GB2606172A - Biocompatible polymer films with antimicrobial, antibacterial, and/or antiviral properties - Google Patents
Biocompatible polymer films with antimicrobial, antibacterial, and/or antiviral properties Download PDFInfo
- Publication number
- GB2606172A GB2606172A GB2106026.4A GB202106026A GB2606172A GB 2606172 A GB2606172 A GB 2606172A GB 202106026 A GB202106026 A GB 202106026A GB 2606172 A GB2606172 A GB 2606172A
- Authority
- GB
- United Kingdom
- Prior art keywords
- biocompatible polymer
- metal
- coating composition
- biocompatible
- polymer coating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920000249 biocompatible polymer Polymers 0.000 title claims abstract description 218
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 33
- 230000000845 anti-microbial effect Effects 0.000 title claims abstract description 33
- 230000000840 anti-viral effect Effects 0.000 title claims abstract description 33
- 229910052751 metal Inorganic materials 0.000 claims abstract description 131
- 239000002184 metal Substances 0.000 claims abstract description 131
- 239000008199 coating composition Substances 0.000 claims abstract description 111
- 239000002245 particle Substances 0.000 claims abstract description 93
- 229920000642 polymer Polymers 0.000 claims abstract description 77
- 229910044991 metal oxide Inorganic materials 0.000 claims abstract description 73
- 150000004706 metal oxides Chemical class 0.000 claims abstract description 73
- 229910001092 metal group alloy Inorganic materials 0.000 claims abstract description 70
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims abstract description 58
- 229920002635 polyurethane Polymers 0.000 claims abstract description 49
- 239000004814 polyurethane Substances 0.000 claims abstract description 49
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 36
- -1 glycidyl epoxide Chemical class 0.000 claims abstract description 29
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims abstract description 28
- 239000000203 mixture Substances 0.000 claims abstract description 26
- 239000003960 organic solvent Substances 0.000 claims abstract description 26
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 16
- 239000004815 dispersion polymer Substances 0.000 claims abstract description 13
- 230000001681 protective effect Effects 0.000 claims abstract description 12
- 239000012948 isocyanate Substances 0.000 claims abstract description 10
- 238000004519 manufacturing process Methods 0.000 claims abstract description 9
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 claims abstract description 5
- 150000001718 carbodiimides Chemical class 0.000 claims abstract description 5
- 150000002513 isocyanates Chemical class 0.000 claims abstract description 5
- 150000001412 amines Chemical class 0.000 claims abstract description 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 4
- SWXVUIWOUIDPGS-UHFFFAOYSA-N diacetone alcohol Chemical compound CC(=O)CC(C)(C)O SWXVUIWOUIDPGS-UHFFFAOYSA-N 0.000 claims abstract description 4
- 150000002118 epoxides Chemical class 0.000 claims abstract description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 4
- 239000000758 substrate Substances 0.000 claims description 44
- 238000000576 coating method Methods 0.000 claims description 26
- 239000004744 fabric Substances 0.000 claims description 26
- QPLDLSVMHZLSFG-UHFFFAOYSA-N Copper oxide Chemical compound [Cu]=O QPLDLSVMHZLSFG-UHFFFAOYSA-N 0.000 claims description 23
- 229910052802 copper Inorganic materials 0.000 claims description 23
- 239000010949 copper Substances 0.000 claims description 23
- BERDEBHAJNAUOM-UHFFFAOYSA-N copper(I) oxide Inorganic materials [Cu]O[Cu] BERDEBHAJNAUOM-UHFFFAOYSA-N 0.000 claims description 21
- 239000000463 material Substances 0.000 claims description 21
- 239000011248 coating agent Substances 0.000 claims description 20
- 229920003023 plastic Polymers 0.000 claims description 19
- 239000004033 plastic Substances 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 15
- 238000001723 curing Methods 0.000 claims description 13
- 229920000728 polyester Polymers 0.000 claims description 13
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 12
- 229920000570 polyether Polymers 0.000 claims description 12
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 11
- 238000011065 in-situ storage Methods 0.000 claims description 11
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 9
- 239000000194 fatty acid Substances 0.000 claims description 9
- 229930195729 fatty acid Natural products 0.000 claims description 9
- 150000004665 fatty acids Chemical class 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 9
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 8
- 239000000560 biocompatible material Substances 0.000 claims description 8
- 229910052737 gold Inorganic materials 0.000 claims description 8
- 239000010931 gold Substances 0.000 claims description 8
- 229920000515 polycarbonate Polymers 0.000 claims description 8
- 239000004417 polycarbonate Substances 0.000 claims description 8
- 238000005507 spraying Methods 0.000 claims description 8
- 239000004743 Polypropylene Substances 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- 230000001747 exhibiting effect Effects 0.000 claims description 6
- 229920001155 polypropylene Polymers 0.000 claims description 6
- 229910052709 silver Inorganic materials 0.000 claims description 6
- CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 5
- 239000007921 spray Substances 0.000 claims description 5
- 229920000742 Cotton Polymers 0.000 claims description 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 4
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 4
- 229920002334 Spandex Polymers 0.000 claims description 4
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 4
- 239000004411 aluminium Substances 0.000 claims description 4
- 229910052782 aluminium Inorganic materials 0.000 claims description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 4
- 229920001971 elastomer Polymers 0.000 claims description 4
- 239000002657 fibrous material Substances 0.000 claims description 4
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 4
- 229910052742 iron Inorganic materials 0.000 claims description 4
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 claims description 4
- 239000004816 latex Substances 0.000 claims description 4
- 229920000126 latex Polymers 0.000 claims description 4
- 229910052749 magnesium Inorganic materials 0.000 claims description 4
- 239000011777 magnesium Substances 0.000 claims description 4
- 239000004579 marble Substances 0.000 claims description 4
- 229920001296 polysiloxane Polymers 0.000 claims description 4
- 239000005060 rubber Substances 0.000 claims description 4
- 239000004332 silver Substances 0.000 claims description 4
- 239000004759 spandex Substances 0.000 claims description 4
- 239000010936 titanium Substances 0.000 claims description 4
- 229910052719 titanium Inorganic materials 0.000 claims description 4
- 239000002023 wood Substances 0.000 claims description 4
- 210000002268 wool Anatomy 0.000 claims description 4
- 229910052725 zinc Inorganic materials 0.000 claims description 4
- 239000011701 zinc Substances 0.000 claims description 4
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims description 3
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 3
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 claims description 3
- 239000000654 additive Substances 0.000 claims description 3
- 239000000443 aerosol Substances 0.000 claims description 3
- IEJIGPNLZYLLBP-UHFFFAOYSA-N dimethyl carbonate Chemical compound COC(=O)OC IEJIGPNLZYLLBP-UHFFFAOYSA-N 0.000 claims description 3
- 238000010894 electron beam technology Methods 0.000 claims description 3
- 125000000524 functional group Chemical group 0.000 claims description 3
- 238000007654 immersion Methods 0.000 claims description 3
- QULYNCCPRWKEMF-UHFFFAOYSA-N parachlorobenzotrifluoride Chemical compound FC(F)(F)C1=CC=C(Cl)C=C1 QULYNCCPRWKEMF-UHFFFAOYSA-N 0.000 claims description 3
- 238000000016 photochemical curing Methods 0.000 claims description 3
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 claims description 3
- 230000005855 radiation Effects 0.000 claims description 3
- WMOVHXAZOJBABW-UHFFFAOYSA-N tert-butyl acetate Chemical compound CC(=O)OC(C)(C)C WMOVHXAZOJBABW-UHFFFAOYSA-N 0.000 claims description 3
- KRFJLUBVMFXRPN-UHFFFAOYSA-N cuprous oxide Chemical compound [O-2].[Cu+].[Cu+] KRFJLUBVMFXRPN-UHFFFAOYSA-N 0.000 claims description 2
- 239000003000 extruded plastic Substances 0.000 claims description 2
- 208000008469 Peptic Ulcer Diseases 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 description 25
- 150000002009 diols Chemical class 0.000 description 13
- 229920003009 polyurethane dispersion Polymers 0.000 description 11
- 238000000518 rheometry Methods 0.000 description 11
- 239000000178 monomer Substances 0.000 description 9
- 239000000080 wetting agent Substances 0.000 description 8
- 239000004971 Cross linker Substances 0.000 description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 5
- 125000001931 aliphatic group Chemical group 0.000 description 5
- 230000009931 harmful effect Effects 0.000 description 5
- 238000001000 micrograph Methods 0.000 description 5
- 238000004378 air conditioning Methods 0.000 description 4
- 125000005442 diisocyanate group Chemical group 0.000 description 4
- 229920005862 polyol Polymers 0.000 description 4
- 150000003077 polyols Chemical class 0.000 description 4
- 229920006264 polyurethane film Polymers 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 238000009423 ventilation Methods 0.000 description 4
- UPMLOUAZCHDJJD-UHFFFAOYSA-N 4,4'-Diphenylmethane Diisocyanate Chemical compound C1=CC(N=C=O)=CC=C1CC1=CC=C(N=C=O)C=C1 UPMLOUAZCHDJJD-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 208000025721 COVID-19 Diseases 0.000 description 2
- 239000005057 Hexamethylene diisocyanate Substances 0.000 description 2
- 239000005058 Isophorone diisocyanate Substances 0.000 description 2
- QORUGOXNWQUALA-UHFFFAOYSA-N N=C=O.N=C=O.N=C=O.C1=CC=C(C(C2=CC=CC=C2)C2=CC=CC=C2)C=C1 Chemical compound N=C=O.N=C=O.N=C=O.C1=CC=C(C(C2=CC=CC=C2)C2=CC=CC=C2)C=C1 QORUGOXNWQUALA-UHFFFAOYSA-N 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 2
- 229920003232 aliphatic polyester Polymers 0.000 description 2
- 229920005603 alternating copolymer Polymers 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- RASZIXQTZOARSV-BDPUVYQTSA-N astacin Chemical compound CC=1C(=O)C(=O)CC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)C(=O)CC1(C)C RASZIXQTZOARSV-BDPUVYQTSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- KAKZBPTYRLMSJV-UHFFFAOYSA-N butadiene group Chemical group C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 2
- 235000013877 carbamide Nutrition 0.000 description 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 150000002170 ethers Chemical class 0.000 description 2
- RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 description 2
- NIMLQBUJDJZYEJ-UHFFFAOYSA-N isophorone diisocyanate Chemical compound CC1(C)CC(N=C=O)CC(C)(CN=C=O)C1 NIMLQBUJDJZYEJ-UHFFFAOYSA-N 0.000 description 2
- 239000000711 locust bean gum Substances 0.000 description 2
- 239000001912 oat gum Substances 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 239000004014 plasticizer Substances 0.000 description 2
- 239000004848 polyfunctional curative Substances 0.000 description 2
- 229920006254 polymer film Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- DVKJHBMWWAPEIU-UHFFFAOYSA-N toluene 2,4-diisocyanate Chemical compound CC1=CC=C(N=C=O)C=C1N=C=O DVKJHBMWWAPEIU-UHFFFAOYSA-N 0.000 description 2
- 150000003672 ureas Chemical class 0.000 description 2
- OVSKIKFHRZPJSS-UHFFFAOYSA-N 2,4-D Chemical compound OC(=O)COC1=CC=C(Cl)C=C1Cl OVSKIKFHRZPJSS-UHFFFAOYSA-N 0.000 description 1
- OAYXUHPQHDHDDZ-UHFFFAOYSA-N 2-(2-butoxyethoxy)ethanol Chemical compound CCCCOCCOCCO OAYXUHPQHDHDDZ-UHFFFAOYSA-N 0.000 description 1
- 102000034498 Astacin Human genes 0.000 description 1
- 108090000658 Astacin Proteins 0.000 description 1
- 229920005714 BASONAT® HW 1000 Polymers 0.000 description 1
- FMKGDHLSXFDSOU-BDPUVYQTSA-N Dienon-Astacin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)C(=O)C(=CC1(C)C)O)C=CC=C(/C)C=CC2=C(C)C(=O)C(=CC2(C)C)O FMKGDHLSXFDSOU-BDPUVYQTSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 235000003676 astacin Nutrition 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 229940047586 chemet Drugs 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 229940116318 copper carbonate Drugs 0.000 description 1
- GEZOTWYUIKXWOA-UHFFFAOYSA-L copper;carbonate Chemical compound [Cu+2].[O-]C([O-])=O GEZOTWYUIKXWOA-UHFFFAOYSA-L 0.000 description 1
- 229940112669 cuprous oxide Drugs 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- JBTWLSYIZRCDFO-UHFFFAOYSA-N ethyl methyl carbonate Chemical compound CCOC(=O)OC JBTWLSYIZRCDFO-UHFFFAOYSA-N 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000011941 photocatalyst Substances 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920001692 polycarbonate urethane Polymers 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- ACTRVOBWPAIOHC-XIXRPRMCSA-N succimer Chemical compound OC(=O)[C@@H](S)[C@@H](S)C(O)=O ACTRVOBWPAIOHC-XIXRPRMCSA-N 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
- A01N59/20—Copper
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D175/00—Coating compositions based on polyureas or polyurethanes; Coating compositions based on derivatives of such polymers
- C09D175/04—Polyurethanes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L75/00—Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
- C08L75/04—Polyurethanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pest Control & Pesticides (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Agronomy & Crop Science (AREA)
- Materials Engineering (AREA)
- Dermatology (AREA)
- Dentistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Polymers & Plastics (AREA)
- Materials For Medical Uses (AREA)
Abstract
A biocompatible polymer coating composition comprising the following components: a polymer, such as a polyurethane polymer in the form of a water-based polyurethane polymer dispersion (PUD); a crosslinking agent, such as a polyfunctional compound comprising a carbodiimide, glycidyl epoxide, acetoacetoxy, diacetone, alkoxysilane, amine, hydroxyl, isocyanate, aziridine, hydrazide, or epoxide; and an elemental metal, metal alloy, metal carbonate, and/or metal oxide particles. The components are dispersed in a mixture of a volatile organic solvent, such as acetone, and water, and the metal based component exhibits antimicrobial, antibacterial and/or antiviral properties. Also disclosed is a biocompatible polymer film comprising the biocompatible polymer coating composition, an item of protective equipment, and a method of manufacturing a biocompatible polymer coating composition and a personal protection equipment mask comprising the biocompatible polymer coating composition.
Description
Biocompatible Polymer Films with Antimicrobial, Antibacterial, and/or Antiviral Properties
Technical Field
The present invention relates to antimicrobial, antibacterial, and/or antiviral biocompatible polymer coating compositions, biocompatible polymer films, and articles comprising biocompatible polymer films, their preparation, methods of manufacture, and their use.
Background of the Invention
Antimicrobial, antibacterial, and/or antiviral coatings may be used to reduce the transmission of, or kill, microbes, bacteria, and/or viruses. Such coatings may be applied to a variety of surfaces or materials for a variety of purposes.
The COVID-19 pandemic has caused an increased reliance on both Personal Protective Equipment ('PPE') and antimicrobial, antibacterial, and/or antiviral products, some of which rely on chemicals which are either potentially harmful to people or animals, or to the environment.
It is therefore proposed to provide a way of delivering antimicrobial, antibacterial, and/or antiviral properties without the potentially harmful effects, and it is further envisaged that such properties may be delivered as part of an antimicrobial, antibacterial, and/or antiviral coating which may be applied to surfaces or articles to impart such properties without the use of potentially harmful chemicals.
There is therefore a need for antimicrobial, antibacterial, and/or antiviral polymer coatings which may be applied to surfaces and/or PPE.
Summary of the Invention
In a first aspect of the invention is a biocompatible polymer coating composition 25 comprising: i) a polymer; ii) a crosslinking agent; iii) elemental metal, metal alloy, metal carbonate, and/or metal oxide particles; wherein components i) to iii) are dispersed in a mixture of a volatile organic solvent and water, and wherein component iii) exhibits antimicrobial, antibacterial, and/or antiviral properties.
In a second aspect of the invention is a biocompatible polymer film obtainable by coating at least one surface of a substrate with the biocompatible polymer coating composition according to the first aspect of the invention and subsequently curing said biocompatible polymer coating composition in situ, wherein elemental metal, metal alloy, metal carbonate, and/or metal oxide particles are embedded within the biocompatible polymer film and protrude from surfaces thereof.
In a third aspect of the invention is an article comprising a substrate and a biocompatible polymer film bound to at least one surface of said substrate, wherein elemental metal, metal alloy, metal carbonate, and/or metal oxide particles exhibiting antimicrobial, antibacterial, and/or antiviral properties are embedded within the biocompatible polymer film and protrude from surfaces thereof.
In a fourth aspect of the invention is an item of protective equipment, the protective equipment being formed of at least one layer of a substrate material, wherein at least one layer of the substrate material is coated with a biocompatible polymer film obtainable by coating at least one surface of a substrate with the biocompatible polymer coating composition and subsequently curing said biocompatible polymer coating composition in situ, wherein elemental metal, metal alloy, metal carbonate and/or metal oxide particles are embedded within the biocompatible polymer film and protrude from surfaces thereof.
In a fifth aspect of the invention is a method of manufacturing a biocompatible material including the steps of spraying the biocompatible polymer coating composition onto a substrate material, and curing the biocompatible polymer coating composition.
In a sixth aspect of the invention is a method of manufacturing a biocompatible material including the steps of extruding a plastic polymer, spraying the biocompatible polymer coating composition into the extruded plastic polymer, and collecting the plastic polymer and the biocompatible polymer coating as a melt-blown material.
In a seventh aspect of the invention is an item of personal protective equipment mask formed of the biocompatible material derived from the method of the sixth aspect of the invention, the item selected from at least one of masks, gloves, and/or tunics.
In an eighth aspect of the invention is an item of coated fabric, formed of the biocompatible material derived from the method of the sixth aspect of the invention, the item being selected from at least one of clothing, furnishings, and/or upholstery.
In a ninth aspect of the invention is a polymer surface formed of the biocompatible material derived from the method of the sixth aspect of the invention, the item being selected from one of ventilation components and/or ventilation grills, air conditioning components and/or air conditioning grills, and/or general work surfaces.
Definitions As used herein, if an agent or material exhibits antimicrobial, antibacterial, and/or antiviral properties, this means that the agent is capable of killing or stopping the growth of microbes, bacteria, and/or viruses, respectively.
As used herein, if an agent or material is biocompatible this means that it is not harmful to living tissue (i.e. in the setting in which it is utilised the agent or material it is not toxic, harmful to physiological processes, and does not induce an immunological response). For example, for a mask to be biocompatible it must not cause irritation or damage to the skin it comes into contact with on the face.
As used herein, wt% refers to the percentage by weight a given component contributes to the total weight of a mixture (i.e. the totality).
Unless otherwise stated, the terms used herein have their usual meaning in the art as would be understood by the skilled person.
Detailed Description of the Invention
Hereinafter, the antimicrobial, antibacterial, and/or antiviral biocompatible polymer coating compositions, biocompatible polymer films, and articles comprising biocompatible polymer films, their preparation, methods of manufacture, and their use will be described in more detail, and with reference to the accompanying drawings, in which: Figure 1 shows a first microscope image of Cu20 particles protruding from the surface of a polyurethane film, in accordance with the invention disclosed herein; and Figure 2 shows a second microscope image of Cu20 particles protruding from the surface of a polyurethane film, in accordance with the invention disclosed herein; and Figure 3 shows a third microscope image of Cu20 particles protruding from the surface of a polyurethane film, in accordance with the invention disclosed herein.
Figure 4 show a fourth microscope image of a mixture of 0u20 and Cu2(OH)2CO3 particles protruding from the surface of a polyurethane film, in accordance with the invention disclosed herein.
