GB8332646D0 - Antibodies - Google Patents

Antibodies

Info

Publication number: GB8332646D0
Authority: GB; United Kingdom
Prior art keywords: antibodies
Prior art date: 1982-04-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

GB838332646A

Other versions

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Hybritech Inc

Original Assignee

Hybritech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-04-12

Filing date

1983-04-12

Publication date

1984-01-11

1983-04-12 Application filed by Hybritech Inc filed Critical Hybritech Inc

1984-01-11 Publication of GB8332646D0 publication Critical patent/GB8332646D0/en

1984-05-02 Publication of GB2128631A publication Critical patent/GB2128631A/en

1987-02-25 Application granted granted Critical

1987-02-25 Publication of GB2128631B publication Critical patent/GB2128631B/en

Status Expired legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1084—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin
- A61K51/109—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin immunoglobulins having two or more different antigen-binding sites or multifunctional antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo

Landscapes

Health & Medical Sciences (AREA)
Immunology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Epidemiology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Physics & Mathematics (AREA)
Optics & Photonics (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)

GB08332646A 1982-04-12 1983-04-12 Antibodies having dual specificities their preparation and uses therefor Expired GB2128631B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US36778482A	1982-04-12	1982-04-12
PCT/US1983/000525 WO1983003679A1 (en)	1982-04-12	1983-04-12	Antibodies having dual specificities, their preparation and uses therefor

Publications (3)

Publication Number	Publication Date
GB8332646D0 true GB8332646D0 (en)	1984-01-11
GB2128631A GB2128631A (en)	1984-05-02
GB2128631B GB2128631B (en)	1987-02-25

Family

ID=23448582

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
GB08332646A Expired GB2128631B (en)	1982-04-12	1983-04-12	Antibodies having dual specificities their preparation and uses therefor
GB08530308A Expired GB2168998B (en)	1982-04-12	1985-12-09	Antibodies having dual specificities, their preparation and uses therefor
GB08530309A Expired GB2169921B (en)	1982-04-12	1985-12-09	Antibodies having dual specificities, their preparation and uses therefor
GB08530310A Expired GB2167086B (en)	1982-04-12	1985-12-09	Antibodies having dual specificities, their preparation and uses therefor

Family Applications After (3)

Application Number	Title	Priority Date	Filing Date
GB08530308A Expired GB2168998B (en)	1982-04-12	1985-12-09	Antibodies having dual specificities, their preparation and uses therefor
GB08530309A Expired GB2169921B (en)	1982-04-12	1985-12-09	Antibodies having dual specificities, their preparation and uses therefor
GB08530310A Expired GB2167086B (en)	1982-04-12	1985-12-09	Antibodies having dual specificities, their preparation and uses therefor

Country Status (11)

