GB833149A - Rauwolfia alkaloids and their extraction - Google Patents
Rauwolfia alkaloids and their extractionInfo
- Publication number
- GB833149A GB833149A GB12014/58A GB1201458A GB833149A GB 833149 A GB833149 A GB 833149A GB 12014/58 A GB12014/58 A GB 12014/58A GB 1201458 A GB1201458 A GB 1201458A GB 833149 A GB833149 A GB 833149A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkaloids
- raugustine
- raunescine
- acetyl
- extraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The invention comprises Raugustine of the formula <FORM:0833149/IV (b)/1> its esters, and salts thereof, together with a process for isolating weakly basic alkaloids of the raunescine series wherein an aqueous solution of a weak acid containing alkaloids of the raunescine group in admixture with other alkaloids from Rauwolfia plants is extracted with benzene (or other organic solvent having similar extraction properties for the alkaloids) to remove the reserpine alkaloids and the greater part of the ajmalicine alkaloids, the residual aqueous solution is extracted with ethylene chloride (or other organic solvent of similar action) to obtain the raunescine alkaloids, which are isolated if desired in pure form by adsorption, elution or crystallization of the mixture so obtained. Detailed examples illustrate the extraction of raugustine, raunescine, isoraunescine, reserpiline and pseudoreserpine from various Rauwolfia species, and the preparation of 18-O-acetyl-raugustine and raugustine nitrate. The conversion of raugustine to 17-acetyl-pseudorescopine by treatment with pyridine hydrochloride, then sodium methylate, acetylation to methyl 17-acetyl pseudoreserpic acid ester and esterification with trimethoxybenzoyl chloride is described.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH833149X | 1957-04-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB833149A true GB833149A (en) | 1960-04-21 |
Family
ID=4540465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB12014/58A Expired GB833149A (en) | 1957-04-15 | 1958-04-15 | Rauwolfia alkaloids and their extraction |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB833149A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3247183A (en) * | 1966-04-19 | New process for the manufacture of yohimbane compounds | ||
| WO2010113180A3 (en) * | 2009-03-31 | 2010-12-16 | Council Of Scientific & Industrial Research | Antipsychotic agents and standardized antipsychotic fractions from rauwolfia tetraphylla and process of their isolation |
-
1958
- 1958-04-15 GB GB12014/58A patent/GB833149A/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3247183A (en) * | 1966-04-19 | New process for the manufacture of yohimbane compounds | ||
| WO2010113180A3 (en) * | 2009-03-31 | 2010-12-16 | Council Of Scientific & Industrial Research | Antipsychotic agents and standardized antipsychotic fractions from rauwolfia tetraphylla and process of their isolation |
| GB2481179A (en) * | 2009-03-31 | 2011-12-14 | Council Scient Ind Res | Antipsychotic agents and standardized antipsychotic fractions from rauwolfia tetraphylla and process of their isolation |
| GB2481179B (en) * | 2009-03-31 | 2014-04-09 | Council Scient Ind Res | Antipsychotic agents and standardized antipsychotic fractions from Rauwolfia tetraphylla and process of their isolation |
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