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GB2596849A - Nutritional supplement composition for treating coronavirus infections, cancer, ME, post viral & Chronic fatigue syndrome & neurodegeneration in an individual - Google Patents

Nutritional supplement composition for treating coronavirus infections, cancer, ME, post viral & Chronic fatigue syndrome & neurodegeneration in an individual Download PDF

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Publication number
GB2596849A
GB2596849A GB2010600.1A GB202010600A GB2596849A GB 2596849 A GB2596849 A GB 2596849A GB 202010600 A GB202010600 A GB 202010600A GB 2596849 A GB2596849 A GB 2596849A
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GB
United Kingdom
Prior art keywords
amount
vitamin
formulation
composition
composition further
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB2010600.1A
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GB202010600D0 (en
Inventor
Jardine Romy
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Biotech Life Sciences
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Biotech Life Sciences
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Filing date
Publication date
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Priority to GB2010600.1A priority Critical patent/GB2596849A/en
Publication of GB202010600D0 publication Critical patent/GB202010600D0/en
Publication of GB2596849A publication Critical patent/GB2596849A/en
Pending legal-status Critical Current

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
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    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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Abstract

A chemo-preventative and cytotoxic formulation for treating coronavirus and other infections, cancer, PVFS/ME/CFS, fibromyalgia, improving immune, mitochondrial, stem cell and brain function, and reversing epigenetic aging, in an individual, comprising NMN, NAD, PQQ, CoQ10, piperine, vitamin B7, vitamin B9, and vitamin B12. Further disclosed is a chemo-preventative and cytotoxic formulation for treating coronavirus and other infections, cancer, PVFS/ME/CFS, fibromyalgia, improving immune, mitochondrial, stem cell and brain function, and reversing epigenetic aging, in an individual, comprising Resveratol, Pterostilbene, Quercetin, Baikal Skullcap, L-Theanine, Curcuminoids (Turmeric Extract), Lion’s Mane Mushrooms, vitamin B1, vitamin B2, vitamin B5, vitamin B6, Piperine and Zinc Complex. Further disclosed is chemo-preventative and cytotoxic formulation for treating coronavirus and other infections, cancer, PVFS/ME/CFS, fibromyalgia, improving immune, mitochondrial, stem cell and brain function, and reversing epigenetic aging, in an individual, comprising Alpha Lipoic Acid (ALA), Acetyl-L-Carnitine (ALCAR), N-Acetyl Cysteine (NAC), Ginkgo Biloba, Beta Glucans, Epigallocatechin 3-Gallate (EGCG), Green Tea Extract, Pomegranate Extract (incl. Ellagic Acid), Olive Leaf Extract (incl. Oleuropein and Hydroxytyrosol), Green Coffee Bean Extract (incl. Chlorogenic Acids), Theacrine and piperine.

Description

NUTRITIONAL SUPPLEMENT COMPOSITION FOR TREATING CORONAVIRUS
INFECTIONS, CANCER, ME, POST VIRAL & CHRONIC FATIGUE SYNDROME &
NEURODEGENERATION IN AN INDIVIDUAL
BACKGROUND OF THE INVENTION
A. Technical field
[0001] The present invention relates to a composition for treating covid-19 (coronavirus infections), diabetes, respiratory tract infections and acute lung injury, post viral fatigue syndrome (PVFS) and chronic fatigue syndrome (CFS) / myalgic encephalomyelitis (ME), fibromyalgia, heart diseases, inflammation, cancers, and cytokine storms and also improving immune system, stem cells, mitochondrial function, brain heath, slowing and reversing epigenetic ageing in an individual by using an active combination of substances selected from the group consisting of phytochemicals and bio-tech nutraceuticals and thereof
B. Description of related art
[0002] Human brain changes with age and mental function changes along with it. Mental decline is common, and it's one of the most feared consequences of aging but cognitive impairment is not inevitable. Many attempts have been made to develop treatments and formulations to extend and improve the brain health and the quality of life. Numerous approaches are known in the art to enhance cognitive performance in normal individuals. More recently, certain nutraceutical agents have claimed cognitive enhancing effects. In other examples, various supplements and formulations comprising a multiplicity of allegedly active ingredients are marketed as nootropics, or cognitive enhancing agents to enhance brain function, mood and cognitive ability in normal individuals. However, currently most available nutraceutical supplements and formulations may therefore have no significant in the brain health of relatively wide age range and also fail to provide optimal health benefits [0003] One such a prior art device is described in US20160038552 assigned to Dale E. Bredesen et.al, entitled "Improved cognitive supplements" discloses nootropics sublingual power supplements are used to improve the cognitive functions such as learning, memory, concentration, focus, attention, and mood. The supplements comprising vitamin B9 (folate) can dose 0.4 mg to about 10 mg, vitamin B9 (methylcobalamin) can dose 2.5 mg to about 10 mg, L-Alpha Glycerylphosphorylcholine (Alpha GPC) can dose 100 mg to about 2000 mg, Magnesium Threonate can dose 200 mg to about 800 mg, L-theanine, ginkgo biloba, acetyl L-camitine (ALCAR), sweeteners and flavorings are added. The Alpha GPC is the one of the brain's most important neurotransmitters associated with heightened states of attention, improved memory and learning. ALCAR enhances cognitive ability because it increases the production and release of acetylcholine in the brain. Studies have shown that ALCAR supplementation enhances mood, memory, visuo-spatial capacity, and vocabulary recall. The Ginkgo leaf extract has been reported to have neuroprotective, anticancer, cardioprotective, stress alleviating, and memory enhancing effects and possible effects on tinnitus, geriatric complaints, and psychiatric disorders.
100041 Another prior art W02019074617 assigned to Kilman Clarke lewis, discloses about dietary supplement comprises combinations of vitamins and substances that are naturally endogenous to the brain, are known to decline with age, injury and disease and are essential for membrane structure, mitochondria] respiration and stem cell differentiation. The powder is administered by means of sublingual. The composition comprising pyrroloquinoline quinone (PQQ) can dosage in the range 1 mg to about 200mg, Folic acid can dose in the range mg to 200mg, Vitamin B12 can dose in the range mg to 200mg, alpha lipoic acid and acetyl-L-carnitine. However, the existing nootropics sublingual power supplements and dietary supplements are not effective in improving brain's health and cognitive functions such as learning, memory, concentration, focus, attention, and mood.
100051 Accordingly, there is a need for a nutritional supplement composition or formulation in the form of capsules or a tablet or liquid, liposomal, micelle, phospholipids or topical form, soft gels, drinks, powder, medical food, intravenous and an oral composition for improving cognition or rejuvenating ability and brain function and also treating covid-19 (coronavirus infections) of an individual using an active combination of substance selected from the group consisting of phytochemicals and bio-tech nutraceuticals and thereof Further, there is also a need for a nutritional supplement to provide one or more benefits include, but not limited to, promote immune system health, healthy nerve and neural stem cell function, treats post viral fatigue / chronic fatigue syndrome / myalgic encephalomyeltis and also decreases inflammation, free radicals, and provides anti-aging benefits.
SUMMARY OF THE INVENTION
100061 According to an embodiment, the present invention discloses a chemo-preventative and cytotoxic formulation or composition is effective in treating coronavirus and other infections, cancer, PVLS/M1E/CES, fibromyalgia, improving immune, mitochondrial, stem cell and brain function, and reversing epigenetic aging, in an individual.
100071 In one embodiment, the chemo-preventative and cytotoxic formulation comprises Nicotinamide Mononucleotide (NMN), Nicotinamide Adenine Dinucleotide (NAD), Pyrroquinoline Quinone (PQQ), Coenzyme Q10 (CoQ10), Piperine (black pepper extract), vitamin B7 (Biotin), vitamin B9, and vitamin B12.
100081 In one embodiment, the vitamin B9 is selected from at least any one of but not limited to, Folic Acid, L-5-Methyl tetrahydrofolate-Ca (calcium & non calcium salt of MethylFolate) and (6S)-5-methyl tetrahydrofol ate (glucosamine salt) In one embodiment, the vitamin B12 is selected from at least any one of, but not limited to Methylcobalamin, Adenocobalamin, Hydroxocobalamin, and Cyanocobalamin.
100091 In one embodiment, the composition further comprises vitamin B1. In one embodiment, the composition further comprises vitamin B1 in the amount from about 10 mg to 300 mg. In one embodiment, the composition further comprises vitamin B1 in the amount of about 100 mg. In one embodiment, the vitamin B1 is selected from at least any one of, but not limited to, Benfoti amine, Thiamine and Sulbutiamine.
100101 In one embodiment, the composition further comprises vitamin B5. In one embodiment, the composition further comprises vitamin B5 in the amount from about 25 mg to 350 mg. In one embodiment, the composition further comprises vitamin B5 in the amount of about 100 mg. In one embodiment, the vitamin B5 is selected from at least any one of, but not limited to, Pantethine, Pantothenic Acid, Pantothenol (Panthenol), Dexpanthenol and Calcium Pantothenate.
100111 In one embodiment, the composition further comprises vitamin B6. In one embodiment, the composition further comprises vitamin B6 in the amount from about 25 mg to 350 mg. In one embodiment, the composition further comprises vitamin B6 in the amount of about 100 mg. In one embodiment, the vitamin B6 is selected from at least any one of, but not limited to, Pyridoxine, Pyridoxal, Pyridoxine 5'-phosphate (P5P) and Pyridoxal 5'-phosphate (PLP).
100121 In one embodiment, the composition further comprises a methyl source, wherein the methyl source is selected from at least any one of, but not limited to, Betaine HC1, Betaine Anhydrous, Trimethylglycine (TNIG), Betaine Nitrate or Dimethylglycine (DNIG). In one embodiment, the composition further comprises methyl source in the amount from about 25 mg to 250 mg. In one embodiment, the composition further comprises methyl source in the amount of about 100 mg [0013] In one embodiment, the composition further comprises choline and magnesium sources, and also flavourings and sweeteners. In one embodiment, the composition further comprises the choline and magnesium sources in the amount from about 100 mg to 1000 mg. In one embodiment, the composition further comprises choline and magnesium sources in the amount of about 500 mg. In one embodiment, the choline source is selected from at least any one of but not limited to, Alpha Glycerol Phosphotyl Choline (Alpha GPC), CDP Citicoline, Phosphatidyl Choline or Choline Bitartrate. In one embodiment, the magnesium source is selected from at least any one of, but not limited to, Magnesium L-Threonate, Magnesium Orotate, Magnesium Citrate, Magnesium Taurate, Magnesium Bisglycinate, Magnesium Aspartate or Magnesium Lactate. In one embodiment, the composition is provided in at least any one or more forms include, but not limited to, capsules, tablets, liquid, liposomal, micelle, phospholipid or topical form, softgels, drinks, powder, medical food, intravenous and an oral composition.
[0014] In one embodiment, the composition further comprises nicotinamide mononucleotide (NMN) in the amount ranges from about 100 mg to 1000 mg taken into four equal doses, nicotinamide adenine dinucleotide (NAD) in the amount from about 100 mg to 1000 mg, pyrroloquinoline quinone (PQQ) in the amount from about 5 mg to 50 mg, coenzyme Q10 (CoQ10) in the amount from about 50 mg to 500 mg, piperine in the amount ranges from about 5 mg to 50 mg, vitamin B7 (Biotin) in the amount from about 0.25 mg to 5 mg, vitamin B9 (L-Methyl tetrahydrofolate-Ca) in the amount ranges about 0.25 mg to 5 mg, and vitamin B12 (Nlethylcobalamin) in the amount from about 0.25 mg to 5 mg.
[0015] In one embodiment, the composition further comprises nicotinamide Mononucleotide (NMN) in the amount of about 750 mg, nicotinamide Adenine Dinucleotide (NAB) in the amount of about 250 mg, pyrroloquinoline Qui none (PQQ) in the amount of about 20 mg, coenzyme Q10 (CoQ10) in the amount of about 200 mg, piperine in the amount of about 15 mg, vitamin B7 in the amount of about 1 mg, vitamin B9 in the amount of about I mg, and vitamin B12 in the amount of about 1 mg.
[0016] In another embodiment, the chemo-preventative and cytotoxic formulation is effective in treating coronavirus and other infections, cancer, PVFS/ME/CFS, fibromyalgia, improving immune, mitochondrial, stem cell and brain function, and reversing epigenetic aging, in an individual In one embodiment, composition further comprises Resveratrol, Pterostilbene, Quercetin, Baikal Skullcap, L-Theanine, Curcuminoids (Turmeric Extract), Lion's Mane Mushrooms, vitamin Bl, vitamin B2, vitamin B5, vitamin B6, Piperine and Zinc Complex.
[0017] In one embodiment, the composition comprises Resveratrol in the amount ranges from about 100 mg to 1000 mg, Pterostilbene in the amount ranges from about 100 to 750 mg, Quercetin in the amount ranges from about 100 mg to 750 mg; Baikal Skullcap in the amount ranges from about 50 mg to 500 mg; L-Theanine in the amount from about 50 mg to 500 mg; Curcuminoids (Turmeric Extract) in the amount from about 50 mg to 500 mg, Lions Mane Mushroom in the amount from about 100 mg to 1000 mg; vitamin BI in the amount from about 20 mg to 250 mg, vitamin B2 in the amount from about 25 mg to 350 mg; vitamin B5 in the amount ranges from about 50 mg to 500 mg; vitamin B6 in the amount ranges from about 25 mg to 350 mg; Piperine in the amount ranges from about 5 mg to 50 mg; and Zinc complex in the amount ranges from about 5 mg to 50 mg elemental zinc.