Country	Link
EP (1)	EP0105360A4 (en)
JP (2)	JPH0753119B2 (en)
AT (1)	AT394577B (en)
AU (1)	AU550486B2 (en)
CA (1)	CA1213229A (en)
CH (1)	CH672796A5 (en)
ES (7)	ES8504461A1 (en)
FI (1)	FI834529A0 (en)
GB (4)	GB2128631B (en)
IT (1)	IT1219778B (en)
WO (1)	WO1983003679A1 (en)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
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JP3177776B2 (en) *	1988-09-27	2001-06-18	武田薬品工業株式会社	Hybrid monoclonal antibodies, antibody-producing polydomas and antibody-containing drugs
US5292668A (en) *	1981-12-21	1994-03-08	Boston Biomedical Research Institute, Inc.	Bispecific antibody determinants
CA1214123A (en) *	1983-01-20	1986-11-18	Masashi Matsui	Cell lines for use in the preparation of hybridoma cells
EP0467416A1 (en) *	1983-09-01	1992-01-22	Hybritech Incorporated	Antibody compositions of therapeutic agents having an extended serum half-life
GB2148299B (en) *	1983-09-01	1988-01-06	Hybritech Inc	Antibody compositions of therapeutic agents having an extended serum half-life
ATE64622T1 (en) *	1984-04-23	1991-07-15	Boston Biomed Res Inst	DOUBLE SPECIFIC ANTIBODY DETERMINANTS.
NL8501219A (en) *	1985-04-29	1986-11-17	Stichting Vrienden Van De Stic	IMMUNOLOGICAL COMPLEX, ITS PREPARATION AND APPLICATION.
US5453269A (en) *	1986-04-14	1995-09-26	The General Hospital Corporation	Heterobifunctional antibodies having dual specificity for fibrin and thrombolylic agents and methods of use
JP2635343B2 (en)	1986-04-14	1997-07-30	ザ・ジェネラル・ホスピタル・コーポレーション	Heterobifunctional antibodies and methods of use
FR2604092B1 (en) *	1986-09-19	1990-04-13	Immunotech Sa	IMMUNOREACTIVES FOR TARGETING ANIMAL CELLS FOR VISUALIZATION OR DESTRUCTION IN VIVO
GB8626412D0 (en) *	1986-11-05	1986-12-03	Clark M R	Antibodies
GB8626413D0 (en) *	1986-11-05	1986-12-03	Gilliland L K	Antibodies
US5053226A (en) *	1987-07-15	1991-10-01	Board Of Regents, The University Of Texas System	Monoclonal antibodies binding platinum complexes
ES2058199T3 (en) *	1987-09-23	1994-11-01	Bristol Myers Squibb Co	ANTIBODY HETEROCONJUGATES FOR THE ELIMINATION OF HIV-INFECTED CELLS.
GB2218100A (en) *	1988-03-02	1989-11-08	Erling Sundrehagen	Conjugates for the detection and/or quantification of antigenic substances in body fluids
US4892824A (en) *	1988-03-15	1990-01-09	Synbiotics Corporation	Fast track method for producing monoclonal bi-specific immunoglobulins
US5372812A (en) *	1988-04-04	1994-12-13	The General Hospital Corporation	Composition and method for acceleration of clot lysis
US5582862A (en)	1988-04-04	1996-12-10	General Hospital Corporation	Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin
JPH02196799A (en) *	1988-04-08	1990-08-03	Agency Of Ind Science & Technol	Complex of anti-human cancer protein
US5851527A (en) *	1988-04-18	1998-12-22	Immunomedics, Inc.	Method for antibody targeting of therapeutic agents
IT1235349B (en) *	1988-12-23	1992-06-30	Biodata Spa	IMMUNOLOGICAL TEST FOR HOMOGENEOUS DETERMINATIONS
US5217713A (en) *	1988-12-27	1993-06-08	Takeda Chemical Industries, Ltd.	Cytotoxic bispecific monoclonal antibody, its production and use
CA2006408A1 (en) *	1988-12-27	1990-06-27	Susumu Iwasa	Bispecific monoclonal antibody, its production and use
WO1990012109A1 (en) *	1989-03-30	1990-10-18	Board Of Regents, The University Of Texas System	Monoclonal antibodies binding platinum complexes
FR2652004B1 (en) *	1989-09-21	1994-10-28	Immunotech Partners	NOVEL HYDROPHILIC DERIVATIVES, APPLICATION TO DIAGNOSIS AND THERAPEUTICS, DIAGNOSTIC OR THERAPEUTIC KITS AND IMMUNOLOGICAL REAGENTS.
CA2075927A1 (en) *	1990-02-16	1991-08-17	Victor A. Raso	Hybrid reagents capable of selectively releasing molecules into cells
TW212184B (en) *	1990-04-02	1993-09-01	Takeda Pharm Industry Co Ltd
JP3431140B2 (en) *	1991-04-26	2003-07-28	サーフィス・アクティブ・リミテッド	Antibodies and methods of use
GB9316369D0 (en) *	1993-08-06	1993-09-22	Surface Active Ltd	Diagnostic method
US5541110A (en)	1994-05-17	1996-07-30	Bristol-Myers Squibb	Cloning and expression of a gene encoding bryodin 1 from Bryonia dioica
GB9421468D0 (en) *	1994-10-18	1994-12-07	Surface Active Ltd	Biosensor