In a first aspect of the invention is a biocompatible polymer coating composition comprising: i) a polymer; ii) a crosslinking agent; iii) elemental metal, metal alloy, metal carbonate, and/or metal oxide particles; wherein components i) to iii) are dispersed in a mixture of a volatile organic solvent and water, and wherein component iii) exhibits antimicrobial, antibacterial, and/or antiviral properties.
Preferably, the volatile organic solvent is miscible with water.
Preferably, the volatile organic solvent is selected from the list consisting of acetone, dimethyl carbonate, methyl acetate, parachlorobenzotrifluoride (Oxsol 100), tert-Butyl acetate, and propylene carbonate, further preferably the volatile organic solvent is acetone.
Preferably, the ratio of volatile organic solvent to water is 55:45 to 70:30, further preferably 60:40 to 66:33, more preferably 60:40. Preferably, the water is distilled de-ionised water. For example, the ratio of volatile organic solvent to water is 55:45, 56:44, 57:43, 58:42, 59:41, 60:40, 61:39, 62:38, 63:37, 64:36, 65:35, 66:34, 67:33, 68:32, 69:31, or 70:30, or any subrange therebetween.
Preferably, the water accounts for 7.5 wt% to 15 wt% of the biocompatible polymer coating composition, more preferably 7.5 wt% to 11.5 wt%, further preferably 8 wt% to 10 wt%, even further preferably 8 wt% to 9 wt%. For example, the water accounts for 7.5, 7.6, 7.7, 7.8, 7.9, 8, 8.1, 8.2, 8.3, 8.4, 8.5, 8.6, 8.7, 8.8, 8.9, 9, 9.1, 9.2, 9.3, 9.4, 9.5, 9.6, 9.7, 9.8, 9.9, 10, 10.1, 10.2, 10.3, 10.4, 10.5, 10.6, 10.7, 10.8, 10.9, 11, 11.1, 11.2, 11.3, 11.4, 11.5, 11.6, 11.7, 11.8, 11.9, 12, 12.1, 12.2, 12.3, 12.4, 12.5, 12.6, 12.7, 12.8, 12.9, 13, 13.1, 13.2, 13.3, 13.4, 13.5, 13.6, 13.7, 13.8, 13.9, 14, 14.1, 14.2, 14.3, 14.4, 14.5, 14.6, 14.7, 14.8, 14.9, or 15 wt% of the biocompatible polymer coating composition, or any subrange therebetween.
Preferably, the volatile organic solvent accounts for 12.5 wt% to 20 wt% of the biocompatible polymer coating composition, more preferably 13.5 wt% to 18 wt%, further preferably 15 wt% to 17.5 wt%, even further preferably 16 wt% to 17.5 wt%.
For example, the volatile organic solvent accounts for 12.5, 12.6, 12.7, 12.8, 12.9, biocompatible polymer coating composition, or any subrange therebetween.
The selection of polymer and crosslinking agent are not particularly limited, provided they are biocompatible and compatible with each other, as would be understood by the skilled person.
Preferably, the polymer is a polyurethane selected from the list consisting of polycarbonate-based polyurethanes, polyester-based polyurethanes, polyetherbased polyurethanes, fatty acid modified polyurethanes, and UV-curable polyurethanes, further preferably a polyether-based polyurethane. Most preferably, the polymer is in the form of a water-based polyurethane polymer dispersion (Le. a "PUD"). For example, preferably polycarbonate-based PUDs, polyester-based PUDs, polyether-based PUDs, fatty acid modified PUDs, and UV-curable PUDs, further preferably a polyether-based PUD.
Preferably, the polymer is an alternating copolymer comprising di-and/or tri-isocyanate monomers and polyol monomers. The di-and/or tri-isocyanate monomers may be selected from the list consisting of aliphatic diisocyanates, aromatic diisocyanates, oligomeric diisocyanates, polymeric diisocyanates, aliphatic triisocyanates, aromatic triisocyanates, oligomeric triisocyanates, and polymeric triisocyanates, for example isophorone diisocyanate, hexamethylene diisocyanate, toluene diisocyanate, diphenylmethane diisocyanate, and triphenylmethane triisocyanate. The polyol monomers may be selected from the list consisting of diolcontaining esters, diol-containing acrylates, diol-containing carbonates, diol- 13, 13.1, 13.2, 13.3, 13.4, 13.5, 13.6, 13.7, 13.8, 13.9, 14, 14.1, 14.2, 14.3, 14.4, 14.5, 14.6, 14.7, 14.8, 14.9, 15, 15.1, 15.2, 15.3, 15.4, 15.5, 15.6, 15.7, 15.8, 15.9, 16, 16.1, 16.2, 16.3, 16.4, 16.5, 16.6, 16.7, 16.8, 16.9, 17, 17.1, 17.2, 17.3, 17.4, 17.5, 17.6, 17.7, 17.8, 17.9, 18, 18.1, 18.2, 18.3, 18.4, 18.5, 18.6, 18.7, 18.8, 18.9, 19, 19.1, 19.2, 19.3, 19.4, 19.5, 19.6, 19.7, 19.8, 19.9, or 20 wt% of the containing ureas, diol-containing butadienes, diol-containing ethers, diol-containing amides, oligomeric diols, and polymeric diols.
Polyurethane polymer dispersions (PUDs) are available commercially for use in the present invention and are not particularly limited. For example, HYBRIDURO 870 and 878 (NMP-free, anionically stabilized urethane-acrylic hybrid polymer dispersion, from Air Products and Chemicals, Inc), HYBRI DURO 570 and 580 (urethane-acrylic hybrid polymer dispersion, from Air Products and Chemicals, Inc), NEOREZ® (water-based polyurethanes from DSM), NEOPACO (water-based hybrid urethane/ acrylic hybrids from DSM), PICASSIAN® (PU-635 aqueous aliphatic polyester urethane hybrid polymer dispersion, from Stahl), PICASSIAN® PU-648 (aqueous, solvent free aliphatic polyether urethane hybrid polymer dispersion, from Stahl), Incorez C58101, RELCAO FU-406 (aqueous, NMP free aliphatic polycarbonate urethane hybrid polymer dispersion, from Stahl), RELCA® PU-968 (aqueous, NMP free aliphatic polyester urethane hybrid polymer dispersion, from Stahl), UROTUF0 (polyurethane and aliphatic urethane polymer dispersions, from Reichhold), and UNITHANE0 (water-based polyurethane dispersions, from Union Specialties Inc.).
The polymer's weight average molecular weight (Mw) is not particularly limited as the skilled person would be able to select an appropriate Mw for the setting in which the biocompatible polymer composition is used; preferably, the Mw is less than 200,000, more preferably less than 150,000, further preferably less than 100,000, even further preferably less than 80,000. Mw is preferably more than 5,000, further preferably more than 10,000.
Preferably, the polymer accounts for 15 wt% to 30 wt% of the biocompatible polymer coating composition, more preferably 15 wt% to 25 wt%, further preferably 17.5 wt% to 22.5 wt%, even further preferably 20 wt% to 22.5 wt%. For example, the polymer accounts for 15, 15.1, 15.2, 15.3, 15.4, 15.5, 15.6, 15.7, 15.8, 15.9, 16, 16.1, 16.2, 16.3, 16.4, 16.5, 16.6, 16.7, 16.8, 16.9,17, 17.1, 17.2, 17.3, 17.4, 17.5, 17.6, 17.7, 17.8, 17.9, 18, 18.1, 18.2, 18.3, 18.4, 18.5, 18.6, 18.7, 18.8, 18.9, 19, 19.1, 19.2, 19.3, 19.4, 19.5, 19.6, 19.7, 19.8, 19.9,20, 20.1, 20.2, 20.3, 20.4, 20.5, 20.6, 20.7, 20.8, 20.9, 21, 21.1, 21.2, 21.3, 21.4, 21.5, 21.6, 21.7, 21.8, 21.9, 22, 22.1, 22.2, 22.3, 22.4, 22.5, 22.6, 22.7, 22.8, 22.9, 23, 23.1, 23.2, 23.3, 23.4, 23.5, 23.6, 23.7, 23.8, 23.9, 24, 24.1, 24.2, 24.3, 24.4, 24.5, 24.6, 24.7, 24.8, 24.9, 25, 25.1, 25.2, 25.3, 25.4, 25.5, 25.6, 25.7, 25.8, 25.9, 26, 26.1, 26.2, 26.3, 26.4, 26.5, 26.6, 26.7, 26.8, 26.9, 27, 27.1, 27.2, 27.3, 27.4, 27.5, 27.6, 27.8, 27.9, 28, 28.1, 28.2, 28.3, 28.4, 28.5, 28.6, 28.7, 28.8, 28.9, 29, 29.1, 29.2, 29.3, 29.4, 29.5, 29.6, 29.7, 29.8, 29.9, or 30 wt% of the biocompatible polymer coating composition, or any subrange therebetween.
Preferably, the crosslinking agent may be a polyfuncfional compound wherein the polyfunctionality comprises at least one of the following functional groups: carbodiimide, glycidyl epoxide, acetoacetoxy, diacetone, alkoxysilane, amine, hydroxyl, isocyanate, aziridine, hydrazide, and epoxide. Further preferably, the crosslinking agent is a waterbased polycarbodiimide crosslinker.
Crosslinkers are available commercially for use in the present invention and are not particularly limited. For example: carbodiimide crosslinkers include PICASSIAN® XL-701, XL-702, XL-725, XL-732, XL-755 from Stahl, ZOLDINEO XL-295E from Angus Chemical Company, XL-1V and CX-300® from DSM Coatings, CARBODILITEO V02, V-04, E-02, and SV-02 from GS! Exim America, and UCARLINK® XL-29SE from Union Carbide Corporation; aziridine crosslinkers include CX-1 00® from DSM Coatings, and CORIAL® Hardener from BASF; isocyanate crosslinkers include BASONAT® HW 1000, BASONAT 2000, and BASONAT 3000 from BASF, ASTACIN® Hardener C I from BASF, ISONATE® and PAR® from The Dow Chemical Company, PICASSIANO XL-728 from Stahl, and RHODOCOATO EZ-M502 from Rhodia.