[0018] In one embodiment, the comprises further comprises D-ribose, and methyl source. In one embodiment, the composition comprises D-Ribose in the amount ranges from about 1 g to 10 g and methyl source in the amount from about 250 mg to 2500 mg. In one embodiment, the composition further comprises D-Ribose in the amount of about 5000 mg and the methyl source in the amount of about 1000 mg. In one embodiment, the zinc complex is selected from at least any one of but not limited to, Zinc Picolinate, Zinc Citrate, Zinc Gluconate, and Zinc Oxide. In one embodiment, the methyl source is selected from at least any one of, but not limited to, Betaine HCI, Betaine Anhydrous, Trimethylglycine (TMG), Betaine Nitrate or Dimethylglycine (DMG).
[0019] In one embodiment, the composition further comprises Taurine and Creatine. In one embodiment, the creatine source is selected from at least any one of, but not limited to, Creatine Monohydrate, Creatine Hydrochloride, Creatine Citrate, Creatine Magnesium Chelate and Creatine Nitrate. In one embodiment, the composition comprises Taurine in the amount ranges from about 150 mg to 1500 mg and creatine in the amount ranges from about 250 mg to 2500 mg.
In one embodiment, the composition further comprises Taurine in the amount of about 500 mg and creatine in the amount of about 1000 mg. In one embodiment, the composition is provided in at least any one or more forms include capsules, tablets, liquid, liposomal, micelle, phospholipid or topical form, soft gels, drinks, powder, medical food, intravenous and an oral composition.
[0020] In one embodiment, the composition comprises Resveratrol in the amount of about 300 mg, Pterostilbene in the amount of about 200 mg, Quercetin in the amount of about 250 mg, Baikal Skullcap in the amount of about 200 mg, L-Theanine in the amount of about 250 mg, Curcuminoids (Turmeric Extract) in the amount of about 200 mg, Lion's Mane Mushrooms in the amount of about 200 mg, vitamin B1 in the amount of about 100 mg, vitamin B2 in the amount of about 150 mg, vitamin B5 in the amount of about 250 mg, vitamin B6 in the amount of about 100 mg, Piperine in the amount of about 15 mg, and Zinc complex in the amount of about 15 mg elemental zinc.
[0021] In yet another embodiment, the composition comprises Alpha Lipoic Acid (ALA), AcetylL-C arnitine (ALCAR), N-Acetyl Cysteine (NAC), Ginkgo Biloba, Beta Glucans, Epigallocatechin 3-Gallate (EGCG), Green Tea Extract, Pomegranate Extract (incl. Ellagic Acid), Olive Leaf Extract (incl. Oleuropein and Hydroxytyrosol), Green Coffee Bean Extract (incl. Chlorogenic Acids), Theacrine and piperine. In one embodiment, the Beta glucans are selected from at least any one of, but not limited to Mushrooms, Oat, Barley or Yeast.
[0022] In one embodiment, the composition further comprises Methylliberine. In one embodiment, the composition further comprises Methylliberine in the amount from about 25 mg to 250mg. In one embodiment, the composition further comprises Methylliberine in the amount of about 100 mg. In one embodiment, the composition further comprises Adenosine disodium triphosphate in the amount from about 100 mg to 1000 mg. In one embodiment, the composition further comprises Adenosine disodium triphosphate in the amount of about 200 mg.
[0023] In one embodiment, the composition further comprises Shilajit (mineral pitch containing Humic & Fulvic Acids) In one embodiment, the composition further comprises Shilajit (mineral pitch containing Humic & Fulvic Acids) in the amount of about 25 mg to 250 mg. In one embodiment, the composition further comprises Shilajit (mineral pitch containing Humic & Fulvic Acids) in the amount of about 100 mg.
[0024] In one embodiment, the composition further comprises Alpha Lipoic Acid (ALA) in the amount from about 50 mg to 500 mg, Acetyl-L-Carnitine (ALCAR) in the amount from about 50 mg to 500 mg, N-Acetyl Cysteine (NAC) in the amount from about 100 mg to 1000 mg, Beta Glucans in the amount from about 50 mg to 500 mg, EGCG in the amount from about 50 mg to 500 mg, Green Tea Extract in the amount from about 50 mg to 500 mg, Pomegranate Extract (inch Ellagic Acid) in the amount from about 50 mg to 500 mg, Ginkgo Biloba in the amount from about 50 mg to 500 mg, Olive Leaf Extract (inch Oleuropein and Hydroxytyrosol) in the amount from about 50 mg to 500 mg, Green Coffee Extract (inch Chlorogenic Acids) in the amount from about 50 mg to 500 mg, Theacrine in the amount from about 25 mg to 250 mg, and Piperine in the amount ranges from about 5 mg to 50 mg.
[0025] In one embodiment, the composition further comprises Alpha Lipoic Acid (ALA) in the amount of about 200 mg, Acetyl-L-Camitine (ALCAR) in the amount of about 250 mg, N-Acetyl Cysteine (NAC) in the amount of about 300 mg, Beta Glucans in the amount of about 200 mg, EGCG in the amount of about 150 mg, Green Tea Extract in the amount of about 150 mg, Pomegranate Extract (inch Ellagic Acid) in the amount of about 200 mg, Ginkgo Biloba in the amount of about 200 mg, Olive Leaf Extract (inch Oleuropein and Hydroxytyrosol) in the amount of about 150 mg, Green Coffee Extract (incl. Chlorogenic Acids) in the amount of about 250 mg, Theacrine in the amount of about 100 mg, and Piperine in the amount of about 15 mg.
[0026] In one embodiment, the composition further comprises Vitamin BI. In one embodiment, the composition further comprises Vitamin B1 in the amount from about 25 mg to 250 mg. In one embodiment, the composition further comprises Vitamin B1 in the amount of about 100 mg. In one embodiment, the vitamin B I is selected from at least any one of but not limited to, Benfotiamine, Thiamine and Sulbutiamine.
[0027] In one embodiment, the composition further comprises Vitamin B5. In one embodiment, the composition further comprises Vitamin B5 in the amount from about 50 mg to 500 mg. In one embodiment, the composition further comprises Vitamin B5 in the amount of about 200 mg. In one embodiment, the vitamin B5 is selected from at least any one of but not limited to, Pantethine, Pantothenic Acid, Pantothenol (Panthenol), Dexpanthenol and Calcium Pantothenate.
[0028] In one embodiment, the composition further comprises vitamin B6. In one embodiment, the composition further comprises vitamin B6 in the amount from about 25 mg to 350 mg. In one embodiment, the composition further comprises vitamin B6 in the amount of about 100 mg. In one embodiment, the vitamin B6 is selected from at least any one of but not limited to, Pyridoxine, Pyridoxal, Pyridoxine 5'-phosphate (P5P) and Pyridoxal 5'-phosphate (PLP).
[0029] In one embodiment, the composition further comprises vitamin B7 Biotin. In one embodiment, the composition further comprises vitamin B7 Biotin in the amount from about 0.1 mg to 5 mg. In one embodiment, the composition further comprises vitamin B7 in the amount of about 1 mg [0030] In one embodiment, the composition further comprises vitamin B12. In one embodiment, the composition further comprises vitamin B12 the amount from about 250 mcg to 2.5 mg. In one embodiment, the composition further comprises vitamin B12 in the amount of about 1 mg. In one embodiment, the composition is provided in at least any one or more forms include capsules, tablets, liquid, liposomal, micelle, phospholipid or topical form, soft gels, drinks, powder, medical food, intravenous and an oral composition.
100311 Other objects, features and advantages of the present invention will become apparent from the following detailed description. It should be understood, however, that the detailed description and the specific examples, while indicating specific embodiments of the invention, are given by way of illustration only, since various changes and modifications within the spirit and scope of the invention will become apparent to those skilled in the art from this detailed description.
DETAILED DESCRIPTION OF EMBODIMENTS
100321 A description of embodiments of the present invention will now be given with reference to the below description. It is expected that the present invention may be embodied in other specific forms without departing from its spirit or essential characteristics. The described embodiments are to be considered in all respects only as illustrative and not restrictive. The scope of the invention is, therefore, indicated by the appended claims rather than by the foregoing description. All changes that come within the meaning and range of equivalency of the claims are to be embraced within their scope.
100331 The present invention generally discloses a formulation or composition for improving brain function and treating covid-19 (coronavirus infections) in an individual. The present invention directed to a nutritional supplement composition for improving cognition or rejuvenating ability and brain function and health of an individual using an active combination of substance selected from the group consisting of phytochemicals and bio-tech nutraceuticals and thereof 100341 According to the present invention, the nutritional supplement composition for improving stem cell production, proliferation & differentation, improving cognitive function of the human brain and also treating coronavirus infection and post-viral fatigue, comprising Nicotinamide Mononucleotide (NMN), Nicotinamide Adenine Dinucleotide (NAD), Pyrroquinoline Quinone (PQQ), Coenzyme Q10 (C0Q10), Piperine, vitamin B7 (Biotin), vitamin B9, vitamin B12. In one embodiment, the composition further comprises vitamin B5 and vitamin B6. In one embodiment the vitamin B5 is selected from at least any one of, but not limited to, Pantethine, Pantothenic Acid, Pantothenol (Panthenol), Dexpanthenol and Calcium Pantothenate. In one embodiment the vitamin B6 is selected from at least any one of, but not limited to, Pyridoxine, Pyridoxal, Pyridoxine 5'-phosphate (P5P) and Pyridoxal 5'-phosphate (PLP). In one embodiment, the composition further comprises choline and magnesium sources, and also natural fruit flavoring, mannitol, and sweeteners. In one embodiment, the choline source is selected from at least any one of, but not limited to, Alpha Glycerol Phosphoryl Choline (Alpha GPC), CDP Citicoline, Phosphatidyl Choline or Choline Bitartrate and also the magnesium source is is selected from at least any one of but not limited to, Magnesium L-Threonate, Magnesium Orotate, Magnesium Citrate, Magnesium Taurate, Magnesium Bisglycinate, Magnesium Aspartate or Magnesium Lactate. In one embodiment, the vitamin B9 is selected from at least any one of, but not limited to, L-Methyl tetrahydrofolate-Ca (calcium & non calcium salt of MethylFolate) and (65)-5-methyltetrahydrofolate (glucosamine salt) and the vitamin B12 is selected from at least any one of, but not limited to, Methylcobalamin, Adenocobalamin, Hydroxocobalamin, and Cyanocobalamin. In one embodiment, the nutritional supplement composition could be provided in the form of, but not limited to, capsules or a tablet or liquid, liposomal, micelle, phospholipid, or topical form, softgels, drinks, powder, medical food, intravenous and an oral composition.
[0035] In one embodiment, the composition is effective in the treatment of covid-19 (coronavirus) infections, improves health and mortality and morbidity outcomes in covid-19 (coronavirus infection), reduces discharge time, % progression to ICURTU, requirement of ventilators and intubation, lung damages, inflammation, and fibrosis. It is also effective in reducing covid-19 coagul opathi es, treats and prevents Coy and non-Coy caused thrombosis, protects against Sepsis, and also boosts recovery from Sepsis and septic shock. The composition is also effective in preventing/treating acute respiratory distress syndrome and also endotoxemia. In one embodiment, the composition is effective in reducing covid-19 transmission and preventing / treating post-viral and chronic fatigue syndrome / Myalgic Encephalomyelitis and fibromyalgia.
100361 In one embodiment, the composition has potent anti-viral properties against coronavirus and other viruses. It shows anti-viral activity against SARS-CoV-2 (Covid-19), inhibits coronavirus and viral entry, and also inhibits coronavirus and viral replication. In one embodiment, zinc ionophores in the composition effectively stops RdRp replication of coronayinis in humans by transporting zinc into cellular cytoplasm. It inhibits Covid-19 main protease, SARS-CoV-2 viral docking and reduces infectivity, and also inhibits cleavage of MERS-3CLpro Enzyme (Coronavirus). It also inhibits cellular entry of Sars-Cov-1 and enhances mucosal and respiratory immunity.
[0037] In one embodiment, the composition effectively modulates Sin] activity and mTOR Activity against coronavirus and inhibits SARS-CoV-2 entry via spike protein and also entry via 3CL protease inhibition. In one embodiment, the composition effects in preventing viral cycle via UPR modulation and acts as an anti-coyid-19 via Furin inhibition and PLpro inhibition. In one embodiment, the choline in the composition is essential for anti-viral immunity, and balancing choline levels in the brain, and increasing levels of the neurotransmitter acetylcholine, and formation of new brain cells and nerves via synthesis of phosphatidylcholine.
[0038] In one embodiment, the composition effectively protects respiratory tract from covid and non-coyid caused infections and acute lung injuries. The composition effectively reduces susceptibility to infection, improves influenzas mortality and morbidity outcomes, decreases incidence of infection in the elderly, reduces duration and severity of respiratory infections. In one embodiment, the composition is effective in alleviating symptoms of pneumonia, protects against cold and flu, reduces days of illness and work-related sick days. It also decreases incidence of influenza, prevents respiratory distress and dyspnoea, and also enhances response to flu vaccine 100391 In one embodiment, the composition is effective in reducing endothelial cell dysfunction (ECD), which is a main cause of morbidity in covid-19. Tn one embodiment, the composition effectively reverses CD38 associated chronic inflammation, which is also a main cause of covid19 morbidity and mortality. The composition effectively protects from covid caused thrombosis and blood clotting, reduces oxidized glutathione and double sulfide bonds into glutathione. The composition can chop up von Willebrand factor (VWF) and clotting factor 8 dimers into shorter strands, and directly reduce/solve blood clotting and thrombosis.