AU741338B2 (en) *	1996-09-20	2001-11-29	Bristol-Myers Squibb Company	Chimeric, humanized and single chain antibodies to alpha-2-antiplasmin
US20020132274A1 (en)	2001-01-17	2002-09-19	Nevalainen Marja T.	Diagnostic and monitorings methods for cancer
WO2004010957A2 (en)	2002-07-31	2004-02-05	Seattle Genetics, Inc.	Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
AU2004316290C1 (en)	2003-11-06	2012-02-02	Seagen Inc.	Monomethylvaline compounds capable of conjugation to ligands
EP3138832A1 (en)	2004-03-16	2017-03-08	Temple University - Of The Commonwealth System of Higher Education	Substituted phenoxy- and phenylthio- derivatives for treating proliferative disorders
AU2005332660A1 (en)	2004-11-12	2006-12-14	Seattle Genetics, Inc.	Auristatins having an aminobenzoic acid unit at the N terminus
EP1871418B1 (en)	2005-04-19	2014-03-19	Seattle Genetics, Inc.	Humanized anti-cd70 binding agents and uses thereof
PL1912671T3 (en)	2005-07-18	2018-02-28	Seattle Genetics, Inc.	Beta-glucuronide-linker drug conjugates
WO2008070593A2 (en)	2006-12-01	2008-06-12	Seattle Genetics, Inc.	Variant target binding agents and uses thereof
ES2374330T3 (en)	2007-01-22	2012-02-15	Genentech, Inc.	PRECIPITATION WITH POLYELECTROLYTE AND PURIFICATION OF ANTIBODIES.
WO2009135181A2 (en)	2008-05-02	2009-11-05	Seattle Genetics, Inc.	Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
WO2011133658A1 (en)	2010-04-22	2011-10-27	Boston Medical Center Corporation	Compositions and methods for targeting and delivering therapeutics into cells
US9353150B2 (en)	2012-12-04	2016-05-31	Massachusetts Institute Of Technology	Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
PL2968440T3 (en)	2013-03-15	2019-12-31	Zymeworks Inc.	Cytotoxic and anti-mitotic compounds, and methods of using the same
US10227407B2 (en)	2013-10-10	2019-03-12	Yukinari Kato	Anti-podoplanin antibody
CA2935077C (en)	2013-12-27	2022-03-15	Geoffrey C. Winters	Sulfonamide-containing linkage systems for drug conjugates
CA2960899C (en)	2014-09-17	2021-08-17	Zymeworks Inc.	Cytotoxic and anti-mitotic compounds, and methods of using the same
CN107029242A (en)	2015-11-03	2017-08-11	财团法人工业技术研究院	Antibody drug complex and method for producing same
US11844839B2 (en)	2016-03-25	2023-12-19	Seagen Inc.	Process for the preparation of pegylated drug-linkers and intermediates thereof
US10918627B2 (en)	2016-05-11	2021-02-16	Massachusetts Institute Of Technology	Convergent and enantioselective total synthesis of Communesin analogs
EP3600443A1 (en)	2017-03-24	2020-02-05	Seattle Genetics, Inc.	Process for the preparation of glucuronide drug-linkers and intermediates thereof
US11932650B2 (en)	2017-05-11	2024-03-19	Massachusetts Institute Of Technology	Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en)	2017-10-13	2020-05-05	Massachusetts Institute Of Technology	Diazene directed modular synthesis of compounds with quaternary carbon centers
US10869888B2 (en)	2018-04-17	2020-12-22	Innovative Cellular Therapeutics CO., LTD.	Modified cell expansion and uses thereof
CA3110096A1 (en) *	2018-08-30	2020-03-05	Innovative Cellular Therapeutics CO., LTD.	Chimeric antigen receptor cells for treating solid tumor
US20220409734A1 (en)	2019-05-10	2022-12-29	Yutaka Nishimoto	Antibody drug conjugates
TW202138388A (en)	2019-12-30	2021-10-16	美商西根公司	Methods of treating cancer with nonfucosylated anti-cd70 antibodies
US12076343B2 (en)	2020-02-19	2024-09-03	Innovative Cellular Therapeutics Holdings, Ltd.	Engineered safety in cell therapy
US12043654B2 (en)	2020-06-02	2024-07-23	Innovative Cellular Therapeutics Holdings, Ltd.	Anti-GCC antibody and CAR thereof for treating digestive system cancer
US20220168330A1 (en)	2020-11-09	2022-06-02	Takeda Pharmaceutical Company Limited	Antibody drug conjugates
US12030888B2 (en)	2021-02-24	2024-07-09	Massachusetts Institute Of Technology	Himastatin derivatives, and processes of preparation thereof, and uses thereof
WO2023278377A1 (en)	2021-06-29	2023-01-05	Seagen Inc.	Methods of treating cancer with a combination of a nonfucosylated anti-cd70 antibody and a cd47 antagonist