Preferably, the crosslinking agent accounts for 1 wt% to 10 wt% of the biocompatible polymer coating composition, further preferably 1 wt% to 5 wt%, most preferably 1 to 3 wt%. For example, the crosslinking agent accounts for 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3, 3.1, 3.2, 3.3, 3.4, 3.5, 3.6, 3.7, 3.8, 3.9, 4, 4.1, 4.2, 4.3, 4.4, 4.5, 4.6, 4.7, 4.8, 4.9, 5, 5.1, 5.2, 5.3, 5.4, 5.5, 5.6, 5.7, 5.8, 5.9, 6, 6.1, 6.2, 6.3, 6.4, 6.5, 6.6, 6.7, 6.8, 6.9, 7, 7.1, 7.2, 7.3, 7.4, 7.5, 7.6, 7.7, 7.8, 7.9, 8, 8.1, 8.2, 8.3, 8.4, 8.5, 8.6, 8.7, 8.8, 8.9, 9, 9.1, 9.2, 9.3, 9.4, 9.5, 9.6, 9.7, 9.8, 9.9, or 10 wt% of the biocompatible polymer coating composition, or any subrange therebetween.
Preferably, the biocompatible polymer coating composition additionally comprises a coalescing agent. The coalescing agent may be selected from an organic solvent and/or a plasticizer. Preferably, where the coalescing agent comprises at least one member selected from the group consisting of butyl diglycol, ethylene glycol, propylene glycol, ethylene glycol ether, pyrrolidone, phosphate ester solvent, dibenzoate solvent, monobenzoate solvent, and phthalate solvent.
Preferably, the coalescing agent accounts for 1 wt% to 10 wt% of the biocompatible polymer coating composition, further preferably 2 wt% to 8 wt%, most preferably 3 wt% to 5 wt%. For example, the coalescing agent accounts for 1, 1.1, 1.2, 1.3, 1.4, or any subrange therebetween.
Preferably, the biocompatible polymer coating composition additionally comprises a rheology agent. The coalescing agents are available commercially for use in the present invention and are not particularly limited; for example, BYK-E410, BYK-E411, 15 BYK-E420, BYK-7410ET, BYK-7411ES and BYK-7420ES from BYK.
Preferably, the rheology agent accounts for 0 wt% to 2 wt% of the biocompatible polymer coating composition, further preferably 0 wt% to 1 wt%, most preferably 0 wt% to 0.5 wt%. For example, the rheology agent accounts for 0, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, or 2 wt% of the biocompatible polymer coating composition, or any subrange therebetween.
Preferably, the biocompatible polymer coating composition additionally comprises a flow wetting agent. The flow wetting agents are available commercially for use in the present invention and are not particularly limited; for example, SCHWEGOCI flow 6527, 6533, 8057, and 8058 from Bernd Schwegmann GmbH &Co. KG, and SCHWEGO® wett 6295, 6267, and 8081 from Bernd Schwegmann GmbH &Co. KG.
Preferably, the flow wetting agent accounts for 0 wt% to 2 wt% of the biocompatible polymer coating composition, further preferably 0 wt% to 1 wt%, most preferably 0 wt% to 0.5 wt%. For example, the rheology agent accounts for 0, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, or 2 wt% of the biocompatible polymer coating composition, or any subrange therebetween.
The selection of elemental metal and/or metal oxide particles is not particularly limited, provided they exhibit antimicrobial, antibacterial, and/or antiviral properties.
1.5, 1.6, 1.7, 1.8, 1.9, 2, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3, 3.1, 3.2, 3.3, 3.4, 3.5, 3.6, 3.7, 3.8, 3.9, 4, 4.1, 4.2, 4.3, 4.4, 4.5, 4.6, 4.7, 4.8, 4.9, 5, 5.1, 5.2, 5.3, 5.4, 5.5, 5.6, 5.7, 5.8, 5.9, 6, 6.1, 6.2, 6.3, 6.4, 6.5, 6.6, 6.7, 6.8, 6.9, 7, 7.1, 7.2, 7.3, 7.4, 7.5, 7.6, 7.7, 7.8, 7.9, 8, 8.1, 8.2, 8.3, 8.4, 8.5, 8.6, 8.7, 8.8, 8.9, 9, 9.1, 9.2, 9.3, 9.4, 9.5, 9.6, 9.7, 9.8, 9.9, or 10 wt% of the biocompatible polymer coating composition, Preferably, the elemental metal, metal alloy, metal carbonate, and/or metal oxide particles are selected from the group consisting of silver-containing, aluminium-containing, gold-containing, copper-containing, iron-containing, magnesium-containing, titanium-containing, or zinc-containing metal, metal alloy, metal carbonate, and/or metal oxide particles, or any combination thereof, preferably selected from Ag, A1203, Au, Cu, Cu2(OH)2CO3, CuO, Cu20, Fe304, MgO, Ti02, and ZnO particles, or any combination thereof. Preferably the elemental metal, metal alloy, metal carbonate, and/or metal oxide particles are copper-containing metal, metal alloy, and/or metal oxide particles, more preferably selected from the group consisting of Cu, Cu2(OH)2CO3, CuO, Cu20, or any combination thereof, further preferably selected from the group consisting of Cu, CuO, and Cu20 particles, or any combination thereof even further preferably CuO or Cu20 particles.
Preferably, the elemental metal, metal alloy, metal carbonate, and/or metal oxide particles have a mean diameter of between 10 pm and 80 pm, preferably between 20 pm and 60 pm, further preferably between 30 pm and 40 pm.
Preferably, the elemental metal, metal alloy, metal carbonate, and/or metal oxide particles account for 40 wt% to 60 wt% of the biocompatible polymer coating composition, further preferably 45 wt% to 60 wt%, most preferably 45 wt% to 55 wt%. For example, the metal, metal alloy, metal carbonate, and/or metal oxide particles account for 40, 40.1, 40.2, 40.3, 40.4, 40.5, 40.6, 40.7, 40.8, 40.9, 41, 41.1, 41.2, 41.3, 41.4, 41.5, 41.6, 41.7, 41.8, 41.9, 42, 42.1, 42.2, 42.3, 42.4, 42.5, 42.6, 42.7, 42.8, 42.9, 43, 43.1, 43.2, 43.3, 43.4, 43.5, 43.6, 43.7, 43.8, 43.9, 44, 44.1, 44.2, 44.3, 44.4, 44.5, 44.6, 44.7, 44.8, 44.9,45, 45.1, 45.2, 45.3, 45.4, 45.5, 45.6, 45.7, 45.8 45.9, 46, 46.1, 46.2, 46.3, 46.4, 46.5, 46.6, 46.7, 46.8, 46.9, 47, 47.1, 47.2, 47.3 47.4, 47.5, 47.6, 47.7, 47.8, 47.9,48, 48.1, 48.2, 48.3, 48.4, 48.5, 48.6, 48.7, 48.8 48.9, 49, 49.1, 49.2, 49.3, 49.4, 49.5, 49.6, 49.7, 49.8, 49.9, 50, 50.1, 50.2, 50.3 50.4, 50.5, 50.6, 50.7, 50.8, 50.9, 51, 51.1, 51.2, 51.3, 51.4, 51.5, 51.6, 51.7, 51.8 51.9, 52, 52.1, 52.2, 52.3, 52.4, 52.5, 52.6, 52.7, 52.8, 52.9, 53, 53.1, 53.2, 53.3 53.4, 53.5, 53.6, 53.7, 53.8, 53.9, 54, 54.1, 54.2, 54.3, 54.4, 54.5, 54.6, 54.7, 54.8 54.9, 55, 55.1, 55.2, 55.3, 55.4, 55.5, 55.6, 55.7, 55.8, 55.9, 56, 56.1, 56.2, 56.3 56.4, 56.5, 56.6, 56.7, 56.8, 56.9, 57, 57.1, 57.2, 57.3, 57.4, 57.5, 57.6, 57.7, 57.8 57.9, 58, 58.1, 58.2, 58.3, 58.4, 58.5, 58.6, 58.7, 58.8, 58.9, 59, 59.1, 59.2, 59.3, 59.4, 59.5, 59.6, 59.7, 59.8, 59.9, and 60 wt% of the biocompatible polymer coating composition, or any subrange therebetween.
-10 -Preferably, the biocompatible polymer coating composition comprises: i) 17.5 wt% to 22.5 wt% of a water-based polyurethane polymer dispersion (PUD), as defined above; ii) 1 wt% to 3 wt% of a crosslinking agent, as defined above; iii) 0 wt% to 1 wt% of a flow wetting agent, as defined above; iv) 0 wt% to 1 wt% of a rheology agent, as defined above; v) 45 wt% to 60 wt% of copper-based particles, as defined above; wherein i) to v) are dispersed in a mixture of acetone and water, wherein said acetone accounts for 15 wt% to 17.5 wt% of the biocompatible polymer coating composition and said water accounts for 8 wt% to 10 wt% of the biocompatible polymer coating composition.
Also within the scope of the first aspect of the invention is a method of manufacturing a biocompatible polymer coating composition, wherein the method comprises dispersing the following components i) to iii), and optionally components iv) to vi), in a mixture of a volatile organic solvent and water.
i) a polymer, preferably a water-based polyurethane dispersion (PUD); ii) a crosslinking agent; iii) elemental metal, metal alloy, metal carbonate, and/or metal oxide particles, preferably copper-containing elemental metal, metal alloy, metal carbonate, and/or metal oxide particles; iv) optionally a coalescing agent; v) optionally a rheology agent; and vi) optionally a flow wetting agent; wherein component iii) exhibits antimicrobial, antibacterial, and/or antiviral properties and components i) to vi), the volatile organic solvent, and water are defined in the preceding pages In a second aspect of the invention is a biocompatible polymer film obtainable by coating at least one surface of a substrate with the biocompatible polymer coating composition according to the first aspect of the invention and subsequently curing said biocompatible polymer coating composition in situ, wherein elemental metal, metal alloy, metal carbonate and/or metal oxide particles are embedded within the biocompatible polymer film and protrude from surfaces thereof.