100401 In one embodiment, the composition is effective in increasing and enhancing innate and adaptive immune response, enhancing innate immune cell development, immune cell function & macrophage phagocytosis. The composition effectively promotes macrophage function, activates Sirtuin 1 for immune protection, and stimulates cholinergic system and acetylcholine production which is essential for immune function.
100411 In one embodiment, the composition is effective in boosting adaptive immune response, increasing development & proliferation of lymphocytes, enhancing T Cell differentiation and T cell killing activity, improving antibody response, preventing lymphocyte death & dysfunction, attenuating age-related DNA damage in lymphocytes and essential for haematopoiesis & leukocyte production. The composition effectively improves mitochondrial biogenesis & protects T Cells, 100421 In one embodiment, the composition is effective in regulating immune response to treat and prevent chronic inflammation and cytokine storm caused by covid-19 or other infections. The composition effectively regulates immune response to prevent covid & non-covid related cytokine storm & chronic inflammation. In one embodiment, the composition is effective in regulating lung immune response via activation of enzymes including PARP, ART and Sirtl, and controlling inflammation and cytokine release. The composition acts an anti-inflammatory and immunomodulatory for T-cells, and also Anti-inflammatory for dendritic cells. 1]
[0043] In one embodiment, the composition effectively protects from both covid & non covid related acute lung injury, regulates lung immune response and decreases airway inflammation, protects lungs from excessive pro-inflammatory cytokine response, and also protects from oxidative stress & free radicals. In one embodiment, the composition is effective in boosting white blood cell haematopoiesis for fighting infection via sirtuins, protecting upper respiratory tract from infection and lungs from excess inflammatory damage & fibrosis. The composition also maintains lung integrity and function post insult, reduces incidence duration and severity of Chronic Obstructive Pulmonary Disease (COPD), reduces rate of COPD exacerbations, and also alleviates chronic bronchitis. In one embodiment, the composition is effective in reducing COPD adhesions and improving respiratory function, and also restoring lung antioxidant levels and treating allergies such as asthma & allergic bronchitis.
[0044] In one embodiment, the composition acts as a chemo preventative and is cytotoxic to cancer cells, suppresses cancer stem cell (CSC) proliferation, targets and enhances anti-tumour T-cell response. In one embodiment, the composition is effective in inducing cancer cell apoptosis, preventing cancer progression and metastasis, promoting tumour cell death, epigenetic regulation for chemoprevention, and also promotes the P53 anti-cancer gene. In one embodiment, the composition is effective in reducing the chance of cancer recurrence and is essential for DNA methylation. The composition includes vitamin B, choline, and magnesium. to prevent deficiencies in these substances. The deficiency of vitamin B could lead to cancer. The deficiency in choline could lead to mitochondrial dysfunction and could be carcinogenic and magnesium deficiency is linked to colon & lung cancer. In one embodiment, the composition could effectively reverse multidrug resistance in cancer cells, and quercetin inhibits cancer cell cycle progression at a low dose, is synergistic with other chemotherapy agents, prevents chemotherapy toxic side effects, and has anti-cancer properties via DNA stabilization and repair.
[0045] In one embodiment, the composition is effective in preventing and treating different cancers such as, but not limited to, breast cancer, lung cancer, prostate cancer, ovarian cancer, hepatocellular melanoma & myeloma cancers, colon & pancreatic cancers. In one embodiment, the composition is effective in lowering breast cancer risk, inducing cytotoxicity in leukaemia & breast cancer cells, and suppressing cervical cancer cells. In one embodiment, the composition has anti-tumour activity in gallbladder carcinoma.
[0046] In one embodiment, the composition is effective in boosting stem cell production of all forms (proliferation) and stem cell maturation (differentiation). The composition increases stem cells maturing into functional cells (differentiation) and also increases neurogenesis (formation of new brain cells and neurons). In one embodiment, the composition rejuvenates stem cells and reactivates senescent (inactive) stem cells, improves stem cell function, rejuvenates gut adult stem cells & boosts intestinal stem cell populations, promotes stem cell self-renewal, improves cell survival & reprogramming via rock inhibition, and also enhances stem cell therapy for liver fibrosis. In one embodiment, the composition effectively reverses age-related decline in intestinal stem cells, improves neural stem cell self-renewal & proliferation, reprograms dysfunctional stem cells, promotes osteogenesis & inhibits apoptosis and aging of mesenchymal stem cells, and also stimulates bone marrow-derived mesenchymal stem/stromal cells (BMSC) proliferation & differentiation via ERK and P38. In one embodiment, the composition is effective in stimulating BMSC proliferation & differentiation, modulating neural crest stem cell development, and promoting proliferation & migration of neural stem cells. The composition effectively increases stem cell function in the treatment of damaged pancreas, stimulates hemopoietic stem cells, activates cardiac stem cells & improves myocardial regeneration, activates Sirtl for stem cell maintenance, aids in stem cell transplantation, and enhances cardiomyogenic stem cell differentiation.
100471 In one embodiment, the composition is effective in increasing mitochondrial function & biogenesis and enhancing energy production. The composition effectively reduces metabolic syndrome disorder & associated co-morbidities, increases mitochondrial biogenesis, stimulates mitochondrial biogenesis through cAMP & PGC-la expression, improves mitochondrial function & bioenergetics, corrects mitochondrial dysfunction, and also restores, protects, and boosts mitochondria In one embodiment the composition effectively prevents and treats chronic fatigue syndrome / myalgic encephalomyelitis and fibromyalgia through restoration of the antioxidant glutathi one, supporting methionine synthase, restoring function of the methyl ati on cycle, reversing mitochondrial dysfunction and supplying necessary cofactors and vitamins to alleviate deficiencies. In one embodiment, the composition effectively protects mitochondria via Sirt3, upregulates skeletal muscle mitochondrial biogenesis, modulates mitochondrial DNA content & alters lysine metabolism. Folates essential for mitochondrial translation and mitochondrial production of betaine In one embodiment, the composition effectively promotes mitochondrial biogenesis via PGC-la, induces mitochondrial biogenesis in endothelial (vascular) cells, upregulates gene expression for mitochondrial function, activates 1-10-1 signalling to alleviate mitochondrial damage, and protects mitochondrial integrity. In one embodiment, the composition is effective in alleviating age-associated decline in mitochondrial respiratory activity, attenuating mitochondrial dysfunction & biogenesis via AMPK / Sirtl, increasing brain mitochondrial biogenesis, restoring cellular homeostasis, and preventing/treating mitochondrial metabolism disorders. In one embodiment, the composition is effective in restoring Heme synthesis and reversing mitochondri al dysfunction.
100481 In one embodiment, the composition is effective in preventing and treating post viral fatigue syndrome, chronic fatigue syndrome, Myalgic Encephalomyelitis (ME) and fibromyalgi a. The composition effectively increases mitochondria biogenesis & efficiency, increases mitochondria fat & carbohydrate metabolism into ATP & helps in reducing weight, and vastly increasing energy production. In one embodiment, the composition effectively enhances strength, endurance & performance, improves sleep quality, reduces fatigue, prevents/treats post viral fatigue syndrome, chronic fatigue syndrome & fibromyalgia, treats chronic fatigue syndrome via altering mitochondrial bioenergetics, reduces muscle fatigue and also restores mitochondrial function in neurons.
[0049] In one embodiment, the composition is effective in increasing repair of DNA breakage, particularly double strand DNA breaks through Sirtl and PARP1 activity and, protecting DNA from toxic insults, oxidative stress, and age-related deterioration. The composition effectively increases telomeres length and telomerase activity, stabilizes DNA telomeres, restores normal gene expression, promotes DNA repair, prevents telomere shortening & cell apoptosis. Deficiency of certain ingredients within composition compromises DNA protection, repair & telomere length.
[0050] In one embodiment, the composition effectively and positively manipulates epigenetics, switching certain "good genes on" and "bad genes off'. In one embodiment, the composition effectively acts as a neuroprotective agent against various forms of dementia and prevents/treats Alzheimer's disease & neurodegeneration. In one embodiment, the composition could effectively reduce neuroinflammation, increase cognitive ability, increase short-& long-term memory formation & retrieval, increase synaptic strength and excitability (aka Long-Term Potentiation, LTP), improve learning and focus, reduce jet lag and increase cognitive function in humans. In one embodiment, the composition is effective in preventing and treating Parkinson's, protecting neural stem cells against neurotoxicity, and improving reasoning ability. The composition is effective in protecting against oxidative stress, cognitive injury excitotoxicity. The composition slows mental decline & dementia by preventing neuron loss, targets SARNIA to prevent neurodegeneration, may be beneficial in the case of epilepsy, advances stroke recovery and treats/slows progression of multiple sclerosis.
[0051] In one embodiment, the composition acts as an anti-nociceptive and relieves symptoms of pain. It also effectively increases angiogenesis (blood supply), enhances blood flow to vital organs & tissues, promotes healthy vision & prevents diseases related to the eyes. In one embodiment, the composition is effective in preventing and treating retinal degeneration, reducing macular degeneration risks, preventing/treating glaucoma and improving vision.
[0052] In one embodiment, the composition is effective in increasing dopamine, norepinephrine, epinephrine and serotonin production which boosts mood and helps treat symptoms of cognitive disorders and depression. In one embodiment, the composition effectively promotes good mood, is a strong natural anti-depressant, prevents/treats Schizophrenia, and also improves addictive behaviour.
[0053] In one embodiment, the composition effectively reverses physical and biochemical aspects of aging & reduces biological age in multiple quantifiable metrics. It increases feelings of youth, improves quality of life and improves mood & sense of wellbeing. boosts Sirtuin activity to mediate aging. The composition effectively boosts Sirtuin activity to mediate aging, activating Sirtl, Sirt3, and Sirt6. It also increases strength & endurance.
[0054] In one embodiment, the composition could effectively improve male fertility, reproductive health, sexual health, libido and increase mitochondrial function in Sertoli cells. In females it could effectively improve fertility, improve pregnancy outcomes, prevent preterm birth, prevent/treat nausea during pregnancy, relieve symptoms of PIVIS and some ingredients have been identified as important for pregnancy during the covid-19 pandemic. The composition effectively supports bone & joint health, prevents/treats osteoporosis and bone disease, prevents/treats arthritis via anti-inflammatory mechanisms, alleviates suppressed osteogeni c dysfunction, and improves ambulatory activity.
[0055] In one embodiment, the composition is effective in improving cosmetic appearance of skin, improving areas of skin damage, and reducing wrinkles and signs of aging. In one embodiment, the composition effectively supports healthy hair, skin and nails, promotes wound healing, restores hair colour, and helps treat acne. The composition could prevent or reduce headaches and migraines, enhance athletic performance, improve exercise endurance, increase strength and lean muscle mass, and enhance growth hormone production. In one embodiment, the composition could effectively improve mitochondrial function which in turn increases physical endurance and improves running performance.
[0056] In one embodiment, the composition is cardioprotective and is effective in treating heart disease and promoting heart health. The composition effectively reduces risk of heart disease, prevents/treats atherosclerosis, prevents/treats Anaemia, improves heart health by decreasing homocysteine, prevents/treats hypertension, improves cardiac mitochondrial fiinction, and also improves cholesterol metabolism, preventing/treating high cholesterol.
[0057] In one embodiment, the composition is effective in preventing, controlling, and treating diabetes, for example, type-1 diabetes and type-2 diabetes, as well as diabetic complications including diabetic neuropathy, diabetic nephropathy and diabetic retinopathy. The composition also effectively decreases insulin resistance, prevents/treats hyperglycaemia and aids in weight control, acting as an anti-obesity agent.
[0058] In one embodiment, the compostion is hepatoprotectA e and promotes liver & kidney health. The composition also effectively prevents/treats liver di seas including NAFLD (nonalcoholic fatty liver disease). Choline deficiency can lead to mitochondrial dysfunction & liver disease, which is prevented by the addition of choline to the formulation. In one embodiment, the composition effectively ameliorates and attenuates liver damage via enhancing mitochondrial respiration and prevents/treats renal disease.
[0059] In another embodiment, the nutritional supplement composition comprises nicotinamide mononucleotide (NMN) in the amount of about 100 mg to 1000 mg taken into four equal doses, nicotinamide adenine dinucleotide (NAD) in the amount of about 1000 mg to 1000 mg, pyrroquinoline quinone (PQQ) in the amount of about 5 mg to 50 mg, coenzyme Q10 (CoQ10) in the amount of about 50 mg to 400 mg, vitamin B7 (Biotin) in the amount of about 250 mcg 2.5 mg, vitamin B9 (L-Methyl tetrahydrofol ate-Ca / (6S)-5-methyltetrahydrofol ate) in the amount of about 250 mcg 2.5 mg, vitamin B12 (Methylcobalamin) in the amount of about 250 mcg 2.5 mg, vitamin B5 and vitamin B6 each in the amount of about 25 mg to 350 mg, each choline and magnesium sources in the amount of about 250 mg to 750 mg.
