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GB2317109A - Therapeutic composition for the treatment and repair of connective tissue in mammals - Google Patents

Therapeutic composition for the treatment and repair of connective tissue in mammals Download PDF

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Publication number
GB2317109A
GB2317109A GB9617905A GB9617905A GB2317109A GB 2317109 A GB2317109 A GB 2317109A GB 9617905 A GB9617905 A GB 9617905A GB 9617905 A GB9617905 A GB 9617905A GB 2317109 A GB2317109 A GB 2317109A
Authority
GB
United Kingdom
Prior art keywords
repair
connective tissue
treatment
therapeutic composition
mammals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB9617905A
Other versions
GB2317109B (en
GB9617905D0 (en
Inventor
David Haythornthwaite
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FARMSENSE
Original Assignee
FARMSENSE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FARMSENSE filed Critical FARMSENSE
Priority to GB9617905A priority Critical patent/GB2317109B/en
Publication of GB9617905D0 publication Critical patent/GB9617905D0/en
Publication of GB2317109A publication Critical patent/GB2317109A/en
Application granted granted Critical
Publication of GB2317109B publication Critical patent/GB2317109B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A therapeutic composition comprises therapeutic quantities of glucosamine or salts thereof in combination with chondroitin sulphate and one or both of zinc sulphate and ascorbic acid.

Description

A Therapeutic Composition for the Treatment and Repair of Connective Tissue in Mammals.
The present invention relates to therapeutic compositions for the repair of connective tissue in humans and animals and, in particular, to compositions, which may be considered as food supplements, capable of promoting chondri protection, namely repair and replacement of human and animal connected tissue.
Both glucosamine and compounds thereof and chondroitin sulphate are known as chondri protection agents. They are known to enhance the building blocks of cartilage and at the same time inhibit degradation of these building blocks. Indeed, these substances are themselves used for the production of cartilage.
The useful summary of the current state of knowledge is provided by L R Bucci in Townsend Letters for Doctors - January 1994 pages 52 to 54.
Vetinary products are commercially available which incorporavte one or both of the above named compounds.
A therapeutic composition consisting of gluocosamine, chondroitin sulphate and optionally manganese ascorbate is disclosed in WO94/22453.
According to the present invention, a novel composition for the treatment and repair of connective tissue comprises of glucosamine or salts thereof in combination with chondoritin sulphate and one or both of zinc sulphate and ascorbic acid.
A preferred formulation is given in the following tables.
1. eMil Animal - (Canine/Feline etc).
1 1 Active Ingredient (ngg) Chondroitin Sulphate 400 I Glucosamine HCI 250 N-Acetyl-d-Glucosamine 125 11 D-Glucuronic Acid 125 Ascorbic Acid 50 11 Zn Sulphate 15 11 TOTAL 965.00 2. Equine
1 I Chondroitin Sulphate 200 Gluocosamine HCI 300 N-Acetyl-D-Glucosamine 150 l D-Glucuroinic Acid 150 Ascorbic Acid 30 Zn Sulphate 30 Total 860.00 The same animal product will be marketed in capsule form with the active ingredients listed above in an inert filler matrix of any suitable composition to make up the total to 1000. The product will be sold in granule form, again with enough filler to make the total up to 1000, for mixture into food stuffs.
The invention is not, however, limited to the precise quantities shown above. The amounts of the listed ingredients may vary widely from that shown. Moreover, as stated, N-Acetyl-d Glucosamine and D-Glucuronic acid may be omitted altogether and the glucosamine HCI may be replaced by any other suitable glucosamine salt.
Also, one of the ascorbic acid and zinc sulphate components may be omitted, if appropriate and one should, however, always be present as they serve as catalysts in the metabolic pathways whereby cartilage and related tissues are produced from the chondroitin sulphate and glucosamine building blocks.

Claims (2)

Claim
1. A therapeutic composition for the treatment and repair of connective tissue in mammals comprising therapeutic quantities of glucosamine or salts thereof in combination with chondroitin sulphate and one or both of zinc sulphate and ascorbic acid.
2. A therapeutic composition for the treatment and repair of connective tissue in mammals substantially as herein before described.
GB9617905A 1996-08-28 1996-08-28 A therapeutic composition for the treatment and repair of connective tissue in mammals Expired - Lifetime GB2317109B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9617905A GB2317109B (en) 1996-08-28 1996-08-28 A therapeutic composition for the treatment and repair of connective tissue in mammals

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9617905A GB2317109B (en) 1996-08-28 1996-08-28 A therapeutic composition for the treatment and repair of connective tissue in mammals

Publications (3)

Publication Number Publication Date
GB9617905D0 GB9617905D0 (en) 1996-10-09
GB2317109A true GB2317109A (en) 1998-03-18
GB2317109B GB2317109B (en) 2000-06-21

Family

ID=10799005

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9617905A Expired - Lifetime GB2317109B (en) 1996-08-28 1996-08-28 A therapeutic composition for the treatment and repair of connective tissue in mammals

Country Status (1)