Preferably, coating methods may utilise, for example, immersion, brush, spray, dip, curtain, agitated bath, aerated baths, or aerosol techniques to coat the biocompatible polymer composition onto the at least one surface of the substrate.
Once at least one surface of the substrate has been coated with the biocompatible polymer composition, the biocompatible polymer composition is cured in situ onto said at least one surface of the substrate.
Preferably, curing may be initiated by any method as would be known to the skilled person such as the application of heat, radiation, electron beams, or chemical additives. Preferably, accelerated drying or photocuring is utilised to cure the biocompatible polymer composition onto the at least one surface of the substrate.
Preferably, the biocompatible polymer film has a mean thickness of between 10 pm and 100 pm, further preferably between 20 pm and 80 pm, even further preferably between 30 pm and 60 pm, most preferably between 40 pm and 50 pm.
The beneficial antimicrobial, antibacterial, and/or antiviral properties of the biocompatible polymer film of the present invention is realised by the protrusion of metal, metal alloy, metal carbonate, and/or metal oxide particles exhibiting antimicrobial, antibacterial, and/or antiviral properties from the surface of the polymer film.
Preferably, between 20% and 50% of the diameter of one or more of the elemental metal, metal alloy, metal carbonate, and/or metal oxide particles protrude from the surface of the biocompatible polymer, further preferably wherein between 25% and 40% of the diameter of one or more of the elemental metal, metal alloy, metal carbonate, and/or metal oxide particles protrude from the surface of the biocompatible polymer, even further preferably wherein between 30% and 35% of the diameter of one or more of the elemental metal, metal alloy, metal carbonate, and/or metal oxide particles protrude from the surface of the biocompatible polymer.
Preferably, one or more of the elemental metal, metal alloy, metal carbonate, and/or metal oxide particles protrude from the surface of the biocompatible polymer by between 3 pm and 27 pm, preferably between 7 pm and 20 pm, further preferably 30 between 10 pm and 13 pm -12 -Preferably, between 20% and 50% by mass of total the elemental metal, metal alloy, metal carbonate, and/or metal oxide particles protrudes from the surface of the biocompatible polymer, further preferably wherein between 25% and 40% by mass of the total elemental metal, metal alloy, metal carbonate, and/or metal oxide particles protrudes from the surface of the biocompatible polymer, even further preferably wherein between 30% and 35% by mass of the total elemental metal, metal alloy, metal carbonate, and/or metal oxide particles protrudes from the surface of the biocompatible polymer.
The substrates to which the biocompatible polymer film may be applied is not particularly limited, provided that, once cured in situ, the biocompatible polymer film adheres to the substrate, as would be understood by the skilled person.
Preferably, the substrate is selected from naturally occurring or man-made materials.
For example, the substrate may be selected from plastic polymers, cloth, fabric, polyester, polypropylene, wool, plastic, cotton, spandex, paper, linoleum, silicone, latex, rubber, marble, and wood, fibrous materials derived therefrom, and mixtures or combinations thereof.
In a third aspect of the invention is an article comprising a substrate and a biocompatible polymer film bound to at least one surface of said substrate, wherein elemental metal, metal alloy, metal carbonate, and/or metal oxide particles exhibiting antimicrobial, antibacterial, and/or antiviral properties are embedded within the biocompatible polymer film and protrude from surfaces thereof.
The selection of polymer of the biocompatible polymer film is not particularly limited, provided it is biocompatible, as would be understood by the skilled person.
The polymer of the biocompatible polymer is outlined in the first aspect of the invention. Preferably, the polymer of the biocompatible polymer film is selected from the list consisting of polycarbonate-based polyurethanes, polyester-based polyurethanes, polyether-based polyurethanes, fatty acid modified polyurethanes, and UV-curable polyurethanes, further preferably a polyether-based polyurethane.
Preferably, the biocompatible polymer film has a mean thickness of between 10 pm and 100 pm, further preferably between 20 pm and 80 pm, even further preferably between 30 pm and 60 pm, most preferably between 40 pm and 50 pm.
-13 -The selection of elemental metal, metal alloy, metal carbonate and/or metal oxide particles is not particularly limited, provided they exhibit antimicrobial, antibacterial, and/or antiviral properties.
Preferably, the elemental metal, metal alloy, metal carbonate, and/or metal oxide particles are selected from the group consisting of silver-containing, aluminium-containing, gold-containing, copper-containing, iron-containing, magnesium-containing, titanium-containing, or zinc-containing metal, metal alloy, metal carbonate, and/or metal oxide particles, or any combination thereof, preferably selected from Ag, A1203, Au, Cu, Cu2(OH)2CO3, CuO, Cu20, Fe304, MgO, Ti02, and ZnO particles, or any combination thereof. Preferably the elemental metal, metal alloy, metal carbonate, and/or metal oxide particles are copper-containing metal, metal alloy, metal carbonate, and/or metal oxide particles, or any combination thereof, more preferably selected from the group consisting of Cu, Cu2(OH)2CO3, CuO, Cu20, or any combination thereof, further preferably selected from the group consisting of Cu, CuO, and Cu20 particles, or any combination thereof, even further preferably CuO or Cu20 particles.
Preferably, the elemental metal, metal alloy, metal carbonate, and/or metal oxide particles have a mean diameter of between 10 pm and 80 pm, preferably between 20 pm and 60 pm, further preferably between 30 pm and 40 pm.
The beneficial antimicrobial, antibacterial, and/or antiviral properties of the biocompatible polymer film of the present invention is realised by the protrusion of metal, metal alloy, metal carbonate, and/or metal oxide particles exhibiting antimicrobial, antibacterial, and/or antiviral properties from the surface of the polymer film.
Preferably, between 20% and 50% of the diameter of one or more of the elemental metal, metal alloy, metal carbonate, and/or metal oxide particles protrude from the surface of the biocompatible polymer, further preferably wherein between 25% and 40% of the diameter of one or more of the elemental metal, metal alloy, metal carbonate, and/or metal oxide particles protrude from the surface of the biocompatible polymer, even further preferably wherein between 30% and 35% of the diameter of one or more of the elemental metal, metal carbonate, metal alloy, and/or metal oxide particles protrude from the surface of the biocompatible polymer.
-14 -Preferably, one or more of the elemental metal, metal alloy, metal carbonate, and/or metal oxide particles protrude from the surface of the biocompatible polymer by between 3 pm and 27 pm, preferably between 7 pm and 20 pm, further preferably between 10 pm and 13 pm.
Preferably, between 20% and 50% by mass of total the elemental metal, metal alloy, metal carbonate, and/or metal oxide particles protrudes from the surface of the biocompatible polymer, further preferably wherein between 25% and 40% by mass of the total elemental metal, metal alloy, metal carbonate, and/or metal oxide particles protrudes from the surface of the biocompatible polymer, even further preferably wherein between 30% and 35% by mass of the total elemental metal, metal alloy, metal carbonate, and/or metal oxide particles protrudes from the surface of the biocompatible polymer.
The substrates to which the biocompatible polymer film may be applied is not particularly limited, provided that, once cured in situ, the biocompatible polymer film adheres to the substrate, as would be understood by the skilled person.
Preferably, the substrate is selected from naturally occurring or man-made materials. For example, the substrate may be selected from plastic polymers, cloth, fabric, polyester, polypropylene, wool, plastic, cotton, spandex, paper, linoleum, silicone, latex, rubber, marble, and wood, fibrous materials derived therefrom, and mixtures or combinations thereof.
Preferably, the article is obtainable by coating at least one surface of a substrate with the biocompatible polymer coating composition according to the first aspect of the invention and subsequently curing said biocompatible polymer coating composition in situ, wherein elemental metal and/or metal oxide particles are embedded within the biocompatible polymer film and protrude from surfaces thereof.
The antimicrobial, antibacterial, and/or antiviral biocompatible polymer coating compositions described herein may be applied to a variety of different materials, substrates, and/or products, and may be used for a variety of applications.
Of particular interest is the application of the biocompatible polymer film of the present invention to Personal Protective Equipment (PPE).
-15 -One particular use of the antimicrobial, antibacterial, and/or antiviral biocompafible polymer coating compositions may be the application to PPE, namely facemasks. This application may be achieved in a number of ways, and the coating compositions described herein may be applied do different types of facemasks in a variety of different ways.
Of particular interest is the application of the coating compositions to so-called 'N95' and/or KN95' masks. 'N95' and KN95' masks are formed from multiple layers of synthetic material, often a polypropylene plastic polymer, and such masks are designed to be worn over the mouth and nose. These masks are designed to filter out and capture 95 percent of 0.3-micron particles in the air -giving rise to the designation of '95' in the name.
It is noted that COVID-19 particles are of around 0.1-micron size, but are often attached to larger particles in the air.
As described above, 'N95' and KN95' masks are generally formed from layers of a polypropylene or polyurethane plastic polymer, which is 'melt-blown' and then fashioned into a mask. During the melt blowing process, the plastic polymer, generally provided in pellet form, are fed into a drum, passed through a corkscrew arrangement to convey the pellets into a heater, heated, passed through a mandrel at around 300°C and then extruded in a continuous strand. This causes spiral-like fibres to be formed of the polymer, and resembles candyfloss when it passes out of the mandrel.
The extruded polymer is then conveyed onto heated rollers, passed through the heated rollers and compressed into a sheet, and wound onto a roller for later use.
This melt-blown fabric may then be formed into masks. 'N95' and 'KN95' masks are often formed of at least three layers of the melt-blown fabric.
The antimicrobial, antibacterial, and/or antiviral biocompatible polymer coating compositions described herein may be sprayed onto the melt-blown fabric before it is formed into masks. This may take the form of a simple spraying operation, with the polymer cured after the spraying operation. In an example, three spraying operations may be carried out to ensure appropriate coverage of the fabric with the polymer coating, whilst still allowing for appropriate air passage through the fabric.
-16 -When the polymer coating is sprayed onto the melt-blown fabric, the polymer coats individual strands of the fabric. By the nature of the melt-blown material allowing air to pass therethrough, there is space for the polymer to coat each individual fibre.