[0060] In yet another embodiment, the nutritional supplement composition comprises nicotinamide mononucleotide (NMN) in the amount of about 500 mg, nicotinamide adenine dinucleotide (NAD) in the amount of about 500 mg, pyrroquinoline quinone (PQQ) in the amount of about 20 mg, coenzyme Q10 (C0Q10) in the amount of about 200 mg, vitamin B7 (Biotin) in the amount of about 1 mg, vitamin B9 (L-Methyl tetrahydrofolate-Ca/) in the amount of about 1 mg, vitamin B12 (Methylcoba1amin) in the amount of about 1 mg, vitamin B5 and B6 each in the amount of about 100 mg, choline and magnesium sources in the amount of about 500 mg.
[0061] In one embodiment, multiple flavoured variants include fruit and other flavorings and mannitol/other sweeteners could be added to the nutritional supplement composition. In one embodiment, the composition further comprises resveratrol, pterostilbene, Quercetin, Taurine, Baikal Skullcap (with Baicalin), L-Theanine, vitamin Bl, vitamin B2, vitamin B5, vitamin B6, D-ribose, Piperine, and Zinc complex. In one embodiment, the composition further comprises Curcumin. In one embodiment, the composition comprises Curcumin in the amount from about 50 mg to 500 mg. In one embodiment, the composition further comprises Curcumin the amount of about 200 mg In one embodiment, the composition further comprises D-ribose, methyl source, and Zinc complex. In one embodiment, the composition comprises D-Ribose in the amount ranges from about 200 mg to 2000 mg and methyl source in the amount from about 100 mg to 1000 mg. In one embodiment, the composition further comprises D-Ribose in the amount of about 200 mg and the methyl source in the amount of about 200 mg. In one embodiment, the methyl source is selected from at least any one of, but not limited to, Betaine HC1, Betaine Anhydrous, Betaine Nitrate or Trimethylglcyine.
100621 In one embodiment, the composition comprises the resveratrol in the amount of about 300 mg, Pterostilbene in the amount of about 200 mg, Quercetin in the amount of about 250 mg, Curcumin in the amount of about 200 mg, Baikal Skullcap in the amount of about 200 mg, LTheanine in the amount of about 250 mg, vitamin B1 in the amount of about 100 mg, vitamin B2 (riboflavin) in the amount of about 150 mg, vitamin B5 in the amount of about 250 mg, vitamin B6 in the amount of about 100 mg, Piperine in the amount of about 150 mg, and Zinc complex in the amount of about 15 mg elemental zinc. In one embodiment, the zinc complex is selected from at least any one of but not limited to Zinc Picolinate, Zinc Citrate, Zinc Gluconate, Zinc Oxide.
100631 In another embodiment, the composition comprises alpha 1 poic acid (ALA), acetyl-Lcamitine (ALCAR), N-acetyl cysteine (NAC), beta glucans, ginkgo biloba extract, EGCG from green tea, theacrine, pomegranate extract (with Ellagic Acid), olive leaf extract (with Oleuropein & Hydroxytyrosol), lion's mane mushrooms, green coffee bean extract (with Chlorogenic Acids), shilajit (mineral pitch incl. humic & fulvic acids), vitamin B1, piperine, and zinc complex. In one embodiment, the composition further comprises Alpha Lipoic Acid (ALA) in the amount of about 200 mg, Acetyl-L-Camitine (ALCAR) in the amount of about 250 mg, N-Acetyl Cysteine (NAC) about 300 mg, Beta Glucans in the amount of about 200 mg, Ginkgo Biloba Extract in the amount about 200 mg, EGCG in the amount of about 150 mg, Green Tea Extract in the amount of about 150 mg, Theacrine in the amount of about 100 mg, Pomegranate Extract in the amount of 200 mg, Olive Leaf Extract in the amount of 150 mg, Lion's Mane Mushrooms in the amount of about 250 mg, Green Coffee Bean Extract in the amount of about 250 mg, Shilajit in the amount of about 100 mg, Vitamin B1 in the amount of about 100 mg, piperine in the amount of about 15 mg, and zinc complex in the amount of about 15 mg elemental zinc.
100641 In one embodiment, the preferred sources of beta glucans for supplement use is derived from yeast. f3-glucans found in the cell walls of yeast contain a 1,3 carbon backbone with elongated 1,6 carbon branches. In another embodiment, the sources of beta glucans for supplement use include, but not limited to, various medicinal mushrooms e.g. lingzhi/reishi, auaricus blazei muril, cordyceps, shitake, mitaike and lions mane are also alternative and good sources of beta glucans and other polysaccharides and the lesser sources of beta glucans are oat and barley, which feature 1,4 branches.
100651 In yet another embodiment, the composition comprises alpha lipoic acid (ALA), AcetylL-Carnitine (ALCAR), N-Acetyl Cysteine (NAC), beta glucans, EGCG, green tea extract, methylliberine, pomegranate extract (incl. Ellagic acid), olive leaf extract (incl. Oleuropein and Hydroxytyrosol), green coffee bean extract (incl, Chlorogenic Acids), adenosine disodium triphosphate, 1-carnosine, shilajit,l-theanine, theacrine, vitamin B1, vitamin B7 (biotin), piperine, and zinc complex. In one embodiment, the beta glucans is selected from at least any one of, but not limited to, Mushrooms, Oat, Barley or Yeast.
[0066] In one embodiment, the composition comprises the Alpha Lipoic Acid (ALA) in the amount ranges from about 100 mg to 500 mg, Acetyl-L-Carnitine (ALCAR) in the amount ranges from about 100 mg to 500 mg, N-Acetyl Cysteine (NAC) in the amount ranges from about 100 mg to 500 mg, Beta Glucans in the amount ranges from about 100 mg to 500 mg, EGCG in the amount ranges from about about 50 mg to 500 mg, Green Tea Extract in the amount ranges from about about 50 mg to 500 mg, Pomegranate Extract (incl. Ellagic Acid) in the amount ranges from about 100 mg to 500 mg, Olive Leaf Extract (incl. Oleuropein and Hydroxytyrosol) in the amount ranges from about 100 mg to 500 mg, Green Coffee Bean Extract (incl. Chlorogenic Acids) in the amount ranges from about 100 mg to 500 mg, the Adenosine disodium triphosphate in the amount ranges from about 100 mg to 500 mg, L-Carnosine in the amount ranges from about 100 mg to 500 mg, Shilajit in the amount ranges from about 50 mg to 500 mg, L-Theanine in the amount ranges from about 100 mg to 500 mg, Theacrine in the amount ranges from about 50 mg to 200 mg, Vitamin B1 in the amount ranges from about 50 mg to 500 mg, Vitamin B7 (biotin) in the amount from about 0.25 mg to 5 mg, and piperine in the amount from about 5 mg to 50 mg, and zinc complex in the amount from about 5 mg to 100 mg elemental zinc. In one embodiment, multiple flavoured variants include fruit/other flavorings and mannitol/other sweeteners could be added to the composition. In one embodiment, the composition further comprises methylliberine in the amount of about 25 mg to 250mg. In another embodiment, the composition further comprises methylliberine in the amount of about 100 mg.
[0067] In one embodiment, the benefits of consuming 500 mg of nicotinamide adenine dinucleotide (NAD) (and/or its precursor NMN) are, but not limited to, improves morbidity outcomes in covid-19 and combats coronavirus, controls and restores immune system, protects lungs, combats diabetes, chemopreventative, inhibits CD38 chronic inflammation and associated covid-19 mortality, prevents / treats post-viral chronic fatigue via correction of protein energy malnutrition (PEM) and improving function of the Krebs / citric acid / tricarboxylic acid cycle for ATP synthesis, and is also cytotoxic to cancer stem cells. The nicotinamide adenine dinucleotide plays a crucial role in innate arid adaptive immunity, and reduces endothelial cell dysfunction (ECD). It activates sirtuin 1, which regulates innate immune cell production and function and also protects lungs. The nicotinamide adenine dinucleotide also stimulates stem cell proliferation, and restores and activates senescent stem cells. The nicotinamide adenine dinucleotide targets and enhances anti-tumor T-cells, is chemopreventative, and is also cytotoxic to cancer stem cells.
[0068] The nicotinamide adenine dinucleotide also increases the production, proliferation & differentiation of stem cells, restores and activates senescent stem cells, controls neural stem cell self-renewal, reprograms dysfunctional stem cells, rejuvenates gut adult stem cells, improves cell survival and reprogramming, reverses age-related decline in intestinal stem cells, boosts intestinal stem cell populations, boosts mitochondria biogenesis, and increases mitochondrial efficiency. It also improves mitochondrial and stem cell function, corrects mitochondrial dysfunction, protects mitochondria from toxic and non-toxic insults and increases telomerase activity to lengthen DNA telomeres.
10069] It also increases the mitochondrial biogenesis process, prevents / treats chronic fatigue synrome / myalgic encephalomyelitis, repairs DNA double-strand breaks, increases telomerase activity, lengthens telomeres, stimulates dopamine synthesis, and aids in the treatment of depression, CFS/ME, fibromyalgia and post viral fatigue. The nicotinamide adenine dinucleotide also has anti-aging properties and strong anti-oxidant activity, combats diabetes, prevents/treats Alzheimer's, prevents fatty liver diseases, and promotes general health by boosting sirtuins.
[0070] In one embodiment, the benefits of consuming 500 mg of nicotinamide mononucleotide (NMN) are boosts the immune system, improves morbidity outcomes from covid-19, and also has anti-cancer properties. It also improves mitochondrial membrane function, restores and activates stem cells, and repairs DNA and telomeres The nicotinamide mononucleotide has anti-aging properties, aids in combating diabetes, increases strength and endurance, improves blood flow, helps with weight loss, prevents/treats Alzheimer's, promotes general health by boosting sirtuins, protects the heart, is integral for neuronal structure, boosts brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and also boosts memory and cognitive function in the brain [0071] In one embodiment, the benefits of consuming 20 mg of Pyrroloquinoline Quinone (PQQ) (one of the main benefits of PQQ is to increase NA D production & intra cellular levels, NAD then does the work) include, but not limited to, improves immune health, acts as a potent immunomodulator via regulating the immune system, prevents/treats cancer and helps treat obesity. It also decreases levels of pro-inflammatory cytokines such as IL-6, Cox-2, TNF-a, and IL-lb, significantly inhibits the production of NO and PGE2 and suppresses the expression of pro-inflammatory mediators. It also acts as an immunomodulator to prevent excessive inflammation and cytokine release in covid-19, aids in creating new mitochondria, neutralizes free radicals, boosts the immune system, is neuroprotective, improves breain function, memory and reasoning abilities, protects the heart, improves sleep and mood, alleviats symptoms of fatigue, and also decreases insulin resistance.
[0072] PQQ is essential for mitochondrial function and energy production. It may help in reducing the formation of melanoma cancers by reducing melanin-producing protein expression, inhibiting tyrosinase expression and reducing gene activity. PQQ also activates genes governing mitochondrial reproduction, protection and repair, protects neural stem cells, promotes osteogenesis and inhibits cell apoptosis i.e. unwanted cell death. It also triggers the DNA reading protein CREB, which plays a key role in growth and gene expression, upregulates skeletal muscle mitochondrial biogenesis, modulates mitochondrial DNA content, stimulates mitochondrial biogenesis through CAMP and PGC-la expression, restores normal gene expression, alters lysine metabolism, and also stimulates the production and release of nerve growth factors in cells that support neurons health. PQQ improves sleep quality, awakening response and treats ME/CFS. is neuroprotective against Alzheimer's, Parkinson's and cognitive injuries and promotes healthy memory formation and cognition in aging animals and humans. It also protects against excitotoxicity, which could cause many neurodegenerative diseases and seizures.
[0073] In one embodiment, the benefits of consuming 100 mg of coenzyme Q10 (CoQ10) promotes immune health. It has potent anti-microbial effects and is anti-viral against DNA & RNA viral infections, protects the respiratory system, decreases age-related immune decline, and improves fertility. It has anti-cancer properties, supports healthy heart function, increases ATP production for energy, is antioxidant and limits oxidative damage, and prevents lymphocyte death and dysfunction. CoQ10 prevents / treats fibromyalgia and PCFS/1VIE/CFS by increasing cellular ATP production via mitochodri al phosphorylation. CoQ10 reduces skin damage from internal and external agents by increasing energy production in skin cells and promoting antioxidant protection. It also improves mitochondrial function, helps decrease the inflammation that may occur during migraines, improves insulin sensitivity and regulates blood sugar levels. It is essential for the health of virtually all human tissues and organs due to its importance in ATP production and improves energy, augments the immune system and acts as an antioxidant.