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4130634A (en) *	1974-03-15	1978-12-19	University Of Illinois Foundation	Method for detecting and quantifying antigens
US4331647A (en) *	1980-03-03	1982-05-25	Goldenberg Milton David	Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
US4376110A (en) *	1980-08-04	1983-03-08	Hybritech, Incorporated	Immunometric assays using monoclonal antibodies
US4474893A (en) *	1981-07-01	1984-10-02	The University of Texas System Cancer Center	Recombinant monoclonal antibodies

1983
- 1983-04-11 ES ES521370A patent/ES8504461A1/en not_active Expired
- 1983-04-11 CA CA000425558A patent/CA1213229A/en not_active Expired
- 1983-04-12 GB GB08332646A patent/GB2128631B/en not_active Expired
- 1983-04-12 EP EP19830901672 patent/EP0105360A4/en not_active Ceased
- 1983-04-12 WO PCT/US1983/000525 patent/WO1983003679A1/en not_active Application Discontinuation
- 1983-04-12 AU AU15559/83A patent/AU550486B2/en not_active Expired
- 1983-04-12 AT AT0901883A patent/AT394577B/en not_active IP Right Cessation
- 1983-04-12 CH CH6700/83A patent/CH672796A5/de not_active IP Right Cessation
- 1983-04-12 IT IT20548/83A patent/IT1219778B/en active
- 1983-12-09 FI FI834529A patent/FI834529A0/en not_active Application Discontinuation
- 1983-12-12 ES ES527963A patent/ES8503441A1/en not_active Expired
1984
- 1984-07-02 ES ES533931A patent/ES8506091A1/en not_active Expired
- 1984-07-02 ES ES533930A patent/ES533930A0/en active Granted
- 1984-10-31 ES ES537257A patent/ES8606655A1/en not_active Expired
- 1984-12-18 ES ES538727A patent/ES8604424A1/en not_active Expired
1985
- 1985-07-16 ES ES545247A patent/ES8607386A1/en not_active Expired
- 1985-12-09 GB GB08530308A patent/GB2168998B/en not_active Expired
- 1985-12-09 GB GB08530309A patent/GB2169921B/en not_active Expired
- 1985-12-09 GB GB08530310A patent/GB2167086B/en not_active Expired
1987
- 1987-01-05 JP JP62000342A patent/JPH0753119B2/en not_active Expired - Lifetime
1994
- 1994-02-10 JP JP6016728A patent/JP2562002B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IT1219778B (en)	1990-05-24
GB2128631B (en)	1987-02-25
ES8604424A1 (en)	1986-02-01
ATA901883A (en)	1991-10-15
CA1213229A (en)	1986-10-28
IT8320548A0 (en)	1983-04-12
ES521370A0 (en)	1985-04-16
EP0105360A4 (en)	1986-07-08
ES533931A0 (en)	1985-06-16
EP0105360A1 (en)	1984-04-18
JPS6312276A (en)	1988-01-19
GB8530310D0 (en)	1986-01-22
FI834529A (en)	1983-12-09
GB2167086A (en)	1986-05-21
ES8607386A1 (en)	1986-05-16
ES538727A0 (en)	1986-02-01
GB2167086B (en)	1987-03-04
GB2169921B (en)	1987-03-04
ES545247A0 (en)	1986-05-16
ES8504461A1 (en)	1985-04-16
AU1555983A (en)	1983-11-04
ES8603080A1 (en)	1985-12-01
ES537257A0 (en)	1986-04-01
GB8530308D0 (en)	1986-01-22
CH672796A5 (en)	1989-12-29
GB2128631A (en)	1984-05-02
GB2168998A (en)	1986-07-02
ES527963A0 (en)	1985-02-16
ES533930A0 (en)	1985-12-01
ES8506091A1 (en)	1985-06-16
ES8503441A1 (en)	1985-02-16
JPH0753119B2 (en)	1995-06-07
AU550486B2 (en)	1986-03-20
GB2168998B (en)	1987-03-04
AT394577B (en)	1992-05-11
GB2169921A (en)	1986-07-23
JP2562002B2 (en)	1996-12-11
JPH0753600A (en)	1995-02-28
FI834529A0 (en)	1983-12-09
WO1983003679A1 (en)	1983-10-27
GB8530309D0 (en)	1986-01-22
ES8606655A1 (en)	1986-04-01