In an example process for manufacture of material which may be formed into a mask, the melt-blown fabric is produced and fed into an arrangement for carrying out the spraying and impregnation of the polymer. The polymer may be sprayed onto the fabric as part of a first pass, the material heated, and then looped back for a further spray, heating, and then a final spray and heating, before being packed on a roller ready for shipping and use.
The heating process causes accelerated drying of the polymer. The temperature at which this may be carried out is around 40°C and may utilise hot air. It is envisaged, however, that the polymer coating may be cured with UV light, using a generic cross-linker with a photoinhibitor, which may be operable as a photocatalyst.
In some examples, it is envisaged that the polymer coating may be sprayed into the 'open' fibres of the melt-blown fabric before it reaches the rollers, so that the polymer may be formed into the melt-blown fabric, without having to be applied to the fabric as a separate step. The melt-blown fabric, after extrusion, comes off like candyfloss.
As described, the antimicrobial, antibacterial, and/or antiviral biocompafible polymer coating compositions for fabric are suitable for application to PPE such as masks, but may also be applied to so-called 'first-touch' surfaces and fabrics which may include seat-belts and seats of vehicles. For application of the polymer coating, it is preferable that the fabric allows the polymer to penetrate.
Further, the antimicrobial, antibacterial, and/or antiviral biocompatible polymer coating compositions may be used to form PPE which may be masks, gloves, tunics, scrubs, headwear, general garments, or any other suitable sort of PPE, which will be understood by the skilled reader.
In addition, the antimicrobial, antibacterial, and/or antiviral biocompafible polymer coating compositions may be used to form more general garments, or the first touch surfaces described above, and these garments or surfaces may include, clothing, furnishings, upholstery, ventilation components and/or ventilation grills, air conditioning components and/or air conditioning grills, and/or general work surfaces, or any other fabric or material which will be understood by the skilled reader.
-17 -It is also noted that the antimicrobial, antibacterial, and/or antiviral biocompatible polymer coating compositions may include a colouring agent or dye, so that the coating when applied to a substrate, for example a mask, is of a particular colour. In some instances, such a colour may derive from the salt of copper in the polymer coating. In an example, this may be copper carbonate, such that the resulting polymer coating is green in colour.
VVhile the invention has been illustrated and described in detail in the drawings and preceding description, such illustration and description are to be considered illustrative or exemplary and not restrictive; the invention is not limited to the disclosed embodiments.
Other variations to the disclosed embodiments can be understood and effected by those skilled in the art in practicing the claimed invention, from a study of the drawings, the disclosure, and the appended claims. Each feature of the disclosed embodiments may be replaced by alternative features serving the same, equivalent or similar purpose, unless stated otherwise. Therefore, unless stated otherwise, each feature disclosed is one example of a generic series of equivalent or similar features.
In the claims, the word "comprising" does not exclude other elements or steps, and the indefinite article "a" or "an" does not exclude a plurality. Any reference signs in the claims should not be construed as limiting the scope.
Examples
Example 1
Formulation of a biocompatible polymer coating composition.
The following components are dispersed in a mixture of 40g distilled deionised water and 80g acetone to produce a polymer coating composition: 100g PICASSIAN PU-648 by Stahl, a PUD; 10g PICASSIAN XL-702 by Stahl, a crosslinker; 240g Cu20 Cuprous Oxide by American CHEMET Corporation, a metal oxide; 2g BYK-7420 by BYK, a rheology agent; and 2g SCHWEGO 6527 by Bernd Schwegmann GmbH &Co. KG, a flow wetting agent.
-18 -
Example 2
Formation of a biocompatible polymer film.
The biocompatible polymer coating composition of Example 1 is cured in situ on a substrate utilising accelerated drying. Fig. 1-3 show microscope images of the resultant film.
Numbered Embodiments of the Invention Embodiment 1.
A biocompatible polymer coating composition comprising: i) a polymer; ii) a crosslinking agent; iii) elemental metal, metal alloy, metal carbonate, and/or metal oxide particles; wherein components i) to iii) are dispersed in a mixture of a volatile organic solvent and water, and wherein component iii) exhibits antimicrobial, antibacterial, and/or antiviral properties.
Embodiment 2.
The biocompatible polymer coating composition according to embodiment 1, wherein the volatile organic solvent is miscible with water.
Embodiment 3 The biocompatible polymer coating composition according to embodiment 1 or 2, wherein the volatile organic solvent is selected from the list consisting of acetone, dimethyl carbonate, methyl acetate, parachlorobenzotrifluoride (Oxsol 100), tert-Butyl acetate, and propylene carbonate.
Embodiment 4 The biocompatible polymer coating composition according to any of embodiments 1 to 3, wherein the volatile organic solvent is acetone.
Embodiment 5.
-19 -The biocompatible polymer coating composition according to any of embodiments 1 to 4, wherein the ratio of volatile organic solvent to water is 55:45 to 70:30 Embodiment 6.
The biocompatible polymer coating composition according to embodiment 5, wherein the ratio of volatile organic solvent to water is 60:40 to 66:33.
Embodiment 7.
The biocompatible polymer coating composition according to embodiment 6, wherein the ratio of volatile organic solvent to water is 60:40.
Embodiment 8 The biocompatible polymer coating composition according to any of embodiments 1 to 7, wherein the polymer is a polyurethane polymer.
Embodiment 9.
The biocompatible polymer coating composition according to embodiment 8, wherein the polymer is a polyurethane polymer selected from the list consisting of polycarbonate-based polyurethanes, polyester-based polyurethanes, polyether-based polyurethanes, fatty acid modified polyurethanes, and UV-curable polyurethanes.
Embodiment 10.
The biocompatible polymer coating composition according to any of embodiments 1 to 9, wherein the polymer is in the form of a water-based polyurethane polymer dispersion (PUD).
Embodiment 11.
The biocompatible polymer coating composition according to embodiment 10, wherein the PUD is selected from the list consisting of polycarbonate-based PUDs, polyester-based PUDs, polyether-based PUDs, fatty acid modified PUDs, and UV-curable PUDs.
Embodiment 12.
-20 -The biocompatible polymer coating composition according to any of embodiments 1 to 11, wherein the polymer of the polymer is an alternating copolymer.
Embodiment 13.
The biocompatible polymer coating composition according to embodiment 12, wherein the polymer comprises di-and/or tri-isocyanate monomers and polyol monomers.
Embodiment 14.
The biocompatible polymer coating composition according to embodiment 13, wherein the di-and/or tri-isocyanate monomers are selected from aliphatic diisocyanates, aromatic diisocyanates, oligomeric diisocyanates, polymeric diisocyanates, aliphatic triisocyanates, aromatic triisocyanates, oligomeric triisocyanates, and polymeric triisocyanates.
Embodiment 15.
The biocompatible polymer coating composition according to embodiment 14, wherein the di-and/or tri-isocyanate monomers are selected from isophorone diisocyanate, hexamethylene diisocyanate, toluene diisocyanate, diphenylmethane diisocyanate, and triphenylmethane triisocyanate Embodiment 16.
The biocompatible polymer coating composition according to any of embodiments 13 to 15, wherein the polyol monomers are selected from diolcontaining esters, diol-containing acrylates, diol-containing carbonates, diolcontaining ureas, diol-containing butadienes, diol-containing ethers, diolcontaining amides, oligomeric diols, and polymeric diols.
Embodiment 17.
The biocompatible polymer coating composition according to any of embodiments 1 to 16, wherein the polymer has a weight average molecular weight (Mw) of less than 200,000 and more than 5,000.
Embodiment 18. -21 -
The biocompatible polymer coating composition according to any of embodiments 1 to 17, wherein the crosslinking agent is a polyfunctional compound comprising at least one functional group selected from the group consisting of carbodiimide, glycidyl epoxide, acetoacetoxy, diacetone, alkoxysilane, amine, hydroxyl, isocyanate, aziridine, hydrazide, and epoxide.
Embodiment 19.
The biocompatible polymer coating composition to any of embodiments 1 to 18, wherein the biocompatible polymer coating composition additionally comprises a coalescing agent, preferably wherein the coalescing agent is selected from an organic solvent and/or a plasticizer.
Embodiment 20.
The biocompatible polymer coating composition to any of embodiments 1 to 19, wherein the biocompatible polymer coating composition additionally comprises a rheology agent, preferably wherein the rheology agent is selected from BYK-E410, BYK-E411, BYK-E420, BYK-7410ET, BYK-7411ES and BYK-7420ES.
Embodiment 21.
The biocompatible polymer coating composition to any of embodiments 1 to 20, wherein the biocompatible polymer coating composition additionally comprises a flow wetting agent, preferably wherein the rheology agent is selected from SCHWEGO® flow 6527, SCHWEGO® flow 6533, SCHWEGO® flow 8057, SCHWEGO® flow 8058, SCHWEGO® wett 6295, SCHWEGO® wett 6267, and SCHWEGO® wett.
Embodiment 22.
A biocompatible polymer film obtainable by coating at least one surface of a substrate with the biocompatible polymer coating composition according to any of embodiments 1 to 21 and subsequently curing said biocompatible polymer coating composition in situ, wherein elemental metal, metal alloy, metal carbonate, and/or metal oxide particles are embedded within the biocompatible polymer film and protrude from surfaces thereof.
-22 -Embodiment 22.
The biocompatible polymer film according to embodiment 21, wherein the coating is achieved by immersion, brush, spray, dip, curtain, agitated bath, aerated baths, or aerosol techniques to coat the biocompatible polymer composition onto the at least one surface of the substrate.
Embodiment 23.
The biocompatible polymer film according to embodiment 21 or 22, wherein the curing is initiated by the application of heat, radiation, electron beams, or chemical additives, preferably accelerated drying or photocuring is utilised to cure the biocompatible polymer composition onto the at least one surface of the substrate.
Embodiment 24.
