GB839911A - Derivatives of etiocholane and the preparation thereof - Google Patents
Derivatives of etiocholane and the preparation thereofInfo
- Publication number
- GB839911A GB839911A GB924/58A GB92458A GB839911A GB 839911 A GB839911 A GB 839911A GB 924/58 A GB924/58 A GB 924/58A GB 92458 A GB92458 A GB 92458A GB 839911 A GB839911 A GB 839911A
- Authority
- GB
- United Kingdom
- Prior art keywords
- etiocholane
- hydroxy
- hemiesters
- carboxylic esters
- hemisuccinate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises 3a -hydroxy-etiocholane-11-one and carboxylic esters and dicarboxylic hemiesters thereof and salts of the hemiesters, and a process for the preparation of 3a - hydroxy - etiocholane - 11 - one by reducing 3a - hydroxy - etiocholane - 11,17 - dione with hydrazine hydrate in the presence of an alkali metal hydroxide in a solvent medium having a boiling point of at least 120 DEG C., the reduction being effected at a temperature of at least 120 DEG C. The above process may be modified in that carboxylic esters of 3a -hydroxy-etiocholane-11,17-dione e.g. the acetate, benzoate or succinate, are used as reactants, the 3-ester groups being hydrolysed during the reaction. A suitable reaction solvent is diethylene glycol, and a suitable alkali metal hydroxide is potassium hydroxide. The carboxylic esters and dicarboxylic hemiesters may be prepared by the usual acylation methods. In the examples 3a -hydroxy-etiocholane-11-one and the 3-acetate and 3-hemisuccinate thereof and the sodium salt of the 3-hemisuccinate are prepared.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR839911X | 1957-01-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB839911A true GB839911A (en) | 1960-06-29 |
Family
ID=9299755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB924/58A Expired GB839911A (en) | 1957-01-29 | 1958-01-09 | Derivatives of etiocholane and the preparation thereof |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB839911A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5925630A (en) * | 1995-06-06 | 1999-07-20 | Cocensys, Inc. | Neuroactive steroids of the androstane and pregnane series |
| US6780853B1 (en) | 1995-06-06 | 2004-08-24 | Euro-Celtique S.A. | Neuroactive steroids of the androstane and pregnane series |
-
1958
- 1958-01-09 GB GB924/58A patent/GB839911A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5925630A (en) * | 1995-06-06 | 1999-07-20 | Cocensys, Inc. | Neuroactive steroids of the androstane and pregnane series |
| US6780853B1 (en) | 1995-06-06 | 2004-08-24 | Euro-Celtique S.A. | Neuroactive steroids of the androstane and pregnane series |
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