Publication	Publication Date	Title
GB8530309D0 (en)	1986-01-22	Antibodies
CS124683A2 (en)	1985-06-13	Zpusob zapouzdreni ucinne latky chemickeho prostredku
GB8300371D0 (en)	1983-02-09	Immunoassay
GB8316001D0 (en)	1983-07-13	Monoclonal antibodies
AR242637A1 (en)	1993-04-30	Staking-machine
IL68601A0 (en)	1983-09-30	Eye-protecting means
CS102482A1 (en)	1984-06-18	Stabilizacni zarizeni plasmoveho generatoru
CS1010682A1 (en)	1985-09-17	Samosvorny hydraulicky obvod
CA50163S (en)	1982-08-30	Skillet-oven
CA50660S (en)	1982-12-20	Gamesboard
CA50080S (en)	1982-08-09	Bruach
IE820162L (en)	1982-07-28	Manufacturing antibodies
BG35837A1 (en)	1984-07-16	Antiicer means
BG35198A1 (en)	1984-03-15	Nitratereductase means
BG46479A1 (en)	1990-01-15	Spasmalytic means
BG33766A1 (en)	1983-05-16	Insectiside means
BG33765A1 (en)	1983-05-16	Insectiside means
CS129983A1 (en)	1985-06-13	Indikator brzdove polohy
BG35995A1 (en)	1984-08-15	Hydrotransmission
CS1006282A1 (en)	1984-03-20	Sposob usmernenej dediferenciacnej transformacie bobovitych rastlin
AU88266S (en)	1984-02-09	Boardgame
AU87474S (en)	1983-08-19	Drain-outlet closure-plug
AU87024S (en)	1983-02-25	Watch-pen
BG34948A1 (en)	1984-01-16	Box- pallet
CS12382A1 (en)	1985-06-13	Spektrofluorometr

Legal Events

Date	Code	Title	Description
1993-12-08	PCNP	Patent ceased through non-payment of renewal fee	Effective date: 19930412