An article comprising a substrate and a biocompatible polymer film bound to at least one surface of said substrate, wherein elemental metal, metal carbonate, metal alloy, and/or metal oxide particles exhibiting antimicrobial, antibacterial, and/or antiviral properties are embedded within the biocompatible polymer film and protrude from surfaces thereof.
Embodiment 25.
The article according to embodiment 24, wherein the polymer of the biocompatible polymer film is selected from the list consisting of polycarbonate-based polyurethanes, polyester-based polyurethanes, polyether-based polyurethanes, fatty acid modified polyurethanes, and UV-curable polyurethanes.
Embodiment 26.
The biocompatible polymer coating composition, biocompatible polymer film, or article according to any of embodiments 1 to 25, wherein the elemental metal, metal alloy, metal carbonate, and/or metal oxide particles are selected from the group consisting of silver-containing, aluminium-containing, gold-containing, copper-containing, iron-containing, magnesium-containing, -23 -titanium-containing, or zinc-containing metal, metal alloy, metal carbonate, and/or metal oxide particles, or any combination thereof.
Embodiment 27.
The biocompatible polymer coating composition, biocompatible polymer film, or article according to embodiment 26, wherein the elemental metal, metal alloy, metal carbonate, and/or metal oxide particles are selected from the group consisting of Ag, A1203, Au, Cu, Cu2(OH)2003, CuO, Cu20, Fe304, MgO, Ti02, and ZnO particles, or any combination thereof.
Embodiment 28.
The biocompatible polymer coating composition, biocompatible polymer film, or article according to embodiment 27, wherein the elemental metal, metal alloy, metal carbonate, and/or metal oxide particles are selected from the group consisting of Cu, Cu2(OH)2CO3, CuO, and Cu20 particles, or any combination thereof Embodiment 29.
The biocompatible polymer coating composition, biocompatible polymer film, or article according to embodiment 28, wherein the elemental metal, metal alloy, and/or metal oxide particles are selected from the group consisting of Cu, CuO, and Cu20, or any combination thereof.
Embodiment 30.
The biocompatible polymer coating composition, biocompatible polymer film, or article according to embodiment 29, wherein the elemental metal, metal alloy, and/or metal oxide particles are CuO or Cu20 particles.
Embodiment 31.
The biocompatible polymer coating composition, biocompatible polymer film, or article according to any of embodiments 1 to 30, wherein the elemental metal, metal alloy, and/or metal oxide particles have a mean diameter of between 10 pm and 80 pm.
Embodiment 32.
-24 -The biocompatible polymer coating composition, biocompatible polymer film, or article according to embodiment 31, wherein the elemental metal, metal alloy, and/or metal oxide particles have a mean diameter of between 20 pm and 60 pm.
Embodiment 33.
The biocompatible polymer coating composition, biocompatible polymer film, or article according to embodiment 32, wherein the elemental metal, metal alloy, and/or metal oxide particles have a mean diameter of between 30 pm and 40 pm.
Embodiment 34.
The biocompatible polymer film or article according to any of embodiments 22 to 33, wherein the biocompatible polymer film has a mean thickness of between 10 pm and 100 pm.
Embodiment 35.
The biocompatible polymer film or article according to embodiment 34, wherein the biocompatible polymer film has a mean thickness of between 20 pm and 80 pm.
Embodiment 36.
The biocompatible polymer film or article according to embodiment 35, wherein the biocompatible polymer film has a mean thickness of between 30 pm and 60 pm.
Embodiment 37.
The biocompatible polymer film or article according to embodiment 36, wherein the biocompatible polymer film has a mean thickness of between 40 pm and 50 pm.
Embodiment 38.
The biocompatible polymer film or article according to any of embodiments 22 to 37, wherein between 20% and 50% of the diameter of one or more of the -25 -elemental metal, metal alloy, metal carbonate, and/or metal oxide particles protrude from the surface of the biocompatible polymer.
Embodiment 39.
The biocompatible polymer film or article according to embodiment 38, wherein between 25% and 40% of the diameter of one or more of the elemental metal, metal alloy, metal carbonate, and/or metal oxide particles protrude from the surface of the biocompatible polymer.
Embodiment 40.
The biocompatible polymer film or article according to embodiment 39, wherein between 30% and 35% of the diameter of one or more of the elemental metal, metal alloy, metal carbonate, and/or metal oxide particles protrude from the surface of the biocompatible polymer.
Embodiment 41.
The biocompatible polymer film or article according to any of embodiments 22 to 40, wherein one or more of the elemental metal, metal alloy, metal carbonate, and/or metal oxide particles protrude from the surface of the biocompatible polymer by between 3 pm and 27 pm.
Embodiment 42.
The biocompatible polymer film or article according to embodiment 41, wherein one or more of the elemental metal, metal alloy, metal carbonate, and/or metal oxide particles protrude from the surface of the biocompatible polymer by between 7 pm and 20 pm.
Embodiment 43.
The biocompatible polymer film or article according to embodiment 42, wherein one or more of the elemental metal, metal alloy, metal carbonate, and/or metal oxide particles protrude from the surface of the biocompatible polymer by between 10 pm and 13 pm.
Embodiment 44.
-26 -The biocompatible polymer film or article according to any of embodiments 20 to 43, wherein the substrate is selected from from plastic polymers, cloth, fabric, polyester, polypropylene, wool, plastic, cotton, spandex, paper, linoleum, silicone, latex, rubber, marble, and wood, fibrous materials derived therefrom, and mixtures or combinations thereof.
Embodiment 45.
A biocompatible polymer coating composition comprising: i) 15 wt% to 30 wt% of a polymer; H) 1 wt% to 10 wt% of a crosslinking agent; iii) 40 wt% to 60 wt% of elemental metal, metal alloy, metal carbonate, and/or metal oxide particles; wherein i) to iii) are dispersed in a mixture of acetone and water, wherein said acetone accounts for 12.5 wt% to 20 wt% of the biocompatible polymer coating composition and said water accounts for 7.5 wt% to 15 wt% of the biocompatible polymer coating composition.
Embodiment 46.
The biocompatible polymer coating composition according to embodiment 45, wherein the polymer is a water-based polyurethane polymer dispersion (PUD) and the elemental metal, metal alloy, metal carbonate, and/or metal oxide particles are copper-based particles.
Embodiment 47.
The biocompatible polymer coating composition according to embodiment 46, comprising: i) 17.5 wt% to 22.5 wt% of a water-based polyurethane polymer dispersion (PUD), as defined above; H) 1 wt% to 3 wt% of a crosslinking agent, as defined above; Hi) 0 wt% to 1 wt% of a flow wetting agent, as defined above; iv) 0 wt% to 1 wt% of a rheology agent, as defined above; v) 45 wt% to 60 wt% of copper-based particles, as defined above; -27 -wherein i) to v) are dispersed in a mixture of acetone and water, wherein said acetone accounts for 15 wt% to 17.5 wt% of the biocompatible polymer coating composition and said water accounts for 8 wt% to 10 wt% of the biocompatible polymer coating composition.
Claims (25)
- -28 -Claims A biocompatible polymer coating composition comprising: i) a polymer; ii) a crosslinking agent; iii) elemental metal, metal alloy, metal carbonate, and/or metal oxide particles; wherein components i) to iii) are dispersed in a mixture of a volatile organic solvent and water, and wherein component iii) exhibits antimicrobial, antibacterial, and/or antiviral properties.
- 2. The biocompatible polymer coating composition according to claim 1, wherein the volatile organic solvent is miscible with water, preferably wherein the volatile organic solvent is selected from the list consisting of acetone, dimethyl carbonate, methyl acetate, parachlorobenzotrifluoride (Oxsol 100), tert-Butyl acetate, and propylene carbonate, further preferably wherein the volatile organic solvent is acetone.
- 3. The biocompatible polymer coating composition according to claim 1 or 2, wherein the ratio of volatile organic solvent to water is 55:45 to 70:30, preferably 60:40 to 66:33, further preferably 60:40.
- 4. The biocompatible polymer coating composition according to any preceding claim, wherein the polymer is a polyurethane polymer, preferably wherein the polymer is a polyurethane polymer selected from the list consisting of polycarbonatebased polyurethanes, polyester-based polyurethanes, polyether-based polyurethanes, fatty acid modified polyurethanes, and UV-curable polyurethanes.
- 5. The biocompatible polymer coating composition according to any preceding claim, wherein the polymer is in the form of a water-based polyurethane polymer dispersion (PUD), preferably wherein the PUD is selected from the list consisting of polycarbonate-based PUDs, polyester-based PUDs, polyether-based PUDs, fatty acid modified PUDs, and UV-curable PUDs.
- 6. The biocompatible polymer coating composition according to any preceding claim, wherein the crosslinking agent is a polyfunctional compound comprising at least one functional group selected from the group consisting of carbodiimide, -29 -glycidyl epoxide, acetoacetoxy, diacetone, alkoxysilane, amine, hydroxyl, isocyanate, aziridine, hydrazide, and epoxide.
- 7. A biocompatible polymer film obtainable by coating at least one surface of a substrate with the biocompatible polymer coating composition according to any of claims 1 to 6 and subsequently curing said biocompatible polymer coating composition in situ, wherein elemental metal, metal alloy, metal carbonate, and/or metal oxide particles are embedded within the biocompatible polymer film and protrude from surfaces thereof.
- 8. The biocompatible polymer film according to claim 7, wherein the coating is achieved by immersion, brush, spray, dip, curtain, agitated bath, aerated baths, or aerosol techniques to coat the biocompatible polymer composition onto the at least one surface of the substrate.
- 9. The biocompatible polymer film according to claim 7 or 8, wherein the curing is initiated by the application of heat, radiation, electron beams, or chemical additives, preferably accelerated drying or photocuring is utilised to cure the biocompatible polymer composition onto the at least one surface of the substrate.
- 10. An article comprising a substrate and a biocompatible polymer film bound to at least one surface of said substrate, wherein elemental metal, metal alloy, metal carbonate, and/or metal oxide particles exhibiting antimicrobial, antibacterial, and/or antiviral properties are embedded within the biocompatible polymer film and protrude from surfaces thereof.