[0074] In one embodiment, the benefits of consuming 100 mg of vitamin B1 (Benfotiamine/Thiamine/sulbutiamine) include, but not limited to, helps prevent diabetic complications, promotes cognitive improvement in Alzheimer's, promotes kidney health, and prevents/treats arthritis. It also protects the liver from oxidative damage due to alcohol consumption and lowers alcohol dependency. It also boosts the immune system, controls the bodies stress-related physiological impairments that may dampen the immune system, and enhances the macrophage response against Mycobacterium tuberculosis infections; deficiency has been linked to a significant decrease in immune function. As an anti-cancer agent, high intake of thiamine, as well as vitamin D, carotenoids, vitamin E and niacin, has been associated with decreased risk of bladder, colon, and prostate cancer. Vitamin B1 is essential in the formation of ATP as a cofactor in carbohydrate metabolism, it also preserves mitochondrial function, specifically in the brain during insult, and accelerates healing and nuerovascularisation in ischaemia induced injury and improves symptoms of fibromyalgia and PVFS/ME/CFS. In the brain, vitamin B1 is essential for neurotrasmitter formation, specifically acetylcholine, and supports the structure and function of nuerons and neuroglia, essental for brain function. Benfotiamine also prevents/treats Wernicke-Karsakoff Syndrome (delirium), which is caused by thiamine deficiency, and prevents/treats Alzheimer's; in clinical trials 300mg daily for 18 months improved Alzheimer's patients cognitive ability. Benfotiamine and Sulbutiamine are fat soluble and can cross the blood brain barrier. Normal Thiamine is not lipid soluble and has trouble in rectifying low B1 levels in the brain.
[0075] In one embodiment, the benefits of consuming 100 mg of vitamin B2 (Riboflavin) include, but not limited to, immune system booster, has anti-viral properties and may help reduce covid-19 transmission. It also boosts the innate immune response, prevents/treats sepsis and improves sepsis mortality rates, all important in covid-19. It both activates immune cells and is immunomdulatmy & anti-inflammatory, so controls an excessive immune response. A high dose of Riboflavin was also indicated to decrease LPS-induced mortality by increasing the expression of heat shock protein 25 (HSP25). Supplementation could boost macrophage function and phagocytosis of pathogens.
[0076] It also has anti-cancer properties, prevents toxic chemotherapy side effects and could increase the efficacy of chemotherapy agents. In the body it is metabolized to flavin mononucleotide (FNIN) and flavin dinucleotide (FAD) which are cofactors in ATP formation and are essential for energy production Therefore riboflavin prevents/treats energy metabolsim disorders, alleviates mitochondria] dysfunction, treats associated neuropathies and can successfully treat ME/CF S, improving tiredness, muscle weakness and short-term memory. In the brain, thiamine is essential in the maintenance of nerve myelin sheaths and nerve conduction, prevents/treats neuropathies such as Multiple Sclerosis, boosts dopamine levels and helps treat traumatic brain injuries. In the case of Parkinson's, riboflavin ameliorates oxiative stress, mitochondrial dysfunction, neuroinflammati on and glutamate excitotoxi city, which improves motor capacity in patients. Vitamin B2 also acts as an anti-nociceptive and relieves pains.
[0077] In one embodiment, the benefits of consuming 100 mg of vitamin B5 include, but not limited to, immune boosting properites such as enhancing macrophage and T cell response, and anti-cancer properties, particularly for ovarian cancer, such as slowing tumor progression and decreasing metastases. It also has anti-obesity and weight controlling properties, lowers cholestrol and prevents/treats diabetes. Vitamin B5 aids in wound healing, restores hair color and helps treat facial acne. Vitamin B5 is essential for many human processes and also reduces risk of cardiovascular disease through lowering LDL cholesterol and triglycerides and raising HDLcholesterol. In neurodegenerative disease, Vitamin B5 restores acetyl Coeznyme-A synthesis (CoA), improves mitochondrial function, rescues brain function, increases lifespan and counteracts gene dysregulation, so is useful in Alzheimer's treatment. Vitamin B5 supplementation increases the production of the neurotransmitter acetylcholine from choline sources, as well as the neurotransmitters epinephrine and serotonin. It helps modulate cortisol levels produced in the adrenal glands, increasing coping mechanisms with stress and lessening depression.
100781 Vitamin B5 is converted Coenzyme-A (CoA),which is an essential cofactor in over 70 enzymatic pathways, including metabolizing amino acids to pyruvate to enter the Krebbs cycle for ATP synthesis. Energy generation for relief of Chronic Fatigue & ME being one of the crucial inventions. In one embodiment, the vitamin B5 could be Pantethine or Pantothenic Acid. The preferred form Pantethine is more bioavailable and shows higher efficacy.
100791 In another embodiment both Panthethine and Pantothenic acid are used. Pantethine creates twice as much CoA compared to Pantothenic Acid. Pantothenic acid also enhances adrenal function and modulates inflammation.
[0080] In one embodiment, the benefits of consuming 100 mg of vitamin B6 (P-5-P) include, but not limited to, treatment in severe casis of covid-19, mitigate covid-19 immune supression, prevent associated covi d-19 blood clotting & mortality and overall booting the immune response. In severe covid-19 patients, especially the elderly or those with underlying health conditions, vitamin B6 may prevent cytokine hypersecretion and blood clotting, improve endothelial integrity and prevent lymphopenia. It also promotes brain health and reduces cognitive decline in neurodegenerative disease, improves moods and combats depression. It promotes healthy red blood cell production, reduces risk of heart diseases, treats inflammation & arthritis and promotes eye health. In women it prevents nausea during pregnancy and relieves symptoms of premenstrual syndrome (PNIS). Vitamin B6 has anti-cancer properties as it is a potent antioxidant and modulates gene expression, so plays a multifaceted role in carcinogenesis. It is essential for mi tochondri al function and protects from oxidative stress. P-5-P (PLP) is the prefered form of of vitamin B6 over pyridoxine. P-5-P is more bioavailable and shows higher efficacy particularly w.r.t. neurodegeneration and the brain in general. P5P is a cofactor in making serotonin and the synthesis of dopamine from dopa. Deficiency is associated with the development of N1E/CFS and vitamin restoration significantly improves symptoms of disease, measured by the Fibro Fatigue Scale, and Quality of Life in patients.
[0081] In one embodiment, the benefits of consuming 1 mg of vitamin B7 (H Biotin) include, but not limited to, has anti-inflammatory properties and acts as an immunomodulator in T-cells It regulates gene expression and metabolism, and restores mitochondrial function in neurons is used in hemaglobin synthesis. Vitamin B7 also reverses mitochondrial dysfunction and treats and slows the progress of multiple sclerosis. Biotin (vitamin B7) is essential for human health because of its involvement, as a cofactor, in a variety of critical cellular metabolic reactions as well as heme synthesis for oxygenation & respiration. It also acts as an anti-inflammatory for dendritic cells (DCs) which play an important role in improving age-associated progressive decline in adaptive immune responses, loss of immune tolerance, and development of chronic inflammation.
100821 In one embodiment, the benefits of consuming 1 mg of vitamin B9 (MethylFolate) include, but not limited to, anti-viral properties including prevention of covid-19 via furin inhibition, increases resistance to infection, boosts the immune system, protects and supports the respiratory system, controls cytokine release & attendant inflammation to mitigate covid-19 mortality, and is also essential for haematopoesis and leukocyte production. It also reduces risk of cancer and promotes stem cell proliferation as well as neural crest stem cell development. Vitamin B9 is essential for mitochondri al translation prevents/treats mi toch on dri al disorders; increased levels are associated with longer telomeres and DNA methylation. Vitamin B9 prevents / treats ME/CFS and fibromyalgia via restoration of methylation function and the Krebs / citric acid cycle for energy production.
100831 Vitamin B9 aids in treating diseases such as schizophrenia, Alzheimer's, mania (mental illness), diabetic neuropathy, cardiovascular diseases, improves pregnancy outcomes and also prevents preterm birth, boosts immune system by increasing resistance to infections and combats depression, impacts cancer risk and is essential for one-carbon metabolism. It also increases resistance to infection and boosts immune system. It also has anti-viral properties and also protects and supports respiratory system. The vitamin B9 controls inflammation and also controls cytokine release. It also essential for the maintenance of Regulatory T Cells, to prevent autoimmunity.
100841 In one embodiment, the benefits of consuming 1 mg of vitamin B12 (Methylcobalamin) include, but not limited to, has therapeutic potential in covid-19 (coronavirus) and may help with acute respiratory distress syndrome. It also plays and supports in immune system regulation and improves T-cell function. Vitamin B 12 acts as chemoprevention and cytotoxicity, improves DNA health and telomere length, and also regulates DNA methylation and disease. In ME/CFS, Vitamin B12 supports methylation and methionine synthase, to alleviate methlyation cycle blocks and to support the conversion of homocysteine to methionine to improve smptoms of the disease.
[0085] Vitamin B12 plays an important role in immune system regulation. It also aids in producing red blood cells and preventing anemia, prevents major birth defects and support bone health and also prevent osteoporosis, reduces risk of macular degeneration and improve mood and symptoms of depression, improves brain health by preventing the loss of neurons and also improves heart health by decreasing homocysteine, and supports healthy skin, hair, and nails.
[0086] In one embodiment, the benefits of consuming 500 mg of Alpha GPC/CDP citicoline/choline bitartrate include, but not limited to, fights against covid-19 (coronvirus) and it is essential during pregnancy and also essential for anti-viral immunity and immune function. It protects against sepisis, also improves cholinergic system and acetylcholine function. Alpha GPC/CDP citicoline/choline bitartrate is also essential for macrophage response and treats Endotoxaemia. It also reduces the risk of carcinogenic, mitochondrial, and liver diseases and also combats mitochondrial dysfunction.
[0087] Alpha GPC/CDP citicoline/choline bitartrate is also essential in methylation and mitochondrial production of betaine, enhances growth hormone production, improves memory capacity, learning and focus, and also athletic performance. It also advances stroke recovery and benefits for epileptic patients.
[0088] In one embodiment, the benefits of consuming of a magnesium source such as Magnesium L-Threon ate include, but not limited to, improves morbidity in covid-19 patients and also improves the immune system. It also reduces the risk of cancer, such as breast cancer, colon cancer, lung cancer, and reduces magnesium linked to inflammation and carcinogenesis. It also essential for mitochondrial homeostasis, regulates and improves energy production, and also improves mitochondrial and cardiac function, cognitive function. Low red cell magnesium is a clinical manifestation of CFS, restoring magnesium in such patients successfully reduces symptoms of disease including improved energy, emotional state and a decrease in pain. Magnesium LThreonate improves learning skills and memory, sleep by controlling nerve activity in the brain.
[0089] In one embodiment, the benefits of consuming 250 mg of Resveratrol include, but not limited to, acts as an immunomodulator and an anti-coronavirus via Sirtuinl and mTOR, boosts immune activity, has anti-viral and antibacterial properties. It also protects from cytokine Storm and against ventilator induced lung damage and also protects T-Cells. It has respiratory anti-inflammatory and anti-fibrotic properties. Resveratrol protects the respiratory system and also respiratory anti-apoptotic effect. It also has substantial anti Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) & MERS-CoV activity.
[0090] Resveratrol has anti-cancer properties, induces cancer cell apoptosis, and reverses multi-drug resistance in cancer cells. It also aids in renewing and differentiating stem cells, activates Sirtl for stem cell maintenance, and also activates cardiac stem cells. Resveratrol improves myocardial regeneration and regeneration of mesenchymal stem cell aggregates, and also stem cell function in the treatment of damaged pancreas. It also promotes mitochondrial biogenesis via PGC-la, improves mitochondrial biogenesis and its function, and also induces mitochondrial biogenesis in endothelial (vascular) cells. Resveratrol prevents / treats post-viral fatigue, PVFS/ME/CFS by enhancing antioxidant status and improving hippocampal atrophy through enhancing neurogenesis and inhibiting cellular apoptosis. Resveratrol improves physical endurance, telomere length, reverses cellular senescence, ameliorates age-related metabolic disease, and also lengthen lifespan.
100911 Resveratrol aids in combating Type 1 & 2 diabetes, improves neuron function, heart health, and also prevents Alzheimer's disease. It has antioxidant properties and anti-cancer properties, treats parkinson's disease, alleviates liver disease, shows positive effect on cholesterol, and also lengthens lifespan. It has anti-viral activity against Epstein-Barr virus one of the main causes of PVES/A4E/CFS, inducing caspase-dependent apoptosis by arresting cell-cycle progression in G1 phase, and strongly induced apoptosis in EBV(-) and latency I EBV(+) cells.
100921 In one embodiment, the benefits of consuming 200 mg of Pterostilbene include, but not limited to, activates against SARS-CoV-2 and it has anti-viral and antimicrobial activities and it supports and protects respiratory system. It could help protect against acute lung injury via induction of heme oxygenase-1. The pterostilbene interacts with the C-terminal of Si domain on the spike glycoprotein found on SARS-CoV-2, with a greater affinity than hydroxychloroquine. The pterostilbene boosts immune response and fights against oxidative stress and inflammation and it also acts as an immunomodulator. Pterostilbene is a potent proteasome inhibitor that suppress expression of genes and production of inflammatory. It acts as a natural anti-cancer agent due to its antioxidant and antineoplastic properties and prevents/treats different cancers such as lung cancer, breast cancer, prostate cancer, hepatocellular melanoma, pancreatic cancers, and also treats colon. Pterostilbene suppresses generation of breast cancer cells and cervical cancer cells, and targets cancer stem cells. It has apoptotic activity against cancer and also non-apoptotic effects against cancer, inhibits telomerase for chemoprevention, and shows epigenetic regulation for chemoprevention. The pterostilbene has been found to be beneficial in improving the function of normal cells and inhibiting malignant cells.