Country Link
GB (1) GB2317109B (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0852946A3 (en) * 1996-11-29 1998-09-16 Gianfranco De Paoli Ambrosi Composition for cosmetic, pharmaceutical or dietetic use based on an amino-sugar and/or a polyhydroxylic acid
EP0979090A1 (en) * 1997-04-28 2000-02-16 Nutramax Laboratories, Inc. Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine
EP1075836A2 (en) * 1999-08-09 2001-02-14 Yaizu Suisankagaku Industry Co., Ltd. Skin care of food composition containing N-acetyl-glucosamine
US6632804B2 (en) 2000-04-28 2003-10-14 Ocean Nutrition Canada Limited Compositions useful in the treatment of diseases of connective tissues
JP2005232089A (en) * 2004-02-19 2005-09-02 Aloe Seiyaku Kk Orally administrable functional agent having bone quantity-increasing activity
JP2007238486A (en) * 2006-03-07 2007-09-20 Yaizu Suisankagaku Industry Co Ltd Method for producing tablet containing glucosamine, glucosamine-containing tablet and glucosamine-containing granule
WO2008157767A1 (en) 2007-06-21 2008-12-24 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage
US7485629B2 (en) 2002-10-16 2009-02-03 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treatment of joint damage
US7504387B2 (en) 2002-10-16 2009-03-17 Arthrodynamic Technologies, Animal Health Division, Inc. Glycosaminoglycan composition and method for treatment and prevention of interstitial cystitis
US7803787B2 (en) 2002-10-16 2010-09-28 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage by transmucosal administration
EP2886104A1 (en) 2013-12-11 2015-06-24 Patir, Suleyman An intra-articular gel
US9186375B2 (en) 2007-06-21 2015-11-17 Arthrodynamic Technologies, Animal Health Division, Inc. Glycosaminoglycan compositions in combination with stem cells

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0314835A1 (en) * 1987-10-19 1989-05-10 Mostafa S. Fahim Composition and process for promoting epithelial regeneration
WO1994022453A1 (en) * 1993-03-31 1994-10-13 Nutramax Laboratories, Inc. Aminosugar and glycosaminoglycan composition for the treatment and repair of connective tissue

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0314835A1 (en) * 1987-10-19 1989-05-10 Mostafa S. Fahim Composition and process for promoting epithelial regeneration
WO1994022453A1 (en) * 1993-03-31 1994-10-13 Nutramax Laboratories, Inc. Aminosugar and glycosaminoglycan composition for the treatment and repair of connective tissue

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0852946A3 (en) * 1996-11-29 1998-09-16 Gianfranco De Paoli Ambrosi Composition for cosmetic, pharmaceutical or dietetic use based on an amino-sugar and/or a polyhydroxylic acid
EP0979090A1 (en) * 1997-04-28 2000-02-16 Nutramax Laboratories, Inc. Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine
EP0979090A4 (en) * 1997-04-28 2000-10-18 Nutramax Lab Inc Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine
EP1075836A2 (en) * 1999-08-09 2001-02-14 Yaizu Suisankagaku Industry Co., Ltd. Skin care of food composition containing N-acetyl-glucosamine
EP1075836A3 (en) * 1999-08-09 2001-04-25 Yaizu Suisankagaku Industry Co., Ltd. Skin care of food composition containing N-acetyl-glucosamine
US6632804B2 (en) 2000-04-28 2003-10-14 Ocean Nutrition Canada Limited Compositions useful in the treatment of diseases of connective tissues
US7504387B2 (en) 2002-10-16 2009-03-17 Arthrodynamic Technologies, Animal Health Division, Inc. Glycosaminoglycan composition and method for treatment and prevention of interstitial cystitis
US8455458B2 (en) 2002-10-16 2013-06-04 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage
US9381211B2 (en) 2002-10-16 2016-07-05 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage
US7485629B2 (en) 2002-10-16 2009-02-03 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treatment of joint damage
US8580766B2 (en) 2002-10-16 2013-11-12 Arthrodynamic Technologies, Animal Health Division, Inc. Glycosaminoglycan composition and method for treatment and prevention of interstitial cystitis
US7803787B2 (en) 2002-10-16 2010-09-28 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage by transmucosal administration
JP2005232089A (en) * 2004-02-19 2005-09-02 Aloe Seiyaku Kk Orally administrable functional agent having bone quantity-increasing activity
US8871742B2 (en) 2004-12-17 2014-10-28 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage
JP2007238486A (en) * 2006-03-07 2007-09-20 Yaizu Suisankagaku Industry Co Ltd Method for producing tablet containing glucosamine, glucosamine-containing tablet and glucosamine-containing granule
US9186375B2 (en) 2007-06-21 2015-11-17 Arthrodynamic Technologies, Animal Health Division, Inc. Glycosaminoglycan compositions in combination with stem cells
WO2008157767A1 (en) 2007-06-21 2008-12-24 Arthrodynamic Technologies, Animal Health Division, Inc. Composition and method for treating connective tissue damage
US9937209B2 (en) 2007-06-21 2018-04-10 Arthrodynamic Holdings, Llc Glycosaminoglycan compositions in combination with stem cells
EP2170055B1 (en) * 2007-06-21 2023-07-05 Arthrodynamic Holdings, LLC Composition for use in treating connective tissue damage
EP2886104A1 (en) 2013-12-11 2015-06-24 Patir, Suleyman An intra-articular gel

Also Published As

Publication number Publication date
GB2317109B (en) 2000-06-21
GB9617905D0 (en) 1996-10-09

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Legal Events

Date Code Title Description
732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
732E Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977)
PE20 Patent expired after termination of 20 years

Expiry date: 20160827