetsuya Tahara Benzoxazine compounds and pharmaceutical use thereof
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8805269D0 (en) * 1988-03-04 1988-04-07 Glaxo Group Ltd Medicaments
JPH0249772A (en) * 1988-04-07 1990-02-20 Glaxo Group Ltd Imidazole derivative
DK185489A (en) * 1988-04-22 1989-10-23 Duphar Int Res IMIDAZOLYLMETHYL-CYCLOALKANOEBAA INDOLONES, THEIR PREPARATION AND USE
EP0339959A3 (en) * 1988-04-27 1991-03-20 Glaxo Group Limited Lactam derivatives
GB8812636D0 (en) * 1988-05-27 1988-06-29 Glaxo Group Ltd Chemical compounds
US5290785A (en) * 1988-09-27 1994-03-01 Fujisawa Pharmaceutical Co., Ltd. Therapeutic agent for ischemic diseases
US5173493A (en) * 1988-09-27 1992-12-22 Fujisawa Pharmaceutical Company, Ltd. Pyridoindole derivatives and processes for preparation thereof
AU627221B2 (en) * 1988-09-27 1992-08-20 Fujisawa Pharmaceutical Co., Ltd. Pyridoindole derivatives and processes for preparation thereof
FR2639944B1 (en) * 1988-12-06 1991-01-18 Adir NEW INDOLE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CA2004911A1 (en) * 1988-12-22 1990-06-22 Mitsuaki Ohta 4,5,6,7-tetrahydrobenzimidazole derivatives
EP0377238A1 (en) * 1988-12-22 1990-07-11 Duphar International Research B.V New annelated indolo (3,2-c)-lactams
US5223625A (en) * 1988-12-22 1993-06-29 Duphar International Research B.V. Annelated indolo [3,2,-C]lactams
KR900013959A (en) * 1989-03-13 1990-10-22 원본미기재 γ-carbline or their pharmaceutically acceptable acid addition salts and / or hydrates, and pharmaceutical compositions composed thereof
JPH0669963B2 (en) * 1989-04-21 1994-09-07 サンド・アクチエンゲゼルシャフト 5HT-Bottom 3 Therapeutic use of receptor antagonists
GB8914804D0 (en) * 1989-06-28 1989-08-16 Glaxo Group Ltd Process
GB8917557D0 (en) * 1989-08-01 1989-09-13 Glaxo Group Ltd Medicaments
US5276050A (en) * 1989-08-01 1994-01-04 Glaxo Group Limited Medicaments
US5126343A (en) * 1989-09-11 1992-06-30 G. D. Searle & Co. N-azabicyclo [3.3.0]octane amides of aromatic acids
GB2236751B (en) 1989-10-14 1993-04-28 Wyeth John & Brother Ltd Heterocyclic compounds
GB8928837D0 (en) * 1989-12-21 1990-02-28 Beecham Group Plc Pharmaceuticals
US5187166A (en) * 1990-07-31 1993-02-16 Nisshin Flour Milling Co., Ltd. Azabicyclo derivatives and their use as antiemetics
JPH05310732A (en) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp Cinnoline-3-carboxylic acid derivative
ES2043535B1 (en) * 1992-03-13 1994-08-01 Vita Invest Sa PROCEDURE FOR OBTAINING 1,2,3,9-TETRAHYDRO-9-METHYL-3- (2-METHYL-1H-IMIDAZOL-1-IL) METHYL * -4H-CARBAZOL-4-ONA.
HU212934B (en) 1992-10-14 1996-12-30 Richter Gedeon Vegyeszet Process for producing novel alkoxalylated carbazolone derivatives
CA2106642C (en) * 1992-10-14 2005-08-16 Peter Bod Carbazolone derivatives and process for preparing the same
HUT68293A (en) * 1993-03-08 1995-06-28 Fujisawa Pharmaceutical Co 5-ht antagonists as acting agent against cerebrovascular deseases
GB9310756D0 (en) * 1993-05-25 1993-07-14 Glaxo Lab Sa Compositions
GB2327348A (en) * 1994-06-28 1999-01-27 Kenneth Francis Prendergast Pharmaceutical use of ondansetron
GB9423588D0 (en) * 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
US6365743B1 (en) 1995-10-13 2002-04-02 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
AU702594B2 (en) * 1995-10-13 1999-02-25 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
US5969137A (en) * 1996-09-19 1999-10-19 Virginia Commonwealth University Benzylamidine derivatives with serotonin receptor binding activity
EP1181015A2 (en) 1999-03-01 2002-02-27 Sepracor Inc. Methods for treating apnea and apnea disorders using optically pure r(+)ondansetron
EP1207160A1 (en) * 2000-11-20 2002-05-22 Hanmi Pharm. Co., Ltd. Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one
ATE364611T1 (en) 2002-04-29 2007-07-15 Teva Gyogyszergyar Zartkoeruee METHOD FOR PRODUCING 1,2,3,9-TETRAHYDRO-9-METHYL-3-(2-METHYL-1H-IMIDAZOL-1-YL)METHYLÖ-H-CARBAZOL-4-ONE
FI6164U1 (en) * 2003-01-09 2004-03-15 Synthon Bv Ondansetronformer
GB2398071B (en) * 2003-01-24 2006-06-07 Synthon Bv Process for making ondansetron and intermediate thereof
ES2238001B1 (en) * 2004-01-21 2006-11-01 Vita Cientifica, S.L. NEW POLYMORPHIC FORMS OF ONDANSETRON, PROCEDURES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANANTIMETICS.
CA2565854A1 (en) 2004-05-07 2005-11-17 Taro Pharmaceutical Industries Ltd. Process for preparing ondansetron hydrochloride dihydrate having a defined particle size
US20090170872A1 (en) * 2005-07-05 2009-07-02 Orchid Research Laboratories Limited Compounds and Their Pharmaceutical Use
SI2432467T1 (en) 2009-05-20 2018-06-29 Inserm (Institut National De La Sante Et De La Recherche Medicale) Serotonin 5-ht3 receptor antagonists for use in the treatment of lesional vestibular disorders
ES2432618T3 (en) 2009-05-20 2013-12-04 Inserm (Institut National De La Santé Et De La Recherche Medicale) Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of a pathology of the inner ear with vestibular deficit
GB202301322D0 (en) 2023-01-30 2023-03-15 Therakind Ltd Antiemetic pharmaceutical compositions for nasal delivery

