GB743043A - Basic ethers of substituted diphenylmethyl carbinols - Google Patents
Basic ethers of substituted diphenylmethyl carbinolsInfo
- Publication number
- GB743043A GB743043A GB28502/53A GB2850253A GB743043A GB 743043 A GB743043 A GB 743043A GB 28502/53 A GB28502/53 A GB 28502/53A GB 2850253 A GB2850253 A GB 2850253A GB 743043 A GB743043 A GB 743043A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ether
- phenyl
- hydrochloride
- ethyl ether
- chlorophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises compounds of formula <FORM:0743043/IV(a)/1> wherein B is dimethylamino, diethylamino, and piperidino, and acid salts thereof. The compounds are prepared by reacting 4-chlorobenzophenone or 4-chloro-acetophenone with an excess (e.g. a 50 per cent or more excess) of a methylmagnesium halide (e.g. methyl magnesium chloride) or a phenyl magnesium halide respectively under Grignard conditions to form a - phenyl - a - para - chlorophenyl - ethanol, treating the latter in an organic solvent (e.g. toluene) and in presence of sodium amide with a compound of formula B-CH2-CH2-Halogen, separating the resulting ether and, if desired, converting this to the hydrochloride by dissolving it in ethyl ether and adding dropwise ethyl ether saturated with an equivalent amount of hydrochloric acid, drying the precipitated hydrochloride in vacuo, redissolving in acetone, precipitating therefrom with ethyl ether, removing the ether, and finally drying the hydrochloride in vacuo over phosphorus pentoxide. The examples describe the preparation of (1 - para - chlorophenyl - 1 - phenyl) - ethyl-(b - dimethylaminoethyl, b - diethylaminoethyl, and b -piperidinoethyl) ether and the hydrochlorides thereof. Specification 667,113 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE743043X | 1952-10-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB743043A true GB743043A (en) | 1956-01-04 |
Family
ID=6646500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB28502/53A Expired GB743043A (en) | 1952-10-25 | 1953-10-15 | Basic ethers of substituted diphenylmethyl carbinols |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB743043A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2932668A (en) * | 1957-01-22 | 1960-04-12 | Asta Werke Ag Chem Fab | Process for the production of aminoalkyl ethers of alcohols of the aromatic-aliphatic series |
| US2999096A (en) * | 1957-05-23 | 1961-09-05 | Endo Lab | Cyanobenzhydryl ethers of amino alcohols |
| US3102072A (en) * | 1959-05-30 | 1963-08-27 | Asta Werke Ag Chem Fab | Hypnotic composition comprising barbituric acid derivatives and n,n-disubstituted - beta - aminoisopropyl-(p-chloro-alpha-methyl-benzhydryl)-ethers |
-
1953
- 1953-10-15 GB GB28502/53A patent/GB743043A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2932668A (en) * | 1957-01-22 | 1960-04-12 | Asta Werke Ag Chem Fab | Process for the production of aminoalkyl ethers of alcohols of the aromatic-aliphatic series |
| US2999096A (en) * | 1957-05-23 | 1961-09-05 | Endo Lab | Cyanobenzhydryl ethers of amino alcohols |
| US3102072A (en) * | 1959-05-30 | 1963-08-27 | Asta Werke Ag Chem Fab | Hypnotic composition comprising barbituric acid derivatives and n,n-disubstituted - beta - aminoisopropyl-(p-chloro-alpha-methyl-benzhydryl)-ethers |
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