[0093] It also aids in improving cholesterol levels, blood pressure, and blood sugar levels, improves insulin sensitivity and protects against diabetes and metabolic syndrome, reduces oxidative stress and the production of reactive oxygen species and boost weight loss, aids in improving eye health and preventing diseases related to neurological disease, for example, Alzheimer's, liver diseases, and arthritis, combats atherosclerosis and increases muscle mass and strength, and also has anti-cancer properties. It as a natural anti-cancer agent due to its antioxidant and antineoplastic properties 100941 In one embodiment, the benefits of consuming 250 mg of quercetin include, but not limited to, fights against coronavirus and inhibits SARS-3CL Protease Activity and SARS-CoV molecular docking. The quercetin modulates the cellular unfolded protein response (UPR). Coronaviruses utilizes the UPR to complete different stages of viral life cycle during infection. Thus, modulating the UPR could be an effective strategy to fight against the coronavirus. The quercetin reduces infectivity of target cells and replication in a wide variety of respiratory viruses such as HSV-1, HSV-2, AdV-3, AdV-8, AdV11, Coronavirus, SARS, parainfluenza type 3, HRSV, and rhinovirus. The quercetin has antibacterial effects have been exhibited amongst almost all bacterial strains including those in the digestive, respiratory, urinary and skin systems. It also reduces viral respiratory infection and effective in respiratory tract infections. Zinc ionophore activity of quercetin stops RdRp Replication of coronavirus in humans, boosts immune system, prevents/treats respiratory infection and also supports lungs, promotes cytokine modulation and protects from cytokine storm.
100951 Quercetin has anti-cancer properties and inhibits cancer cell cycle progression at low dose, shows synergistic action with other chemotherapy agents, and also induces cytotoxicity in Leukaemia and breast cancer cells. It also prevents/treats ovarian cancer and also suppresses prostate cancer & prevent metastasis.
100961 It also stimulates bone marrow stem cell proliferation and differentiation and also BMSc proliferation and differentiation via ERK and P38. Quercetin promotes proliferation and migration of neural stem cells, protects and modulates mitochondrial function & biogenesis, increases mitochondrial biogenesis and exercise endurance, attenuates mitochondria] dysfunction and biogenesis via AMPK/Sirtl, and also improves mitochondrial function in brain injury. It also increases brain mitochondrial biogenesis. Quercetin treats PVFS/MIE/CFS via enhancement of antioxidation and glutathione status, and alleviates associated vascular imparments and reduces inflammatory cytokines. It also has anti-viral activity against the Epstein-Barr virus -a major cause of PVES/ME/CFS.
100971 Quercetin also fights with free radicals arid reduces inflammation, prevents spread of cancerous cells and tumor growth, combats aging and lowers the risk of neurodegenerative disorders, exhibits both antibacterial and antiviral activity, thereby enhancing immunity and preventing infections, relieves from allergy and acts as a natural antihistamine by inhibiting release of histamine from mast cells, prevents heart related diseases and promotes healthy blood pressure and blood sugar, and stimulates brain and muscle mitochondrial biogenesis by endurance exercise.
100981 The combination of Resveratrol, Quercetin & Pterostilbene is highly synergistic, Giving greater efficacy than when used singly. Piperine substantially enhances bioavailability and efficacy of the combination.
100991 In one embodiment, the benefits of consuming 200 mg of taurine include, but not limited to, protects from cytokine storm and acts as an immunomodulator and has anti-coronavirus properties. The taurine controls immune inflammation and supports respiratory system and also promotes pathogen defense. The taurine has a beneficial molecule for stroke and cardiovascular disease and plays an important role in intracellular calcium levels. It promotes immunological defense in humans against pathogens including coronavirus through enhancing metabolism and functions of monocytes and macrophages. Taurine has anti-cancer properties and been shown to have activity against breast cancer and other tumours and fights against diabetes and promotes heart health. It also helps with depression and diabetes, boosts exercise performance, promotes eyes health, liver health, neuroprotective, and brain health, and also may exhibit antidepressant properties.
1001001 In one embodiment, the benefits of consuming 100 mg ofbetaine / trimethylglycine include, but not limited to, has anti-viral properties and anti-cancer properties and also acts as an immunomodulator and regulator. It also supports the respiratory system, reduces inflammation (anti-inflammatory), and also controls the immune system. Trimethylglycine treats high homocysteine, alleviates fatty liver and liver diseases, acts as cardioprotective, enhances exercise performance and mood and cognitive function of the brain. It also increases lean muscle mass and combats against diabetes.
1001011 Trimethylglycine aids in methlyation of DNA. Abbherant methylation is a major cause of cancer. Optimum DNA methylation triggers many epigenetic switches highly influential to longevity and anti-ageing. It also enhances the process of methylation to protect and treat mitochondrial dysfunction and PVFS/ME/CFS [00102] In one embodiment, the benefits of consuming 200 mg of baicalin (Baikal Skullcap Extract) include, but not limited to, has anti-coronavirus activity and fights against coronavirus and acts a SARS-CoV2 PLpro inhibitor. The baicalin has anti-viral and anti-microbial activities and also has anti-cancer properties. The anti-cancer effects down to ability for free radical scavenging, attenuation of NF-kB activity, modification of cell cycle gene expression, COX-2 gene expression control, and has anti-viral capabilities. The baicalin has potent anti-inflammatory and anti-oxidant properties and also neuroprotective effects. It has the ability of a chemical substance to prevent damage to the liver (hepatoprotective) and aids in treating liver problems, and also enhances mitochondrial function. Baicalin has anti-cancer properties and anti-tumor activity in gallbladder carcinoma, induces cancer cell apoptosis and inhibits proliferation, also promotes neural stem cell proliferation and differentiation, aids in stem cell transplantation, and also induces colon cancer apoptosis. It also protects from mitochondrial dysfunction and associated disorders. In one embodiment, the baicalin could be extracted from, but not limited to, Baikal skullcap plant. The baicalin reduces infectivity of target cells and replication in a wide variety of viruses including Epstein-Barr virus implicated in PVFS/ME/CFS, and has efficacy in PVFS/ME/CFS.
[00103] In one embodiment, the benefits of consuming 200 mg of L-Theanine include, but not limited to, boosts immune system function and aids in decreasing the incidence of upper respiratory tract infections. It also supports the respiratory system, enhances vaccine in elderly, fights with viral common cold, and also protects from influenza. The consumption of L-theanine is beneficial for people with high levels of anxiety and helps people to focus better during demanding tasks. It has anti-cancer properties and also lowers blood pressure, improves sleep quality, and helps in relieving sinusitis symptoms. L-Theanine promotes neural stem cell proliferation, differentiation, and neurogenesis, attenuates injury in neural stem cells & protects from cognitive impairment, increases mitochondrial function in Sertoli cells, and also prevents/treats hypertension. It is a powerful nootropic. In one embodiment, the L-theanine is an amino acid found most commonly in tea leaves and in small amounts in Bay Bolete mushrooms.
[00104] In one embodiment, the benefits of consuming 200 mg of alpha lipoic acid include, but not limited to, reduces covid-19 mortality and morbidity rates. It prevents coronavirus entry via main protease inhibition and alleviates Dyspnoea and respiratory symptoms affected due to covid-19 (coronavirus). The alpha lipoic acid boosts immune response and also prevents cytokine storm and respiratory distress. It acts as an immunomodulatory and supports the immune system by protecting from ROS and oxidative stress, as well as downregulates in autoimmune disorders. The alpha lipoic acid lowers inflammatory markers in patients suffering from metabolic syndrome and related disorders. It decreases oxidative stress, thus improves integrity of red blood cells and elevates glutathione levels for antioxidation, consequently preventing / treating disorders such as ME/CFS. The alpha lipoic acid has free radical scavenging properties, as well as a radical generator, are considered important as a potential use for cancer therapy. It has anti-cancer properties and also increases apoptosis of cancer cells. In addition, patients with pancreatic cancer were treated with a combination of low-dose naltrexone (LA-N) and ALA, which showed to have an improved effect on life expectancy. ALA inhibits initiation & promotion of carcinogenesis. The alpha lipoic acid increases stem cells, for example, mesenchymal stem cells (MSCs), which are contribute to tissue repair in vivo and form an attractive cell source for tissue engineering. It is essential for mitochondrial function, promotes Neuroproliferation after a stroke, increases mesenchymal stem cell survival and proliferation, enhances neural stem cell survival post-transplantation, alleviates suppressed osteogenic dysfunction, and also enhances cardiomyogenic stem cell differentiation.
[00105] It enhances life span and promotes longevity, weight loss, and helps to combat diabetes, promotes cognitive health and memory, protects neural tissue and reduce peroxidation via metals, which may benefit the pathophysiology of Alzheimer's, promotes healthy nerve function and lowers risk of heart diseases, and reduces inflammation and signs of aging. The alpha lipoic acid improves age-associated mitochondrial & cognitive dysfunction and age-associated decline in mitochondrial respiratory activity, mitochondrial function & running performance, protects mitochondrial enzymes, increases mitochondrial biogenesis and boosts energy, and also decreases the age-related oxidative mitochondrial decay.
1001061 In one embodiment, the benefits of consuming 200 mg of Acetyl-L-Carnitine (ALCAR) include, but not limited to, boosts immune health and has anti-viral and anti-bacterial properties. It also has anti-cancer properties and prevents cytokine storm. The Acetyl-L-Carnitine enhances mitochondrial function and energy production and reduces fatigue and also increases ambulatory activity. ALCAR is essential for transportaion of fatty acids into the mitochondria for energy generation, and has shown to improve symptoms of PVFS/ME/CFS including improvement in physical function, mental fatigue and cognitive status. It also improves brain function and aids weight loss, enhances heart health and exercise performance by increasing oxygen supply to muscles, and also reduces diabetic symptoms and improves male fertility.
[00107] It also prevents immune system dysfunction, prevents sepsis, shows protective effect in human lymphocytes, and has anti-cancer properties. ALCAR has successfully inhibited angiogenesis by downregulating vessel growth factors related to cancer cells, enhances mesenchymal stem cell neurogenesis, increases telomere length and telomerase activity and methylation, modulate stem cell differentiation via mitochondrial metabolism, and also promotes bone-marrow-derived mesenchymal stem cell production. It also increases telomerase activity in mesenchymal stem cells, restores mitochondrial function and ambulatory activity, boosts mitochondrial function and also prevents/treats cardiovascular disease, regulates mitochondrial homeostasis in the brain, and also enhances mitochondrial function.
[00108] The Acetyl-L-Carnitine improves mitochondrial function and energy production and reduces fatigue and also increases ambulatory activity. Curcumin increases the antioxidant capacity of the body, improves brain function, lowers the risk of heart disease, prevents & treats Alzheimer's disease, treats symptoms of arthritis, fights depression, helps delay aging and fights against age-related chronic diseases [00109] In one embodiment, the benefits of consuming 300 mg of N-Acetyl Cysteine (NAC) include, but not limited to, improves covid-19 morbidity, reduces oxidative stress associated with covid-19, increases lung glutathione, reduces respiratory blood clot and incidence of chronic obstructive pulmonary disease (COPD), and also improves of respiratory function. It also reduces rate of COPD exacerbations, modulates inflammation in COPD patients, increases antioxidant capacity in COPD, reduces COPD adhesions and symptom severity in COPD, and also decreases lung function decline in COPD. N-Acetyl Cysteine also alleviates chronic bronchitis, reduce sick days associated with bronchitis, may help with viral pneumonia, and also blocks HIV in acute and chronic infection.
[00110] It acts as an antioxidant, prevents and treats kidney and liver damages, improves fertility, and also improves psychiatric disorders and addictive behavior. N-Acetyl Cysteine also stabilizes blood sugar, improves cognition and prevents and treats neurological disease, influenza, and pneumonia and also reduce heart disease risk, liver and kidney damages It also improves psychiatric disorders and addictive behavior, improves cognition and prevents/treats neurodegenerative disease, improves male and female fertility, prevents / treats 1VIE/CFS, and also stabilizes blood sugar and improve insulin resistance.
[00111] In one embodiment, the benefits of consuming 200 mg of Ginkgo Biloba extract include, but not limited to, boosts anti-viral and immune system and protects respiratory system and also prevents lung fibrosis. It also controls lung inflammation and aids in treating chronic obstructive pulmonary disease and also beneficial in acute lung injury. The Ginkgo biloba has potent antioxidant and immunostimulatory properties. It also possesses inhibitory effects on various human and animal cancer cells. It has anti-cancer anti-proliferative properties. It also has proven efficacy against ME / CFS. Ginkgolic acids some of the main active constituents of Ginkgo Biloba extracts inhibits fusion of enveloped viruses of all three classes of fusion proteins including HIV, Ebola virus (EBOV), influenza A virus (IAV) and Epstein-Barr virus (EBV), as well as inhibiting HSV-1 (Herpes Simplex Virus 1) and ZIKV (Zika virus), an RNA virus 1001121 It also neutralizes the damage effects of free radicals and oxidative damage, thereby promoting longevity, prevents / treats ME/CFS by reducing oxidative stress in cells, fights against inflammation and promotes heart and circulatory health, supports neurotransmitter, neurogenesis, and neuroprotection and also increases hippocampal (brain) cell proliferation by up to 80%, which is more potent with the addition of quercetin, enhances cognition and alleviates Alzheimer's and dementia, reduces anxiety and depression and also enhances memory and learning, supports eye health and vision, and also treats headaches and migraines, promotes lung health and improves symptoms of asthma and other inflammatory respiratory diseases like chronic obstructive pulmonary disease (COPD), treats both the physical and psychological symptoms of premenstrual syndrome (PM S), and also improves sexual health and libido and treats sexual dysfunction.
