GB748024A - Improved therapeutic preparations of iron - Google Patents
Improved therapeutic preparations of ironInfo
- Publication number
- GB748024A GB748024A GB551953A GB551953A GB748024A GB 748024 A GB748024 A GB 748024A GB 551953 A GB551953 A GB 551953A GB 551953 A GB551953 A GB 551953A GB 748024 A GB748024 A GB 748024A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ferric
- colloidal
- water
- solution
- iron
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 3
- 229910052742 iron Inorganic materials 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 239000000243 solution Substances 0.000 abstract 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- 229920002307 Dextran Polymers 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 239000000084 colloidal system Substances 0.000 abstract 1
- 238000000502 dialysis Methods 0.000 abstract 1
- 235000019441 ethanol Nutrition 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 229960004887 ferric hydroxide Drugs 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- IEECXTSVVFWGSE-UHFFFAOYSA-M iron(3+);oxygen(2-);hydroxide Chemical compound [OH-].[O-2].[Fe+3] IEECXTSVVFWGSE-UHFFFAOYSA-M 0.000 abstract 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Natural products OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
A therapeutic colloidal preparation of iron is obtained by reacting a solution of partially de-polymerized dextran, a solution or suspension of a ferric compound and an alkali, e.g. an alkali metal hydroxide or carbonate, to form a colloidal solution whose pH is, or is adjusted to, between 4 and 11. For injection it is brought to pH 5,5-8,5. Ferric compounds used are salts, precipitated ferric hydroxide, &c. The preparation which may contain 6-10 per cent ferric hydrioxide, may be rendered isotonic by dialysis against running water, or by separating the colloid by adding methyl or ethyl alcohol, and redissolving in water with addition of a suitable amount of sodium chloride or glucose. The colloidal solutions may be dehydrated by evaporation under reduced pressure to yield a solid, which may be reconstituted with water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB551953A GB748024A (en) | 1953-02-27 | 1953-02-27 | Improved therapeutic preparations of iron |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB551953A GB748024A (en) | 1953-02-27 | 1953-02-27 | Improved therapeutic preparations of iron |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB748024A true GB748024A (en) | 1956-04-18 |
Family
ID=9797730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB551953A Expired GB748024A (en) | 1953-02-27 | 1953-02-27 | Improved therapeutic preparations of iron |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB748024A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0044050A3 (en) * | 1980-07-16 | 1982-04-28 | Laboratorien Hausmann Ag | Process for preparing ferrihydroxide-dextran complexes, and a pharmaceutical sterile solution containing them |
| US4770183A (en) * | 1986-07-03 | 1988-09-13 | Advanced Magnetics Incorporated | Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents |
| US4951675A (en) * | 1986-07-03 | 1990-08-28 | Advanced Magnetics, Incorporated | Biodegradable superparamagnetic metal oxides as contrast agents for MR imaging |
| US5219554A (en) | 1986-07-03 | 1993-06-15 | Advanced Magnetics, Inc. | Hydrated biodegradable superparamagnetic metal oxides |
| EP2044946A4 (en) * | 2006-06-29 | 2009-11-11 | Pharma Co Ltd J | Preventive remedial therapeutic agent for phosphorus impairment, oral agent for adsorbing phosphate ion contained in food, beverage and chemical, and process for producing them |
| US8231790B2 (en) | 2006-06-29 | 2012-07-31 | Createrra Inc. | Process for producing an anion adsorbent and anion adsorbent produced by said process |
| US11123321B2 (en) | 2002-10-23 | 2021-09-21 | Vifor (International) Ag | Aqueous iron carbohydrate complexes, their production and medicaments containing them |
| US11344568B2 (en) | 2006-01-06 | 2022-05-31 | American Regent, Inc. | Methods and compositions for administration of iron |
-
1953
- 1953-02-27 GB GB551953A patent/GB748024A/en not_active Expired
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0044050A3 (en) * | 1980-07-16 | 1982-04-28 | Laboratorien Hausmann Ag | Process for preparing ferrihydroxide-dextran complexes, and a pharmaceutical sterile solution containing them |
| US4770183A (en) * | 1986-07-03 | 1988-09-13 | Advanced Magnetics Incorporated | Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents |
| US4951675A (en) * | 1986-07-03 | 1990-08-28 | Advanced Magnetics, Incorporated | Biodegradable superparamagnetic metal oxides as contrast agents for MR imaging |
| US5219554A (en) | 1986-07-03 | 1993-06-15 | Advanced Magnetics, Inc. | Hydrated biodegradable superparamagnetic metal oxides |
| US11123321B2 (en) | 2002-10-23 | 2021-09-21 | Vifor (International) Ag | Aqueous iron carbohydrate complexes, their production and medicaments containing them |
| US11291645B2 (en) | 2002-10-23 | 2022-04-05 | Vifor (International) Ag | Aqueous iron carbohydrate complexes, their production and medicaments containing them |
| US11590097B2 (en) | 2002-10-23 | 2023-02-28 | Vifor (International) Ag | Aqueous iron carbohydrate complexes, their production and medicaments containing them |
| US11344568B2 (en) | 2006-01-06 | 2022-05-31 | American Regent, Inc. | Methods and compositions for administration of iron |
| US11364260B2 (en) | 2006-01-06 | 2022-06-21 | American Regent, Inc. | Methods and compositions for administration of iron |
| US11406656B2 (en) | 2006-01-06 | 2022-08-09 | American Regent, Inc. | Methods and compositions for administration of iron |
| US11433091B2 (en) | 2006-01-06 | 2022-09-06 | American Regent, Inc. | Methods and compositions for administration of iron |
| US11478502B2 (en) | 2006-01-06 | 2022-10-25 | American Regent, Inc. | Methods and compositions for administration of iron |
| US12329772B2 (en) | 2006-01-06 | 2025-06-17 | American Regent, Inc. | Methods and compositions for administration of iron |
| US8231790B2 (en) | 2006-06-29 | 2012-07-31 | Createrra Inc. | Process for producing an anion adsorbent and anion adsorbent produced by said process |
| EP2044946A4 (en) * | 2006-06-29 | 2009-11-11 | Pharma Co Ltd J | Preventive remedial therapeutic agent for phosphorus impairment, oral agent for adsorbing phosphate ion contained in food, beverage and chemical, and process for producing them |
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