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GB798680A - Improvements in or relating to the preparation of pharmaceutical compositions - Google Patents

Improvements in or relating to the preparation of pharmaceutical compositions

Info

Publication number
GB798680A
GB798680A GB8511/57A GB851157A GB798680A GB 798680 A GB798680 A GB 798680A GB 8511/57 A GB8511/57 A GB 8511/57A GB 851157 A GB851157 A GB 851157A GB 798680 A GB798680 A GB 798680A
Authority
GB
United Kingdom
Prior art keywords
acid
salts
acetylaminoisocaproic
piperazine
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8511/57A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc SA
Original Assignee
Rhone Poulenc SA
Societe des Usines Chimiques Rhone Poulenc SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc SA, Societe des Usines Chimiques Rhone Poulenc SA filed Critical Rhone Poulenc SA
Publication of GB798680A publication Critical patent/GB798680A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises salts of a -acetylaminoisocaproic acid and monoethanolamine, piperazine and N-methylglucamine, the preparation of which is described in Examples VI to XI. In Example VII double decomposition in aqueous solution (piperazine sulphate and barium a -acetylaminoisocaproate) is followed by concentration of the solution to produce crystallization. In the other examples the acid is added to a solution of the base in water. The salts are anti-vertigo agents.ALSO:A pharmaceutical composition of utility in combating vertigo comprises at least one compound containing an a -acetylaminoisocaproic anion in a sterile diluent medium. Specified compounds are a -acetylaminoisocaproic acid, the alkali metal (preferably sodium) salts of the acid, and the salts obtained by combining the acid with monoethanolamine, piperazine, morpholine and N-methylglucamine. The compound may be racemic or optically active and its concentration in the composition, calculated as acid, should be at least 1 per cent and preferably 5 to 25 per cent by weight.
GB8511/57A 1956-03-30 1957-03-14 Improvements in or relating to the preparation of pharmaceutical compositions Expired GB798680A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR798680X 1956-03-30

Publications (1)

Publication Number Publication Date
GB798680A true GB798680A (en) 1958-07-23

Family

ID=9236337

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8511/57A Expired GB798680A (en) 1956-03-30 1957-03-14 Improvements in or relating to the preparation of pharmaceutical compositions

Country Status (1)

Country Link
GB (1) GB798680A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2905600A1 (en) * 2006-09-13 2008-03-14 Pierre Fabre Medicament Sa TREATMENT OF VERTIGS BY ACETYL-L-LEUCINE.
US9932277B2 (en) 2010-11-02 2018-04-03 Advansix Resins & Chemicals Llc Method for producing ammonium sulfate nitrate

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2905600A1 (en) * 2006-09-13 2008-03-14 Pierre Fabre Medicament Sa TREATMENT OF VERTIGS BY ACETYL-L-LEUCINE.
WO2008032222A2 (en) * 2006-09-13 2008-03-20 Pierre Fabre Medicament Treatment of vertigo with acetyl-l-leucine
WO2008032222A3 (en) * 2006-09-13 2008-05-02 Pf Medicament Treatment of vertigo with acetyl-l-leucine
FR2943537A1 (en) * 2006-09-13 2010-10-01 Pf Medicament TREATMENT OF VESTIBULAR NEVITIS BY ACETYL-L-LEUCINE
AU2007297181B2 (en) * 2006-09-13 2013-10-17 Pierre Fabre Medicament Treatment of vertigo with acetyl-L-leucine
US9932277B2 (en) 2010-11-02 2018-04-03 Advansix Resins & Chemicals Llc Method for producing ammonium sulfate nitrate

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