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US3634420A (en) * 1969-05-09 1972-01-11 American Cyanamid Co 3(morpholinomethyl)-2 3-dihydro-carbazol-4(1h)-ones
US3740404A (en) * 1969-05-09 1973-06-19 American Cyanamid Co Piperidinomethylenedihydrocarbazolones
DE3680123D1 (en) * 1985-01-23 1991-08-14 Glaxo Group Ltd Tetrahydrocarbazolonderivate.

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5470868A (en) 1991-06-26 1995-11-28 Sepracor Inc. Methods for treating emesis and nausea using optically pure R(+) ondansetron
US5629333A (en) 1991-06-26 1997-05-13 Sepracor Inc. Method treating cognitive disorders using optically pure R(+) ondansetron
US5712302A (en) 1991-06-26 1998-01-27 Sepracor Inc. Compositions using optically pure R(+) ondansetron
US5962494A (en) 1991-06-26 1999-10-05 Sepracor Inc. Methods for treating behavioral and other disorders using optically pure R(+) ondansetron
CN115611864A (en) * 2022-11-01 2023-01-17 常州兰陵制药有限公司 A kind of ondansetron compound and its preparation method and application

Also Published As

Publication number Publication date
AU3809785A (en) 1985-08-01
CH664152A5 (en) 1988-02-15
HUT37784A (en) 1986-02-28
IT1182150B (en) 1987-09-30
LU85743A1 (en) 1986-08-04
PH22672A (en) 1988-11-14
NZ210940A (en) 1989-08-29
ES8801247A1 (en) 1987-12-16
AU579132B2 (en) 1988-11-17
BE901576A (en) 1985-07-25
FI84349C (en) 1991-11-25
NL8500202A (en) 1985-08-16
ES8708224A1 (en) 1987-10-01
FR2561244B1 (en) 1988-03-04
NL940009I2 (en) 1999-05-03
NL940009I1 (en) 1994-07-18
SE8500368L (en) 1985-07-26
KR920003064B1 (en) 1992-04-13
DE19375046I2 (en) 2002-10-10
SG7089G (en) 1989-06-09
SE8500368D0 (en) 1985-01-25
ES539852A0 (en) 1986-07-16
GR850219B (en) 1985-05-23
ES8609309A1 (en) 1986-07-16
FI850323L (en) 1985-07-26
ATA20485A (en) 1990-08-15
NL190373B (en) 1993-09-01
HK33189A (en) 1989-04-28
NO164025C (en) 1990-08-22
AT392276B (en) 1991-02-25
SK404391A3 (en) 1995-08-09
PT79890B (en) 1987-02-03
CY1479A (en) 1989-07-21
NO164025B (en) 1990-05-14
ES556101A0 (en) 1987-12-16
DE3502508A1 (en) 1985-08-14
SE460359B (en) 1989-10-02
CZ404391A3 (en) 1993-04-14
SK277923B6 (en) 1995-08-09
DK169521B1 (en) 1994-11-21
IL74165A (en) 1988-11-15
DK35785A (en) 1985-07-26
ES548430A0 (en) 1987-10-01
DK35785D0 (en) 1985-01-25
FI850323A0 (en) 1985-01-25
GB2153821A (en) 1985-08-29
NO850300L (en) 1985-07-26
FR2561244A1 (en) 1985-09-20
CA1252793A (en) 1989-04-18
GB2153821B (en) 1988-01-20
FI84349B (en) 1991-08-15
PT79890A (en) 1985-02-01
NL190373C (en) 1994-02-01
DE3502508C2 (en) 1990-05-03
IE850187L (en) 1985-07-25
HU193592B (en) 1987-11-30
KR850005439A (en) 1985-08-26
LU88268I2 (en) 1994-02-03
IT8547600A0 (en) 1985-01-25
IE57809B1 (en) 1993-04-21
NO1994022I1 (en) 1994-11-09

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