- 11. The article according to claim 10, wherein the polymer of the biocompatible polymer film is selected from the list consisting of polycarbonate-based polyurethanes, polyester-based polyurethanes, polyether-based polyurethanes, fatty acid modified polyurethanes, and UV-curable polyurethanes.
- 12. The biocompatible polymer coating composition, biocompatible polymer film, or article according to any preceding claim, wherein the elemental metal, metal alloy, metal carbonate, and/or metal oxide particles are selected from the group consisting of silver-containing, aluminium-containing, gold-containing, copper-containing, iron-containing, magnesium-containing, titanium-containing, or zinc-containing metal, metal alloy, metal carbonate, and/or metal oxide particles, or any combination thereof, preferably selected from the group consisting selected from the group -30 -consisting of Ag, A1203, Au, Cu, Cu2(OH)2CO3, CuO, Cu20, Fe304, MgO, h02, and ZnO particles, or any combination thereof, more preferably selected from the group consisting of Cu, Cu2(OH)2CO3, CuO, and Cu2O or any combination thereof, further preferably selected from the group consisting of Cu, CuO, and Cu20, or any combination thereof, even further preferably CuO or Cu20 particles.
- 13. The biocompatible polymer coating composition, biocompatible polymer film, or article according to any preceding claim, wherein the elemental metal, metal alloy, and/or metal oxide particles have a mean diameter of between 10 pm and 80 pm, preferably between 20 pm and 60 pm, further preferably between 30 pm and 40 pm.
- 14. The biocompatible polymer film or article according to any of claims 7to 13, wherein the biocompatible polymer film has a mean thickness of between 10 pm and 100 pm, preferably between 20 pm and 80 pm, further preferably between 30 pm and 60 pm, even further preferably between 40 pm and 50 pm.
- 15. The biocompatible polymer film or article according to any of claims 7 to 14, wherein between 20% and 50% of the diameter of one or more of the elemental metal, metal alloy, and/or metal oxide particles protrude from the surface of the biocompatible polymer, preferably wherein between 25% and 40% of the diameter of one or more of the elemental metal, metal alloy, and/or metal oxide particles protrude from the surface of the biocompatible polymer, further preferably wherein between 30% and 35% of the diameter of one or more of the elemental metal, metal alloy, and/or metal oxide particles protrude from the surface of the biocompatible polymer.
- 16. The biocompatible polymer film or article according to any of claims 7 to 15, wherein one or more of the elemental metal, metal alloy, and/or metal oxide particles protrude from the surface of the biocompatible polymer by between 3 pm and 27 pm, preferably between 7 pm and 20 pm, further preferably between 10 pm and 13 pm.
- 17. The biocompatible polymer film or article according to any of claims 6 to 15, wherein the substrate is selected from plastic polymers, cloth, fabric, polyester, polypropylene, wool, plastic, cotton, spandex, paper, linoleum, silicone, latex, rubber, marble, and wood, fibrous materials derived therefrom, and mixtures or combinations thereof.
- 18. An item of protective equipment, the protective equipment being formed of at least one layer of a substrate material, wherein at least one layer of the substrate -31 -material is coated with a biocompatible polymer film obtainable by coating at least one surface of a substrate with the biocompatible polymer coating composition according to any of claims 1 to 6 and subsequently curing said biocompatible polymer coating composition in situ, wherein elemental metal, metal alloy and/or metal oxide particles are embedded within the biocompatible polymer film and protrude from surfaces thereof.
- 19. The item of protective equipment according to claim 18, wherein the at least one layer of substrate material is a plastic polymer, preferably wherein the plastic polymer is melt-blown.
- 20. The item of protective equipment of any one of claims 17 to 19, wherein the item of protective equipment is a mask.
- 21. A method of manufacturing a biocompatible material including the steps of: spraying the biocompatible polymer coating composition according to any one of claims 1 to 5 onto a substrate material; and curing the biocompatible polymer coating composition
- 22. The method of claim 21, wherein the substrate material is a melt-blown plastic polymer, and wherein the biocompatible polymer coats the strands of the melt-blown plastic polymer.
- 23. The method of claim 21 or 22, wherein the curing step includes the application of heat to accelerate the drying of the biocompatible polymer coating composition.
- 24. A method of manufacturing a biocompatible material including the steps of: extruding a plastic polymer; spraying the biocompatible polymer coating composition according to any one of claims 1 to 5 into the extruded plastic polymer; and collecting the plastic polymer and the biocompatible polymer coating as a melt-blown material.
- 25. A personal protective equipment mask formed of the biocompatible material derived from the method according to claim 24.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2106026.4A GB2606172A (en) | 2021-04-27 | 2021-04-27 | Biocompatible polymer films with antimicrobial, antibacterial, and/or antiviral properties |
| EP22722870.7A EP4329493A1 (en) | 2021-04-27 | 2022-04-27 | Biocompatible polymer films with antimicrobial, antibacterial, and/or antiviral properties |
| PCT/GB2022/051067 WO2022229633A1 (en) | 2021-04-27 | 2022-04-27 | Biocompatible polymer films with antimicrobial, antibacterial, and/or antiviral properties |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2106026.4A GB2606172A (en) | 2021-04-27 | 2021-04-27 | Biocompatible polymer films with antimicrobial, antibacterial, and/or antiviral properties |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB202106026D0 GB202106026D0 (en) | 2021-06-09 |
| GB2606172A true GB2606172A (en) | 2022-11-02 |
Family
ID=76193438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2106026.4A Pending GB2606172A (en) | 2021-04-27 | 2021-04-27 | Biocompatible polymer films with antimicrobial, antibacterial, and/or antiviral properties |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP4329493A1 (en) |
| GB (1) | GB2606172A (en) |
| WO (1) | WO2022229633A1 (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090253848A1 (en) * | 2008-04-08 | 2009-10-08 | Bayer Materialscience Ag | Aqueous silver-containing nonionic polyurethane dispersions |
| US20090253826A1 (en) * | 2008-04-08 | 2009-10-08 | Bayer Materialscience Ag | Silver-containing polyurethaneurea solution |
| US20090319035A1 (en) * | 2006-03-03 | 2009-12-24 | C. R. Bard, Inc. | Antimicrobial coating |
| US20100113871A1 (en) * | 2006-09-13 | 2010-05-06 | Aylvin Jorge Angelo Athanasius Dias | Antimicrobial coating |
| US20190338148A1 (en) * | 2018-05-03 | 2019-11-07 | Aleddra Inc. | Anti-Bacterial Photocatalytic Coated Apparatus |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4871790A (en) * | 1987-11-25 | 1989-10-03 | Minnesota Mining And Manufacturing Company | Colloidal metals in monomers or polymers |
| CN113227264A (en) * | 2018-12-26 | 2021-08-06 | 日东电工株式会社 | Superhydrophilic release coating composition |
-
2021
- 2021-04-27 GB GB2106026.4A patent/GB2606172A/en active Pending
-
2022
- 2022-04-27 WO PCT/GB2022/051067 patent/WO2022229633A1/en active Application Filing
- 2022-04-27 EP EP22722870.7A patent/EP4329493A1/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090319035A1 (en) * | 2006-03-03 | 2009-12-24 | C. R. Bard, Inc. | Antimicrobial coating |
| US20100113871A1 (en) * | 2006-09-13 | 2010-05-06 | Aylvin Jorge Angelo Athanasius Dias | Antimicrobial coating |
| US20090253848A1 (en) * | 2008-04-08 | 2009-10-08 | Bayer Materialscience Ag | Aqueous silver-containing nonionic polyurethane dispersions |
| US20090253826A1 (en) * | 2008-04-08 | 2009-10-08 | Bayer Materialscience Ag | Silver-containing polyurethaneurea solution |
| US20190338148A1 (en) * | 2018-05-03 | 2019-11-07 | Aleddra Inc. | Anti-Bacterial Photocatalytic Coated Apparatus |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022229633A1 (en) | 2022-11-03 |
| EP4329493A1 (en) | 2024-03-06 |
| GB202106026D0 (en) | 2021-06-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6291011B2 (en) | Dispersion and film containing aqueous polyurethaneurea composition | |
| US10544543B2 (en) | Garment incorporating aqueous polyurethane dispersions having altered stress profile | |
| AU2006213644B2 (en) | Solvent free aqueous polyurethane dispersions and shaped articles therefrom | |
| KR101816640B1 (en) | Urethane resin composition, coating agent, urethane resin composition for forming surface layer of leather-like sheet, laminate, and leather-like sheet | |
| JP5391278B2 (en) | Aqueous polyurethaneurea composition including dispersion and film | |
| US20130302574A1 (en) | Solvent free aqueous polyurethane dispersions and shaped articles therefrom | |
| KR20100017682A (en) | Laminated fabric construction with heat activated polyurethaneurea compositions | |
| TWI845469B (en) | Aqueous polyurethane dispersions, prepolymers, and shaped articles made therefrom | |
| CN104395522A (en) | Sizing agent for reinforcing fibers, and use thereof | |
| US11692304B2 (en) | Garment incorporating waterproof or water resilient aqueous polyurethane dispersions and/or having altered stress profile | |
| KR102357750B1 (en) | Eco-friendly vegan leather using tangerine peel and manufacturing method thereof | |
| GB2606172A (en) | Biocompatible polymer films with antimicrobial, antibacterial, and/or antiviral properties | |
| CN106795693A (en) | Dispersion and film including aqueous polyurethane composition | |
| DE102011086103A1 (en) | Silicone rubber on hot melt adhesive | |
| KR102548284B1 (en) | A working gloves having antimicrobial effect | |
| JP7389004B2 (en) | Flexible laminate, its manufacturing method, and waterproof products using the same | |
| CN109440483A (en) | A kind of high scratch resistance mirror surface super fiber leather and preparation method thereof | |
| KR20240046944A (en) | Eco-friendly aplle vegan leather using apple residues and manufacturing method thereof | |
| US20230348743A1 (en) | Antimicrobial inkjet composition | |
| HK1147276A (en) | Aqueous polyurethaneurea compositions including dispersions and films |