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GB2528070B - Nerve stimulating and monitoring device - Google Patents

Nerve stimulating and monitoring device

Info

Publication number
GB2528070B
GB2528070B GB1412137.0A GB201412137A GB2528070B GB 2528070 B GB2528070 B GB 2528070B GB 201412137 A GB201412137 A GB 201412137A GB 2528070 B GB2528070 B GB 2528070B
Authority
GB
United Kingdom
Prior art keywords
monitoring device
nerve stimulating
nerve
stimulating
monitoring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB1412137.0A
Other versions
GB201412137D0 (en
GB2528070A (en
Inventor
Eftekhar Amir
Toumazou Christofer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
VAGONYX Ltd
Original Assignee
VAGONYX Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by VAGONYX Ltd filed Critical VAGONYX Ltd
Priority to GB1412137.0A priority Critical patent/GB2528070B/en
Publication of GB201412137D0 publication Critical patent/GB201412137D0/en
Priority to PCT/EP2015/065511 priority patent/WO2016005400A1/en
Publication of GB2528070A publication Critical patent/GB2528070A/en
Application granted granted Critical
Publication of GB2528070B publication Critical patent/GB2528070B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551Spinal or peripheral nerve electrodes
    • A61N1/0556Cuff electrodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4836Diagnosis combined with treatment in closed-loop systems or methods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/40Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4029Detecting, measuring or recording for evaluating the nervous system for evaluating the peripheral nervous systems
    • A61B5/4041Evaluating nerves condition
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/685Microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551Spinal or peripheral nerve electrodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372Arrangements in connection with the implantation of stimulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2505/00Evaluating, monitoring or diagnosing in the context of a particular type of medical care
    • A61B2505/05Surgical care
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02Details of sensors specially adapted for in-vivo measurements
    • A61B2562/028Microscale sensors, e.g. electromechanical sensors [MEMS]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04Arrangements of multiple sensors of the same type
    • A61B2562/046Arrangements of multiple sensors of the same type in a matrix array
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/686Permanently implanted devices, e.g. pacemakers, other stimulators, biochips
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6867Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
    • A61B5/6877Nerve
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403Cells and electrode assemblies
    • G01N27/414Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4145Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403Cells and electrode assemblies
    • G01N27/414Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4148Integrated circuits therefor, e.g. fabricated by CMOS processing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/4833Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
    • G01N33/4836Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures using multielectrode arrays

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physiology (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Electrotherapy Devices (AREA)
GB1412137.0A 2014-07-08 2014-07-08 Nerve stimulating and monitoring device Active GB2528070B (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB1412137.0A GB2528070B (en) 2014-07-08 2014-07-08 Nerve stimulating and monitoring device
PCT/EP2015/065511 WO2016005400A1 (en) 2014-07-08 2015-07-07 Nerve stimulating and monitoring device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1412137.0A GB2528070B (en) 2014-07-08 2014-07-08 Nerve stimulating and monitoring device

Publications (3)

Publication Number Publication Date
GB201412137D0 GB201412137D0 (en) 2014-08-20
GB2528070A GB2528070A (en) 2016-01-13
GB2528070B true GB2528070B (en) 2016-12-14

Family

ID=51410803

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1412137.0A Active GB2528070B (en) 2014-07-08 2014-07-08 Nerve stimulating and monitoring device

Country Status (2)

Country Link
GB (1) GB2528070B (en)
WO (1) WO2016005400A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12135308B2 (en) * 2018-09-21 2024-11-05 Teralytic Holdings Inc. Extensible, multimodal sensor fusion platform for remote, proximal terrain sensing

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101700886B1 (en) * 2015-07-24 2017-02-01 한국과학기술연구원 Neural probe array of high performance and for minimized damage of neuron
DK3522773T3 (en) 2016-10-04 2021-04-12 Ecole Polytechnique Fed Lausanne Epfl INTRA-FASCULAR ELECTRODE IMPLANT
KR101887024B1 (en) * 2016-11-10 2018-08-09 한국과학기술연구원 Neural Probe Structure and Neural Probe Assembly having the same
GB2563651A (en) * 2017-06-22 2018-12-26 Galvani Bioelectronics Ltd Nerve stimulation and monitoring device
WO2019122817A1 (en) * 2017-12-21 2019-06-27 Galvani Bioelectronics Limited Nerve stimulation device for current steering
EP3727563A1 (en) 2017-12-21 2020-10-28 Galvani Bioelectronics Limited Nerve stimulation device for unidirectional stimulation and current steering
IT202200023493A1 (en) 2022-11-15 2024-05-15 Scuola Superiore Di Studi Univ E Di Perfezionamento Santanna SELF-PENETRANT PERIPHERAL NEURAL INTERFACE
GB2628593A (en) 2023-03-29 2024-10-02 Toumazou Christofer Vagus nerve stimulation system and method

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1726329A1 (en) * 2005-05-25 2006-11-29 Alfred E. Mann Foundation for Scientific Research Hermetically sealed three-dimensional electrode array
WO2008007065A2 (en) * 2006-07-10 2008-01-17 Imperial Innovations Limited Method and apparatus for measuring activity in the peripheral nervous system
US7991475B1 (en) * 2005-06-08 2011-08-02 The Regents Of The University Of California High density micromachined electrode arrays useable for auditory nerve implants and related methods
GB2487416A (en) * 2011-01-21 2012-07-25 Dna Electronics Ltd Chemical Sensor
US20130253299A1 (en) * 2012-03-20 2013-09-26 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Monitoring and regulating physiological states and functions via sensory neural inputs to the spinal cord

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4969468A (en) * 1986-06-17 1990-11-13 Alfred E. Mann Foundation For Scientific Research Electrode array for use in connection with a living body and method of manufacture
US5400784A (en) * 1993-10-15 1995-03-28 Case Western Reserve University Slowly penetrating inter-fascicular nerve cuff electrode and method of using
US20130046148A1 (en) * 2009-11-09 2013-02-21 Prashant Tathireddy Three Dimensional Penetrating Optical-Electrical Neural Interface for Selective Stimulation and Recording

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1726329A1 (en) * 2005-05-25 2006-11-29 Alfred E. Mann Foundation for Scientific Research Hermetically sealed three-dimensional electrode array
US7991475B1 (en) * 2005-06-08 2011-08-02 The Regents Of The University Of California High density micromachined electrode arrays useable for auditory nerve implants and related methods
WO2008007065A2 (en) * 2006-07-10 2008-01-17 Imperial Innovations Limited Method and apparatus for measuring activity in the peripheral nervous system
GB2487416A (en) * 2011-01-21 2012-07-25 Dna Electronics Ltd Chemical Sensor
US20130253299A1 (en) * 2012-03-20 2013-09-26 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Monitoring and regulating physiological states and functions via sensory neural inputs to the spinal cord

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12135308B2 (en) * 2018-09-21 2024-11-05 Teralytic Holdings Inc. Extensible, multimodal sensor fusion platform for remote, proximal terrain sensing

Also Published As

Publication number Publication date
WO2016005400A1 (en) 2016-01-14
GB201412137D0 (en) 2014-08-20
GB2528070A (en) 2016-01-13

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Legal Events

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Free format text: REGISTERED BETWEEN 20190912 AND 20190918