1001131 In one embodiment, the benefits of consuming 150 mg of EGCG from green tea extracts include, but not limited to, acts as an Immunostimulatory, decreases incidence of influenza, anti-viral against RNA viruses, and also promotes lymphocyte proliferation and differentiation. It also promotes macrophage phagocytosis, enhances anti-infective cytokine production, improves influenza mortality outcomes, and effective against ssRNA (+) viruses including covid-19 (coronavirus). It acts as an immunomodulator, protects immune cells from inflammation and oxidative stress, and also reduces incidence and severity of flu. EGCG also reduces oxidative stress and lipid peroxidation, and has shown to improve biocheial and behavioural parameters in ME/CFS. In one embodiment, green tea extract various grades include, but not limited to, 95% Polyphenols, 98% Polyphenols, 80% Catechins, 50% EGCG. EGCG inhibits Epstein-Barr virus (EBV) spontaneous lytic infection at the DNA, gene transcription and protein levels and can improve certain ME/CFS pathology.
[00114] In one embodiment, the benefits of consuming 100 mg of Methylliberine include, but not limited to, boost energy without side effects of caffeine, enhances mood, focus, and motivation and improves performances. Exerts effects on dopamine receptor and adenosine inhibition to increase cellular energy with limited side effects. Successfully crosses the blood brain barrier and activates neurons.
[00115] In one embodiment, the benefits of consuming 100 mg of Theacrine include, but not limited to, stimulate adenosine and dopaminergic signalling similar to caffeine, antinociceptive, increase alertness and may reduce stress. It also protects from oxidative stress and has anti-inflammatory properties.
[00116] In one embodiment, the benefits of consuming 200 mg of Pomegranate Extract (with Ellagic Acid) include, but not limited to, has anti-viral and anti-bacterial properties and anti-inflammatory effect. It also protects from oxidative stress immune system antioxidant effects, blocks RNA virus replication, protects lungs from inflammation and fibrosis. Ellagic Acid (EA) enhances mucosal immunity, EA and gallic acid (GA) reduces acute lung injury (ALT) Pro-inflammatory cytokine damage, decreases airway inflammation, may help with sepsis. It also increases antioxidant enzymes and the GA protects against pulmonary fibrosis and COPD, promotes cytokine modulation, and also protects respiratory system, treats lung inflammation, and also cytokine storm.
[00117] In one embodiment, the benefits of consuming 200 mg of curcumin include, but not limited to, has anti-coronavirus activity and anti-viral activity and also inhibits covid-19 protease. The curcumin has potent antiviral activities against SARS-Coronavirus via inhibiting 3CL protease. It also boosts immune system and helps fight free radicals and prevents oxidative stress to cells and also binds to SARS-CoV-2 RBD of S-protein. The curcumin has potent antiviral effects, supports and protects respiratory system, and it also prevents cytokine storm. Curcumin may be a potential therapy for patients with severe viral infections, to help tackle the cytokine storm. It fights against several viruses such as Parainfluenza virus type 3 (PIV-3), Feline infectious peritonitis virus (FLPV), Vesicular stomatitis virus (VSV), Herpes simplex virus (HSV), Flock house virus (FHV), and Respiratory syncytial virus (RSV).
[00118] It also boosts immune health and has anti-viral and anti-bacterial and anti-inflammatory properties. It also prevents cytokine storm and has anti-cancer properties. Curcumin has been studied as a beneficial herb in cancer treatment and contributes to the death of cancerous cells, reduces angiogenesis (growth of new blood vessels in tumors), and also reduce metastasis (spread of cancer). In one embodiment, 95% Curcumin is extracted from, but not limited to, turmeric. Curcumin has potent antioxidant and anti-inflammatory effects, alleviating symptoms of ME/CFS, as well as being extremely potent in inhibiting Epstein-Barr virus activity.
100119] In one embodiment, the benefits of consuming 150 mg of olive leaf extract (with oleuropein + hydroxytyrosol) include, but not limited to, has antimicrobial activities and acts as an immunomodulator. It also protects the respiratory tract, increases interferon production in T NK Cells, stimulates phagocytosis, and enhances innate immunity. It also shortens symptoms of common cold, inhibits viral replication in respiratory tract, and acts as a cardioprotective by increasing nitric oxide. It also has anti-cancer properties and also supports respiratory system. Oleuropein and derivatives such as elenolic acid have been effective in vitro and animal studies against many microorganisms such as retroviruses, influenza, parainfluenza 3 in animal models, and bacteria. Plus has potent antioxidant and anti-inflammatory effects, illustrated by its very high ORAC score (a measure of anti-oxidant activity), alleviating symptoms of ME/CFS, as well as being effective in inhibiting Epstein-Barr virus activity.
100120] In one embodiment, the benefits of consuming 200 mg of Lions mane mushroom (with polyaccharides) include, but not limited to, acts as an immunomodulator and immunostimulatory. It also improves immune system function and has anti-microbial properties. Polysaccharides most important as immune stimulator, particularly in the intestinal tract for innate immunity. It is rich in active constituents of diterpenoid compounds, steroids, polysaccharides and other functional ingredients.
100121] In one embodiment, the benefits of consuming 250 mg of 50% Chlorogenic Acid, which could be extracted from the green coffee beans include, but not limited to, boosts the immune system, prevents fatigue, controls weight and obesity, and also has anti-viral and antibacterial activities. It acts as hepatoprotective, cardioprotective anti-inflammatory and neuroprotective. It also protects from respiratory viruses, promotes immune cell activation & proliferation, enhances immune cell surveillance, and also enhances immune cell killing capabilities. It may help treats influenza and alleviates lung inflammation. Chlorogenic Compounds from coffee beans exert activity against respiratory viruses. It could change gene expression and that the responsive genes involved in immune pathways had been significantly upregulated. Chlorogenic acid is an important and biologically active dietary polyphenol, playing several important and therapeutic roles such as antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, antimicrobial, anti-hypertension, free radicals scavenger and a central nervous system (CNS) stimul ator.
1001221 In one embodiment, the benefits of consuming 15 mg of elemental zinc from Zinc Picolinate /Oxide /Gluconate/ Citrate include, but not limited to, protects against respiratory infection and common cold, decreases incidence infection in elderly, and also inhibits coronavirus replication in Vitro. It stops RDRP replication of coronavirus in humans. It shows deficiency compromises immune health, inhibits viral replication and spread, developments and functions innate immunity, growths, developments and function of lymphocytes. It also reduces other infections Diarrhoea & UTI and also reduces incidence & duration resp tract infections and pneumonia.
100123] Zinc Picolinate/Oxide/Gluconate/Citrate has anti-cancer properties and also stabilizes and repairs DNA, and also prevents and treats oesophageal cancer. It promotes stem cell proliferation and differentiation into neurons, enhances stem cell thearapy for liver fibrosis, and also enhances cellular energy. The role of zinc in cancer has received increasing attention as a link between zinc deficiency and cancer has now been established in human studies and it is an essential element required for cell division, migration, and proliferation. Deficiency is linked to NIE/CFS, and administration increases antioxidant status, decreases oxidative stress thus treats symptoms of the disease.
1001241 In one embodiment, the benefits of consuming 15 mg of Piperine include, but not limited to, acts as an immunomodulator and also has anti-cancer properties. Piperine has been reported to inhibit the proliferation and survival of many types of cancer cells. It also has anti-viral and anti-inflammatory properties. It also prevents oxidative stress, thereby enhancing health and also ability to fight inflammation, improves cognitive and neurological health and brain function, as well as protect from the neurodegenerative disease, improves blood sugar metabolism and combat diabetes and also regulates cholesterol, inhibits proliferation and survival of many types of cancer cells, and also increases the absorption of essential nutrients and plant compounds, thereby boosting nutrient absorption and gut health. In one embodiment, the Piperine is extracted from black pepper.
1001251 In one embodiment, the benefits of consuming 5000 mg of D-ribose include, but not limited to, binds to various nucleic acids that allows these nucleic acids to act as energy intermediates (NADH, FADH, and ATP) or to form the structural basis of DNA and RNA. D-Ribose, a critical building block for nucleotides, plays an important role in energy metabolism, transcription, translation, and second messenger systems. It promotes immune cell differentiation and function, essential for mitochondrial function, and also enhances mitochondrial function. D-Ribose prevents / treats fibromyalgia and PFVS/MiE/CFS via reversing mitochondrial dysfunction, imparied cellular metabolism and enhancing ATP synthesis. It also enhances ATP recovery and reduces cellular injury and also prevents/treats chronic fatigue syndrome and fibromyalgia.
[00126] In one embodiment, the benefits of consuming 100 mg of Shilajit include, but not limited to, stimulates innate immune response, stimulates humoral and cellular immune response. It acts as an immunomodulator and has anti-viral and anti-cancer properties and also promotes cancer therapies and treatments. Shilajit has anti-cancer properties and also reduces anti-cancer drug side effects via antioxidant and by reducing inflammation. Shilajit can prevent / treat CFS/ ME via modulation of the hypothalamic pituitary adrenal (HPA) axis and preservation of mitochondiral function and integrity. Shilajit is a potent rejuvenator and having adaptogenic action. It also induces cancer cell apoptosis and inhibits proliferation, stimulates mesenchymal stem cell differentiation, and also treats osteoporosis and chronic fatigue syndrome by altering mitochondrial bioenergetics. It has anti-inflammatory properties and also prevents chronic inflammatory diseases and reduces muscle fatigue. In one embodiment, the shilajit includes fulvic acid and humic acid.
[00127] In one embodiment, the benefits of consuming 150 mg of Adenosine disodium triphosphate include, but not limited to, helps mitochondrial production of ATP (energy).
[00128] In one embodiment, the benefits of consuming 100 mg of L-carnosine include, but not limited to, enhances immune system response, acts as an immunoregulatory and promotes tissue repair, and also protects from immune dysfunction. It has anti-cancer properties and inhibits human gastric cancer by altering mitochondrial bioenergetics. L-carnosine alters mitochondrial bioenergetics, stimulates hemopoietic stem cells, and also prevents and treats chronic fatigue syndrome via scavenging free radicals in nervous tissue It acts as a neuroprotective against neurodegeneration [00129] Although a single embodiment of the invention has been described in the above detailed description, it will be understood that the invention is not limited to the embodiment developed herein, but is capable of numerous rearrangements, modifications, substitutions of parts and elements without departing from the spirit and scope of the invention.
[00130] The foregoing description comprises illustrative embodiments of the present invention. Having thus described exemplary embodiments of the present invention, it should be noted by those skilled in the art that the within disclosures are exemplary only, and that various other alternatives, adaptations, and modifications may be made within the scope of the present invention. Merely listing or numbering the steps of a method in a certain order does not constitute any limitation on the order of the steps of that method. Many modifications and other embodiments of the invention will come to mind to one skilled in the art to which this invention pertains having the benefit of the teachings presented in the foregoing descriptions. Although specific terms may be employed herein, they are used only in generic and descriptive sense and not for purposes of limitation. Accordingly, the present invention is not limited to the specific embodiments illustrated herein.

Claims (69)

  1. CLAIMSWhat is claimed is 1 A chemo-preventative and cytotoxic formulation for treating coronavirus and other infections, cancer, PVFS/ME/CFS, fibromyalgia, improving immune, mitochondrial, stem cell and brain function, and reversing epigenetic aging, in an individual, comprising: Ni cotin ami de Mononucl eoti de (NMN), Ni cotin am i de Adenine Dinucleotide (NAD), Pyrroquinoline Quinone (PQQ), Coenzyme Q10 (C0Q10), Piperine (black pepper extract), vitamin B7 (Biotin), vitamin B9, and vitamin B12.
  2. 2 The formulation of claim 1, further comprises Vitamin B1
  3. 3. The formulation of claim 2, wherein the composition further comprises Vitamin BI in the amount of about 10 mg to 300 mg.
  4. 4. The formulation of claim 2, wherein the composition further comprises Vitamin B I in the amount of about 100 mg.
  5. 5. The formulation of claim 2, wherein the vitamin B1 is selected from at least any one of; Benfotiamine, Thiamine and Sulbutiamine.
  6. 6. The formulation of claim 1, further comprises Vitamin B5.
  7. 7. The formulation of claim 6, wherein the composition further comprises Vitamin B5 in the amount from about 25 mg to 350 mg.
  8. 8. The formulation of claim 6, wherein the composition further comprises Vitamin B5 in the amount of about 100 mg.
  9. 9. The formulation of claim 6, wherein the vitamin B5 is selected from at least any one of Pantethine, Pantothenic Acid, Pantothenol (Panthenol), Dexpanthenol and Calcium Pantothenate.
  10. 10. The formulation of claim 1, further comprises Vitamin B6.
  11. 11. The formulation of claim 10, wherein the composition further comprises Vitamin B6 in the amount from about 25 mg to 350 mg.
  12. 12. The formulation of claim 10, wherein the composition further comprises Vitamin B6 in the amount of about 100 mg.
  13. 13 The formulation of claim 10, wherein the vitamin B6 is selected from at least any one of, Pyridoxine, Pyridoxal, Pyridoxine 5'-phosphate (P5P) and Pyridoxal 5'-phosphate (PLP).
  14. 14. The formulation of claim 1, further comprises a methyl source, wherein the methyl source is selected from at least any one of, Betaine HC1, Betaine Anhydrous, Trimethylglcyine (TMG), Betaine Nitrate or Dimethylglycine (DMG).
  15. 15. The formulation of claim 14, wherein the composition further comprises methyl source in the amount from about 25 mg to 250 mg.
  16. 16. The formulation of claim 14, wherein the composition further comprises methyl source in the amount of about 100 mg.
  17. 17. The formulation of claim 1, further comprises choline and magnesium sources, and also flavourings and sweeteners.
  18. 18. The formulation of claim 17, wherein the choline source is selected from at least any one of, Alpha Glycerol Phosphoryl Choline (Alpha GPC), CDP Citicoline, Phosphatidyl Choline or Choline Bitartrate.
  19. 19. The formulation of claim 17, wherein the magnesium source is selected from at least any one of, Magnesium L-Threonate, Magnesium Orotate, Magnesium Citrate, Magnesium Taurate, Magnesium Bisglycinate, Magnesium Aspartate or Magnesium Lactate
  20. 20. The formulation of claim 17, wherein the composition further comprises the choline and magnesium sources in the amount ranges from about 100 mg to 1000 mg.
  21. 21. The formulation of claim 17, wherein the composition further comprises choline and magnesium sources in the amount of about 500 mg.
  22. 22. The formulation of claim 1, wherein the vitamin B9 is selected from at least any one of Folic Acid, L-5-Methyl tetrahydrofolate-Ca (calcium & non calcium salt of MethylFolate) and (6S)-5-methyltetrahydrofolate (glucosamine salt)
  23. 23 The formulation of claim 1, wherein the vitamin B12 is selected from at least any one of, Methylcobalamin, Adenocobalamin, Hydroxocobalamin, and Cyanocobalamin
  24. 24. The formulation of claim 1, is provided in at least any one or more forms include capsules, tablets, liquid, liposomal, micelle, phospholipid or topical form, softgels, drinks, powder, medical food, intravenous and an oral composition.The formulation of claim 1, wherein the composition comprises: nicotinamide mononucleotide (NMN) in the amount from about 100 mg to 1000 mg taken into four equal doses; nicotinamide adenine dinucleotide (MAD) in the amount from about 100 mg to 1000 mg; pyrroquinoline quinone (PQQ) in the amount from about 5 mg to 50 mg; coenzyme Q10 (CoQ10) in the amount from about 50 mg to 500 mg; piperine in the amount ranges from about 5 mg to 50 mg; vitamin B7 (Biotin) in the amount from about 0.25 mg to 5 mg, vitamin B9 (L-Methyl tetrahydrofolate-Ca) in the amount from about 0.25 mg to 5 mg, and vitamin B12 (Methylcobalamin) in the amount from about 0.
  25. 25 mg to 5 mg.
  26. 26. The formulation of claim 1, wherein the composition comprises: nicotinamide Mononucleotide (NMN) in the amount of about 750 mg; nicotinamide Adenine Dinucleotide (MAD) in the amount of about 250 mg; pyrroquinoline Quinone (PQQ) in the amount of about 20 mg; coenzyme Q10 (C0Q10) in the amount of about 200 mg; piperine in the amount of about 15 mg; vitamin B7 in the amount of about 1 mg, vitamin B9 in the amount of about 1 mg, and vitamin B12 in the amount of about 1 mg.
  27. 27. A chemo-preventative and cytotoxic formulation for treating coronavirus and other infections, cancer, PVESTME/CFS, fibromyalgia, improving immune, mitochondrial, stem cell and brain function, and reversing epigenetic aging, in an individual, comprising: Resveratol, Pterostilbene, Quercetin, Baikal Skullcap, L-Theanine, Curcuminoids (Turmeric Extract), Lion's Mane Mushrooms, vitamin B1, vitamin B2, vitamin B5, vitamin B6, Piperine and Zinc Complex.
  28. 28 The formulation of claim 27, wherein the composition comprises Resveratrol in the amount from about 100 mg to 1000 mg, Pterostilbene in the amount from about 100 to 750 mg; Quercetin in the amount from about 100 mg to 750 mg; Baikal Skullcap in the amount from about 50 mg to 500 mg; L-Theanine in the amount from about 50 mg to 500 mg; Curcuminoids (Turmeric Extract) in the amount from about 50 mg to 500 mg; Lion's Mane Mushrooms in the amount from about 100 mg to 1000 mg; vitamin B1 in the amount from about 20 mg to 250 mg; vitamin B2 in the amount from about 25 mg to 350 mg; vitamin B5 in the amount from about 50 mg to 500 mg, vitamin B6 in the amount from about 25 mg to 350 mg, Piperine in the amount from about 5 mg to 50 mg, and Zinc complex in the amount from about 5 mg to 50 mg elemental zinc.
  29. 29. The formulation of claim 27, further comprises D-ribose, and methyl source.
  30. 30. The formulation of claim 29, wherein the composition comprises D-Ribose in the amount from about 1 g to 10 g and methyl source in the amount from about 250 mg to 2500 mg.
  31. 31. The formulation of claim 29, wherein the composition further comprises D-Ribose in the amount of about 5000 mg and the methyl source in the amount of about 1000 mg.
  32. 32. The formulation of claim 27, wherein the zinc complex is selected from at least any one of Zinc Picolinate, Zinc Citrate, Zinc Gluconate, and Zinc Oxide.
  33. 33 The formulation of claim 29, wherein the methyl source is selected from at least any one of Betaine HC1, Betaine Anhydrous, Trimethylglcyine (TMG), Betaine Nitrate or Dimethylglycine (DNIG).
  34. 34. The formulation of claim 27, further comprises Taurine and Creatine.
  35. 35. The formulation of claim 34, wherein the creatine source is selected from at least any one of Creatine Monohydrate, Creatine Hydrochloride, Creatine Citrate, Creatine Magnesium Chel ate and Creatine Nitrate.
  36. 36. The formulation of claim 34, wherein the composition comprises Taurine in the amount ranges from about 150 mg to 1500 mg and creatine in the amount ranges from about 250 mg to 2500 mg.
  37. 37. The formulation of claim 34, wherein the composition further comprises Taurine in the amount of about 500 mg and creatine in the amount of about 1000 mg.
  38. 38. The formulation of claim 27, wherein the composition is provided in at least any one or more forms include capsules, tablets, liquid, liposomal, micelle, phospholipid or topical form, soft gels, drinks, powder, medical food, intravenous and an oral composition.
  39. 39. The formulation of claim 27, wherein the composition comprises Resveratrol in the amount of about 300 mg; Pterostilbene in the amount of about 200 mg; Quercetin in the amount of about 250 mg; Baikal Skullcap in the amount of about 200 mg; L-Theanine in the amount of about 250 mg; Curcuminoids (Turmeric Extract) in the amount of about 200 mg; Lion's Mane Mushrooms in the amount of about 200 mg; vitamin B1 in the amount of about 100 mg; vitamin B2 in the amount of about 150 mg; vitamin B5 in the amount of about 250 mg; vitamin B6 in the amount of about 100 mg, Piperine in the amount of about 15 mg, and Zinc complex in the amount of about 15 mg elemental zinc
  40. 40. A chemo-preventative and cytotoxic formulation for treating coronavirus and other infections, cancer, PVFS/ME/CFS, fibromyalgia, improving immune, mitochondrial, stem cell and brain function, and reversing epigenetic aging, in an individual, comprising: Alpha Lipoic Acid (ALA), Acetyl-L-Carnitine (ALCAR), N-Acetyl Cysteine (NAC), Ginkgo Biloba, Beta Glucans, Epigallocatechin 3-Gallate (EGCG), Green Tea Extract, Pomegranate Extract (incl. Ellagic Acid), Olive Leaf Extract (incl. Oleuropein and Hydroxytyrosol), Green Coffee Bean Extract (incl. Chlorogenic Acids), Theacrine and piperine.
  41. 41 The formulation of claim 40, wherein the composition further comprises Methylliberine in the amount from about 25 mg to 250mg
  42. 42. The formulation of claim 41, wherein the composition further comprises Nlethylliberine in the amount of about 100 mg.
  43. 43. The formulation of claim 40, wherein the composition further comprises Adenosine disodium triphosphate in the amount from about 100 mg to 1000 mg.
  44. 44. The formulation of claim 43, wherein the composition further comprises Adenosine disodium triphosphate in the amount of about 200 mg.
  45. 45. The formulation of claim 40, wherein the composition further comprises Shilajit (mineral pitch containing Humic & Fulvic Acids).
  46. 46. The formulation of claim 45, wherein the composition further comprises Shilajit (mineral pitch containing Humic & Fulvic Acids) in the amount from about 25 mg to 250mg.
  47. 47. The formulation of claim 45, wherein the composition further comprises Shilajit (mineral pitch containing Humic & Fulvic Acids) in the amount of about 100 mg.
  48. 48 The formulation of claim 40, wherein the composition comprises: Alpha Lipoic Acid (ALA) in the amount from about 50 mg to 500 mg; Acetyl-L-Carnitine (ALCAR) in the amount from about 50 mg to 500 mg; N-Acetyl Cysteine (NAC) in the amount from about 100 mg to 1000 mg; Beta Glucans in the amount from about 50 mg to 500 mg; EGCG in the amount from about about 50 mg to 500 mg; Green Tea Extract in the amount from about about 50 mg to 500 mg; Pomegranate Extract (incl. Ellagic Acid) in the amount from about 50 mg to 500 mg; Ginkgo Biloba in the amount from about 50 mg to 500 mg Olive Leaf Extract (incl. Oleurope n and Hydroxytyrosol) in the amount from about 50 mg to 500 mg, Green Coffee Extract (incl, Chlorogenic Acids) in the amount from about 50 mg to 500 mg; Theacrine in the amount from about 25 mg to 250 mg, and Piperine in the amount ranges from about 5 mg to 50 mg.
  49. 49. The formulation of claim 40, wherein the composition comprises: Alpha Lipoic Acid (ALA) in the amount of about 200 mg; Acetyl-L-Carnitine (ALCAR) in the amount of about 250 mg; N-Acetyl Cysteine (NAC) in the amount of about 300 mg; Beta Glucans in the amount of about 200 mg; EGCG in the amount of about 150 mg; Green Tea Extract in the amount of about 150 mg; Pomegranate Extract (incl. Ellagic Acid) in the amount of about 200 mg; Ginkgo Biloba in the amount of about 200 mg; Olive Leaf Extract (incl. Oleuropein and Hydroxytyrosol) in the amount of about 150 mg; Green Coffee Extract (incl. Chlorogenic Acids) in the amount of about 250 mg; Theacrine in the amount of about 100 mg, and Piperine in the amount of about 15 mg.
  50. 50. The formulation of claim 40, further comprises Vitamin BL
  51. 51. The formulation of claim 50, wherein the composition further comprises Vitamin B1 in the amount from about 25 mg to 250 mg.
  52. 52. The formulation of claim 50, wherein the composition further comprises Vitamin B1 in the amount of about 100 mg.
  53. 53 The formulation of claim 50, wherein the vitamin B1 is selected from at least any one of Benfotiamine, Thiamine and Sulbutiamine.
  54. 54. The formulation of claim 40, further comprises Vitamin B5.
  55. 55. The formulation of claim 54, wherein the composition further comprises Vitamin B5 in the amount from about 50 mg to 500 mg.
  56. 56. The formulation of claim 54, wherein the composition further comprises Vitamin B5 in the amount of about 200 mg.
  57. 57 The formulation of claim 54, wherein the vitamin B5 is selected from at least any one of, Pantethine, Pantothenic Acid, Pantothenol (Panthenol), Dexpanthenol and Calcium Pantothenate,
  58. 58 The formulation of claim 40, further comprises Vitamin B6.
  59. 59. The formulation of claim 58, wherein the composition further comprises Vitamin B6 in the amount from about 25 mg to 350 mg.
  60. 60. The formulation of claim 58, wherein the composition further comprises Vitamin B6 in the amount of about 100 mg.
  61. 61. The formulation of claim 58, wherein the vitamin B6 is selected from at least any one of Pyridoxine, Pyridoxal, Pyridoxine 5'-phosphate (P5P) and Pyridoxal 5'-phosphate (PLP).
  62. 62. The formulation of claim 40, further comprises Vitamin B7 Biotin.
  63. 63. The formulation of claim 62, wherein the composition further comprises Vitamin B7 Biotin in the amount from about 0.1 mg to 5 mg.
  64. 64. The formulation of claim 62, wherein the composition further comprises Vitamin B7 Biotin in the amount of about I mg.
  65. The formulation of claim 40, further comprises Vitamin B2
  66. 66. The formulation of claim 65, wherein the composition further comprises Vitamin B2 in the amount from about 25 mg to 250 mg.
  67. 67. The formulation of claim 65, wherein the composition further comprises Vitamin B2 in the amount of about 200 mg.
  68. 68. The formulation of claim 40, wherein the Beta glucans is selected from at least any one of, Mushrooms, Oat, Barley or Yeast.
  69. 69 The formulation of claim 40, is provided in at least any one or more forms include capsules, tablets, liquid, lipisomal, micelle, phospholipid or topical form, soft gels, drinks, powder, medical food, intravenous and an oral composition.
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